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Bone density and functioning in postmenopausal women engaged in various physical exercises
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ABSTRACTS / Bone 43 (2008) S76–S93
human bone quality, particularly in the trabecular bone region where remodeling occurs initially. This technology can be used for instant and follow-up measurement of bone demineralization occurring during long-term space flights, and osteoporotic bone loss on Earth. [Supported by the National Space Biomedical Research Institute through NASA.] doi:10.1016/j.bone.2008.07.100
T23 Bone status in infants measured by axial transmission quantitative ultrasound (QUS): are all measurements equal? Winston Koo Wayne State University, Detroit, MI, USA Objectives: To determine the effect of 2 commercial ultrasound probes for speed of sound (SOS) measurements at multiple skeletal sites in infants and to determine the physiologic parameters that may affect the SOS. Methods: Healthy singleton infants with appropriate in utero growth studied prior to hospital discharge. A commercial multi-site QUS instrument (Sunlight Omnisense 7000S, Tel Aviv, Israel) and 2 manufacturer supplied probes (CS and CR) were used to measure SOS at mid left tibia and distal left radius. In vitro and in vivo CV for SOS measurement was Results: 183 infants (132 Black and 51 non-Black, 101 males) with BW 3229 +/− 733 (SD) g and gestation 38.4 +/− 2.9 weeks. At the radius, all SOS measurements were unsuccessful with CS probe (n = 49) and for 40 of 42 infants with CR probe. At the tibia, SOS measurements were successful for 162 of 180 (90%) infants using the CS probe and in 140 of 144 (97.2%) infants using the CR probe (p b 4.2% of the variance of SOS irrespective of probes. Conclusions: Commercial axial transmission QUS instrument can provide consistent SOS measurements in tibia but not radii in infants. Different probes have varied success rate and systematic differences in bone SOS measurements, and physiological effects on SOS measurements is also probe dependent. doi:10.1016/j.bone.2008.07.101
T24 Bone density and functioning in postmenopausal women engaged in various physical exercises Vladyslav Povoroznyuk, Oksana Slusarenko, M. Shachlina, R. Bannikova Institute of Gerontology AMS Ukraine, Kyiv, Ukraine Aim: Influence of physical exercises on bone density and functioning in postmenopausal women. Methods: 52 women of postmenopausal age were divided into five groups: 1) attending yoga class no less than 5 years, n = 8; 2) jogging no less than 5 years, n = 12; 3) former gymnastic champions with nearly 10–20-year sporting life, n = 10; 4) unengaged in any sports (control, n = 13); and 5) postmenopausal women (14.0 ± 2.2 years, n = 10) at around 65 years of age, suffering from osteoporosis and doing physical exercises with loads (1 kg weight). The women of the last group participated in this study during 6 months. All women were standardized by age, body weight and post menopause duration. Bone tissue measurements of speed of sound (SOS), broadband ultrasound attenuation (BUA), Stiffness index (STF), T and Z (SD) were performed by ultrasonic densitometry (“Achilles+).
Results: The SOS parameter values were (1526 ± 12.8; 1529 ± 5.1; 1534 ± 9.3; 1520 ± 8.4) in groups 1, 2, 3 and 4, respectively, and had no significant differences among study groups. The BUA value was higher in gr. 3 (113.7 ± 3.1) in comparison with gr. 4 (106 ± 1.4; p 0.05). In gr. 1 and gr. 2, this parameter was 0.0 ± 0.5 and 0.4 ± 0.3 (p N 0.05). Performance of physical exercises with loads against the background of calcium drugs intake by post-menopausal women led to the increase of SOS parameter after 6 months of exercising in comparison with its basal value (1497.3 ± 5.7 and 1501.3 ± 6.0, p N 0.05), while the values of BUA parameter remained almost unchanged (66.3 ± 1.9 and 71.7 ± 4.2). The Stf parameter was 66.3 ± 1.9 and 71.7 ± 4.2; Z (SD) changed from −0.8 ± 0.1 to −0.6 ± 0.1 (p b 0.05). Conclusion: Sports at young age and performance of physical exercises with loads lead to the increase of bone density indices at the postmenopausal period. doi:10.1016/j.bone.2008.07.102
T25 Associations between the metabolic syndrome and bone mineral density in Ukrainian women in postmenopausal period Vladyslav Povoroznyuk 1, Larisa Martynyuk 2, Mykola Shved 2, Nataliia Dzerovych 1, Volodymyr Vayda 1, Lilya Martyntyuk 2 1 Institute of Gerontology AMS Ukraine, Kyiv, Ukraine 2 I.Hobachevsky Ternopil State Medical University, Ternopil, Ukraine Aim: The purpose of our study was to reveal associations between components of the metabolic syndrome (MS) and bone mineral density (BMD) in postmenopausal women. Methods: The sample consisted of 47 postmenopausal women (age: mean = 62.1; S.D. = 1.2; duration of menopause: mean = 12.7; S.D. = 1.2). Women were considered to have the MS (according to IDF (2005 yr) criteria) if they had waist circumference N80 cm and two or more of the following abnormalities: hypertriglyceridemia 1.7 mmol/l; low high-density lipoprotein (HDL) cholesterol b 1.29 mmol/l; high blood pressure130/85 mm Hg or use of antihypertensive medication; high fasting glucose 5.6 mmol/l or use of antidiabetic medication (insulin or oral agents). Total body, lumbar spine, femoral neck, ulna radius bone mineral density (BMD) measured by dual-energy X-ray absoprtiometry were compared for the cohorts with the MS. Other parameters including age, weight, height, waist circumference, the level of glucose, lipids were taken into account. Data were analyzed using Statistical Package 6.0 (Statsoft). Results: Findings revealed that 28 (59.6 %) of these postmenopausal women had MS. 18 (64.3%) of them had 3 components of MS, 8 (28.6 %) had 4 components and 2 (7.1 %) had all of them. In patients with and without MS compared, BMD was lower in the former group at lumber spine (1,01 ± 0,03 and 1,17 ± 0.04, respectively; F = 10.2; p = 0.002), femoral neck (0,83 ± 0.02; 0.97 ± 0.03, respectively; F = 14.6; p = 0.0004), ulna radius (0.59 ± 0.02; 0.69± 0.02, respectively; F = 13.1; p = 0.0008), total body (1.03± 0.02; 1.16 ± 0.02, respectively; F = 20.5; p = 0.00005). Increasing quantity of the MS components in women during the postmenopausal period had a negative correlation with BMD at every site. Conclusions: Development of MS in postmenopausal women increases the risk for the negative changes in BMD (such as osteopenia and osteoporosis). Furthermore, postmenopausal women need observation to prevent the development osteoporotic fractures. doi:10.1016/j.bone.2008.07.103
ABSTRACTS / Bone 43 (2008) S76–S93
human bone quality, particularly in the trabecular bone region where remodeling occurs initially. This technology can be used for instant and follow-up measurement of bone demineralization occurring during long-term space flights, and osteoporotic bone loss on Earth. [Supported by the National Space Biomedical Research Institute through NASA.] doi:10.1016/j.bone.2008.07.100
T23 Bone status in infants measured by axial transmission quantitative ultrasound (QUS): are all measurements equal? Winston Koo Wayne State University, Detroit, MI, USA Objectives: To determine the effect of 2 commercial ultrasound probes for speed of sound (SOS) measurements at multiple skeletal sites in infants and to determine the physiologic parameters that may affect the SOS. Methods: Healthy singleton infants with appropriate in utero growth studied prior to hospital discharge. A commercial multi-site QUS instrument (Sunlight Omnisense 7000S, Tel Aviv, Israel) and 2 manufacturer supplied probes (CS and CR) were used to measure SOS at mid left tibia and distal left radius. In vitro and in vivo CV for SOS measurement was Results: 183 infants (132 Black and 51 non-Black, 101 males) with BW 3229 +/− 733 (SD) g and gestation 38.4 +/− 2.9 weeks. At the radius, all SOS measurements were unsuccessful with CS probe (n = 49) and for 40 of 42 infants with CR probe. At the tibia, SOS measurements were successful for 162 of 180 (90%) infants using the CS probe and in 140 of 144 (97.2%) infants using the CR probe (p b 4.2% of the variance of SOS irrespective of probes. Conclusions: Commercial axial transmission QUS instrument can provide consistent SOS measurements in tibia but not radii in infants. Different probes have varied success rate and systematic differences in bone SOS measurements, and physiological effects on SOS measurements is also probe dependent. doi:10.1016/j.bone.2008.07.101
T24 Bone density and functioning in postmenopausal women engaged in various physical exercises Vladyslav Povoroznyuk, Oksana Slusarenko, M. Shachlina, R. Bannikova Institute of Gerontology AMS Ukraine, Kyiv, Ukraine Aim: Influence of physical exercises on bone density and functioning in postmenopausal women. Methods: 52 women of postmenopausal age were divided into five groups: 1) attending yoga class no less than 5 years, n = 8; 2) jogging no less than 5 years, n = 12; 3) former gymnastic champions with nearly 10–20-year sporting life, n = 10; 4) unengaged in any sports (control, n = 13); and 5) postmenopausal women (14.0 ± 2.2 years, n = 10) at around 65 years of age, suffering from osteoporosis and doing physical exercises with loads (1 kg weight). The women of the last group participated in this study during 6 months. All women were standardized by age, body weight and post menopause duration. Bone tissue measurements of speed of sound (SOS), broadband ultrasound attenuation (BUA), Stiffness index (STF), T and Z (SD) were performed by ultrasonic densitometry (“Achilles+).
