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British Association of Surgical Oncology Scientific Meeting held at The Royal College of Surgeons of England, London, UK on 27–28 November 2000
European Journal of Surgical Oncology 2000; 26: 821–833 doi:10.1053/ejso.2000.1014, available online at http://www.idealibrary.com on
British Association of Surgical Oncology Scientific Meeting held at The Royal College of Surgeons of England, London, UK on 27–28 November 2000 PROGRAMME MONDAY, 27 NOVEMBER 2000 08.00 08.00
Registration and coffee Oral posters day one
Main Foyer Webb Johnson Hall
Parallel session I—Breast Cancer Detection Diagnosis 08.30–10.00
Lecture Room 1
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Chairman: Mr J. Winstanley
10.00–10.30 10.00–10.30
Ultrasound by surgeons is accurate in the diagnosis of breast disease P. A. Whitehouse, Y. Baber, G. Brown, E. Moskovic, D. M. King, G. P. H. Gui Academic Surgery and Radiology, Breast Unit, Royal Marsden Hospital, London, UK Surgeon directed ultrasound guided core biopsies in the breast—a prospective study L. A. Donaldson, A. Cliff, L. Gardiner, M. A. Ashton Breast Clinic, Diana Princess of Wales Hospital, Grimsby, UK Fibrofatty nodule in the breast: is inadequate cytology sufficient for diagnosis? R. Achuthan∗, K. Munot∗, J. Sutton†, G. Parkin‡, K. Horgan∗ Departments of Surgery∗, Pathology† and Radiology‡, Leeds General Infirmary, Leeds, UK An evaluation of the accuracy of imprint cytology of core biopsy D. R. Cheetham, J. Aps, T. K. Walters, M. Khan Queen Mary’s Hospital, Sidcup, UK Histological assessment of breast tissue by optical biopsy G. M. Briggs∗, C. D. O. Pickard†, M. M. Keshtgar†, I. J. Bigio‡, P. M. Ripley‡, C. Kelly‡, C. M. Saunders†, S. Lakhani¶, S. G. Brown∗ ∗National Medical Laser Center, †Department of Surgery, ‡Department of Histopathology, Royal Free and University College Medical School, London and ¶Los Alamos National Laboratory, New Mexico, USA Ultrasound core biopsy of breast lesions which are indeterminate on imaging (R3) is essential P. Sinha, W. Webb, T. Bates The Breast Unit, William Harvey Hospital, Ashford, Kent, UK Changes in vascular phenotype with the development of ductal cancer in situ (DICS) of the breast N. B. Teo, B. S. Shoker, C. M. Jarvis, C. Holcombe, L. Martin, J. P. Sloane Pathology Department, University of Liverpool Breast Unit, Royal Liverpool University Hospital, Liverpool UK Core biopsy analysis of C3 and C4 breast lesions J. Wayman, T. Johnson, J. R. Young, L. A. Webb, L. Glunt, D. A. Browell, J. D. Hemming, W. J. Cunliffe The Breast Screening Unit and Departments of Histopathology and Surgery, The Queen Elizabeth Hospital, Gateshead Coffee & exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
08.30–10.00
Lecture Room 2
Parallel Session II—Colorectal 08.30
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0748–7983/00/080821+13 $35.00/0
Chairman: Mr K. Hosie
Immunohistochemistry in the detection of microsatellite instability in colorectal cancer D. A. Lawes, T. Pearson, S. SenGupta, I. Taylor, P. B. Boulos Department of Surgery, Royal Free and University College London Medical School, UK 2000 Harcourt Publishers Ltd
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10.00–10.30 10.00–10.30
Ten year experience of endoscopic trans-anal resection (ETAR) L. J. Marshall, C. D. Sutton, N. Flint, M. J. Kelly Department of Surgery, Leicester General Hospital, Leicester, UK Colorectal anastomotic leaks regularly masquerade as ‘cardiac complications’ C. D. Sutton, N. Williams, L. J. Marshall, D. P. Berry, W. M. Thomas, M. J. Kelly Department of Surgery, Leicester General Hospital, Leicester, UK Morbidity following colorectal resection K. L. R. Grace, P. Durdey, M. G. Thomas Department of Surgery, Bristol Royal Infirmary, Bristol, UK Long-term outcome after surgery for malignant large bowel obstruction C. Staudacher, A. Chiappa San Raffaele Scientific Institute, Milano, Italy Local formalin instillation: an effective treatment for uncontrolled haemorrhagic proctitis R. Ouwendijk∗ G. W. M. Tetteroo∗, W. Bode†, E. R. de Graaf∗ Departments of ∗General Surgery and †Gastroenterology, Ijsselland Hospital, Capelle aa/d Ijssel, Netherlands Colorectal cancer—is standard intensive clinical follow-up necessary? S. Chatterjee, M. C. Parker Department of Surgery, Joyce Green Hospital, Dartford, Kent, UK The role of positron emission tomography in the management of recurrent colorectal cancer T. H. A. Arulampalam, B. Lovett, M. Loizidou, D. C. Costa, P. B. Boulos, P. J. Ell, I. Taylor Royal Free and University College Medical School, London, UK Extensive cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal origin E. de Bree, A. J. Witkamp, M. M. Kaag, G. W. van Slooten, F. A. N. Zoetmulder The Netherlands Cancer Institute, Amsterdam, The Netherlands Coffee & exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
Parallel Session III—Hepato-Pancreato-biliary Cancer 08.30–10.00
Council Room Chairman: Mr G. J. Poston Note: Each paper 7 minutes & 3 minutes discussion
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Pseudomyxoma peritonei treated by extensive cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy E. de Bree, A. J. Witkamp, M. M. Kaag, G. W. van Slooten, F. A. N. Zoetmulder The Netherlands Cancer Institute, Amsterdam, The Netherlands Intrahepatic chemotherapy via the subcutaneous jet port system J. Wayman, S. MacFarlane, G. Appleby, R. Uberoi, W. J. Cunliffe Departments of Surgery and Interventional Radiology, Queen Elizabeth Hospital, Gateshead, Tyne and Wear, UK Role of COX-2, APC and NSAIDs in colorectal cancer G. Katti, D. F. McWilliams, N. C. Armitage, P. A. Clarke, T. A. Morris, S. A. Watson Cancer Studies Unit, Section of Surgery, University Hospital, Notts, UK T cells are activated in anergic patients with colorectal liver metastases A. Huang∗, H. Quinn∗, Cl Glover∗, D. C. Henderson†, T. G. Allen-Mersh∗ Departments of ∗Surgery and †Immunology, Chelsea and Westminster Hospital, London, UK An in vivo study of two new photosensitizers following interstitial photodynamic therapy of the liver S. F. Purkiss, M. F. Grahn, J. P. Rovers, N. S. Williams St Bartholomew’s and the Royal London School of Medicine and Dentristy, UK The gluthathione depleting agent BSO radiosensitizes cholangiocarcinoma cells to apoptosis A. C. Okaro, F. A. Cotter, B. R. Davidson Hepatobiliary Unit, Department of Surgery, Royal Free and University College Medical School, London, UK Electrolytic liver ablation: the effect of intermittent pringle manoeuvre D. P. Berry∗, P. Vanderzon†, A. R. Dennison∗, G. J. Maddern† Departments of Surgery∗, Leicester General Hospital and Queen Elizabeth Hospital, Adelaide, Australia Expression of endothelin receptors in human colorectal liver metastases K. Dawas∗, M. Dashwood∗, M. Loizidou∗, H. Ali∗, G. Burnstock†, I. Taylor∗ ∗Department of Surgery, and the †Autonomic Neuroscience Institute, Royal Free and University College Medical School, University College, London, UK Loss of taste and smell after upper gastro-intestinal surgery A. M. Harris, M. Lamberts, S. M. Davies, N. Hayes, S. M. Griffin Northern Oesophago-Gastric Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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Programme 10.00–10.30 10.00–10.30
Coffee & exhibition Poster viewing
Edward Lumley Hall Webb Johnson Hall
Plenary Session I—Raven Prize Lecture Room 1 Chairman: Professor D. George 10 minutes each plus 4 mins discussion 10.30
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Surgery for breast cancer—no wound drains and early discharge—a randomized clinical trial A. Purushotham∗, E. McLatchie∗, D. Young†, D. George∗, S. Stallard∗, J. Doughty∗, D. Brown∗, C. Farish‡, A. Walker†, K. Millar¶, G. Murray∀ ∗Department of Surgery, Western Infirmary, Glasgow, †Health Economics, Greater Glasgow Health Board, ‡Physiotherapy, Western Infirmary, ¶Behavioural Science, University of Glasgow, ∀Medical Statistics, Edinburgh, UK Systematic review of the methodological quality of randomized controlled trials of the surgical excision of cancer B. Lovett, W. Swayer, J. Houghton, I. Taylor Department of Surgery, Royal Free and University College Hospital Medical School, University College London, UK Patient education as part of a multi-faceted strategy increases the detection of curable oesophagogastric cancer P. McCulloch, L. Williams, P. Brown Department of Surgery, University of Liverpool, UK Monitoring of minimal residual disease (MRD) during adjuvant therapy in breast cancer B. M. Smith∗, A. Singh∗, E. Hall¶, H. D. Sinnett†, N. C. P. Cross‡, R. C. Coombes∗ and M. J. Slade∗ ∗CRC Laboratories and ‡Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, †Department of Surgery, Charing Cross Hospital, London and ¶Department of Epidemiology, Institute of Cancer Research, Sutton, UK Antioxidants enhance susceptibility to 5FU toxicity in colon cancer cells in vitro D. Adeyemo, M. Davies, S. Toffa, M. Lowdell, M. C. Winslet Academic Departments of Surgery and Haematology, Royal Free and University College Medical School, London, UK bFGF infusion increases 5 fluorouracil uptake in a model of established colorectal liver metastases P. Mathur∗, P. Carnochan†, T. G. Allen-Mersh ∗Department of Academic Surgery, Imperial College School of Medicine, Chelsea and Westminster Hospital and †Institute of Cancer Research, Surrey, UK Axillary node staging in the Trent Breast Screening Programme 1996–1999: audit of surgeons’ protocols and practice I. A. F. Azmy∗, J. A. Reed†, M. W. R. Reed ∗Section of Surgical Oncology, University of Sheffield and †Trent QA Reference, Nottingham, UK Outcome of local recurrence following sarcoma surgery R. J. Grimer, R.M. Tillman, S. R. Carter, D. Spooner, D. Peake The Royal Orthopaedic Hospital, Birmingham, UK
Plenary Session II—2000 BASO British Journal of Surgery Lecture 12.30–13.00
Lecture Room 1 Chairman: Mr G. J. Poston Professor R. Daniel Beauchamp (USA) The role of TGF-beta in colorectal cancer: tumour suppressor or tumour promoter?
