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SUCKER INCREASES PREVALENCE OF EARLY CHILDHOOD ASTHMA
PAEDIATRIC RESPIRATORY REVIEWS (2006) 7S, S264–S272
VII. YOUNG INVESTIGATOR’S PRESENTATIONS F1/233 – Meta-analysis of inhaled corticosteriods and short term growth in asthmatic children Mandana Arshi, Rebecca J. Hill, Shahriar Shafiee and Peter S.W. Davies Children’s Nutrition Research Centre Paediatrics and Child Health Brisbane Australia
OBJECTIVE Inhaled corticosteriods (ICS) are the first-line therapy for many inflammatory disorders, including asthma. Concerns still exist regarding the safety of these drugs most specifically related to the potential for growth retardation in children. Therefore, this study aims to evaluate the short term effects of ICS on growth and their potential clinical implications by a review of the relevant literature.
F2/219 – Boiling baby soother/sucker increases prevalence of early childhood asthma B. Morass, U. Kiechl-Kohlendorfer and E. Horak Medical University, Department for Children and Adolescents, Innsbruck, Austria
INTRODUCTION The prevalence of asthma and related allergic disorders has increased considerably over the last several decades and it is likely that environmental and lifestyle factors may have influenced this rise. The aim of this study was to investigate the influence of lifestyle factors on the prevalence of asthma and wheezing in preschool children in Tyrol/ Austria.
METHODS METHODS Relevant key studies (1991–2005) with a total of 1972 subjects aged 1–13 years and a duration that allowed for potential confounding factors where required were selected and reviewed. Data were extracted from each study on exposure status, clinical outcome and study characteristics. The results of studies were quantified to a standard metric that allows the use of satirical techniques as a means of analysis. Effect size (ES) is calculated for each study by Meta-analysis by statistical package (SPSS software).
The parents of 4100 children (age 3 to 6 years) were asked to complete a questionnaire about respiratory symptoms and lifestyle-factors. Questions about symptoms targeted wheezing in the past 12 months (W12), doctor diagnosed asthma (DDA) and doctor diagnosed wheezy bronchitis (DWB). Questions regarding lifestyle factors included growing up with pets, living on a farm, number of siblings, attending daycare facility, smoking in the household, smoking during pregnancy, breast feeding for at least 4 months, use of a baby soother and frequency of boiling the baby soother or bottle sucker.
RESULTS
RESULTS
Examination of relevant retrospective and prospective data presented in studies on short term growth, dose not suggest a significant relationship between ICSs and growth suppression, however, a mild and transient growth suppression may occur in the first weeks of ICS administration.
1761 questionnaires were returned (51% female, 49% male). 3% of the children had DDA, 17.5% DWB and 14.1% W12. Growing up with pets or on a farm and visiting daycare facilities showed no significant influence on DDA, DWB and W12 in this age group. Having siblings reduced the prevalence of DDA (OR 0.5; 95% CI 0.3–1.0) as well as breast feeding for at least 4 months (OR 0.4; 95% CI 0.2– 0.7). Smoking during pregnancy (OR 2.1; 95% CI 1.1–4.0) as well as during the first year (OR 1.9; 95% CI 1.0–3.5) increased the prevalence of DDA only. As regards further lifestyle factors, the frequency of boiling the baby soother/sucker influenced the prevalence
CONCLUSIONS As ICS treatment appears to have transient effect on children’s growth; it is advised to monitor children’s growth during ICS treatment. DOI: 10.1016/j.prrv.2006.05.006 1526-0542/$ – see front matter ß 2006 Published by Elsevier Ltd.
YOUNG INVESTIGATOR’S PRESENTATIONS
of W12, DWB and DDA: W12 (OR 1.6; 95% CI 1.2–2.1), DWB (OR 1.4; 95% CI 1.1–1.9) DDA (OR 2.3; 95% CI 1.3– 4.1). Using a baby soother increased the prevalence of W12 (OR 1.5; 95% CI 1.1–2.0).
CONCLUSION Additionally to the well known lifestyle factors of breast feeding and smoking, our study shows that asthma prevalence in early childhood is influenced by frequent boiling of the baby soother / sucker, a factor not yet discussed in the literature. More studies are necessary to investigate whether frequent boiling is just a good indicator for a ‘‘clean’’ environment (hygiene-hypothesis) or whether there are other related undefined factors responsible for the increase in asthma prevalence.
S265
RESULTS The mean higher level of HsCRP (14.288.45 mg/L) measured during an acute exacerbation was significantly higher than the mean lower level (1.92 3.16 mg/L) in relief (p < 0.0001). The decrease of HsCRP from the higher level during the exacerbation to the lower level in relief was much more prominent in children with a low body mass index (p < 0.05). A reciprocal relationship was found between forced expiratory volume in 1 second (FEV1) and HsCRP values (p = 0.49): the cutoff HsCRP level for predicting an FEV1 >90% was 0.721 mg/L. This association remained significant after adjusting for age, gender, passive smoking, duration of asthma, body mass index, age at first symptoms of asthma and family history of asthma.