Results: The SOS parameter values were (1526 ± 12.8; 1529 ± 5.1; 1534 ± 9.3; 1520 ± 8.4) in groups 1, 2, 3 and 4, respectively, and had no significant differences among study groups. The BUA value was higher in gr. 3 (113.7 ± 3.1) in comparison with gr. 4 (106 ± 1.4; p 0.05). In gr. 1 and gr. 2, this parameter was 0.0 ± 0.5 and 0.4 ± 0.3 (p N 0.05). Performance of physical exercises with loads against the background of calcium drugs intake by post-menopausal women led to the increase of SOS parameter after 6 months of exercising in comparison with its basal value (1497.3 ± 5.7 and 1501.3 ± 6.0, p N 0.05), while the values of BUA parameter remained almost unchanged (66.3 ± 1.9 and 71.7 ± 4.2). The Stf parameter was 66.3 ± 1.9 and 71.7 ± 4.2; Z (SD) changed from −0.8 ± 0.1 to −0.6 ± 0.1 (p b 0.05). Conclusion: Sports at young age and performance of physical exercises with loads lead to the increase of bone density indices at the postmenopausal period. doi:10.1016/j.bone.2008.07.102
T25 Associations between the metabolic syndrome and bone mineral density in Ukrainian women in postmenopausal period Vladyslav Povoroznyuk 1, Larisa Martynyuk 2, Mykola Shved 2, Nataliia Dzerovych 1, Volodymyr Vayda 1, Lilya Martyntyuk 2 1 Institute of Gerontology AMS Ukraine, Kyiv, Ukraine 2 I.Hobachevsky Ternopil State Medical University, Ternopil, Ukraine Aim: The purpose of our study was to reveal associations between components of the metabolic syndrome (MS) and bone mineral density (BMD) in postmenopausal women. Methods: The sample consisted of 47 postmenopausal women (age: mean = 62.1; S.D. = 1.2; duration of menopause: mean = 12.7; S.D. = 1.2). Women were considered to have the MS (according to IDF (2005 yr) criteria) if they had waist circumference N80 cm and two or more of the following abnormalities: hypertriglyceridemia 1.7 mmol/l; low high-density lipoprotein (HDL) cholesterol b 1.29 mmol/l; high blood pressure130/85 mm Hg or use of antihypertensive medication; high fasting glucose 5.6 mmol/l or use of antidiabetic medication (insulin or oral agents). Total body, lumbar spine, femoral neck, ulna radius bone mineral density (BMD) measured by dual-energy X-ray absoprtiometry were compared for the cohorts with the MS. Other parameters including age, weight, height, waist circumference, the level of glucose, lipids were taken into account. Data were analyzed using Statistical Package 6.0 (Statsoft). Results: Findings revealed that 28 (59.6 %) of these postmenopausal women had MS. 18 (64.3%) of them had 3 components of MS, 8 (28.6 %) had 4 components and 2 (7.1 %) had all of them. In patients with and without MS compared, BMD was lower in the former group at lumber spine (1,01 ± 0,03 and 1,17 ± 0.04, respectively; F = 10.2; p = 0.002), femoral neck (0,83 ± 0.02; 0.97 ± 0.03, respectively; F = 14.6; p = 0.0004), ulna radius (0.59 ± 0.02; 0.69± 0.02, respectively; F = 13.1; p = 0.0008), total body (1.03± 0.02; 1.16 ± 0.02, respectively; F = 20.5; p = 0.00005). Increasing quantity of the MS components in women during the postmenopausal period had a negative correlation with BMD at every site. Conclusions: Development of MS in postmenopausal women increases the risk for the negative changes in BMD (such as osteopenia and osteoporosis). Furthermore, postmenopausal women need observation to prevent the development osteoporotic fractures. doi:10.1016/j.bone.2008.07.103