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Calcium Metabolism in Uremic Nephrocalcinosis: Preventive Effects of Verapamil
DISEASES OF BLOOD VESSELS, HYPERTENSION AND RENOVASCULAR SURGERY
breathing patients. The authors suggest that inexperienced physicians should attempt central vein catheterizations first in unconscious and mechanically ventilated patients. W. W. H. 3 tables, 29 references Long-Term Experience in Percutaneous Transluminal Dilatation of Renal Artery Stenosis U. KUHLMANN, P. GREMINGER, A. GR-ONTZIG, E. SCHNEIDER, G. POULIADIS, T. L-0SCHER, J. STEURER, W. SIEGENTHALER AND W. VETTER, Departments of Internal Medicine and Radiology, University Hospital, Zurich, Sweden
Amer. J. Med., 79: 692-698 (Dec.) 1985 Percutaneous transluminal dilation of the renal artery was completed in 60 of 65 patients (35 with atherosclerosis and 25 with fibromuscular dysplasia). The mean control period for blood pressure was 21.6 months. Of the patients with fibromuscular dysplasia 50 per cent had long-term control compared to 29 per cent of the atherosclerotic patients. Of 33 patients undergoing repeat angiography 2 had occlusion of the dilated vessel and 9 had recurrence of slight stenosis. Of these 9 patients 5 had successful re-dilation. The authors not surprisingly favor percutaneous transluminal dilation of stenotic renal arteries for hypertension. J. H. N. 5 figures, 3 tables, 29 references
1343
Brit. Med. J., 292: 237-238 (Jan. 25) 1986 Experimental studies suggest that prostaglandins have an important role in the cause of pain in patients with renal colic, and studies have suggested that antiprostaglandins may be of value in the management of this condition. The authors designed this trial to compare the efficacy of and tolerance to diclofenac sodium, a potent inhibitor of prostaglandin synthetase, to those of the commonly prescribed narcotic pethidine in the management of acute renal colic. They conclude that a dose of 75 mg. diclofenac sodium intramuscularly is more effective than 100 mg. pethidine intramuscularly in the management of acute renal colic and has fewer side effects. 1 table, 5 references
Abstracter's comment. Pethidine is the British equivalent to meperidine hydrochloride. Diclofenac is the British equivalent to ibuprofen. W. W. H. Calcium Metabolism in Uremic Nephrocalcinosis: Preventive Effects of Verapamil M. S. GOLIGORSKY, C. CHAIMOVITZ, J. RAPOPORT, J. GOLDSTEIN AND R. KOL, Departments of Nephrology and Pathology, Soroka University Hospital, and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Kidney Int., 27: 774-779 (May) 1985 Renal Kallikrein-Kinin System A. G. ScICLI AND 0. A. CARRETERO, Hypertension Research Division, Henry Ford Hospital, Detroit, Michigan
Kidney Int., 29: 120-130 (Jan.) 1986 Although the primary function of the kidney is regulation of the volume and ionic composition of body fluids, it also is an endocrine organ with an important role in the regulation of blood pressure. Some renal hormones have vasoconstrictor and antinatriuretic effects (vasopressor systems), while others have vasodilator and natriuretic effects (vasodepressor systems). A characteristic of these systems is that they act not only on distant target organs but also in the kidney itself (local hormones or autocoids). For example, the renin-angiotensin, prostaglandin and kallikrein-kinin systems, whose activation and actions appear to be interrelated, may participate in the control of blood pressure not only by altering the tone of extrarenal blood vessels but also by regulating directly intrarenal sodium and water excretion, perhaps by regulating renal blood flow distribution. The renal kallikrein-kinin system is the least well defined of these systems, yet it has been implicated in the control of renal blood flow and function, in the pathogenesis of hypertension, Bartter's syndrome and renal diseases, and in the antihypertensive mechanism of drugs, such as diuretics and angiotensin I converting enzyme inhibitors. However, the unequivocal role of the renal kallikrein-kinin system in these normal and pathological conditions remains unknown. W. W. H. 2 figures, 1 table, 99 references Diclofenac Sodium Versus Pethidine in Acute Renal Colic J. W. HETHERINGTON AND N. H. PHILP, Department of Urology, St. James's University Hospital, and the General Infirmary, Leeds, England
Nephrocalcinosis is a common complication of chronic renal insufficiency. The exact mechanism of pathogenesis is not clearly understood. However, it appears that secondary hyperparathyroidism has some role in the cause by inducing calcium accumulation within the renal cortical cells. The authors conducted an experimental study to determine the effect of chronic administration of a calcium channel blocker, verapamil,
