Can personality traits predict the likelihood of a donor sucessfully completing a donation cycle?

OBJECTIVE: To evaluate parent and donor-conceived child characteristics in families headed by single mothers (SM) compared with same-sex female couples (SSC) and heterosexual couples (HC). DESIGN: Cross-sectional study of 216 parents (n ¼ 85 SM, n ¼ 72 SSC, n ¼ 59 HC). Participants were recruited from fertility clinics, donor programs, and parenting groups. The 216 children (4-17 years old; M age ¼ 7.56 years, SD age ¼ 3.82 years) were conceived via IVF (31.0%) or IUI (69.0%) with donor sperm (83.4%), donor egg (10.6%), or donor sperm and donor egg (6.0%). Participating families were from the U.S. (77.4%), Canada (14.3%), Europe (7.4%), and Australia (0.9%). MATERIALS AND METHODS: Parents completed an online survey assessing parental well-being (Center for Epidemiological Studies - Depression - 10 items; Radloff, 1977), parent-child relationship satisfaction (Marital Opinion Questionnaire; Huston & Vangelisti, 1991), parent-child communication climate, which facilitates positive, open communication on various topics (Revised Family Communication Pattern Instrument - Conversation; Ritchie & Fitzpatrick, 1990), and child psychosocial adjustment (Strengths and Difficulties Questionnaire; Goodman, 1997). Covariates included parent age, family income, multiple birth status, child’s sex and age. ANCOVAs were used to test differences in outcomes across family types. RESULTS: After accounting for covariates, parents in SM, SSC and HC families had similar levels of parental well-being (Msm ¼ 5.76, Mssc ¼ 6.20, Mhc ¼ 5.61; clinical cutoff: 10.00), parent-child relationship satisfaction (Msm ¼ 4.30, Mssc ¼ 3.80, Mhc ¼ 4.29), and child emotional (Msm ¼ 2.89, Mssc ¼ 4.07, Mhc ¼ 3.10; normal range: 0.00 - 5.00), behavioral (Msm ¼ 4.22, Mssc ¼ 4.17, Mhc ¼ 4.95; normal range: 0.00 - 7.00), and prosocial adjustment (Msm ¼ 8.54, Mssc ¼ 8.66, Mhc ¼ 8.36; normal range: 6.00 10.00). SSC families had a more open parent-child communication climate (Mssc ¼ 4.42) than SM families (Msm ¼ 4.28) and HC families (Mhc ¼ 4.23; F(2, 205) ¼ 3.46, p ¼ .033). CONCLUSIONS: Families headed by single mothers should not be perceived as differing substantially from traditional nuclear families. SM families appear to be functioning well. References: 1. Goodman R. The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry 1997;38:581-586. 2. Huston TL, Vangelisti AL. Socioemotional behavior and satisfaction in marital relationships: a longitudinal study. J Pers Soc Psychol 1991;61:721-733. 3. Radloff LS. The CES-D scale: a self-report depression scale for research in the general. Appl Psych Meas 1977;1:385-401. 4. Ritchie LD, Fitzpatrick MA. Family communication patterns: measuring interpersonal perceptions of interpersonal relationships. Comm Res 1990;17:523-544. Supported by: University of Minnesota (UMN) Agriculture Experiment Station, UMN Grant-in-Aid, UMN College of Education & Human Development Research Development Investment Grant. P-729 Wednesday, October 21, 2015 MENTAL HEALTH DISORDERS IN INFERTILE WOMEN: PREVALENCE, PERCEIVED EFFECT ON FERTILITY, AND WILLINGNESS FOR TREATMENT FOR ANXIETY AND DEPRESSION. H. S. Hoff,a N. M. Crawford,b J. E. Mersereau.c aReproductive Endocrinology and Infertility, University of North Carolina, Chapel Hill, NC; bUniversity of North Carolina, Chapel Hill, NC; cUNC, Chapel Hill, NC. OBJECTIVE: To evaluate whether women with infertility identify with being anxious or depressed, assess their perception that mental health disorders affect fertility, and determine their willingness to undergo treatment. DESIGN: Prospective, observational study. MATERIALS AND METHODS: An electronic survey was sent to all new infertile female patients over a period of 2 years at UNC Fertility. Informed consent was obtained prior to survey initiation. The proportion of respondents affected by anxiety and depression was evaluated using the NIH PROMIS, a validated 4 question scale, and we assessed their views about mental health disorders. Summary statistics were used to evaluate the population cohort. Data was analyzed using student’s ttest and Person’s chi square for continuous and categorical variables, respectively.

FERTILITY & STERILITYÒ

RESULTS: A survey response rate of 43% was achieved (414/959). Overall, the cohort was young (<36 years), Caucasian, married, and well educated. A significant portion of the population perceived themselves as depressed (50%) and anxious (62%) due to their infertility. Further, 41% and 47% of women screened positive for depression and anxiety using NIH PROMIS, respectively. There was a significant correlation between women who perceived themselves as anxious or depressed and those who screened positive with the respective PROMIS scale (p<0.01 for both). Most patients felt that depression and anxiety had a detrimental impact on fertility (76 and 83%, respectively). There was no correlation between those who were affected by anxiety and depression and those who perceived that these illnesses negatively impacted fertility (anxiety p¼0.88, depression p¼0.65). Patients reported that physicians inquired about mental health less than a third of the time. Even if counseling or medication was recommended by a physician, patient willingness to pursue treatment was low (54%, 29%, respectively). Major barriers to initiating psychotherapy included time and belief that the discussions would not alleviate anxiety or depression. Reluctance to take medication was often due to concerns about adverse effects and impact on fertility and pregnancy. CONCLUSIONS: A significant segment of the infertile population is affected by anxiety and depression. The vast majority of women believe mental health impacts fertility; however, they report physicians are not addressing mood disorders and infertility. Identification and education of infertile women with depression and anxiety may lead to resolution of the perceived barriers to treatment for mental health disorders and, ultimately, improved patient care.

P-730 Wednesday, October 21, 2015 CAN PERSONALITY TRAITS PREDICT THE LIKELIHOOD OF A DONOR SUCESSFULLY COMPLETING A DONATION CYCLE? S. E. Yerkes,a H. S. Reis,a J. A. Lee,a M. Daneyko,a A. B. Copperman,a,b G. Witkin.a aReproductive Medicine Associates of New York, New York, NY; bObstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, NY. OBJECTIVE: Women who participate in an oocyte donation program must diligently comply with pre-screening requirements as well as frequent visits during ovarian stimulation and retrieval. Most selected donors fulfill their obligations, but if they unexpectedly withdraw from participation, it may lead to emotional and financial consequences to the recipients. This study sought to evaluate donors who withdrew from our ovum donation to discern if there were associated predictive personality traits that could have been prospectively noticed. DESIGN: Retrospective analysis. MATERIALS AND METHODS: Women who participated in an ovum donation program and took the Minnesota Multiphasic Personality Inventory (MMPI) exam from April 2010 to March 2015 were included. Personality traits were assessed by numerical scoring for each of the following categories: Lie (L), Defensiveness (K), Infrequency (F), Hypochondriasis (HS), Depression (D), Hysteria (HY), Psychopathic Deviate (PD), Masculinity/Femininity (MF), Paranoia (PA), Psychasthenia (PT), Schizophrenia

Selection of MMPI Results in Donors.

MMPI Category

Complete - Oocytes Retrieved (n¼45)

Incomplete Dropout (n¼15)

Lie Infrequency Defensiveness Hypochondriasis Depression Hysteria Psychopathic Deviate Masculinity/Femininity Paranoia Psychasthenia Schizophrenia

58.24  14.13 47  8.89 58.96  9.15 45.11  5.83 42.91  5.68 46.09  7.62 50.36  7.43 41.87  9.42 48.6  7.4 46.56  6.25 48.18  6.51

58.38  14.37 46.2  6.43 59.67  9.42 46.4  5.01 44.4  6.67 50.27  7.5 50.13  5.44 45  10.84 52.53  5.36 46.97  5.47 49.67  4.51