13.00–14.00 13.00–14.00
Lunch & exhibition Poster viewing
14.00–16.00
Lecture Room 1
Edward Lumley Hall Webb Johnson Hall
Plenary Session III—Alan Edwards Prize 14.00
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Chairman: Professor J. Elder
Magnetic resonance imaging as an adjunct to triple assessment in equivocal breast disease K. C. Munot, R. Achuthan, S. Radjenovic, A. Barr, B. Dall, K. Horgan Leeds General Infirmary, Leeds, UK PK11195, a mitochondrial benzodiazepine receptor antagonist radiosensitizes Bcl-XL and Mcl-1 expressing human cholangiocarcinoma to apoptosis M. C. Okaro∗†, D. Fennel†, F. E. Cotter†, B. F. Davidson∗ ∗University Department of Surgery, London and †Department of Exp. Hematology, St Bartholomews and the Royal Free and University College Medical School, London, UK
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16.00–16.30 16.00–16.30
Changed pattern and incidence of first site recurrences following sentinel node procedure in melanoma patients M. G. Statius Muller, R. J. C. L. M. Vuylsteke, P. A. M. van Leeuwen, R. Pijpers, P. J. cn Diest, S. Meijer Departments of Surgical Oncology, Nuclear Medicine and Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands Angiogenesis in ductal carcinoma in situ (DCIS) of the breast and its relationship to the risk of recurrence N. B. Teo, B. S. Shoker, C. M. Jarvis, C. Holcombe, L. Martin, J. P. Sloane Pathology Department, University of Liverpool, Breast Unit, Royal Liverpool University Hospital, Liverpool, UK Anorectal irradiation in pelvic radiotherapy: an assessment using in vivo dosimetry D. Hayne∗, U. Johnson†, D. D’Souza†, H. Payne‡, P. B. Boulos∗ ∗Department of Surgery, Royal Free University College Medical School, London, †Department of Medical Physics and ‡Department of Oncology, Royal Free University College Medical School, UK Pathological response of breast cancers to primary docetaxel is predicted by HER-2 and ER status K. N. Ogston∗, I. C . Smith∗, S. Payne†, I. D. Miller†, A. W. Hutcheon‡, T. Whitaker‡, T. K. Sarkar∗, S. D. Heys∗ Departments of ∗Surgery, †Pathology and ‡Oncology, University of Aberdeen, UK Thrombin regulation of vascular endothelial growth factor (VEGF) and tissue factor (TF) in human breast cancer cells A. Salih, R. T. Mathie, R. C. N. Williamson, A. K. Kakkar Department of Surgery, Imperial College School of Medicine, Hammersmith Hospital London, UK Endoscopic assisted intrathoracic oesophagogastrectomy without thoracotomy for tumours of the lower oesophagus and cardia C. D. Sutton, L. J. Marshall, S. A. White, D. P. Berry, P. S. Veitch Department of Surgery, Leicester General Hospital, UK Tea Edward Lumley Hall Poster viewing Webb Johnson Hall
16.30–17.30
Lecture Room 1
Parallel Session IV—Breast Oral Posters Chairman: Mr D. A. Rew
Screening Diagnosis—2 Week Rule 16.30
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The effect of the two week rule for providers, users and cancers J. Adjogatse, R. Kushwaha, S. Walker, B. Isgar New Cross Hospital, Wolverhampton, West Midlands, UK The relevance of reported symptoms in a breast screening programme R. S. Williams, D. L. Brook, K. Gower-Thomas, I. J. Monypenny Breast Test Wales, Cardiff, UK Factors affecting breast cancer risk perception in women attending a family history clinic V. Vijay, J. Stein, C. Saunders, M. Keshtgar, M. Baum Department of Surgery, Royal Free and University College Medical School, London, UK Survival of patients with screen detected cancer. Is the effectt limited to ER negative patients? K. Chin, A. Harris, P. J. Clarke, A. Jones, M. Greenall Departments of Surgery and Oncology, John Radcliffe Hospital, Oxford, UK
Localization, Cytology 16.46
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Fine needle aspiration cytology of breast. Audit of number of slides required for diagnosis S. Natu∗, J. Jeffree†, Z. Saad‡, M. S. Bashir∗ ∗Department of Histopathology, †Department of Radiology, ‡Department of Surgery, Hope Hospital, Stott Lane, Salford, Manchester, UK Does accuracy of localization influence the benign breast biopsy weight? O. Ravisekar, B. Mucci West Cumberland Hospital, UK Routine hospital follow-up of breast cancer—time for a new approach? J. Donnelly, P. Mack, L. D. Donaldson Diana Princess of Wales Hospital, Grimsby, UK
Programme 16.58
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Breast conservation surgery versus mastectomy after priary chemotherapy—changing clinical practice K. N. Ogston∗, T. K. Sarkar†, S. D. Heys∗ Departments of ∗Surgery and †Oncology, University of Aberdeen, UK Does immediate reconstruction after mastectomy for breast cancer delay adjuvant therapy? S. M. Tan, D. Landau, G. M. Ross, R. P. A’Hern, N. P. M. Sacks, G. P. H. Gui Department of Surgery and Oncology, Royal Marsden Hospital, London, UK
Basic Science, Immunology 17.06
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Mononuclear phagocytes but not tumour cells are the main source of elevated interleukin (IL)-10 levels in human breast cancer B. Al-Sarireh∗, S. Sathaporn∗, A. Robins†, D. Jenkins‡, W. Vassanasiri¶, M. El-Sheemy¶, J. A. Jibril¶, D. Clark¶, O. Eremin¶ ∗Section of Surgery, †Department of Immunology and ‡Department of Pathology, University Hospital, Nottingham and ¶Department of Surgery, Lincoln County Hospital, Lincoln, UK Defective function of dendritic cells in patients with breast cancer S. Satthaport∗, B. Sarireh∗, W. Vassanasiri†, M. El-Sheemy†, J. A. Jibril†, D. Clark†, A. Robins‡, O. Eremin∗† ∗Section of Surgery, Queen’s Medical Centre, University of Nottingham, †Breast Unit, Department of Surgery, Lincoln County Hospital, ‡Section of Immunology, Queen’s Medical Centre, University of Nottingham, UK Are the anti-tumour effects of conjugated linoleic acid mediated by increased p53 expression? B. Majumder∗, A. Farquharson†, K Wahle†, S. D. Heys∗ ∗Department of Surgery, University of Aberdeen and †Rowett Research Institute, Aberdeen, UK
Parallel Session V—GI Oral Posters 16.30–17.30
Lecture Room 2
Chairman: Mr T. C. Holme
Diagnosis 16.30
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Improving access to barium enema examinations in suspected colorectal cancer D. A. Slade, B. Jones, M. Lipton, C. A. Makin Wirral Colorectal Unit, Arrowe Park Hospital, Mersey, UK Pelvic CT scanning for rectal cancer—useful predictor of extraluminal disease? G. N. Buchanan, K. Thakur, J. Jacomb-Hood, G. Phillip, J. Linsell University Hospital, Lewisham, UK
Guidelines, 2 Week Rule 16.38
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Knowledge of cancer symptoms among patients attending one-stop breast and rectal bleeding clinics A. M. Pullyblank, S. J. Cawthorn, A. R. Dixon Department of General Surgery, Frenchay Hospital, Bristol, UK Coping with the ‘two week rule’ in suspected colorectal cancer. A pilot study D. A. J. Slade, T. Y. El-Sayed, S. H. Suliman, C. J. Walsh, C. A. Making Wirral Colorectal Unit, Arrowe Park Hospital, Mersey, UK
Surgery, Chemotherapy 16.46
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A new technique for combined synchronous on table antegrade and retrograde colonic lavage D. Francis, T. Satyadas, J. Peters Princess Alexandra Hospital, Harlow, Essex, UK A phase 1 study of photodynamic therapy of patients with advanced colorectal cancer using temoporfin I. M. Hah, M. F. Grahn, S. F. Purkiss, N. S. Williams St Bartholomew’s and the Royal London Hospital School of Medicine and Dentristy, QMW, UK 5 ASA induces susceptibility to 5 FU in colon cancer cells in vitro D. Adeyemo, M. Davies, S. Toffa, M. Lowdell, M. C. Winslet Academic Departments of Surgery and Haematology, Royal Free and University College Medical School, London, UK
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Basic Science 16.58
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Investigating the role of IGFBP-4 in colorectal cancer M. Davies∗, S. Coe∗, S. Gupta, D. Adeymo, G. Goldspink†, M. Winslet∗ University Department of Surgery, ∗Department of Anatomy and †Developmental Biology, Royal Free and University College Medical School, London, UK The value of P15 and P16 in the prognosis of colorectal cancer J. K. C. Huang∗, H. W. Taylor†, S. Tran, I. P. Lineham†, M. C. Winslet ∗University Department of Surgery, Royal Free and University College Medical School, London and †Department of Surgery, Basildon Hospital, Essex, UK Comparison of orthotopic cell implantation (OCI) vs orthotopic tumour implantation (OTI) in the HaP-T1 Syrian hamster pancreatic cancer model A. T. Abraham, S. R. Shah, B. R. Davidson Royal Free and University College Medical School, London, UK
Upper GI 17.06
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The diagnostic yield of extended en bloc resection for (adeno) carcinoma of the oesophagus or gastric cardia J. B. F. Hulscher∗, B. P. L. Wijnhoven†, G. J. A. Offerhaus‡, H. W. Tilanus†, H. Obertop∗, J. J. B. van Lanschot∗ Departments of ∗Surgery and ‡Pathology, Academic Medical Center/University of Amsterdam and †Department of Surgery, Academic Hospital Dijkzigt-Rotterdam, The Netherlands Electrolytic liver ablation: the effect of multiple electrodes D. P. Berry∗, P. Vanderzon†, A. R. Dennison, G. J. Maddern∗ Departments of Surgery∗, Leicester General Hospital, UK and †Queens Elizabeth Hospital, Adelaide, Australia
Plenary Session Four 2000 Stanford Cade Memorial Lecture Lecture Room 1
Chairman: Mr D Rosin
Professor I. Taylor (London, UK) What constitutes Good Practice in Surgical Oncology? 18.00–18.30
BASO Annual General Meeting (Members Only) Close
Lecture Theatre One
18.30 Evening Social Programme Dress: Lounge Suit 19.30 for 20.00 Reception & Annual Dinner of the Association at the Law Society, Chancery Lane, London
TUESDAY, 28 NOVEMBER 2000 08.00 08.00
Registration, Coffee & Exhibition Edward Lumley Hall Non-oral posters to be displayed in Webb Johnson Hall
Parallel Session VI—Breast Cancer Surgery Short Papers 08.30–10.30
Lecture Room 1
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Chairman: Mr A. D. Baildam
Review of trilucent breast implants in south Manchester E. A. E. Elangovan∗, I. Hadjiloucas∗, M. Wilson†, J. M. Hawnaur‡, L. Barr∗, A. D. Baildam∗, N. J. Bundred∗ Academic Department of ∗Surgery and †Radiology, University Hospitals of South Manchester and ‡Medical School, Manchester, UK Breast reconstruction in the UK and Ireland—is there uniformity of care? A. Purushotham∗, C. Callaghan∗, M. Kerin†, D. Rainsbury‡, D. George¶ ∗Cambridge Breast Unit, †The Mater Hospital, Dublin, Ireland, ‡Royal Hampshire Hospital and ¶Western Infirmary, Glasgow, UK
Programme 08.50
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10.30–11.00 10.30–11.00
