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C119: Five-year results of treatment of localized prostate cancer using high intensity focused ultrasound
C119: Five-year results of treatment of localized prostate cancer using high intensity focused ultrasound Nicolescu S.1, Pop C.D.1, Logigan H.1, Boc A.1, Manea C.2, Coman I.3 1
Clinical Municipal Hospital, Dept. of Urology, Cluj Napoca, Romania, 2Endo Plus Urology Clinic, HIFU Center, Cluj Napoca, Romania, 3University of Medicine and Pharmacy "Iuliu Hatieganu", Dept. of Medicine, Cluj Napoca, Romania INTRODUCTION & OBJECTIVES: High-Intensity Focused Ultrasound (HIFU) therapy represents an alternative choice in minimally invasive treatment of clinically localized prostate cancer. The Romania Endoplus study aims to demonstrate the oncological and functional efficiency of this procedure. MATERIAL & METHODS: From June 2009 to July 2014, we performed 204 HIFU procedures using the Sonablate 500 TCM system. For 193 cases we applied HIFU as first-line therapy, while for the other 11 cases, HIFU was used as salvage therapy of local recurrence after radical prostatectomy (4 cases), external radiation therapy (7 cases) or after brachytherapy (2 cases). We included in this study 173 patients wich have been followed minimum 6 months up to 55 months. We used the Stuttgart critteria to highlight post-therapeutic oncological local recurrence and to demonstrate HIFU effectiveness. All interventions were carried out by the same surgeon. RESULTS: The medium operating time was 85 minutes. Biochemical disease-free outcome was recorded in 84.5% of cases at five years, and 33.5% of patients have a PSA value <= 0.03 ng/ml after 48 months. Erectile dysfunction was noted in 14.42% of cases, urethral stricture in 10.5%, bladder neck sclerosis in 11.6%, and urinary incontinence in 2.84% of cases. No patient developed rectal fistula and no intraoperative complications were recorded. CONCLUSIONS: The results and the number of patients treated with HIFU therapy demonstrate that this minimally invasive radical procedure has low morbidity and high efficiency. Strict compliance with the criteria for inclusion renders the procedure feasible and secure, while oncological and functional results are comparable with those of prostate excision. Eur Urol Suppl 2014; 13(6) e1305
Clinical Municipal Hospital, Dept. of Urology, Cluj Napoca, Romania, 2Endo Plus Urology Clinic, HIFU Center, Cluj Napoca, Romania, 3University of Medicine and Pharmacy "Iuliu Hatieganu", Dept. of Medicine, Cluj Napoca, Romania INTRODUCTION & OBJECTIVES: High-Intensity Focused Ultrasound (HIFU) therapy represents an alternative choice in minimally invasive treatment of clinically localized prostate cancer. The Romania Endoplus study aims to demonstrate the oncological and functional efficiency of this procedure. MATERIAL & METHODS: From June 2009 to July 2014, we performed 204 HIFU procedures using the Sonablate 500 TCM system. For 193 cases we applied HIFU as first-line therapy, while for the other 11 cases, HIFU was used as salvage therapy of local recurrence after radical prostatectomy (4 cases), external radiation therapy (7 cases) or after brachytherapy (2 cases). We included in this study 173 patients wich have been followed minimum 6 months up to 55 months. We used the Stuttgart critteria to highlight post-therapeutic oncological local recurrence and to demonstrate HIFU effectiveness. All interventions were carried out by the same surgeon. RESULTS: The medium operating time was 85 minutes. Biochemical disease-free outcome was recorded in 84.5% of cases at five years, and 33.5% of patients have a PSA value <= 0.03 ng/ml after 48 months. Erectile dysfunction was noted in 14.42% of cases, urethral stricture in 10.5%, bladder neck sclerosis in 11.6%, and urinary incontinence in 2.84% of cases. No patient developed rectal fistula and no intraoperative complications were recorded. CONCLUSIONS: The results and the number of patients treated with HIFU therapy demonstrate that this minimally invasive radical procedure has low morbidity and high efficiency. Strict compliance with the criteria for inclusion renders the procedure feasible and secure, while oncological and functional results are comparable with those of prostate excision. Eur Urol Suppl 2014; 13(6) e1305