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Bromocriptine treatment of postoperative prolactinoma patients
Citations from the Chinese literature/International tively. Statistical analysis showed that the relative risk (RR) of association between HP VI6 infection and the development of cervicitis, CIN s and cervical carcinomas was increased with the severity of cervical lesions, from 1.0 (normal) to 1.67, 4.62 (P < 0.05; 95% CI 0.28-8.95) and II.54 (P < 0.001; 95% CI 3.94-33.81), results strongly support the idea that the development of cervical precancerous lesions and cervical carcinomas is closely associated with HP VI6 infection. Concomitant cbemoradiotberapy for advanced epidermoid carcinoma of the uterine cervix: A preliminary report Lin J.-C.; Ho ES-C.; Jan J.-S.; Yang C.-H.; Hsu W.-P CHIN MED J TAIPEI 1994 54/l (26-32) Background. Because the prognosis of advanced carcinoma of the uterine cervix is poor, and has improved very little in the last 20 years, a prospective study was initiated to evaluate the of concomitant toxicities feasibility, response and chemoradiotherapy for such cervical cancer. Methods. From May 1992 to December 1992, 22 patients entered the study, 21 of them completed the entire treatment. Their ages ranged from 47 to 72 years, median 57. There were I6 FIG0 stage IIIB, and 5 stage IIB. Radiotherapy was administered using I .8 Gyiday, five days a week, to the whole pelvis (50.4 Gy/28 fractions) with or without parametrial boost according to the tumor response. Intracavitary brachytherapy 5 Gy x live to six times was given after one or two weeks of rest. Chemotherapy consisted of etoposide 100 mg/m’ day I + cisplatin 50 mg/m’ day 1 + bleomycin 25 mglm2/day day 2-3, repeated every two weeks during external irradiation. Results. All 21 eligible patients achieved complete response, sustaining during a median follow-up time of I2 months. All the initially elevated tumor markers (XC, CEA, CA-125) returned to normal range after treatment. The toxicity was well tolerated. Conclusions. Concomitant chemoradiotherapy for advanced cervical carcinoma is both feasible and effective, with acceptable toxicities. Longterm follow-up is mandatory, and a randomized trial to confirm the superiority of this protocol will be started soon. ‘Ilte effkacy of different umbilical cord care regimens: An in vitro study on theii drying and antimicrobial effect Jeng M.-J.; Soong W.-J.; Lau M.-C.; Chen S-J.; Hwang B CHIN MED J TAIPEI 1994 53/5 (293-297) Background. Topical regimens have been used for umbilical cord care for different purposes, but their drying efficacy has rarely been statistically analyzed. We designed an in vitro study with six regimens to determine which one can achieve the best drying and antimicrobial effects in umbilical cord care. Methods. Twenty-seven umbilical cords were resected when babies were born. Each cord was cut into seven segments in appropriate length and randomly labeled to seven groups. Six regimens including 75% alcohol, 90% alcohol, tincture povidone-iodine, aqua povidone-iodine, Chinese herbs, and one powder agent (M) were used topically on six groups of umbilical cords once daily. The control group received no treatment. Daily weight of the cords was recorded for 7 days, and bacterial culture was performed on the sixth day. Results. All study groups presented similar algebraic functional relation-
Journal of Gynecology & Obsterrics 48 11995) 137-141
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ship between weight change and time. The drying effect occurred mostly within the first 3 days (weight loss 88.6%) especially on the first day (62.1%). Mean ratio of the final weight/initial weight was 10.2%. Significant day-by-day weight loss was noted from day I to day 5 (P < 0.001). Both aqua and tincture povidone-iodine groups showed not only satisfied drying effect but also significantly better antimicrobial effect than other groups. Conclusions. Povidone-iodine has both good drying and antimicrobial effects in umbilical cord care. As the topical use of povidone-iodine has been reported to relate to transient neonatal hypothyroidism, we suggest it to be used only as a good substitute if there are signs of umbilical cord infection. Bromocriptioe treatment of postoperative prolactinoma patients Yang D.-Y.; Wang Y.