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(SC), Hypomania (MA), and Social Introversion (SI). Cohorts were segregated by status of cycle obligation (‘‘Complete-Oocytes Retrieved’’; ‘‘Incomplete-Dropout’’). A random-number generator was used from a larger subset to isolate the ‘‘Complete-Oocytes Retrieved’’ group. RESULTS: Sixty oocyte donors were evaluated and MMPI was deemed valid and acceptable based on program criteria. Of the MMPI taken by both who completed (n¼45) and did not complete (n¼15) donation cycles, no statistical difference between the 13 personality characteristics was observed. A difference in the PA category was detected, although it did not reach significance. CONCLUSIONS: The MMPI test does not prospectively predict donor compliance to protocols and obligations in an ovum donation program. Donors demonstrated relatively consistent personality traits. Donors who scored the highest on the ‘‘hysteria’’ and ‘‘paranoia’’ scale were less likely to complete the process. These characteristics are common in individuals who display hypervigilance in social interactions, and have a tendency to be apprehensive to interpersonal communication and resist authorities’ direction. Although the MMPI did not find a differentiation in donors’ personality traits, future studies that evaluate alternative personality or psychopathology could assist in identification of appropriate donors who will be compliant with all participation requirements.

P-731 Wednesday, October 21, 2015 EFFECTIVENESS OF A SELF-HELP INTEGRATIVE BODY-MINDSPIRIT INTERVENTION (I-BMS) IN REDUCING INFERTILE WOMEN’S ANXIETY DURING THEIR IN VITRO FERTILIZATION (IVF) TREATMENT RESULT AWAITING PERIOD. C. Chan,a S. Wong,a M. Tam.b aThe University of Hong Kong, Hong Kong, Hong Kong; bDepartment of Social Work and Social Administratio, Hong Kong, Hong Kong. OBJECTIVE: This study aims at evaluating the effectiveness of a series of self-help techniques developed based on the Body-mind-spirit intervention (I-BMS) intervention model to fulfill the psychosocial needs of infertile women during the most distressful treatment stage, which is the result awaiting period after embryo transfer. DESIGN: This is a quasi-experimental study. 20 women who underwent IVF treatment were recruited and randomly assigned into intervention group (n¼10) and control group (n¼10). The study adopted the clinical framework of I-BMS model, which aims at maintaining a dynamic and harmonious balance between physical, psychosocial and spiritual wellbeing. MATERIALS AND METHODS: Participants in the intervention group attended a 3-hour I-BMS workshop organized by a registered social worker in educating the self-help techniques, and received a self-help exercise book containing self-help exercises, spiritual proverbs and journal writing for home practice on a 14-day basis. They were asked to practice the self-help techniques and report their subjective well-being on a daily basis during the result awaiting period after embryo transfer. Meanwhile, participants in control group received educational materials on healthy diet for home reading.All participants were invited to complete a selfadministered at three time points: on the day of recruitment (T0), on the day of embryo transfer (T1), before pregnancy test (T2). The scales used include Importance of Childbearing Index, Chinese Kansas Marital Satisfaction Scale (C-KMS) and Chinese State-Trait Anxiety Inventory (C-STAI). RESULTS: By using ANOVA, participants in the intervention group showed significant reduction in the importance in childbearing (T1: 26.90 + 4.09; T2: 24.30 + 3.98, F¼2.10, p<0.01) and state anxiety (T1: 45.20 + 6.93; T2: 42.80 + 2.53, F¼2.74, p<0.01), as well as significant improvement in marital satisfaction (T1: 16.30 + 2.50; T2: 18.10 + 2.47, F¼3.73, p<0.04). Thus, the intervention was proven effective in alleviating the anxiety, and enhancing spiritual and psychosocial wellbeing of the infertile women during result awaiting period. CONCLUSIONS: Among all treatment stages, the result awaiting period between embryo transfer and pregnancy test were considered as the most anxious period during IVF treatment. However, most existing psychosocial services provide support before the treatment, while their needs during the awaiting period is sometimes overlooked. Women usually prefer hiding from others or staying home to avoid affecting the pregnancy outcome. When in-person support becomes infeasible to them, this specifically de-

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ASRM Abstracts

signed self-help techniques, which allows more autonomy, flexibility and privacy at lower cost, could fulfill their special needs during their most anxious period, and psychologically and physically prepare them for the treatment outcome. Supported by: This study was generously funded by the University Grant Council - General Research Fund (No.: HKU27400414). P-732 Wednesday, October 21, 2015 UNDERSTANDING THE FERTILITY-RELATED QUALITY OF LIFE OF WOMEN UNDERGOING IVF TREATMENT AND HOW CULTURAL BELIEFS SHAPED THEIR TREATMENT EXPERIENCE, OUTCOME EXPECTATIONS AND EMOTIONAL REACTIONS. M. Tam,a C. Chan,b S. Wong,b H. Chan.a aDepartment of Social Work and Social Administration, Hong Kong, Hong Kong; bThe University of Hong Kong, Hong Kong, Hong Kong. OBJECTIVE: This study aims to investigate the impact of treatment procedures on the fertility-related quality of life in women undergoing in vitro fertilization (IVF) treatment procedures, how their personal beliefs affect treatment expectations, and cultural factors influencing their reactions at times of implantation failure. DESIGN: This is a cross-sectional survey conducted with women undergoing IVF treatments at a local university-affiliated assisted reproduction clinic. MATERIALS AND METHODS: One hundred and ninety-eight women was recruited. They have just been notified of an implantation failure with an indication of negative outcome in the pregnancy test. With consent, they completed a battery of questions about their fertility-related quality of life (FertiQoL), beliefs in childbearing, couple relationships, treatment history, and demographic details. Scales included FertilityRelated Quality of Life Scale (FertiQoL) and Chinese Fertility Beliefs Scale (CFBS). RESULTS: On average, participated were aged 37.0 (SD¼3.5), married for 7.4 years (SD¼3.7), and being diagnosed of subfertility for 4.1 years (SD¼2.45). Majority of women received tertiary education and had a fulltime job.Compared with a Western sample, the mean scores of total fertility-related quality of life (Total FertiQoL) (t ¼ 8.10 and 8.36, p < .01) and quality of life across the Chinese’s women emotional, mind-body, relational and social domain (Core FertiQoL) (t ¼ 8.10 and 8.36, p < .01) were found to be better. Nonetheless, their infertility treatment related quality of life (Treatment FertiQoL) was no different from their Western counterparts (t ¼ 1.41, n.s.).Regarding cultural influence on treatment anticipation and outcomes, Total and Core FertiQoL were found to be negatively associated with the women’s identification with Chinese cultural beliefs about childbearing such as ‘‘It’s the Wife responsibility to childbearing’ (b¼ -3.384, p < .001), ‘‘No children is the biggest issue’’ (b¼ -2.97, p < .05). For Treatment FertiQoL, identification with the ‘‘It’s the daughter in-law’s responsibility continue lineage’’ belief significantly predicts poorer outcomes (b¼ -3.356, p < .01). CONCLUSIONS: This study sheds light on the impact of treatment procedures on the fertility-related quality of life in women undergoing in vitro fertilization (IVF) treatment procedures, especially at times of implantation failure. Strong identification with Chinese beliefs of childbearing, which emphasizes the patrilineal culture, was found to be associated with poor well-being in these women.The findings underlines the importance of cultural sensitivity in addressing fertility-related issues in order to better facilitate psychosocial support at the clinic, as well as to empower these women to express their personal values and cultural beliefs throughout the course of infertility treatment. Supported by: This study was generously funded by the University Grant Council - General Research Fund (No: HKU740613). P-733 Wednesday, October 21, 2015 SEEING RED: IMPAIRED QUALITY OF LIFE IN WOMEN WITH SYMPTOMATIC UTERINE FIBROIDS. G. Mendoza,a A. Lawson,b M. Ghant,c K. Sengoba,d E. Confino,a E. E. Marsh.a aObstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL; b Northwestern Medical Group, Chicago, IL; cUniversity of Illinois at Chicago, Chicago, IL; dNorthwestern University Feinberg School of Medicine, Chicago, IL.

Vol. 104, No. 3, Supplement, September 2015