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Assessment of breast form using biodimensional implants in immediate reconstruction after mastectomy with geometric measurements S.-M. Tan, E. C. Faliakou, C. Choy, R. P. A’Hern, G. P. H. Gui Royal Marsden NHS Trust, London, UK The role of harmonic scalpel in breast surgery J. C. C. Hu, K. L. Kirkpatrick, A. Mostafa, C. K. Choy, K. Mokbel, R. Carpenter Breast and Endocrine Unit, St Bartholomew’s Hospital, London, UK The clinical outcome of two new breast reconstructive procedures R. K. Gendy, D. L. Rutherford, R. M. Rainsbury Breast Unit, Royal Hampshire Country Hospital, Winchester, UK Optical biopsy for the assessment of sentinel lymph nodes of the breast G. M. Briggs∗, C. D. O. Pickard∗, M. M. Keshtgar†, I. J. Bigio‡, P. M. Ripley‡, C. Kelly‡, C. M. Saunders†, P. J. Ell¶, S. Lakhani¶, S. G. Brown∗ ∗National Medical Laser Centre, †Department of Surgery, ¶Department of Nuclear Medicine, ¶Department of Histopathology, Royal Free and University College Medical School, London, UK and ‡Los Alamos National Laboratory, New Mexico, USA Mammaglobin expression in sentinel and non-sentinel nodes G. Branagan, D. Hughes, C. Crane-Robinson, M. Perry Queen Alexandra Hospital, Portsmouth and the University of Portsmouth, UK Small breast tumours. Is axillary dissection necessary? S. Chaturvedi, C. J. D. Mortimer, F. MacNeill, P. Sauven, S. K. Marsh, T. J. Archer Mid Anglia Breast Group, Ipswich Hospital, UK Incidence of nodes in completion mastectomy specimens following breast conservation and axillary clearance N. I. Khonji, R. Edwards, H. M. Sweetland, I. J. Monypenny, R. E. Mansel, D. J. Webster Department of Surgery, University of Wales College of Medicine, and Llandough Hospital, Cardiff, UK Pathological assessment of the sentinel node in breast cancer: comparison of H&E and immunohistochemical staining of frozen sections with paraffin sections N. I. Khonji, D. Clarke, S. Goyal, A. G. Douglas-Jones, C. Jasani, H. M. Sweetland, R. E. Mansel Departments of Surgery and Pathology, University of Wales College of Medicine, Cardiff, UK A comparison of the modes of detection of minimal residual disease (MRD) in breast cancer A. Singh, M. Slade, M. Lu¨chtenberg, B. M. Smith, H. D. Sinnett, R. C. Coombes Department of Cancer Cell Biology, Hammersmith Hospital, London, UK Predictive factors of local recurrence and distant metastasis in malignant phyllodes tumour of the breast I. A. Kapiris, M. Nasiri, R. Millis, U. Mahadeva, R. A’Hern, G. P. H. Gui Royal Marsden Hospital, London, UK Coffee & trade exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
Parallel Session VII—Basic Science Council Room 08.30
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Chairman: Professor M. Reed
Effect of oestradiol on integrin 1 expression and function C. J. Pogson, L.-A. Martin, C. M. W. Chan, M. Dowsett, G. P. H. Gui Departments of Academic Surgery and Biochemistry, The Royal Marsden, Fulham Rooad, London, UK Purification and charaterization of primary breast cancer cells M. S. Kothari, S. Ali, H. D. Sinnett, S. Soousha, N. Livni, R. C. Coombes, M. J. Slade Imperial College School of Medicine, Hammersmith Hospital, London, UK Stimulation of peritoneal macrophage activity by non-cytotic components of intraperitoneal chemotherapy P. McCulloch, I. A. Shah, E. Lindup Department of Surgery, University Hospital Aintree and University of Liverpool, Department of Pharmacology, University of Liverpool, UK Transforming growth factor-beta induced IGFBP-3 prevents ceramide-induced apoptosis in human breast cancer cells (Fs578T) C. A. Fowler, C. M. Perks, N. J. Laurence, T. Lai, J. R. Farndor, J. M. P. Holly Department of Surgery, Bristol Royal Infirmary, Bristol, UK Chronic glucose deprivation inhibits aminolaevulinic acid induced photodynamic therapy M. Tomlinson, L. Wyld, N. J. Brown, M. W. R. Reed Department of Surgical and Anaesthetic Sciences, University of Sheffield, UK
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10.30–11.00 10.30–11.00
Modulation of protein kinase C (PKC) isoforms in prostate cancer cells by dietary fat S. S. Pandian, A. A. Sneddon, P. Barker, K. W. J. Wahle, S. McClinton, C. Bestwick, S. D. Heys Departments of Surgery and Urology, Surgical Nutrition and Metabolism Unit, University of Aberdeen and Rowett Research Institute, Aberdeen, UK Thrombin regulation of vascular endothelial growth factor (VEGF) andd tissue factor (TF) in human breast cancer cells A. Salih, R. T. Mathie, R. C. N. Williamson, A. K. Kakkar Department of Surgery, Imperial College School of Medicine, Hammersmith Hospital, London, UK Transcription of components of the renin angiotensin system in human breast and relationship with severity of disease A. J. Ogedegbe∗, J. F. Puddefoot†, M. Tahmasebi†, G. P. Vinson†, A. W. Goode∗, R. Carpenter∗ ∗Breast Unit, St Bartholomew’s Hospital and †Department of Biochemistry, Queen Mary and Westfield College, University of London, UK Intraperitoneal gene therapy for desmoid disease in familial adenomatous polyposis R. M. Bright-Thomas∗, H. S. Wasan†, R. Hargest∗ ∗Department of Surgery, Royal Free and University College Medical School, London and †ICRF Oncology Unit, Hammersmith Hospital, London, UK Bispecific antibody derived from high affinity monoclonal (323A3) to 17.1 antigen (EpCAM) reduces pulmonary metastases, inhibits local tumour growth and prolongs survival in mice given challenge with syngeneic tumour expressing human 17.1A P. M. Safranek, M. J. Glennie, J. A. Smallwood Department of Surgery and Tenovus Research Laboratory, Southampton University Hospital, Southampton, UK Studies of APC and -catenin in the min/+ mouse R. M. Bright-Thomas, H. S. Wasan, R. Hargest Department of Surgery, Royal Free and University College Medical School, London, UK Polymorphism in the interleukin-1 receptor antagonist gene is associated with an increased risk of breast cancer I. A. F. Azmy∗, A. G. Wilson†, C. Cannings†, N. J. Brown, M. W. R. Reed∗ ∗Section of Surgical Oncology and †Department of Molecular Medicine, The University of Sheffield, UK Coffee & trade exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
08.30–10.30
Lecture Room 2
Parallel Session VIII—Sarcoma & Others 08.30
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Chairman: Mr M. Thomas
The role of a plastic surgeon in providing a sarcoma service G. Smith, F. Peart Department of Plastic and Reconstructive Surgery, Selly Oak Hospital, Birmingham, UK Retroperitoneal sarcoma: A one-centre 10-year experience A. Pirayesh, Y. Chee, T. Helliwell, M. J. Hershman, S. J. Leinster, M. V. Fordham, G. J. Poston Royal Liverpool University Hospital, Liverpool, UK Neuropilin-1 expression is associated with increased vascular endothelial growth factor (VEGF) production in colorectal carcinoma J. R. Easterbrook, J. Greenman, J. N. E. Ashman, A. W. MacDonald, J. R. T. Monsoon University of Hull Academic Surgical Unit, Hull, UK Pantobens: all the information for quality control and training in oncological operations M. H. Edwards Friarage Hospital, Northallerton, North Yorkshire, UK Tc-99 Mibi-only parathyroid localization—early experience P. Boorman, M. Buxton-Thomas, D. Scott-Coombes King’s College Hospital, London, UK Modulation of vascular endothelial cell behaviour by extract from normal human dermis in vitro M. El-Sheemy∗†, W. Vassanasiri†, O. Eremin†‡ ∗Department of Surgery, University of Aberdeen, †Lincoln County Hospital, Lincoln and ‡Department of Surgery, University of Nottingham, UK Reliability of the sentinel node procedure in melanoma patients (n=289); incidence of failures after long-term follow-up R. J. C. L. M. Vuylsteke, M. G. Statius Muller, P. A. M. van Leeuwen, P. J. Borgstein, R. Pijpers, P. J. van Diest, S. Meijer Departments of Surgical Oncology, Nuclear Medicine and Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
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10.30–11.00 10.30–11.00
Prognostic factors and survival in malignant pleural mesothelioma J. King∗, R. Swindell†, C. A. Pickering∗, N. Thatcher†, P. Hasleton∗ ∗South Manchester University Hospitals NHS Trust and †Christie Hospital NHS Trust, UK Periosteal osteosarcoma: evaluation of surgical and adjuvant measure in improving survival M. P. Revell, N. Deshmukh, R. J. Grimer, S. R. Carter, R. M. Tillman Royal Orthopaedic Hospital, Birmingham, UK Factors predictive of survival of patients with retroperitoneal soft-tissue sarcoma: does surgical experience influence survival? T. van Dalen, H. J. Hoekstra, B. N. van Geel, F. van Coevorden, A. Hennipman The Dutch Soft Tissue Sarcoma Group, Utrecht, The Netherlands Clinical detection of soft tissue sarcomas—how specific are the four cardinal features? R. J. Grimer, C. Johnson, P. B. Pynsent The Royal Orthopaedic Hospital, Birmingham, UK A biopsy of a suspected soft tissue sarcoma in the retroperitoneal area: the diagnostic yield and the risk of contamination of the different procedures T. van Dalen, F. van Coevorden, B. N. van Geel, H. J. Hoekstra, A. Hennipman The Dutch Soft Tissue Sarcoma Group, Utrecht, The Netherlands Coffee & exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
Plenary Session V—Pitfalls in the Management of Sarcoma 11.00–12.00
Lecture Theatre One
11.00–11.20
Limb soft tissue sarcoma M. Thomas (London, UK) Intra-abdominal sarcoma P. O’Dwyer (Glasgow, UK) The application of chemotherapy and biological responses modifiers in the treatment of advanced soft tissue sarcomas B. Kroon (Rotterdam, The Netherlands)
11.20–11.40 11.40–12.00
Chairman: Mr D. Rosin
Plenary Session VI—2000 Ernest Miles Lecture 12.00–12.30
Lecture Room One
12.30–13.30 12.30–13.30
Jointly with The Royal Marsden Surgical Society Professor Roger Blamey (Nottingham, UK) ‘‘Breast Cancer: The Changing Scene’’ Lunch & trade exhibition Poster viewing
Chairman: Professor D. George
Edward Lumley Hall Webb Johnson Hall
Parallel Session IX—Breast Group Symposium 13.30–15.00
Lecture Room One
13.30–14.10
Professor L. Holmberg (Uppsala, Sweden) ‘‘DCIS’’: aspects on epidemology and prognosis Professor D. George (Glasgow, UK) Preliminary Results DCIS Trial Professor R. A. Haward (Yorkshire, UK) Multi-disciplinary team working in breast cancer: variability and effectiveness Tea & trade exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
14.10–14.30 14.30–15.00 15.00–15.30 15.00–15.30
Chairman: Professor R. E. Mansel
Parallel Session X—British Oesophago-Gastric Cancer Group AGM 13.30–15.00
Lecture Theatre Two
13.30–13.45 13.45–14.05
Introduction and Annual General Meeting Oesophageal cancer update in molecular biology J. Jankowski Neo-adjuvant therapy in operable oesphageal cancer D. Girling
14.05–14.25
Chairman: Professor J. Elder
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Programme
14.25–15.00 15.00–15.30 15.00–15.30
Oesophageal cancer in a clinical perspective G. O’Sullivan Tea & trade exhibition Poster viewing
15.30–16.30
Lecture Room One
Edward Lumley Hall Webb Johnson Hall
Parallel Session XI—Two week rule 15.30
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15.55–16.30
Chairman: Professor I. Taylor
Is there any difference between routinely and urgently referred cancers? J. Adjogatse, R. Kushwaha, W. Walker, B. Isgar New Cross Hospital, Wolverhampton, West Midlands, UK Prioritization of referrals to a breast clinic: how do clinicians compare with general practitioners? L. Campbell, S. Prance, C. Teasdale, R. M. Watkins Derriford Hospital Breast Care Unit, Plymouth, UK Prioritization of breast referrals: is age the safest criterion? C. Chianakwalam, P. Sinha, R. Barnes, S. Bendell, T. Bates The Breast Unit, Williams Harvey Hospital, Ashford, Kent, UK The impact of colorectal cancer awareness week A. M. Pullyblank∗, N. Dixon†, A. R. Dixon∗ Department of ∗General Surgery and †General Practice, Frenchay Hospital, Bristol Preliminary evaluation of UK national referral guidelines for lowr gastrointestinal tract cancers C. C. W. Mahaon, C. J. Vaizey, I. Taylor, P. B. Boulos Department of Surgery, Royal Free and University College Medical School, London, UK Discussion
Parallel Session XII—Oesophago-Gastric Cancer 15.30–16.30
Lecture Room 2
15.30
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Chairman: Mr P. M. McCulloch
Prospective evaluation of posssum methodology in the audit of oesophageal carcinoma including unresected cases M. J. Midwinter, B. Charalambous, M. Eden, L. Formela, J. Bancewicz, S. E. Attwood Hope Hospital, Salford, UK Positive truncal nodes of oesophageal carcinoma: not always a dismal prognosis C. J. Buskens∗, J. J. G. H. M. Bergman†, J. B. F. Hulscher∗, P. Fockens†, H. Obertrop∗, J. J. B. van Lanschot∗ Departments of ∗Surgery and †Gastroenterology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands Proximal and distal gastric cancer. The influence of extent of resection and tumour subsite on survival S. M. Dresner, P. J. Lamb, N. Hayes, S. M. Griffin Northern Oesophago-Gastric Cancer Unit, Ward 36 Office, Royal Victoria Infirmary, Newcastleupon-Tyne, UK Pure gastric or duodenal reflux is associated with increased risk of Barrett’s oesophagus Y. Koak, S. Davies, M. Winslet Department of Surgery, Royal Free and University College Medical School, London, UK Omeprazole is ineffective in Barrett’s oesophagus caused by pure duodenal reflux Y. Koak, S. Davies, M. Winslet Department of Surgery, Royal Free and University College Medical School, London, UK Early distant recurrence after oesophagectomy—a failure of staging P. J. Lamb, S. M. Dresner, J. Shenfine, S. Robinson, N. Hayes, S. M. Griffin Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary, Newcastle-upon-Tyn, UK
Parallel Session XIII—Breast Adjuvant Therapy 15.30–16.30 15.30
Council Room 114
Chairman: Professor L. Holmberg
A novel grading system assessing pathological response to primary chemotherapy in breast cancer predicts survival K. N. Ogston∗, I. Miller†, S. Payne†, A. W. Hutcheon‡, T. K. Sarkar‡, S. D. Heys∗ Department of Surgery∗, Pathology† and Oncology‡, University of Aberdeen, UK
Programme 15.40
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Improvements in response rate and disease-free interval in patients receiving primary chemotherapy with taxotere for breast cancer K. N. Ogston and the Aberdeen Breast Group Departments of Surgery, University of Aberdeen, UK Clinical and biological factors that predict response of operable breast cancer to neoadjuvant chemotherapy G. Abou-Elnagah∗, F. Knox†, E. Anderson‡, A. Howell‡, N. Bundred∗ ∗Surgical Breast and †Histopathology Departments, South Manchester University Hospital, Nell Lane, Manchester and ‡Paterson Cancer Research Institute, Medical Oncology Departments, Christie Hospital, Manchester, UK Targeted intra-operative radio therapy (Targit): a novel approach for local treatment of breast cancer J. S. Vaidya∗, M. Baum∗, J. S. Tobias†, D. P. D’Souza, S. Morgan‡, M. Metaxas‡, K. Harte¶, A. Sliski¶, E. Thomson¶ Department of ∗Surgery, †Radiation Oncology and ‡Medical Physics, Royal Free University College Medical School, London, UK and ¶Photoelectron Corporation, MA, USA Pre-treatment predictors of survival in locally advanced breast cancer treated with multimodality therapy K. N. Ogston∗, I. Miller†, S. Payne†, A. W. Hutcheon‡, T. Sarkar‡, T. O’Hanrahan∗, S. D. Heys Department of ∗Surgery, †Pathology and ‡Clinical Oncology, University of Aberdeen, UK Prognostic indicators in locally advanced breast cancer treated with primary chemotherapy K. H. Ogston∗, I. Miller†, S. Payne†, A. W. Hutcheon‡, T. K. Sarkar‡, T. O’Hanrahan∗, S. D. Heys∗ Departments of ∗Surgery, †Pathology and ‡Clinical Oncology, University of Aberdeen, UK
Plenary Session VII Lecture Room One 16.30–16.40
Chairman: Mr D. Rosh
1999 Winner of the Ronald Raven Travelling Scholarship Miss Jane M. Blazeby Managing Gastric Cancer in Japan: a British Experience Hunterian Lectureship Mr Philip Drew (Hull, UK) The Next Millennium: New Paradigms and Novel Analyses
16.45–17.30
THURSDAY, 28 NOVEMBER 2000 08.30 P1
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To be set up in Webb Johnson Hall Do P53, TGF and FAS-L play a role in the development of post-transplant dermal neoplasia? Immunohistochemical assessment of serial skin biopsies G. Morris-Stiff∗, M. Gonzalez†, S. Metcalfe‡, S. Negus‡, C. Mower†, W. A. Jurewicz∗ ∗Welsh Transplantation Research Group and †Department of Dermatology, University of Wales College of Medicine and ‡Transplant Molecular Biology Group, Department of Surgery, University of Cambridge, UK A quantitative, microsphere based cytotoxic drug targeting assay for human breast cancer cells using laser flow and scanning cytometry D. Kaur, L. Reeve, A. H. Goodall, D. A. Rew University Units of Surgery and Pathology, Leicester University Hospitals, UK Expression of renin in human breast tissue and correlation with prognostic factors A. J. Ogedegbe∗, J. R. Puddefoot†, M. Tahmasebi† G. P. Vinson†, A. W. Goode∗ and R. Carpenter∗ ∗Breast Unit, St Bartholomew’s Hospital and †Department of Biochemistry, Queen Mary and Westfield College, University of London, UK Integrin 1 expression and long-term oestrogen deprivation C. J. Pogson, C. M. W. Chan, L.-A. Martin, G. P. H. Gui, M. Dowsett Departments of Academic Surgery and Biochemistry, The Royal Marsden, Fulham Road, London, UK Conjugated linoleic acid reduces breast tumour growth B. Majumder∗, S. Moir∗, K. Wahle†, S. D. Heys∗ ∗Department of Surgery, University of Aberdeen and †Rowett Research Institute, Aberdeen, UK Interleukin (IL−-10 as a possible mediator of the defective immune response in human breast cancer B. Al-Sarireh∗, A. Robins†, O. Eremin∗ ∗Section of Surgery and †Department of Immunology, University Hospital, Nottingham, UK
832
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Breast cancer in the elderly and infirm. Does radiotherapy after excision under local anaesthetic help? S. Chaturvedi, C. Rodd, E. F. Shah, J. LeVay, T. J. Archer Surgery after neoadjuvant therapy for locally advanced breast cancer may be reserved for residual or recurrent disease P. Sinha, S. Coltart, G. Vittay, S. Bendall, P. Pheils, T. Bates The Breast Unit, William Harvey Hospital, Ashford, Kent, The Queen Elizabetth, The Queen Mother Hospital, Margate, UK Prevention of chemotherapy-induced premature ovarian failure with goserelin E. F. Shah, J. V. Woodside, R. Chatterjee, J. Houghton, R. Stein, C. Saunders, M. Baum Department of Surgery, Royal Free University College London, UK Is breast MRI superior to clinical examination in the assessment of response to primary medical therapy? M. Douek∗, T. Davidson∗, M. A. Hall-Craggs†, R. Stein‡, S. R. Lakhani¶, M. Kissin∀, M. Baum∗, I. Taylor∗ Departments of ∗Surgery, †Radiology, ‡Medical Oncology and ¶Histopathology, Royal Free and University College, London Medical School, London, UK Is Tamoxifen alone in the treatment of elderly patients with breast cancer justified? A. A. Mavanur, P. R. Armitstead Kidderminster Health Care Trust, Kidderminster General Hospital, Worcs, UK Tubular, lobular and other low-grade carcinomas are difficult to diagnose on FNA cytology requiring core biopsy for definitive pre-operative diagnosis of malignancy C. L. Baxendine, M. J. Jeffrey, D. N. Poller on behalf of The Portsmouth Breast Team Department of Pathology, Queen Alexander Hospital, Cosham, Portsmouth, UK The outcome of C1 fine needle aspiration cytology of breast lumps A. J. Sheen, C. D. Karkos, V. Chandrasekar, C. Emerson, L. Forrest Blackpool Victoria Hospital, Blackpool, UK Factors determining inadequate FNA cytology in patients with palpable breast cancers S. J. Parker, S. A. Harries South Warwickshire Hospital, NHS Trust, Warwick, UK Palpable breast cancer which is mammographically invisible R. Rajentheran, M. C. Rao, E. Lim, T. W. J. Lennard Royal Victoria Infirmary, Newcastle Upon Tyne, UK Mammographic patterns and breast cancer risk S. Goyal, J. Skone, N. Khonji, D. Clarke, R. West, R. E. Mansel Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, UK Use of the Internet to provide information for patients attending breast clinics C. Sweeney, S. Kettlewell, D. Smith, I. Reid Victoria Infirmary Glasgow and University of Glasgow, UK Meeting the two week wait for breast cancer in a district general hospital A. Parvaiz, J. Davies, S. Williams, D. Griffiths, H. Gajraj Yeovil District Hospital, Yeovil, UK The ‘two week wait’ for suspected breast cancer: it’s impact on a symptomatic breast unit and correlation of referrals with outcome L. Campbell, S. Prance, C. Teasdale, R. M. Watkins Derriford Hospital Breat Care Unit, Plymouth, UK Assessment of grade and type of breast cancer on core biopsy: interobserver variability and comparison with excision histology I. A. F. Azmy∗, S. Oliver∗, S. S. Cross†, T. J. Stephenson∗, M. W. R. Reed ∗Section of Surgical Oncology, University of Sheffield and †Department of Histopathology, The Royal Hallamshire Hospital, Sheffield, UK Is the 20 g standard for benign open biopsies in screen detected lesions too generous? R. Kushwaha, J. Adjogatse, C. Deacon, S. Walker, B. Isgar New Cross Hospital, Wolverhampton, West Midlands Predictors of positive margins after local excision of DCIS K. Mokbel, J. C. C. Hu, K. Kirkpatrick, C. Choy, W. Al-Sarakbi, A. Mostafa, C. Wells, N. Perry, R. Carpenter St Bartholomew’s Hospital, London, UK Development of a nurse led family history clinic in a district general hospital breast unit E. Gray, A. Fowler, N. D. Rothnie Southend Breast Unit, UK Graphical risk explanation as a new method of explaining risk to women with a family history of breast cancer V. Vijay, J. Stein, C. Saunders, M. Baum Department of Surgery, Royal Free and University College Medical School, London, UK
Programme P25
