- Email: [email protected]
Breast cancer biology and therapy: From patients to mouse models
2004 Workshop on the Nuclear Radiology of Breast Cancer Rome (Ital!') October 22-23, 2004
,Physica Medical, 9 Vol. XXI, Supplement 1, 2006
Breast Cancer Biology and Therapy: From Patients to Mouse Models Lewis A Chodosh
University qf Pennsylvania,Philadelphia,Pennsylvania(USA) Abstract This talk will summarize essential aspects of our current understanding of the biology of breast cancer. This will include molecular and cellul a:: alterations that are known to contribute to breast cancer in humans, as well as pathways and processes that have been implicated in breast cancer on the basis of animal models. Molecular pathways will be discussed in the context of changes that occur during trar dtions in the evolution of breast cancers, including those that determine the response to therapy. The contribution of geneticall7 engineered mouse models to our understanding of tumor initiation, metastasis and recurrence will be reviewed as will non-invas x,: imaging approaches to visualizing quantifiable aspects of tumor biology in these models.
Address !0r correspondence: Lewis A. Chodosh, University of Pennsylvania, 3451 Walnut Street, Philadelphia, PA 19104. E-mail: [email protected] 1. Breast Cancer Biology and R a d i o l o g y Perspective
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,Physica Medical, 9 Vol. XXI, Supplement 1, 2006
Breast Cancer Biology and Therapy: From Patients to Mouse Models Lewis A Chodosh
University qf Pennsylvania,Philadelphia,Pennsylvania(USA) Abstract This talk will summarize essential aspects of our current understanding of the biology of breast cancer. This will include molecular and cellul a:: alterations that are known to contribute to breast cancer in humans, as well as pathways and processes that have been implicated in breast cancer on the basis of animal models. Molecular pathways will be discussed in the context of changes that occur during trar dtions in the evolution of breast cancers, including those that determine the response to therapy. The contribution of geneticall7 engineered mouse models to our understanding of tumor initiation, metastasis and recurrence will be reviewed as will non-invas x,: imaging approaches to visualizing quantifiable aspects of tumor biology in these models.
Address !0r correspondence: Lewis A. Chodosh, University of Pennsylvania, 3451 Walnut Street, Philadelphia, PA 19104. E-mail: [email protected] 1. Breast Cancer Biology and R a d i o l o g y Perspective
3