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BREAKING THE GLASS CEILING FOR DIABETICS: DOES GENDER REALLY MATTER FOR SPECT-MPI RISK STRATIFICATION?
E1164 JACC March 27, 2012 Volume 59, Issue 13
Imaging BREAKING THE GLASS CEILING FOR DIABETICS: DOES GENDER REALLY MATTER FOR SPECT-MPI RISK STRATIFICATION? ACC Moderated Poster Contributions McCormick Place South, Hall A Saturday, March 24, 2012, 9:30 a.m.-10:30 a.m.
Session Title: Myocardial Perfusion Imaging in the Diabetic Population Abstract Category: 23. Imaging: Nuclear Presentation Number: 1103-186 Authors: Maria Theresa Halili Santos, Matthew Parker, Gary Heller, Hartford Hospital, Hartford, CT, USA Background: Previous data suggest diabetic women are at greater risk for future cardiac events than diabetic men. Increasing awareness of coronary artery disease (CAD) in women and advances in the management of CAD may have narrowed the gender gap. Objective: To investigate gender differences in prognosis among patients with diabetes undergoing single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). Methods: Patients with diabetes undergoing SPECT-MPI from 1996-2006 were followed for 5 years or until cardiac death or nonfatal myocardial infarction. Baseline clinical characteristics and nuclear parameters were compared with r2 and t-tests as appropriate. Annualized cardiac event rates (AER) were calculated among groups. Multivariable Cox regression controlled for baseline differences and tested the impact of gender on survival. Results: A total of 4911 SPECT-MPI patients with diabetes (50% women, mean age 63 ± 12 years) were analyzed. More women underwent pharmacologic stress test than men (72% vs. 63%, p < 0.01). There were 551 events, with crude rates higher in men than women (13% vs. 10%, p < 0.01). AER stratified by nuclear perfusion defects are shown in Figure 1. In the multivariable Cox model, only age, CAD, CHF, nuclear perfusion defect, and LVEF affected survival. Conclusion: Cardiac outcomes are similar regardless of gender after SPECT-MPI in patients with diabetes. The size and severity of stress induced perfusion abnormalities carries equal risk in both genders.
Imaging BREAKING THE GLASS CEILING FOR DIABETICS: DOES GENDER REALLY MATTER FOR SPECT-MPI RISK STRATIFICATION? ACC Moderated Poster Contributions McCormick Place South, Hall A Saturday, March 24, 2012, 9:30 a.m.-10:30 a.m.
Session Title: Myocardial Perfusion Imaging in the Diabetic Population Abstract Category: 23. Imaging: Nuclear Presentation Number: 1103-186 Authors: Maria Theresa Halili Santos, Matthew Parker, Gary Heller, Hartford Hospital, Hartford, CT, USA Background: Previous data suggest diabetic women are at greater risk for future cardiac events than diabetic men. Increasing awareness of coronary artery disease (CAD) in women and advances in the management of CAD may have narrowed the gender gap. Objective: To investigate gender differences in prognosis among patients with diabetes undergoing single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). Methods: Patients with diabetes undergoing SPECT-MPI from 1996-2006 were followed for 5 years or until cardiac death or nonfatal myocardial infarction. Baseline clinical characteristics and nuclear parameters were compared with r2 and t-tests as appropriate. Annualized cardiac event rates (AER) were calculated among groups. Multivariable Cox regression controlled for baseline differences and tested the impact of gender on survival. Results: A total of 4911 SPECT-MPI patients with diabetes (50% women, mean age 63 ± 12 years) were analyzed. More women underwent pharmacologic stress test than men (72% vs. 63%, p < 0.01). There were 551 events, with crude rates higher in men than women (13% vs. 10%, p < 0.01). AER stratified by nuclear perfusion defects are shown in Figure 1. In the multivariable Cox model, only age, CAD, CHF, nuclear perfusion defect, and LVEF affected survival. Conclusion: Cardiac outcomes are similar regardless of gender after SPECT-MPI in patients with diabetes. The size and severity of stress induced perfusion abnormalities carries equal risk in both genders.