Bone mass in adult premenopausal women with two levels of physical activity

ABSTRACTS / Bone 40 (2007) S1–S17

This results is a another piece of evidence that NaF and MFP has different action mechanism on bone. doi:10.1016/j.bone.2006.12.026

Hip fracture incidence in women members of a closed health system Claus-Hermberg H, Lozano Bullrich MP, Ilera V, Malter Terrada J, Pozzo MJ. Hospital Alemán, Buenos Aires, Argentina Division of Endocrinology and Metabolism Division of Orthopedics and Traumatology. Hip fracture incidence varies according to demographic and geographic characteristics of the studied populations. This study contemplates the incidence of hip fractures (HF) in women affiliated to a closed health system (Hospital Alemán, Buenos Aires) over a period of 11 years (1/1/94–31/12/04). A total of 183 HF in 75766/person /year were observed, which represents an incidence of 2.41HF/1000 person/year. Mean age was 77.4 ± 8.5 years. Age adjusted incidence was 50–60 years: 0.21; 61– 70 years: 1.04; 71–80 years: 5.55; >80: 22.03 HF/1000 person/ year. Annual incidence variability (range 1.52–3.91 HF/1000 person/year) was not significant (Chi2 > 0.15) and did not show a trend. Nineteen women suffered previous HF (8.7%). Of the 183 HF 117 HP were cervical (C) and 66 trochanteric (T). C/T ratio was 82/36 in women < = 82 years and 35/30 in women > 82 years (Fisher exact test p = 0.026). Fifteen of 161 women died within 12 months after the HP. They had a significantly higher mean age: 84.6 ± 5 years versus 76.6 ± 8.6 years (Mann–Whitney p < 0.01) and a higher proportion of trochanteric fractures: 66% versus 35% (Fisher exact test p = 0.03) than women who survived longer. Logistic regression analysis showed that only age was a predictor of death within a year following the HP. In conclusion, the incidence of HF increases exponentially with age. Hip fractures are highly prevalent in the studied women. The non-significant annual variability and the amount of women/year followed suggest that HP global incidence is a reliable estimate of the studied population. The risk of trochanteric fractures and of death within 12 months after the fracture increases with age. doi:10.1016/j.bone.2006.12.027

Bone mass in adult premenopausal women with two levels of physical activity Saraví FD, Sayegh FC, Furlán S. Facultad de Ciencias Médicas, Universidad Nacional de Cuyo y Escuela de Medicina Nuclear. Mendoza, Argentina. Both excessive physical activity and inactivity are known risk factors for low bone mass, but the effects of intermediate levels of exercise in adult premenopausal women has been less studied. Subjects and methods: women trained for competition (WTC, 21–46 years old, n = 16) at 5 sessions/week were compared with

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16 women (24–39 years old) with maintenance exercise (WME, 2–3 sessions/week). All were healthy, non-smokers and had normal menses. Calcium intake was surveyed. Body composition, bone mineral content (BMC) and density (BMD) was measured by DXA (Prodigy, GE Lunar) in whole body, lumbar spine, both hips and non-dominant forearm. Data (mean + SD) were analyzed by Student's t test, Mann–Whitney test, linear regression and multiple regression. Results: there was no significant difference in age, height, weight, body mass index (BMI), fat mass index or calcium intake. WTC had higher fatfree mass index (FFMI; p = 0.003) and BMC (2730 + 375 g vs. WME 2431 + 321 g; p = 0.022). Their BMD was higher by 8% in whole body and by 14 to 24% in spine and hip (p 0.0044 to 0.0007), but not in forearm. Linear regression showed positive correlations between weight vs. BMC, total BMD and lumbar BMD, FFMI vs. BMC and total BMD, and hours of activity (HA) vs. total, spine and hip BMD. Multiple regression indicated no effect for calcium intake or age, a major influence of weight on BMC (r2 = 0.644, p < 0.0001) and spine BMD (r2 = 0.372; p = 0.0041), of weight and HA on total BMD (r2 = 0.342; p = 0.0076), and of HA on hip BMD (r2 0.3574 to 0.4974, p 0.0039 to 0.0006). Conclusion: body weight and a higher level of physical activity were associated with higher total BMC and total, lumbar and hip BMD, while age and calcium intake had negligible effects. doi:10.1016/j.bone.2006.12.028

Incidence rates of osteoporotic hip fracture (HFx) in the six districts of Rosario city (Argentina) Morosano ME, Pezzotto SM, Sánchez A, Tamaño VF, Masoni AM. Chair of Biochemistry and Institute of Immunology, School of Medical Sciences, National University of Rosario; Center of Endocrinology, Rosario. The city of Rosario has six administrative districts that are markedly different in demographic structure and social and sanitary indicators. This study was undertaken in order to: (1) calculate global, specific and adjusted incidence rates of HFx in all districts. (2) Determine whether there is a homogeneous distribution of HFx among them. (3) To evaluate the association between HFx, socio-economic indicators and demographic variables. The HFx study database in Rosario (Osteop Int, 2005) was used. Indicators: Mortality rates, Unmet Basic Needs, Housing, Rooms/inhabitant, Mothers aged <20 years, Precarious housing, Free space, Low-weight newborns. Statistical analysis: Calculation of global incidence rates; truncated (≥ 65 years old) incidence rates; sex and age specific incidence rates; adjusted incidence rates in each district; correlation between rates and socio-economic indicators. Multivariate analysis using Poisson's regression, and calculation of rate ratios (RR). There was no significant association between socio-economic indicators and HFx rates in either sex. In the multivariate analysis the incidence rates of HFx were dependent on sex (p < 0.0001), age (p < 0.0001), age–sex interaction (p < 0.05), and independent of