breathing patients. The authors suggest that inexperienced physicians should attempt central vein catheterizations first in unconscious and mechanically ventilated patients. W. W. H. 3 tables, 29 references Long-Term Experience in Percutaneous Transluminal Dilatation of Renal Artery Stenosis U. KUHLMANN, P. GREMINGER, A. GR-ONTZIG, E. SCHNEIDER, G. POULIADIS, T. L-0SCHER, J. STEURER, W. SIEGENTHALER AND W. VETTER, Departments of Internal Medicine and Radiology, University Hospital, Zurich, Sweden
Amer. J. Med., 79: 692-698 (Dec.) 1985 Percutaneous transluminal dilation of the renal artery was completed in 60 of 65 patients (35 with atherosclerosis and 25 with fibromuscular dysplasia). The mean control period for blood pressure was 21.6 months. Of the patients with fibromuscular dysplasia 50 per cent had long-term control compared to 29 per cent of the atherosclerotic patients. Of 33 patients undergoing repeat angiography 2 had occlusion of the dilated vessel and 9 had recurrence of slight stenosis. Of these 9 patients 5 had successful re-dilation. The authors not surprisingly favor percutaneous transluminal dilation of stenotic renal arteries for hypertension. J. H. N. 5 figures, 3 tables, 29 references
1343
Brit. Med. J., 292: 237-238 (Jan. 25) 1986 Experimental studies suggest that prostaglandins have an important role in the cause of pain in patients with renal colic, and studies have suggested that antiprostaglandins may be of value in the management of this condition. The authors designed this trial to compare the efficacy of and tolerance to diclofenac sodium, a potent inhibitor of prostaglandin synthetase, to those of the commonly prescribed narcotic pethidine in the management of acute renal colic. They conclude that a dose of 75 mg. diclofenac sodium intramuscularly is more effective than 100 mg. pethidine intramuscularly in the management of acute renal colic and has fewer side effects. 1 table, 5 references
Abstracter's comment. Pethidine is the British equivalent to meperidine hydrochloride. Diclofenac is the British equivalent to ibuprofen. W. W. H. Calcium Metabolism in Uremic Nephrocalcinosis: Preventive Effects of Verapamil M. S. GOLIGORSKY, C. CHAIMOVITZ, J. RAPOPORT, J. GOLDSTEIN AND R. KOL, Departments of Nephrology and Pathology, Soroka University Hospital, and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Kidney Int., 27: 774-779 (May) 1985 Renal Kallikrein-Kinin System A. G. ScICLI AND 0. A. CARRETERO, Hypertension Research Division, Henry Ford Hospital, Detroit, Michigan
Kidney Int., 29: 120-130 (Jan.) 1986 Although the primary function of the kidney is regulation of the volume and ionic composition of body fluids, it also is an endocrine organ with an important role in the regulation of blood pressure. Some renal hormones have vasoconstrictor and antinatriuretic effects (vasopressor systems), while others have vasodilator and natriuretic effects (vasodepressor systems). A characteristic of these systems is that they act not only on distant target organs but also in the kidney itself (local hormones or autocoids). For example, the renin-angiotensin, prostaglandin and kallikrein-kinin systems, whose activation and actions appear to be interrelated, may participate in the control of blood pressure not only by altering the tone of extrarenal blood vessels but also by regulating directly intrarenal sodium and water excretion, perhaps by regulating renal blood flow distribution. The renal kallikrein-kinin system is the least well defined of these systems, yet it has been implicated in the control of renal blood flow and function, in the pathogenesis of hypertension, Bartter's syndrome and renal diseases, and in the antihypertensive mechanism of drugs, such as diuretics and angiotensin I converting enzyme inhibitors. However, the unequivocal role of the renal kallikrein-kinin system in these normal and pathological conditions remains unknown. W. W. H. 2 figures, 1 table, 99 references Diclofenac Sodium Versus Pethidine in Acute Renal Colic J. W. HETHERINGTON AND N. H. PHILP, Department of Urology, St. James's University Hospital, and the General Infirmary, Leeds, England
Nephrocalcinosis is a common complication of chronic renal insufficiency. The exact mechanism of pathogenesis is not clearly understood. However, it appears that secondary hyperparathyroidism has some role in the cause by inducing calcium accumulation within the renal cortical cells. The authors conducted an experimental study to determine the effect of chronic administration of a calcium channel blocker, verapamil,