C011 Role of the renin-angiotensin system in cardiac hypertrophy and renal glomerular sclerosis in transgenic tsukuba hypertensive mice

9

A

X

A

B

S

I

0T

R

A

AI 1

U

O TA H

]

1 C N 9 4 PH

2 AT

C O

C A

I

A C

C H V G C C

E

U V T

I a t s w o t s a d t i m w m t l v r ( b a a d c ( r w u ( u i m s t a ( a t i w m N a a H t s S a d h m P V 1 m p P d S 5w

H

m m 1( K v 1 1 u m w t

n

i P 5 5 7 m d T H s t a a S r

f

K

W

a -

t

a

h

s p

P V G

S

c f

e

w r

g

f s h

w l m

m

a f

d

m

a ( n

5 S (

w m

~

0 H

t M

W P

V

)b

I

C

N

“

t

C

L

w S W w a a m S ( a + a w r 5w a ap a s d W 1 1 w r O ap a s d W ( 1 1 2 w r P 5 w w m l f T w s S ( P S W s H u c t p e t i m a c p w f a d e a H g h T r t w t M a T m l s ag c t t h m b e t b b t s t h h d J C d c b t

Zg,b *

Niglomerul.

I T

u

:

q a

r

f r a a i

w

a l a k

●*

a

L-NAMa+

o

b al

w

r ey R n

r e

i

d w a Oo

r

m c

e

aT d

i

W

r

e

b

N

o

k

y y

s

e

C T

R A

R

T

“ K * AK F D M O

S S

H SS o E

C

G M K uS M

Tb T U

K

ru KI S

J

T h e h T I C A s m p T Aa g c w & g R e s

h

m a t m c b a a g T a t s t m 0 t n s @ c a r g s T T w t w o t f d f 8 w ( g A h ( n ( N m s a w u n c ( C a t p t h w m r g i a g s c a a h a k w e T s b g Nw a h t t S p w s & t s l g 0 t p m w s b Nt g a d t s l g g T r g s i a g s s & g b t w s b g Ha T o p m Hw s g T r s t t t h v s c h e a b t R a b p h i t r g T

K

W

t

h

c

1 O

m

t

g

a

y

y

C R H T

-

i

c K

i n

N

n

i

i t

a t

g a d

s

n p c

L

y

f

LPS(4)

a

i

i

ie

n

2.48 * 0.36 4/7. .

l

L N

r

os t

w

n

85.1 i + 7.9 4/,..

.

b

l

a

F

0.17 t 0,08 .

●

t

P

a

L-NAME(3)

1.36 fO.41 ,,,. .

i

r

0

F

Y

t s t t t p of endotoxic shock edue to s t t u s u nh b t k y T a m t i y d as a w p e E 6h b t s m d d t t k a t d c l m i.

h

ae l

I XE

S

33’2,6 f 12,8 33,8 k4.2 2/,...

Au.

T

O

h

d

n n h c r L

4,1

O,f 1 i 0,02ci

Arbitrary

c

LPS(2)

CONTROL(1)

NO-FeMGD .U_I/~of!4d”ey

d

NN D M D

R L

T i s N r p s e t t w s NO from rats in a state I ( A E S R ( i a m t p m b t t e c c N ( a r i ( f e N c d A L i ( m i r p w L ( N c w e e n . ( w

h t

H R

c

9 H -

o

Q

D

S E B A A M Q T D I M ‘ W S M R

R S P D B ●G

E M AP

d r I h W

a

S

i

a

0

E L H RK * og s R

C

A

A

A

M

S R

Y 1K

SL

PL

YB E

CG U a

BL P P ai

S H na k ri br de m cu m N s S F O a w c t c e t n T C c b M ( n t D A ( a m S w S w t w M ( m A ( m y p ( f 2m D ( n c w c f v p c m a d a S a c W T D c C w s r c W m A D w l S t W w ac l A D S w s h t W M m w s t A (1 1 n b r h t mW (1 m T D c M a A w m b C an W l i v D i t D c a p d c M a A p a s r c a h a c c c w C A t ( m a c i w r a t S H t d m s a c i M w si h t A c M a A p n t D c a w r a h c a c T m i e M c t A m t c i h h e a d a a a a M s m c

s K

W

c

a

a

m

S

n

Y d

k

ar

R k fa i e

wy i

a

i i

a