-C CHIN MED J TAIPEI 1994 53/6 (346-350) Background. Prolactinoma is the leading cause of pituitary adenoma. It causes amenorrhea in women and impotence in men. Surgical and bromocriptine treatment are the mainstays of therapy in most of the patients with this disease. Determining the outcome for postoperative hyperprolactinemia patients who received bromocriptine treatment was the main purpose of this study. Methods. Thirty-two patients who received operation for prolactinoma have been investigated. Twenty of them had received bromocriptine treatment before conception, I4 were diagnosed as having macroadenoma and all of them had post-operative hyperprolactinemia. Results. Five patients needed bromocriptine treatment of more than 12.5 mgday to decrease the serum prolactin level. Three patients received radiotherapy postoperatively. Other patients were bromocriptine sensitive. Eight of them had menses restored, and of these, live became pregnant. Conclusions. Operation can successfully treat most of the patients with microadenoma. If there has been postoperative hyperprolactinemia, bromocriptine treatment should be the first choice before radiotherapy. Elective cesarean section for macrosomia Jau-Shon Yan; Yeing-Kuan Chang; Chang-Sheng Yin CHIN MED J TAIPEI 1993 51/3 (231-234) Background. Fetal macrosomia is associated with increased risk of dystocia and birth trauma. Elective Cesarean section has been recommended for macrosomic fetus to prevent the associated complications. However, the cost/benefit ration of such practice should be known before it can be considered appropriate. Methods. The record of 6230 women delivered consecutively at Tri.-Service General Hospital were reviewed retrospectively. The occurrence rates of dystocia and birth trauma were cp, [were between normal birthweight group (2500-3999 pm)] and macrosomic group (2 4000 gm). The complication rates were calculated specifically among those macrosomic infants delivered vaginally. Results. Of the 6230 singleton pregnancies, 207 had an infant weighing at least 4 000 gm. One hundred and three macrosomic infants allowing an adequate trial of labor were considered, the frequency of Cesarean section for dystocia was 19.1% in the 4000-4999 gn:
Journal of Gynecology & Obsterrics 48 11995) 137-141
139
ship between weight change and time. The drying effect occurred mostly within the first 3 days (weight loss 88.6%) especially on the first day (62.1%). Mean ratio of the final weight/initial weight was 10.2%. Significant day-by-day weight loss was noted from day I to day 5 (P < 0.001). Both aqua and tincture povidone-iodine groups showed not only satisfied drying effect but also significantly better antimicrobial effect than other groups. Conclusions. Povidone-iodine has both good drying and antimicrobial effects in umbilical cord care. As the topical use of povidone-iodine has been reported to relate to transient neonatal hypothyroidism, we suggest it to be used only as a good substitute if there are signs of umbilical cord infection. Bromocriptioe treatment of postoperative prolactinoma patients Yang D.-Y.; Wang Y.-C CHIN MED J TAIPEI 1994 53/6 (346-350) Background. Prolactinoma is the leading cause of pituitary adenoma. It causes amenorrhea in women and impotence in men. Surgical and bromocriptine treatment are the mainstays of therapy in most of the patients with this disease. Determining the outcome for postoperative hyperprolactinemia patients who received bromocriptine treatment was the main purpose of this study. Methods. Thirty-two patients who received operation for prolactinoma have been investigated. Twenty of them had received bromocriptine treatment before conception, I4 were diagnosed as having macroadenoma and all of them had post-operative hyperprolactinemia. Results. Five patients needed bromocriptine treatment of more than 12.5 mgday to decrease the serum prolactin level. Three patients received radiotherapy postoperatively. Other patients were bromocriptine sensitive. Eight of them had menses restored, and of these, live became pregnant. Conclusions. Operation can successfully treat most of the patients with microadenoma. If there has been postoperative hyperprolactinemia, bromocriptine treatment should be the first choice before radiotherapy. Elective cesarean section for macrosomia Jau-Shon Yan; Yeing-Kuan Chang; Chang-Sheng Yin CHIN MED J TAIPEI 1993 51/3 (231-234) Background. Fetal macrosomia is associated with increased risk of dystocia and birth trauma. Elective Cesarean section has been recommended for macrosomic fetus to prevent the associated complications. However, the cost/benefit ration of such practice should be known before it can be considered appropriate. Methods. The record of 6230 women delivered consecutively at Tri.-Service General Hospital were reviewed retrospectively. The occurrence rates of dystocia and birth trauma were cp, [were between normal birthweight group (2500-3999 pm)] and macrosomic group (2 4000 gm). The complication rates were calculated specifically among those macrosomic infants delivered vaginally. Results. Of the 6230 singleton pregnancies, 207 had an infant weighing at least 4 000 gm. One hundred and three macrosomic infants allowing an adequate trial of labor were considered, the frequency of Cesarean section for dystocia was 19.1% in the 4000-4999 gn: