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Ed. Board
Metabolic Engineering EDITOR-IN-CHIEF
Gregory N. Stephanopoulos Massachusetts Institute of Technology Cambridge, Massachusetts
ASSOCIATE EDITORS BIOINFORMATICS
Vassily Hatzimanikatis Swiss Federal Institute of Technology Lausanne, Switzerland
DEVELOPMENT OF STRAINS AND BIOPROCESSES
Sang Yup Lee
HEALTH & DISEASE
INDUSTRIAL APPLICATIONS
Martin Yarmush
Barry C. Buckland
Massachusetts General Hospital Boston, Massachusetts
KAIST, Daejeon, South Korea
Merck & Co., Inc West Pint, Pennsylvania
PATHWAY MODIFICATION & ANALYSIS
PHYSIOLOGY
WEB SITE EDITOR
REVIEW EDITOR
Jens Nielsen
Joanne Kelleher
Costas Maranas
Jens Nielsen
Technical University of Denmark Lyngby, Denmark
Massachusetts Institute of Technology Cambridge, Massachusetts
Pennsylvania State University University Park, Pennsylvania
Chalmers University of Technology, Göteborg, Sweden
SYSTEMS AND SYNTHETIC BIOLOGY
James Liao University of California, Los Angeles Los Angeles, California
EDITORIAL BOARD Dean R. Appling The University of Texas at Austin Austin, Texas
Douglas Cameron Piper Jaffray & Co. Minneapolis, Minnesota
Arnold Demain Drew University Madison, New Jersey
Jonathan S. Dordick Rensselaer Polytechnic Institute Troy, New York
David Fell Oxford Brookes University Oxford, United Kingdom
Peter Gray University of Queensland Queensland, Australia
Andrew D. Hanson University of Florida Gainesville, Florida
J.J. Heijnen Technical University Delft Delft, The Netherlands
Marc K. Hellerstein University of California, Berkeley Berkeley, California
Lonnie Ingram University of Florida Gainesville, Florida
Ka-Yiu San Rice University Houston, Texas
Uwe Sauer ETH Hönggerberg Zürich, Switzerland
Thomas Jeffries USDA Forest Service Madison, Wisconsin
Jay D. Keasling University of California, Berkeley Berkeley, California
Chaitan S. Khosla Stanford University Stanford, California
Charles E. Nakamura DuPont Company Wilmington, Delware
Eleftherios Papoutsakis University of Delaware Newark, Delaware
Matthias Reuss Universität Stuttgart Stuttgart, Germany
Philippe Soucaille INSA, Toulouse, France
Willem Stemmer Amunix Inc. Mountain View, California
Kenneth N. Timmis Gesselschaft für Biotechnologie Forschung Braunschweig, Germany
Craig Venter The Institute for Genomic Research Rockville, Maryland
Hans Westerhoff Vrije Universiteit Amsterdam Amsterdam, The Netherlands
Cover figure. Transformation of Pelargonium sidoides using Agrobacterium rhizogenes. (A) Induction of hairy roots on explants. Root initials (RI) appearing on an explant together with callus (C); (B) C58C1-transformed roots. Note the presence of residual agrobacterial growth (AR); (C) Transgenic plantlets with prolific hairy roots. Regeneration of transgenic shoots occurred spontaneously; (D) A4T-transformed hairy roots with a typical non-gravitropic character; (E) Lateral root (LR) formation on a primary root (PR) with numerous root hairs (RHs); (F) Liquid culture of transgenic roots after a month in culture; (G) Transgenic roots were extensively branched, a typical characteristic of hairy roots; (H) Untransformed roots (Untr’) grew slowly compared to transformed root cultures such as the A4T-A clone after one month in culture; (I) Transgenic roots extracted from liquid culture showing unusual black root tips and formation of tubers (T). Please see article by Colling et al. on pages 561–572 in this issue.
Gregory N. Stephanopoulos Massachusetts Institute of Technology Cambridge, Massachusetts
ASSOCIATE EDITORS BIOINFORMATICS
Vassily Hatzimanikatis Swiss Federal Institute of Technology Lausanne, Switzerland
DEVELOPMENT OF STRAINS AND BIOPROCESSES
Sang Yup Lee
HEALTH & DISEASE
INDUSTRIAL APPLICATIONS
Martin Yarmush
Barry C. Buckland
Massachusetts General Hospital Boston, Massachusetts
KAIST, Daejeon, South Korea
Merck & Co., Inc West Pint, Pennsylvania
PATHWAY MODIFICATION & ANALYSIS
PHYSIOLOGY
WEB SITE EDITOR
REVIEW EDITOR
Jens Nielsen
Joanne Kelleher
Costas Maranas
Jens Nielsen
Technical University of Denmark Lyngby, Denmark
Massachusetts Institute of Technology Cambridge, Massachusetts
Pennsylvania State University University Park, Pennsylvania
Chalmers University of Technology, Göteborg, Sweden
SYSTEMS AND SYNTHETIC BIOLOGY
James Liao University of California, Los Angeles Los Angeles, California
EDITORIAL BOARD Dean R. Appling The University of Texas at Austin Austin, Texas
Douglas Cameron Piper Jaffray & Co. Minneapolis, Minnesota
Arnold Demain Drew University Madison, New Jersey
Jonathan S. Dordick Rensselaer Polytechnic Institute Troy, New York
David Fell Oxford Brookes University Oxford, United Kingdom
Peter Gray University of Queensland Queensland, Australia
Andrew D. Hanson University of Florida Gainesville, Florida
J.J. Heijnen Technical University Delft Delft, The Netherlands
Marc K. Hellerstein University of California, Berkeley Berkeley, California
Lonnie Ingram University of Florida Gainesville, Florida
Ka-Yiu San Rice University Houston, Texas
Uwe Sauer ETH Hönggerberg Zürich, Switzerland
Thomas Jeffries USDA Forest Service Madison, Wisconsin
Jay D. Keasling University of California, Berkeley Berkeley, California
Chaitan S. Khosla Stanford University Stanford, California
Charles E. Nakamura DuPont Company Wilmington, Delware
Eleftherios Papoutsakis University of Delaware Newark, Delaware
Matthias Reuss Universität Stuttgart Stuttgart, Germany
Philippe Soucaille INSA, Toulouse, France
Willem Stemmer Amunix Inc. Mountain View, California
Kenneth N. Timmis Gesselschaft für Biotechnologie Forschung Braunschweig, Germany
Craig Venter The Institute for Genomic Research Rockville, Maryland
Hans Westerhoff Vrije Universiteit Amsterdam Amsterdam, The Netherlands
Cover figure. Transformation of Pelargonium sidoides using Agrobacterium rhizogenes. (A) Induction of hairy roots on explants. Root initials (RI) appearing on an explant together with callus (C); (B) C58C1-transformed roots. Note the presence of residual agrobacterial growth (AR); (C) Transgenic plantlets with prolific hairy roots. Regeneration of transgenic shoots occurred spontaneously; (D) A4T-transformed hairy roots with a typical non-gravitropic character; (E) Lateral root (LR) formation on a primary root (PR) with numerous root hairs (RHs); (F) Liquid culture of transgenic roots after a month in culture; (G) Transgenic roots were extensively branched, a typical characteristic of hairy roots; (H) Untransformed roots (Untr’) grew slowly compared to transformed root cultures such as the A4T-A clone after one month in culture; (I) Transgenic roots extracted from liquid culture showing unusual black root tips and formation of tubers (T). Please see article by Colling et al. on pages 561–572 in this issue.