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Breast reconstruction in general surgical practice E. Harper, B. R. Gwynn Stafford General Hospital, UK Fibroblast growth factor 8, a breast oncogene, has protein expression in normal and lactational breast tissue C. Zammit, S. K. Maargh, J. Gomm, D. Sinnett, S. Shousha, R. C. Combes, C. L. Johnston Department of Cancer Cell Biology, Imperial College School of ???? Improved sentinel node localization by preoperative assessment of node depth by lymphoscinitigraphy and ultrasound R. S. Uppal, D. Hofland, M. A. Masoomi, F. Fuechsel, A. J. Britten, R. A. Allan, B. W. E. B. Powell St Georges Hospital, London, UK Hormone or surgery, local or general anaesthesia? A one year audit of treatment of carcinoma of breast in elderly patients S. Chaturvedi, C. J. D. Mortimer, T. J. Archer The Ipswich Hospital, Ipswich, Suffolk, UK The role of gastrin in pancreatic and oesophageal tumour growth A. Gilliam, P. A. Clarke, D. McWilliams, J. Jankowski, S. A. Watson Queens Medical Centre, Nottingham, UK Can p53 and Ki67 be useful in the clinical management of Paget’s disease? P. E. Ellis, L. F. Wong Te Fong, K. J. Rolfe, J. C. Crow, A. B. Maclean, T. Davidson, G. W. Perrett University Department of Surgery, Royal Free and University College Medical School, London, UK
British Association of Surgical Oncology Scientific Meeting held at The Royal College of Surgeons of England, London, UK on 27–28 November 2000 PROGRAMME MONDAY, 27 NOVEMBER 2000 08.00 08.00
Registration and coffee Oral posters day one
Main Foyer Webb Johnson Hall
Parallel session I—Breast Cancer Detection Diagnosis 08.30–10.00
Lecture Room 1
08.30
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Chairman: Mr J. Winstanley
10.00–10.30 10.00–10.30
Ultrasound by surgeons is accurate in the diagnosis of breast disease P. A. Whitehouse, Y. Baber, G. Brown, E. Moskovic, D. M. King, G. P. H. Gui Academic Surgery and Radiology, Breast Unit, Royal Marsden Hospital, London, UK Surgeon directed ultrasound guided core biopsies in the breast—a prospective study L. A. Donaldson, A. Cliff, L. Gardiner, M. A. Ashton Breast Clinic, Diana Princess of Wales Hospital, Grimsby, UK Fibrofatty nodule in the breast: is inadequate cytology sufficient for diagnosis? R. Achuthan∗, K. Munot∗, J. Sutton†, G. Parkin‡, K. Horgan∗ Departments of Surgery∗, Pathology† and Radiology‡, Leeds General Infirmary, Leeds, UK An evaluation of the accuracy of imprint cytology of core biopsy D. R. Cheetham, J. Aps, T. K. Walters, M. Khan Queen Mary’s Hospital, Sidcup, UK Histological assessment of breast tissue by optical biopsy G. M. Briggs∗, C. D. O. Pickard†, M. M. Keshtgar†, I. J. Bigio‡, P. M. Ripley‡, C. Kelly‡, C. M. Saunders†, S. Lakhani¶, S. G. Brown∗ ∗National Medical Laser Center, †Department of Surgery, ‡Department of Histopathology, Royal Free and University College Medical School, London and ¶Los Alamos National Laboratory, New Mexico, USA Ultrasound core biopsy of breast lesions which are indeterminate on imaging (R3) is essential P. Sinha, W. Webb, T. Bates The Breast Unit, William Harvey Hospital, Ashford, Kent, UK Changes in vascular phenotype with the development of ductal cancer in situ (DICS) of the breast N. B. Teo, B. S. Shoker, C. M. Jarvis, C. Holcombe, L. Martin, J. P. Sloane Pathology Department, University of Liverpool Breast Unit, Royal Liverpool University Hospital, Liverpool UK Core biopsy analysis of C3 and C4 breast lesions J. Wayman, T. Johnson, J. R. Young, L. A. Webb, L. Glunt, D. A. Browell, J. D. Hemming, W. J. Cunliffe The Breast Screening Unit and Departments of Histopathology and Surgery, The Queen Elizabeth Hospital, Gateshead Coffee & exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
08.30–10.00
Lecture Room 2
Parallel Session II—Colorectal 08.30
9
0748–7983/00/080821+13 $35.00/0
Chairman: Mr K. Hosie
Immunohistochemistry in the detection of microsatellite instability in colorectal cancer D. A. Lawes, T. Pearson, S. SenGupta, I. Taylor, P. B. Boulos Department of Surgery, Royal Free and University College London Medical School, UK 2000 Harcourt Publishers Ltd
822
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10.00–10.30 10.00–10.30
Ten year experience of endoscopic trans-anal resection (ETAR) L. J. Marshall, C. D. Sutton, N. Flint, M. J. Kelly Department of Surgery, Leicester General Hospital, Leicester, UK Colorectal anastomotic leaks regularly masquerade as ‘cardiac complications’ C. D. Sutton, N. Williams, L. J. Marshall, D. P. Berry, W. M. Thomas, M. J. Kelly Department of Surgery, Leicester General Hospital, Leicester, UK Morbidity following colorectal resection K. L. R. Grace, P. Durdey, M. G. Thomas Department of Surgery, Bristol Royal Infirmary, Bristol, UK Long-term outcome after surgery for malignant large bowel obstruction C. Staudacher, A. Chiappa San Raffaele Scientific Institute, Milano, Italy Local formalin instillation: an effective treatment for uncontrolled haemorrhagic proctitis R. Ouwendijk∗ G. W. M. Tetteroo∗, W. Bode†, E. R. de Graaf∗ Departments of ∗General Surgery and †Gastroenterology, Ijsselland Hospital, Capelle aa/d Ijssel, Netherlands Colorectal cancer—is standard intensive clinical follow-up necessary? S. Chatterjee, M. C. Parker Department of Surgery, Joyce Green Hospital, Dartford, Kent, UK The role of positron emission tomography in the management of recurrent colorectal cancer T. H. A. Arulampalam, B. Lovett, M. Loizidou, D. C. Costa, P. B. Boulos, P. J. Ell, I. Taylor Royal Free and University College Medical School, London, UK Extensive cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal origin E. de Bree, A. J. Witkamp, M. M. Kaag, G. W. van Slooten, F. A. N. Zoetmulder The Netherlands Cancer Institute, Amsterdam, The Netherlands Coffee & exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
Parallel Session III—Hepato-Pancreato-biliary Cancer 08.30–10.00
Council Room Chairman: Mr G. J. Poston Note: Each paper 7 minutes & 3 minutes discussion
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Pseudomyxoma peritonei treated by extensive cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy E. de Bree, A. J. Witkamp, M. M. Kaag, G. W. van Slooten, F. A. N. Zoetmulder The Netherlands Cancer Institute, Amsterdam, The Netherlands Intrahepatic chemotherapy via the subcutaneous jet port system J. Wayman, S. MacFarlane, G. Appleby, R. Uberoi, W. J. Cunliffe Departments of Surgery and Interventional Radiology, Queen Elizabeth Hospital, Gateshead, Tyne and Wear, UK Role of COX-2, APC and NSAIDs in colorectal cancer G. Katti, D. F. McWilliams, N. C. Armitage, P. A. Clarke, T. A. Morris, S. A. Watson Cancer Studies Unit, Section of Surgery, University Hospital, Notts, UK T cells are activated in anergic patients with colorectal liver metastases A. Huang∗, H. Quinn∗, Cl Glover∗, D. C. Henderson†, T. G. Allen-Mersh∗ Departments of ∗Surgery and †Immunology, Chelsea and Westminster Hospital, London, UK An in vivo study of two new photosensitizers following interstitial photodynamic therapy of the liver S. F. Purkiss, M. F. Grahn, J. P. Rovers, N. S. Williams St Bartholomew’s and the Royal London School of Medicine and Dentristy, UK The gluthathione depleting agent BSO radiosensitizes cholangiocarcinoma cells to apoptosis A. C. Okaro, F. A. Cotter, B. R. Davidson Hepatobiliary Unit, Department of Surgery, Royal Free and University College Medical School, London, UK Electrolytic liver ablation: the effect of intermittent pringle manoeuvre D. P. Berry∗, P. Vanderzon†, A. R. Dennison∗, G. J. Maddern† Departments of Surgery∗, Leicester General Hospital and Queen Elizabeth Hospital, Adelaide, Australia Expression of endothelin receptors in human colorectal liver metastases K. Dawas∗, M. Dashwood∗, M. Loizidou∗, H. Ali∗, G. Burnstock†, I. Taylor∗ ∗Department of Surgery, and the †Autonomic Neuroscience Institute, Royal Free and University College Medical School, University College, London, UK Loss of taste and smell after upper gastro-intestinal surgery A. M. Harris, M. Lamberts, S. M. Davies, N. Hayes, S. M. Griffin Northern Oesophago-Gastric Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
823
Programme 10.00–10.30 10.00–10.30
Coffee & exhibition Poster viewing
Edward Lumley Hall Webb Johnson Hall
Plenary Session I—Raven Prize Lecture Room 1 Chairman: Professor D. George 10 minutes each plus 4 mins discussion 10.30
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Surgery for breast cancer—no wound drains and early discharge—a randomized clinical trial A. Purushotham∗, E. McLatchie∗, D. Young†, D. George∗, S. Stallard∗, J. Doughty∗, D. Brown∗, C. Farish‡, A. Walker†, K. Millar¶, G. Murray∀ ∗Department of Surgery, Western Infirmary, Glasgow, †Health Economics, Greater Glasgow Health Board, ‡Physiotherapy, Western Infirmary, ¶Behavioural Science, University of Glasgow, ∀Medical Statistics, Edinburgh, UK Systematic review of the methodological quality of randomized controlled trials of the surgical excision of cancer B. Lovett, W. Swayer, J. Houghton, I. Taylor Department of Surgery, Royal Free and University College Hospital Medical School, University College London, UK Patient education as part of a multi-faceted strategy increases the detection of curable oesophagogastric cancer P. McCulloch, L. Williams, P. Brown Department of Surgery, University of Liverpool, UK Monitoring of minimal residual disease (MRD) during adjuvant therapy in breast cancer B. M. Smith∗, A. Singh∗, E. Hall¶, H. D. Sinnett†, N. C. P. Cross‡, R. C. Coombes∗ and M. J. Slade∗ ∗CRC Laboratories and ‡Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, †Department of Surgery, Charing Cross Hospital, London and ¶Department of Epidemiology, Institute of Cancer Research, Sutton, UK Antioxidants enhance susceptibility to 5FU toxicity in colon cancer cells in vitro D. Adeyemo, M. Davies, S. Toffa, M. Lowdell, M. C. Winslet Academic Departments of Surgery and Haematology, Royal Free and University College Medical School, London, UK bFGF infusion increases 5 fluorouracil uptake in a model of established colorectal liver metastases P. Mathur∗, P. Carnochan†, T. G. Allen-Mersh ∗Department of Academic Surgery, Imperial College School of Medicine, Chelsea and Westminster Hospital and †Institute of Cancer Research, Surrey, UK Axillary node staging in the Trent Breast Screening Programme 1996–1999: audit of surgeons’ protocols and practice I. A. F. Azmy∗, J. A. Reed†, M. W. R. Reed ∗Section of Surgical Oncology, University of Sheffield and †Trent QA Reference, Nottingham, UK Outcome of local recurrence following sarcoma surgery R. J. Grimer, R.M. Tillman, S. R. Carter, D. Spooner, D. Peake The Royal Orthopaedic Hospital, Birmingham, UK
Plenary Session II—2000 BASO British Journal of Surgery Lecture 12.30–13.00
Lecture Room 1 Chairman: Mr G. J. Poston Professor R. Daniel Beauchamp (USA) The role of TGF-beta in colorectal cancer: tumour suppressor or tumour promoter?
13.00–14.00 13.00–14.00
Lunch & exhibition Poster viewing
14.00–16.00
Lecture Room 1
Edward Lumley Hall Webb Johnson Hall
Plenary Session III—Alan Edwards Prize 14.00
35
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36
Chairman: Professor J. Elder
Magnetic resonance imaging as an adjunct to triple assessment in equivocal breast disease K. C. Munot, R. Achuthan, S. Radjenovic, A. Barr, B. Dall, K. Horgan Leeds General Infirmary, Leeds, UK PK11195, a mitochondrial benzodiazepine receptor antagonist radiosensitizes Bcl-XL and Mcl-1 expressing human cholangiocarcinoma to apoptosis M. C. Okaro∗†, D. Fennel†, F. E. Cotter†, B. F. Davidson∗ ∗University Department of Surgery, London and †Department of Exp. Hematology, St Bartholomews and the Royal Free and University College Medical School, London, UK
824
Programme
14.30
37
14.45
38
15.00
39
15.15
40
15.30
41
15.45
42
16.00–16.30 16.00–16.30
Changed pattern and incidence of first site recurrences following sentinel node procedure in melanoma patients M. G. Statius Muller, R. J. C. L. M. Vuylsteke, P. A. M. van Leeuwen, R. Pijpers, P. J. cn Diest, S. Meijer Departments of Surgical Oncology, Nuclear Medicine and Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands Angiogenesis in ductal carcinoma in situ (DCIS) of the breast and its relationship to the risk of recurrence N. B. Teo, B. S. Shoker, C. M. Jarvis, C. Holcombe, L. Martin, J. P. Sloane Pathology Department, University of Liverpool, Breast Unit, Royal Liverpool University Hospital, Liverpool, UK Anorectal irradiation in pelvic radiotherapy: an assessment using in vivo dosimetry D. Hayne∗, U. Johnson†, D. D’Souza†, H. Payne‡, P. B. Boulos∗ ∗Department of Surgery, Royal Free University College Medical School, London, †Department of Medical Physics and ‡Department of Oncology, Royal Free University College Medical School, UK Pathological response of breast cancers to primary docetaxel is predicted by HER-2 and ER status K. N. Ogston∗, I. C . Smith∗, S. Payne†, I. D. Miller†, A. W. Hutcheon‡, T. Whitaker‡, T. K. Sarkar∗, S. D. Heys∗ Departments of ∗Surgery, †Pathology and ‡Oncology, University of Aberdeen, UK Thrombin regulation of vascular endothelial growth factor (VEGF) and tissue factor (TF) in human breast cancer cells A. Salih, R. T. Mathie, R. C. N. Williamson, A. K. Kakkar Department of Surgery, Imperial College School of Medicine, Hammersmith Hospital London, UK Endoscopic assisted intrathoracic oesophagogastrectomy without thoracotomy for tumours of the lower oesophagus and cardia C. D. Sutton, L. J. Marshall, S. A. White, D. P. Berry, P. S. Veitch Department of Surgery, Leicester General Hospital, UK Tea Edward Lumley Hall Poster viewing Webb Johnson Hall
16.30–17.30
Lecture Room 1
Parallel Session IV—Breast Oral Posters Chairman: Mr D. A. Rew
Screening Diagnosis—2 Week Rule 16.30
43
16.34
44
16.38
45
16.42
46
The effect of the two week rule for providers, users and cancers J. Adjogatse, R. Kushwaha, S. Walker, B. Isgar New Cross Hospital, Wolverhampton, West Midlands, UK The relevance of reported symptoms in a breast screening programme R. S. Williams, D. L. Brook, K. Gower-Thomas, I. J. Monypenny Breast Test Wales, Cardiff, UK Factors affecting breast cancer risk perception in women attending a family history clinic V. Vijay, J. Stein, C. Saunders, M. Keshtgar, M. Baum Department of Surgery, Royal Free and University College Medical School, London, UK Survival of patients with screen detected cancer. Is the effectt limited to ER negative patients? K. Chin, A. Harris, P. J. Clarke, A. Jones, M. Greenall Departments of Surgery and Oncology, John Radcliffe Hospital, Oxford, UK
Localization, Cytology 16.46
47
16.50
48
16.54
49
Fine needle aspiration cytology of breast. Audit of number of slides required for diagnosis S. Natu∗, J. Jeffree†, Z. Saad‡, M. S. Bashir∗ ∗Department of Histopathology, †Department of Radiology, ‡Department of Surgery, Hope Hospital, Stott Lane, Salford, Manchester, UK Does accuracy of localization influence the benign breast biopsy weight? O. Ravisekar, B. Mucci West Cumberland Hospital, UK Routine hospital follow-up of breast cancer—time for a new approach? J. Donnelly, P. Mack, L. D. Donaldson Diana Princess of Wales Hospital, Grimsby, UK
Programme 16.58
50
17.02
51
825
Breast conservation surgery versus mastectomy after priary chemotherapy—changing clinical practice K. N. Ogston∗, T. K. Sarkar†, S. D. Heys∗ Departments of ∗Surgery and †Oncology, University of Aberdeen, UK Does immediate reconstruction after mastectomy for breast cancer delay adjuvant therapy? S. M. Tan, D. Landau, G. M. Ross, R. P. A’Hern, N. P. M. Sacks, G. P. H. Gui Department of Surgery and Oncology, Royal Marsden Hospital, London, UK
Basic Science, Immunology 17.06
52
17.10
53
17.14
54
Mononuclear phagocytes but not tumour cells are the main source of elevated interleukin (IL)-10 levels in human breast cancer B. Al-Sarireh∗, S. Sathaporn∗, A. Robins†, D. Jenkins‡, W. Vassanasiri¶, M. El-Sheemy¶, J. A. Jibril¶, D. Clark¶, O. Eremin¶ ∗Section of Surgery, †Department of Immunology and ‡Department of Pathology, University Hospital, Nottingham and ¶Department of Surgery, Lincoln County Hospital, Lincoln, UK Defective function of dendritic cells in patients with breast cancer S. Satthaport∗, B. Sarireh∗, W. Vassanasiri†, M. El-Sheemy†, J. A. Jibril†, D. Clark†, A. Robins‡, O. Eremin∗† ∗Section of Surgery, Queen’s Medical Centre, University of Nottingham, †Breast Unit, Department of Surgery, Lincoln County Hospital, ‡Section of Immunology, Queen’s Medical Centre, University of Nottingham, UK Are the anti-tumour effects of conjugated linoleic acid mediated by increased p53 expression? B. Majumder∗, A. Farquharson†, K Wahle†, S. D. Heys∗ ∗Department of Surgery, University of Aberdeen and †Rowett Research Institute, Aberdeen, UK
Parallel Session V—GI Oral Posters 16.30–17.30
Lecture Room 2
Chairman: Mr T. C. Holme
Diagnosis 16.30
55
16.34
56
Improving access to barium enema examinations in suspected colorectal cancer D. A. Slade, B. Jones, M. Lipton, C. A. Makin Wirral Colorectal Unit, Arrowe Park Hospital, Mersey, UK Pelvic CT scanning for rectal cancer—useful predictor of extraluminal disease? G. N. Buchanan, K. Thakur, J. Jacomb-Hood, G. Phillip, J. Linsell University Hospital, Lewisham, UK
Guidelines, 2 Week Rule 16.38
57
16.42
58
Knowledge of cancer symptoms among patients attending one-stop breast and rectal bleeding clinics A. M. Pullyblank, S. J. Cawthorn, A. R. Dixon Department of General Surgery, Frenchay Hospital, Bristol, UK Coping with the ‘two week rule’ in suspected colorectal cancer. A pilot study D. A. J. Slade, T. Y. El-Sayed, S. H. Suliman, C. J. Walsh, C. A. Making Wirral Colorectal Unit, Arrowe Park Hospital, Mersey, UK
Surgery, Chemotherapy 16.46
59
16.50
60
16.54
61
A new technique for combined synchronous on table antegrade and retrograde colonic lavage D. Francis, T. Satyadas, J. Peters Princess Alexandra Hospital, Harlow, Essex, UK A phase 1 study of photodynamic therapy of patients with advanced colorectal cancer using temoporfin I. M. Hah, M. F. Grahn, S. F. Purkiss, N. S. Williams St Bartholomew’s and the Royal London Hospital School of Medicine and Dentristy, QMW, UK 5 ASA induces susceptibility to 5 FU in colon cancer cells in vitro D. Adeyemo, M. Davies, S. Toffa, M. Lowdell, M. C. Winslet Academic Departments of Surgery and Haematology, Royal Free and University College Medical School, London, UK
826
Programme
Basic Science 16.58
62
17.02
63
17.04
64
Investigating the role of IGFBP-4 in colorectal cancer M. Davies∗, S. Coe∗, S. Gupta, D. Adeymo, G. Goldspink†, M. Winslet∗ University Department of Surgery, ∗Department of Anatomy and †Developmental Biology, Royal Free and University College Medical School, London, UK The value of P15 and P16 in the prognosis of colorectal cancer J. K. C. Huang∗, H. W. Taylor†, S. Tran, I. P. Lineham†, M. C. Winslet ∗University Department of Surgery, Royal Free and University College Medical School, London and †Department of Surgery, Basildon Hospital, Essex, UK Comparison of orthotopic cell implantation (OCI) vs orthotopic tumour implantation (OTI) in the HaP-T1 Syrian hamster pancreatic cancer model A. T. Abraham, S. R. Shah, B. R. Davidson Royal Free and University College Medical School, London, UK
Upper GI 17.06
65
17.10
66
The diagnostic yield of extended en bloc resection for (adeno) carcinoma of the oesophagus or gastric cardia J. B. F. Hulscher∗, B. P. L. Wijnhoven†, G. J. A. Offerhaus‡, H. W. Tilanus†, H. Obertop∗, J. J. B. van Lanschot∗ Departments of ∗Surgery and ‡Pathology, Academic Medical Center/University of Amsterdam and †Department of Surgery, Academic Hospital Dijkzigt-Rotterdam, The Netherlands Electrolytic liver ablation: the effect of multiple electrodes D. P. Berry∗, P. Vanderzon†, A. R. Dennison, G. J. Maddern∗ Departments of Surgery∗, Leicester General Hospital, UK and †Queens Elizabeth Hospital, Adelaide, Australia
Plenary Session Four 2000 Stanford Cade Memorial Lecture Lecture Room 1
Chairman: Mr D Rosin
Professor I. Taylor (London, UK) What constitutes Good Practice in Surgical Oncology? 18.00–18.30
BASO Annual General Meeting (Members Only) Close
Lecture Theatre One
18.30 Evening Social Programme Dress: Lounge Suit 19.30 for 20.00 Reception & Annual Dinner of the Association at the Law Society, Chancery Lane, London
TUESDAY, 28 NOVEMBER 2000 08.00 08.00
Registration, Coffee & Exhibition Edward Lumley Hall Non-oral posters to be displayed in Webb Johnson Hall
Parallel Session VI—Breast Cancer Surgery Short Papers 08.30–10.30
Lecture Room 1
08.30
67
08.40
68
Chairman: Mr A. D. Baildam
Review of trilucent breast implants in south Manchester E. A. E. Elangovan∗, I. Hadjiloucas∗, M. Wilson†, J. M. Hawnaur‡, L. Barr∗, A. D. Baildam∗, N. J. Bundred∗ Academic Department of ∗Surgery and †Radiology, University Hospitals of South Manchester and ‡Medical School, Manchester, UK Breast reconstruction in the UK and Ireland—is there uniformity of care? A. Purushotham∗, C. Callaghan∗, M. Kerin†, D. Rainsbury‡, D. George¶ ∗Cambridge Breast Unit, †The Mater Hospital, Dublin, Ireland, ‡Royal Hampshire Hospital and ¶Western Infirmary, Glasgow, UK
Programme 08.50
69
09.00
70
09.10
71
09.20
72
09.30
73
09.40
74
09.50
75
10.00
76
10.10
77
10.20
78
10.30–11.00 10.30–11.00
827
Assessment of breast form using biodimensional implants in immediate reconstruction after mastectomy with geometric measurements S.-M. Tan, E. C. Faliakou, C. Choy, R. P. A’Hern, G. P. H. Gui Royal Marsden NHS Trust, London, UK The role of harmonic scalpel in breast surgery J. C. C. Hu, K. L. Kirkpatrick, A. Mostafa, C. K. Choy, K. Mokbel, R. Carpenter Breast and Endocrine Unit, St Bartholomew’s Hospital, London, UK The clinical outcome of two new breast reconstructive procedures R. K. Gendy, D. L. Rutherford, R. M. Rainsbury Breast Unit, Royal Hampshire Country Hospital, Winchester, UK Optical biopsy for the assessment of sentinel lymph nodes of the breast G. M. Briggs∗, C. D. O. Pickard∗, M. M. Keshtgar†, I. J. Bigio‡, P. M. Ripley‡, C. Kelly‡, C. M. Saunders†, P. J. Ell¶, S. Lakhani¶, S. G. Brown∗ ∗National Medical Laser Centre, †Department of Surgery, ¶Department of Nuclear Medicine, ¶Department of Histopathology, Royal Free and University College Medical School, London, UK and ‡Los Alamos National Laboratory, New Mexico, USA Mammaglobin expression in sentinel and non-sentinel nodes G. Branagan, D. Hughes, C. Crane-Robinson, M. Perry Queen Alexandra Hospital, Portsmouth and the University of Portsmouth, UK Small breast tumours. Is axillary dissection necessary? S. Chaturvedi, C. J. D. Mortimer, F. MacNeill, P. Sauven, S. K. Marsh, T. J. Archer Mid Anglia Breast Group, Ipswich Hospital, UK Incidence of nodes in completion mastectomy specimens following breast conservation and axillary clearance N. I. Khonji, R. Edwards, H. M. Sweetland, I. J. Monypenny, R. E. Mansel, D. J. Webster Department of Surgery, University of Wales College of Medicine, and Llandough Hospital, Cardiff, UK Pathological assessment of the sentinel node in breast cancer: comparison of H&E and immunohistochemical staining of frozen sections with paraffin sections N. I. Khonji, D. Clarke, S. Goyal, A. G. Douglas-Jones, C. Jasani, H. M. Sweetland, R. E. Mansel Departments of Surgery and Pathology, University of Wales College of Medicine, Cardiff, UK A comparison of the modes of detection of minimal residual disease (MRD) in breast cancer A. Singh, M. Slade, M. Lu¨chtenberg, B. M. Smith, H. D. Sinnett, R. C. Coombes Department of Cancer Cell Biology, Hammersmith Hospital, London, UK Predictive factors of local recurrence and distant metastasis in malignant phyllodes tumour of the breast I. A. Kapiris, M. Nasiri, R. Millis, U. Mahadeva, R. A’Hern, G. P. H. Gui Royal Marsden Hospital, London, UK Coffee & trade exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
Parallel Session VII—Basic Science Council Room 08.30
79
08.40
80
08.50
81
09.00
82
09.10
83
Chairman: Professor M. Reed
Effect of oestradiol on integrin 1 expression and function C. J. Pogson, L.-A. Martin, C. M. W. Chan, M. Dowsett, G. P. H. Gui Departments of Academic Surgery and Biochemistry, The Royal Marsden, Fulham Rooad, London, UK Purification and charaterization of primary breast cancer cells M. S. Kothari, S. Ali, H. D. Sinnett, S. Soousha, N. Livni, R. C. Coombes, M. J. Slade Imperial College School of Medicine, Hammersmith Hospital, London, UK Stimulation of peritoneal macrophage activity by non-cytotic components of intraperitoneal chemotherapy P. McCulloch, I. A. Shah, E. Lindup Department of Surgery, University Hospital Aintree and University of Liverpool, Department of Pharmacology, University of Liverpool, UK Transforming growth factor-beta induced IGFBP-3 prevents ceramide-induced apoptosis in human breast cancer cells (Fs578T) C. A. Fowler, C. M. Perks, N. J. Laurence, T. Lai, J. R. Farndor, J. M. P. Holly Department of Surgery, Bristol Royal Infirmary, Bristol, UK Chronic glucose deprivation inhibits aminolaevulinic acid induced photodynamic therapy M. Tomlinson, L. Wyld, N. J. Brown, M. W. R. Reed Department of Surgical and Anaesthetic Sciences, University of Sheffield, UK
828
Programme
09.20
84
09.30
85
09.40
86
09.50
87
10.00
88
10.10
89
10.20
90
10.30–11.00 10.30–11.00
Modulation of protein kinase C (PKC) isoforms in prostate cancer cells by dietary fat S. S. Pandian, A. A. Sneddon, P. Barker, K. W. J. Wahle, S. McClinton, C. Bestwick, S. D. Heys Departments of Surgery and Urology, Surgical Nutrition and Metabolism Unit, University of Aberdeen and Rowett Research Institute, Aberdeen, UK Thrombin regulation of vascular endothelial growth factor (VEGF) andd tissue factor (TF) in human breast cancer cells A. Salih, R. T. Mathie, R. C. N. Williamson, A. K. Kakkar Department of Surgery, Imperial College School of Medicine, Hammersmith Hospital, London, UK Transcription of components of the renin angiotensin system in human breast and relationship with severity of disease A. J. Ogedegbe∗, J. F. Puddefoot†, M. Tahmasebi†, G. P. Vinson†, A. W. Goode∗, R. Carpenter∗ ∗Breast Unit, St Bartholomew’s Hospital and †Department of Biochemistry, Queen Mary and Westfield College, University of London, UK Intraperitoneal gene therapy for desmoid disease in familial adenomatous polyposis R. M. Bright-Thomas∗, H. S. Wasan†, R. Hargest∗ ∗Department of Surgery, Royal Free and University College Medical School, London and †ICRF Oncology Unit, Hammersmith Hospital, London, UK Bispecific antibody derived from high affinity monoclonal (323A3) to 17.1 antigen (EpCAM) reduces pulmonary metastases, inhibits local tumour growth and prolongs survival in mice given challenge with syngeneic tumour expressing human 17.1A P. M. Safranek, M. J. Glennie, J. A. Smallwood Department of Surgery and Tenovus Research Laboratory, Southampton University Hospital, Southampton, UK Studies of APC and -catenin in the min/+ mouse R. M. Bright-Thomas, H. S. Wasan, R. Hargest Department of Surgery, Royal Free and University College Medical School, London, UK Polymorphism in the interleukin-1 receptor antagonist gene is associated with an increased risk of breast cancer I. A. F. Azmy∗, A. G. Wilson†, C. Cannings†, N. J. Brown, M. W. R. Reed∗ ∗Section of Surgical Oncology and †Department of Molecular Medicine, The University of Sheffield, UK Coffee & trade exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
08.30–10.30
Lecture Room 2
Parallel Session VIII—Sarcoma & Others 08.30
91
08.40
92
08.50
93
09.00
94
09.10
95
09.20
96
09.30
97
Chairman: Mr M. Thomas
The role of a plastic surgeon in providing a sarcoma service G. Smith, F. Peart Department of Plastic and Reconstructive Surgery, Selly Oak Hospital, Birmingham, UK Retroperitoneal sarcoma: A one-centre 10-year experience A. Pirayesh, Y. Chee, T. Helliwell, M. J. Hershman, S. J. Leinster, M. V. Fordham, G. J. Poston Royal Liverpool University Hospital, Liverpool, UK Neuropilin-1 expression is associated with increased vascular endothelial growth factor (VEGF) production in colorectal carcinoma J. R. Easterbrook, J. Greenman, J. N. E. Ashman, A. W. MacDonald, J. R. T. Monsoon University of Hull Academic Surgical Unit, Hull, UK Pantobens: all the information for quality control and training in oncological operations M. H. Edwards Friarage Hospital, Northallerton, North Yorkshire, UK Tc-99 Mibi-only parathyroid localization—early experience P. Boorman, M. Buxton-Thomas, D. Scott-Coombes King’s College Hospital, London, UK Modulation of vascular endothelial cell behaviour by extract from normal human dermis in vitro M. El-Sheemy∗†, W. Vassanasiri†, O. Eremin†‡ ∗Department of Surgery, University of Aberdeen, †Lincoln County Hospital, Lincoln and ‡Department of Surgery, University of Nottingham, UK Reliability of the sentinel node procedure in melanoma patients (n=289); incidence of failures after long-term follow-up R. J. C. L. M. Vuylsteke, M. G. Statius Muller, P. A. M. van Leeuwen, P. J. Borgstein, R. Pijpers, P. J. van Diest, S. Meijer Departments of Surgical Oncology, Nuclear Medicine and Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
829
Programme 09.40
98
09.50
99
10.00
100
10.10
101
10.20
102
10.30–11.00 10.30–11.00
Prognostic factors and survival in malignant pleural mesothelioma J. King∗, R. Swindell†, C. A. Pickering∗, N. Thatcher†, P. Hasleton∗ ∗South Manchester University Hospitals NHS Trust and †Christie Hospital NHS Trust, UK Periosteal osteosarcoma: evaluation of surgical and adjuvant measure in improving survival M. P. Revell, N. Deshmukh, R. J. Grimer, S. R. Carter, R. M. Tillman Royal Orthopaedic Hospital, Birmingham, UK Factors predictive of survival of patients with retroperitoneal soft-tissue sarcoma: does surgical experience influence survival? T. van Dalen, H. J. Hoekstra, B. N. van Geel, F. van Coevorden, A. Hennipman The Dutch Soft Tissue Sarcoma Group, Utrecht, The Netherlands Clinical detection of soft tissue sarcomas—how specific are the four cardinal features? R. J. Grimer, C. Johnson, P. B. Pynsent The Royal Orthopaedic Hospital, Birmingham, UK A biopsy of a suspected soft tissue sarcoma in the retroperitoneal area: the diagnostic yield and the risk of contamination of the different procedures T. van Dalen, F. van Coevorden, B. N. van Geel, H. J. Hoekstra, A. Hennipman The Dutch Soft Tissue Sarcoma Group, Utrecht, The Netherlands Coffee & exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
Plenary Session V—Pitfalls in the Management of Sarcoma 11.00–12.00
Lecture Theatre One
11.00–11.20
Limb soft tissue sarcoma M. Thomas (London, UK) Intra-abdominal sarcoma P. O’Dwyer (Glasgow, UK) The application of chemotherapy and biological responses modifiers in the treatment of advanced soft tissue sarcomas B. Kroon (Rotterdam, The Netherlands)
11.20–11.40 11.40–12.00
Chairman: Mr D. Rosin
Plenary Session VI—2000 Ernest Miles Lecture 12.00–12.30
Lecture Room One
12.30–13.30 12.30–13.30
Jointly with The Royal Marsden Surgical Society Professor Roger Blamey (Nottingham, UK) ‘‘Breast Cancer: The Changing Scene’’ Lunch & trade exhibition Poster viewing
Chairman: Professor D. George
Edward Lumley Hall Webb Johnson Hall
Parallel Session IX—Breast Group Symposium 13.30–15.00
Lecture Room One
13.30–14.10
Professor L. Holmberg (Uppsala, Sweden) ‘‘DCIS’’: aspects on epidemology and prognosis Professor D. George (Glasgow, UK) Preliminary Results DCIS Trial Professor R. A. Haward (Yorkshire, UK) Multi-disciplinary team working in breast cancer: variability and effectiveness Tea & trade exhibition Edward Lumley Hall Poster viewing Webb Johnson Hall
14.10–14.30 14.30–15.00 15.00–15.30 15.00–15.30
Chairman: Professor R. E. Mansel
Parallel Session X—British Oesophago-Gastric Cancer Group AGM 13.30–15.00
Lecture Theatre Two
13.30–13.45 13.45–14.05
Introduction and Annual General Meeting Oesophageal cancer update in molecular biology J. Jankowski Neo-adjuvant therapy in operable oesphageal cancer D. Girling
14.05–14.25
Chairman: Professor J. Elder
830
Programme
14.25–15.00 15.00–15.30 15.00–15.30
Oesophageal cancer in a clinical perspective G. O’Sullivan Tea & trade exhibition Poster viewing
15.30–16.30
Lecture Room One
Edward Lumley Hall Webb Johnson Hall
Parallel Session XI—Two week rule 15.30
103
15.35
104
15.40
105
15.45
106
15.50
107
15.55–16.30
Chairman: Professor I. Taylor
Is there any difference between routinely and urgently referred cancers? J. Adjogatse, R. Kushwaha, W. Walker, B. Isgar New Cross Hospital, Wolverhampton, West Midlands, UK Prioritization of referrals to a breast clinic: how do clinicians compare with general practitioners? L. Campbell, S. Prance, C. Teasdale, R. M. Watkins Derriford Hospital Breast Care Unit, Plymouth, UK Prioritization of breast referrals: is age the safest criterion? C. Chianakwalam, P. Sinha, R. Barnes, S. Bendell, T. Bates The Breast Unit, Williams Harvey Hospital, Ashford, Kent, UK The impact of colorectal cancer awareness week A. M. Pullyblank∗, N. Dixon†, A. R. Dixon∗ Department of ∗General Surgery and †General Practice, Frenchay Hospital, Bristol Preliminary evaluation of UK national referral guidelines for lowr gastrointestinal tract cancers C. C. W. Mahaon, C. J. Vaizey, I. Taylor, P. B. Boulos Department of Surgery, Royal Free and University College Medical School, London, UK Discussion
Parallel Session XII—Oesophago-Gastric Cancer 15.30–16.30
Lecture Room 2
15.30
108
15.40
