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Bovine Collagen Promotes Gingival Healing, Researchers Report
NEWS
JADA INTRODUCES ONLINE-ONLY CONTENT
ith this issue of The Journal of the American Dental Association, JADA is moving further into the electronic publishing age: readers will find content available exclusively in the online edition of the issue. Two articles are available solely online: da Research report titled “The Effect of At-Home Bleaching and Toothbrushing on Removal of Coffee and Cigarette Smoke Stains and Color Stability of Enamel” by Dr. Evelise Machado de Souza and colleagues; d a Trends article titled “Primary Care Providers and Practice Locations: Examining the Relationships” by Dr. Susan C. McKernan and colleagues. Both articles are identified on the table of contents by page numbers that start with the prefix “e.” Dr. Michael Glick, JADA editor, says he is pleased to be offering this content enhancement to JADA readers. “By providing e-articles, JADA is able to offer more rapid publication to authors and a faster transfer of information to readers,” said Dr. Glick. “The Journal can better keep pace with the needs of those it serves.” Initial plans are to include one or two e-publications in each JADA issue. Look for the online-only content in May JADA at http://jada.ada.org.
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By Lisbeth R. Maxwell, editorial director.
BOVINE COLLAGEN PROMOTES GINGIVAL HEALING, RESEARCHERS REPORT
ovine-derived collagen can enhance gingival healing, say researchers in a study published in the March 5 issue of Head & Face Medicine. German and Swiss researchers led by Dr. Shahram Ghanaati, Department of Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt, Germany, and Institute of Pathology, Johannes Gutenberg Universität Mainz, Germany, and Dr. Markus Schlee, a private practitioner in Forchheim, Germany, investigated the possibility of using collagen extracted from bovine pericardium to form a support mechanism for connective tissues used to repair receding gingivae and exposed roots. They extracted collagen by
B
means of a process involving osmotic, oxidative and alkaline treatment. Use of this process ensured that the cell walls were broken down, proteins and fats were dissolved, and bacteria, viruses and other pathogens were inactivated and removed. The study followed 14 otherwise healthy nonsmoker patients who had at least one buccal recession. There were 62 total cases of recession among these patients. After performing a professional tooth cleaning and scaling and root planing, researchers implanted the bovine-derived collagen, which was held in place with loops of surgical thread around the affected tooth. After two weeks, they removed the sutures. Researchers examined the patients at six months. “In all cases the healed-over implant improved the look and severity of the recession, and, in over half of all treatments, resulted JADA 143(5)
in total coverage of the exposed root,” said Dr. Schlee. “We would not have expected any of these patients to get better without surgery.” The researchers concluded that the bovine-derived collagen acted as a scaffold and was integrated by the patients’ connective tissues, which enhanced the gingival thickness. DIABETES DRUG MAY LOWER RISK OF ORAL CANCER, STUDY SHOWS
he diabetes drug metformin may protect against oral cancer, according to an article published online March 31 in Cancer Prevention Research. Researchers led by J. Silvio Gutkind, PhD, chief of the Oral and Pharyngeal Cancer Branch of the National Institute of Dental and Craniofacial Research at the National Institutes of Health, induced premalignant lesions in laboratory mice and studied the effect metformin had as these lesions progressed into oral cancers. They found that the introduction of metformin reduced the size and number of carcinogen-induced oral tumoral lesions in mice and significantly reduced the development of squamous cell carcinomas by about 70 to 90 percent. They also found that metformin inhibited the function of
T
JADAPreview COMING IN JUNE
dTooth loss in geriatric patients dCalcium and phosphorus concentrations in enamel after different bleaching treatments dSex differences in pain perception Look for this and more in the June issue of JADA. http://jada.ada.org
Copyright © 2012 American Dental Association. All rights reserved.
May 2012 449
JADA INTRODUCES ONLINE-ONLY CONTENT
ith this issue of The Journal of the American Dental Association, JADA is moving further into the electronic publishing age: readers will find content available exclusively in the online edition of the issue. Two articles are available solely online: da Research report titled “The Effect of At-Home Bleaching and Toothbrushing on Removal of Coffee and Cigarette Smoke Stains and Color Stability of Enamel” by Dr. Evelise Machado de Souza and colleagues; d a Trends article titled “Primary Care Providers and Practice Locations: Examining the Relationships” by Dr. Susan C. McKernan and colleagues. Both articles are identified on the table of contents by page numbers that start with the prefix “e.” Dr. Michael Glick, JADA editor, says he is pleased to be offering this content enhancement to JADA readers. “By providing e-articles, JADA is able to offer more rapid publication to authors and a faster transfer of information to readers,” said Dr. Glick. “The Journal can better keep pace with the needs of those it serves.” Initial plans are to include one or two e-publications in each JADA issue. Look for the online-only content in May JADA at http://jada.ada.org.
W
By Lisbeth R. Maxwell, editorial director.
BOVINE COLLAGEN PROMOTES GINGIVAL HEALING, RESEARCHERS REPORT
ovine-derived collagen can enhance gingival healing, say researchers in a study published in the March 5 issue of Head & Face Medicine. German and Swiss researchers led by Dr. Shahram Ghanaati, Department of Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt, Germany, and Institute of Pathology, Johannes Gutenberg Universität Mainz, Germany, and Dr. Markus Schlee, a private practitioner in Forchheim, Germany, investigated the possibility of using collagen extracted from bovine pericardium to form a support mechanism for connective tissues used to repair receding gingivae and exposed roots. They extracted collagen by
B
means of a process involving osmotic, oxidative and alkaline treatment. Use of this process ensured that the cell walls were broken down, proteins and fats were dissolved, and bacteria, viruses and other pathogens were inactivated and removed. The study followed 14 otherwise healthy nonsmoker patients who had at least one buccal recession. There were 62 total cases of recession among these patients. After performing a professional tooth cleaning and scaling and root planing, researchers implanted the bovine-derived collagen, which was held in place with loops of surgical thread around the affected tooth. After two weeks, they removed the sutures. Researchers examined the patients at six months. “In all cases the healed-over implant improved the look and severity of the recession, and, in over half of all treatments, resulted JADA 143(5)
in total coverage of the exposed root,” said Dr. Schlee. “We would not have expected any of these patients to get better without surgery.” The researchers concluded that the bovine-derived collagen acted as a scaffold and was integrated by the patients’ connective tissues, which enhanced the gingival thickness. DIABETES DRUG MAY LOWER RISK OF ORAL CANCER, STUDY SHOWS
he diabetes drug metformin may protect against oral cancer, according to an article published online March 31 in Cancer Prevention Research. Researchers led by J. Silvio Gutkind, PhD, chief of the Oral and Pharyngeal Cancer Branch of the National Institute of Dental and Craniofacial Research at the National Institutes of Health, induced premalignant lesions in laboratory mice and studied the effect metformin had as these lesions progressed into oral cancers. They found that the introduction of metformin reduced the size and number of carcinogen-induced oral tumoral lesions in mice and significantly reduced the development of squamous cell carcinomas by about 70 to 90 percent. They also found that metformin inhibited the function of
T
JADAPreview COMING IN JUNE
dTooth loss in geriatric patients dCalcium and phosphorus concentrations in enamel after different bleaching treatments dSex differences in pain perception Look for this and more in the June issue of JADA. http://jada.ada.org
Copyright © 2012 American Dental Association. All rights reserved.
May 2012 449