DOI: 10.1016/j.prrv.2006.04.131
CONCLUSION F3/294 – C-reactive protein levels: a measurement of airway inflammation in asthmatic children Miguel Glatstein1, R. Soferman2 and Y. Weisman3 1 Dana Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv Sackler Faculty of Medicine, Tel-Aviv University, Pediatrics, Tel Aviv, Israel; 2Dana Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv Sackler Faculty of Medicine, Tel-Aviv University, Pediatric Pulmonology Clinic, Tel Aviv, Israel; 3Dana Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv Sackler Faculty of Medicine, Tel-Aviv University, Bone Disease Unit, Tel Aviv, Israel
Raised HsCRP levels were significantly associated with respiratory impairment exhibited by clinical symptoms and decreased FEV1. DOI: 10.1016/j.prrv.2006.04.130
F4/290 – A novel standardized immunoperoxidase method to diagnosis respiratory infections diseases Debora C. Chong-Silva Catholic University of Parana Health Science, Curitiba, Brazil
BACKGROUND The use of airway inflammation markers should optimize treatment for asthma. Highsensitivity C-reactive protein (HsCRP) is an inflammatory marker known to be related to smoking, obesity, cardiovascular disease and non-allergic asthma in adults.
OBJECTIVE To verify respiratory viruses antigens in pulmonary tissue through of a novel standardized immunoperoxidase technique, in autopsied children for acute respiratory disease.
OBJECTIVE
METHODS
The current study was undertaken to determine whether HsCRP is related to respiratory symptoms and pulmonary function test findings in asthmatic children.
The novel immunoperoxidase method was applied in a hundred seventy seven autopsied pulmonary tissue of children whose died for acute respiratories diseases. Children with 28 days to 14 years old formed a Bank of Serious Respiratory Infections of Pathologic Anatomy Department of the Hospital de Clı´nicas of Federal University of Parana. A pool of respiratory viruses with Respiratory Sincycial Virus, Adenovirus and Influenza A and B and Parainfluenza 1, 2 and 3 was used as a primary antibodies, and dextrana polymer as a secundary antibodies. Three experts have been revised the histopathology diagnosis and immunohistochimestry.
METHODS HsCRP was measured in 63 asthmatic children aged 8 months to 12 years. The measurements were performed in 37 children during an episode of acute exacerbation, and 42 children were measured in relief of whom 16 children had been tested during the acute episode of exacerbation.
VII. YOUNG INVESTIGATOR’S PRESENTATIONS F1/233 – Meta-analysis of inhaled corticosteriods and short term growth in asthmatic children Mandana Arshi, Rebecca J. Hill, Shahriar Shafiee and Peter S.W. Davies Children’s Nutrition Research Centre Paediatrics and Child Health Brisbane Australia
OBJECTIVE Inhaled corticosteriods (ICS) are the first-line therapy for many inflammatory disorders, including asthma. Concerns still exist regarding the safety of these drugs most specifically related to the potential for growth retardation in children. Therefore, this study aims to evaluate the short term effects of ICS on growth and their potential clinical implications by a review of the relevant literature.
F2/219 – Boiling baby soother/sucker increases prevalence of early childhood asthma B. Morass, U. Kiechl-Kohlendorfer and E. Horak Medical University, Department for Children and Adolescents, Innsbruck, Austria
INTRODUCTION The prevalence of asthma and related allergic disorders has increased considerably over the last several decades and it is likely that environmental and lifestyle factors may have influenced this rise. The aim of this study was to investigate the influence of lifestyle factors on the prevalence of asthma and wheezing in preschool children in Tyrol/ Austria.
METHODS METHODS Relevant key studies (1991–2005) with a total of 1972 subjects aged 1–13 years and a duration that allowed for potential confounding factors where required were selected and reviewed. Data were extracted from each study on exposure status, clinical outcome and study characteristics. The results of studies were quantified to a standard metric that allows the use of satirical techniques as a means of analysis. Effect size (ES) is calculated for each study by Meta-analysis by statistical package (SPSS software).
The parents of 4100 children (age 3 to 6 years) were asked to complete a questionnaire about respiratory symptoms and lifestyle-factors. Questions about symptoms targeted wheezing in the past 12 months (W12), doctor diagnosed asthma (DDA) and doctor diagnosed wheezy bronchitis (DWB). Questions regarding lifestyle factors included growing up with pets, living on a farm, number of siblings, attending daycare facility, smoking in the household, smoking during pregnancy, breast feeding for at least 4 months, use of a baby soother and frequency of boiling the baby soother or bottle sucker.
RESULTS
RESULTS
Examination of relevant retrospective and prospective data presented in studies on short term growth, dose not suggest a significant relationship between ICSs and growth suppression, however, a mild and transient growth suppression may occur in the first weeks of ICS administration.