109
15.50
110
16.45
111
16.50
112
16.55
113
Chairman: Mr P. M. McCulloch
Prospective evaluation of posssum methodology in the audit of oesophageal carcinoma including unresected cases M. J. Midwinter, B. Charalambous, M. Eden, L. Formela, J. Bancewicz, S. E. Attwood Hope Hospital, Salford, UK Positive truncal nodes of oesophageal carcinoma: not always a dismal prognosis C. J. Buskens∗, J. J. G. H. M. Bergman†, J. B. F. Hulscher∗, P. Fockens†, H. Obertrop∗, J. J. B. van Lanschot∗ Departments of ∗Surgery and †Gastroenterology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands Proximal and distal gastric cancer. The influence of extent of resection and tumour subsite on survival S. M. Dresner, P. J. Lamb, N. Hayes, S. M. Griffin Northern Oesophago-Gastric Cancer Unit, Ward 36 Office, Royal Victoria Infirmary, Newcastleupon-Tyne, UK Pure gastric or duodenal reflux is associated with increased risk of Barrett’s oesophagus Y. Koak, S. Davies, M. Winslet Department of Surgery, Royal Free and University College Medical School, London, UK Omeprazole is ineffective in Barrett’s oesophagus caused by pure duodenal reflux Y. Koak, S. Davies, M. Winslet Department of Surgery, Royal Free and University College Medical School, London, UK Early distant recurrence after oesophagectomy—a failure of staging P. J. Lamb, S. M. Dresner, J. Shenfine, S. Robinson, N. Hayes, S. M. Griffin Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary, Newcastle-upon-Tyn, UK
Parallel Session XIII—Breast Adjuvant Therapy 15.30–16.30 15.30
Council Room 114
Chairman: Professor L. Holmberg
A novel grading system assessing pathological response to primary chemotherapy in breast cancer predicts survival K. N. Ogston∗, I. Miller†, S. Payne†, A. W. Hutcheon‡, T. K. Sarkar‡, S. D. Heys∗ Department of Surgery∗, Pathology† and Oncology‡, University of Aberdeen, UK
Programme 15.40
115
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117
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16.20
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831
Improvements in response rate and disease-free interval in patients receiving primary chemotherapy with taxotere for breast cancer K. N. Ogston and the Aberdeen Breast Group Departments of Surgery, University of Aberdeen, UK Clinical and biological factors that predict response of operable breast cancer to neoadjuvant chemotherapy G. Abou-Elnagah∗, F. Knox†, E. Anderson‡, A. Howell‡, N. Bundred∗ ∗Surgical Breast and †Histopathology Departments, South Manchester University Hospital, Nell Lane, Manchester and ‡Paterson Cancer Research Institute, Medical Oncology Departments, Christie Hospital, Manchester, UK Targeted intra-operative radio therapy (Targit): a novel approach for local treatment of breast cancer J. S. Vaidya∗, M. Baum∗, J. S. Tobias†, D. P. D’Souza, S. Morgan‡, M. Metaxas‡, K. Harte¶, A. Sliski¶, E. Thomson¶ Department of ∗Surgery, †Radiation Oncology and ‡Medical Physics, Royal Free University College Medical School, London, UK and ¶Photoelectron Corporation, MA, USA Pre-treatment predictors of survival in locally advanced breast cancer treated with multimodality therapy K. N. Ogston∗, I. Miller†, S. Payne†, A. W. Hutcheon‡, T. Sarkar‡, T. O’Hanrahan∗, S. D. Heys Department of ∗Surgery, †Pathology and ‡Clinical Oncology, University of Aberdeen, UK Prognostic indicators in locally advanced breast cancer treated with primary chemotherapy K. H. Ogston∗, I. Miller†, S. Payne†, A. W. Hutcheon‡, T. K. Sarkar‡, T. O’Hanrahan∗, S. D. Heys∗ Departments of ∗Surgery, †Pathology and ‡Clinical Oncology, University of Aberdeen, UK
Plenary Session VII Lecture Room One 16.30–16.40
Chairman: Mr D. Rosh
1999 Winner of the Ronald Raven Travelling Scholarship Miss Jane M. Blazeby Managing Gastric Cancer in Japan: a British Experience Hunterian Lectureship Mr Philip Drew (Hull, UK) The Next Millennium: New Paradigms and Novel Analyses
16.45–17.30
THURSDAY, 28 NOVEMBER 2000 08.30 P1
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P2
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P3
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P4
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P5
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To be set up in Webb Johnson Hall Do P53, TGF and FAS-L play a role in the development of post-transplant dermal neoplasia? Immunohistochemical assessment of serial skin biopsies G. Morris-Stiff∗, M. Gonzalez†, S. Metcalfe‡, S. Negus‡, C. Mower†, W. A. Jurewicz∗ ∗Welsh Transplantation Research Group and †Department of Dermatology, University of Wales College of Medicine and ‡Transplant Molecular Biology Group, Department of Surgery, University of Cambridge, UK A quantitative, microsphere based cytotoxic drug targeting assay for human breast cancer cells using laser flow and scanning cytometry D. Kaur, L. Reeve, A. H. Goodall, D. A. Rew University Units of Surgery and Pathology, Leicester University Hospitals, UK Expression of renin in human breast tissue and correlation with prognostic factors A. J. Ogedegbe∗, J. R. Puddefoot†, M. Tahmasebi† G. P. Vinson†, A. W. Goode∗ and R. Carpenter∗ ∗Breast Unit, St Bartholomew’s Hospital and †Department of Biochemistry, Queen Mary and Westfield College, University of London, UK Integrin 1 expression and long-term oestrogen deprivation C. J. Pogson, C. M. W. Chan, L.-A. Martin, G. P. H. Gui, M. Dowsett Departments of Academic Surgery and Biochemistry, The Royal Marsden, Fulham Road, London, UK Conjugated linoleic acid reduces breast tumour growth B. Majumder∗, S. Moir∗, K. Wahle†, S. D. Heys∗ ∗Department of Surgery, University of Aberdeen and †Rowett Research Institute, Aberdeen, UK Interleukin (IL−-10 as a possible mediator of the defective immune response in human breast cancer B. Al-Sarireh∗, A. Robins†, O. Eremin∗ ∗Section of Surgery and †Department of Immunology, University Hospital, Nottingham, UK
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Breast cancer in the elderly and infirm. Does radiotherapy after excision under local anaesthetic help? S. Chaturvedi, C. Rodd, E. F. Shah, J. LeVay, T. J. Archer Surgery after neoadjuvant therapy for locally advanced breast cancer may be reserved for residual or recurrent disease P. Sinha, S. Coltart, G. Vittay, S. Bendall, P. Pheils, T. Bates The Breast Unit, William Harvey Hospital, Ashford, Kent, The Queen Elizabetth, The Queen Mother Hospital, Margate, UK Prevention of chemotherapy-induced premature ovarian failure with goserelin E. F. Shah, J. V. Woodside, R. Chatterjee, J. Houghton, R. Stein, C. Saunders, M. Baum Department of Surgery, Royal Free University College London, UK Is breast MRI superior to clinical examination in the assessment of response to primary medical therapy? M. Douek∗, T. Davidson∗, M. A. Hall-Craggs†, R. Stein‡, S. R. Lakhani¶, M. Kissin∀, M. Baum∗, I. Taylor∗ Departments of ∗Surgery, †Radiology, ‡Medical Oncology and ¶Histopathology, Royal Free and University College, London Medical School, London, UK Is Tamoxifen alone in the treatment of elderly patients with breast cancer justified? A. A. Mavanur, P. R. Armitstead Kidderminster Health Care Trust, Kidderminster General Hospital, Worcs, UK Tubular, lobular and other low-grade carcinomas are difficult to diagnose on FNA cytology requiring core biopsy for definitive pre-operative diagnosis of malignancy C. L. Baxendine, M. J. Jeffrey, D. N. Poller on behalf of The Portsmouth Breast Team Department of Pathology, Queen Alexander Hospital, Cosham, Portsmouth, UK The outcome of C1 fine needle aspiration cytology of breast lumps A. J. Sheen, C. D. Karkos, V. Chandrasekar, C. Emerson, L. Forrest Blackpool Victoria Hospital, Blackpool, UK Factors determining inadequate FNA cytology in patients with palpable breast cancers S. J. Parker, S. A. Harries South Warwickshire Hospital, NHS Trust, Warwick, UK Palpable breast cancer which is mammographically invisible R. Rajentheran, M. C. Rao, E. Lim, T. W. J. Lennard Royal Victoria Infirmary, Newcastle Upon Tyne, UK Mammographic patterns and breast cancer risk S. Goyal, J. Skone, N. Khonji, D. Clarke, R. West, R. E. Mansel Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, UK Use of the Internet to provide information for patients attending breast clinics C. Sweeney, S. Kettlewell, D. Smith, I. Reid Victoria Infirmary Glasgow and University of Glasgow, UK Meeting the two week wait for breast cancer in a district general hospital A. Parvaiz, J. Davies, S. Williams, D. Griffiths, H. Gajraj Yeovil District Hospital, Yeovil, UK The ‘two week wait’ for suspected breast cancer: it’s impact on a symptomatic breast unit and correlation of referrals with outcome L. Campbell, S. Prance, C. Teasdale, R. M. Watkins Derriford Hospital Breat Care Unit, Plymouth, UK Assessment of grade and type of breast cancer on core biopsy: interobserver variability and comparison with excision histology I. A. F. Azmy∗, S. Oliver∗, S. S. Cross†, T. J. Stephenson∗, M. W. R. Reed ∗Section of Surgical Oncology, University of Sheffield and †Department of Histopathology, The Royal Hallamshire Hospital, Sheffield, UK Is the 20 g standard for benign open biopsies in screen detected lesions too generous? R. Kushwaha, J. Adjogatse, C. Deacon, S. Walker, B. Isgar New Cross Hospital, Wolverhampton, West Midlands Predictors of positive margins after local excision of DCIS K. Mokbel, J. C. C. Hu, K. Kirkpatrick, C. Choy, W. Al-Sarakbi, A. Mostafa, C. Wells, N. Perry, R. Carpenter St Bartholomew’s Hospital, London, UK Development of a nurse led family history clinic in a district general hospital breast unit E. Gray, A. Fowler, N. D. Rothnie Southend Breast Unit, UK Graphical risk explanation as a new method of explaining risk to women with a family history of breast cancer V. Vijay, J. Stein, C. Saunders, M. Baum Department of Surgery, Royal Free and University College Medical School, London, UK
Programme P25
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Breast reconstruction in general surgical practice E. Harper, B. R. Gwynn Stafford General Hospital, UK Fibroblast growth factor 8, a breast oncogene, has protein expression in normal and lactational breast tissue C. Zammit, S. K. Maargh, J. Gomm, D. Sinnett, S. Shousha, R. C. Combes, C. L. Johnston Department of Cancer Cell Biology, Imperial College School of ???? Improved sentinel node localization by preoperative assessment of node depth by lymphoscinitigraphy and ultrasound R. S. Uppal, D. Hofland, M. A. Masoomi, F. Fuechsel, A. J. Britten, R. A. Allan, B. W. E. B. Powell St Georges Hospital, London, UK Hormone or surgery, local or general anaesthesia? A one year audit of treatment of carcinoma of breast in elderly patients S. Chaturvedi, C. J. D. Mortimer, T. J. Archer The Ipswich Hospital, Ipswich, Suffolk, UK The role of gastrin in pancreatic and oesophageal tumour growth A. Gilliam, P. A. Clarke, D. McWilliams, J. Jankowski, S. A. Watson Queens Medical Centre, Nottingham, UK Can p53 and Ki67 be useful in the clinical management of Paget’s disease? P. E. Ellis, L. F. Wong Te Fong, K. J. Rolfe, J. C. Crow, A. B. Maclean, T. Davidson, G. W. Perrett University Department of Surgery, Royal Free and University College Medical School, London, UK