1761 questionnaires were returned (51% female, 49% male). 3% of the children had DDA, 17.5% DWB and 14.1% W12. Growing up with pets or on a farm and visiting daycare facilities showed no significant influence on DDA, DWB and W12 in this age group. Having siblings reduced the prevalence of DDA (OR 0.5; 95% CI 0.3–1.0) as well as breast feeding for at least 4 months (OR 0.4; 95% CI 0.2– 0.7). Smoking during pregnancy (OR 2.1; 95% CI 1.1–4.0) as well as during the first year (OR 1.9; 95% CI 1.0–3.5) increased the prevalence of DDA only. As regards further lifestyle factors, the frequency of boiling the baby soother/sucker influenced the prevalence
CONCLUSIONS As ICS treatment appears to have transient effect on children’s growth; it is advised to monitor children’s growth during ICS treatment. DOI: 10.1016/j.prrv.2006.05.006 1526-0542/$ – see front matter ß 2006 Published by Elsevier Ltd.
YOUNG INVESTIGATOR’S PRESENTATIONS
of W12, DWB and DDA: W12 (OR 1.6; 95% CI 1.2–2.1), DWB (OR 1.4; 95% CI 1.1–1.9) DDA (OR 2.3; 95% CI 1.3– 4.1). Using a baby soother increased the prevalence of W12 (OR 1.5; 95% CI 1.1–2.0).
CONCLUSION Additionally to the well known lifestyle factors of breast feeding and smoking, our study shows that asthma prevalence in early childhood is influenced by frequent boiling of the baby soother / sucker, a factor not yet discussed in the literature. More studies are necessary to investigate whether frequent boiling is just a good indicator for a ‘‘clean’’ environment (hygiene-hypothesis) or whether there are other related undefined factors responsible for the increase in asthma prevalence.
S265
RESULTS The mean higher level of HsCRP (14.288.45 mg/L) measured during an acute exacerbation was significantly higher than the mean lower level (1.92 3.16 mg/L) in relief (p < 0.0001). The decrease of HsCRP from the higher level during the exacerbation to the lower level in relief was much more prominent in children with a low body mass index (p < 0.05). A reciprocal relationship was found between forced expiratory volume in 1 second (FEV1) and HsCRP values (p = 0.49): the cutoff HsCRP level for predicting an FEV1 >90% was 0.721 mg/L. This association remained significant after adjusting for age, gender, passive smoking, duration of asthma, body mass index, age at first symptoms of asthma and family history of asthma.
DOI: 10.1016/j.prrv.2006.04.131
CONCLUSION F3/294 – C-reactive protein levels: a measurement of airway inflammation in asthmatic children Miguel Glatstein1, R. Soferman2 and Y. Weisman3 1 Dana Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv Sackler Faculty of Medicine, Tel-Aviv University, Pediatrics, Tel Aviv, Israel; 2Dana Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv Sackler Faculty of Medicine, Tel-Aviv University, Pediatric Pulmonology Clinic, Tel Aviv, Israel; 3Dana Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv Sackler Faculty of Medicine, Tel-Aviv University, Bone Disease Unit, Tel Aviv, Israel
Raised HsCRP levels were significantly associated with respiratory impairment exhibited by clinical symptoms and decreased FEV1. DOI: 10.1016/j.prrv.2006.04.130
F4/290 – A novel standardized immunoperoxidase method to diagnosis respiratory infections diseases Debora C. Chong-Silva Catholic University of Parana Health Science, Curitiba, Brazil
BACKGROUND The use of airway inflammation markers should optimize treatment for asthma. Highsensitivity C-reactive protein (HsCRP) is an inflammatory marker known to be related to smoking, obesity, cardiovascular disease and non-allergic asthma in adults.
OBJECTIVE To verify respiratory viruses antigens in pulmonary tissue through of a novel standardized immunoperoxidase technique, in autopsied children for acute respiratory disease.
OBJECTIVE
METHODS
The current study was undertaken to determine whether HsCRP is related to respiratory symptoms and pulmonary function test findings in asthmatic children.
The novel immunoperoxidase method was applied in a hundred seventy seven autopsied pulmonary tissue of children whose died for acute respiratories diseases. Children with 28 days to 14 years old formed a Bank of Serious Respiratory Infections of Pathologic Anatomy Department of the Hospital de Clı´nicas of Federal University of Parana. A pool of respiratory viruses with Respiratory Sincycial Virus, Adenovirus and Influenza A and B and Parainfluenza 1, 2 and 3 was used as a primary antibodies, and dextrana polymer as a secundary antibodies. Three experts have been revised the histopathology diagnosis and immunohistochimestry.
METHODS HsCRP was measured in 63 asthmatic children aged 8 months to 12 years. The measurements were performed in 37 children during an episode of acute exacerbation, and 42 children were measured in relief of whom 16 children had been tested during the acute episode of exacerbation.