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Candida and candidosis
62
BIOCHEMICAL EDUCATION
July 1979 vol 7 no 3
TABLE 1 Examples of enzymes purified by chromatography on immobilized Cibacron Blue F3GA, Blue Dextran or Procion Red HE3B
NAD +-dependent d e h y d r o g e n a s e s
N A D P + - d e p e n d dehydrogenases ent
Kinases
Lactate DH Malate DH Glyceraldehyde 3-phosphate DH Alcohol DH Pyruvate DH
Glucose 6-phosphate DH Glutamate DH 6-phosphogluconate DH Glutathione reductase Aldehyde reductase
Adenylate kinase Pyruvate kinase Phosphofructokinase Phosphoglycerate kinase NAD+-kinase
DH = dehydrogenase. These examples are merely illustrative and are by no means comprehensive. For further details see refs 1-3, 5-8, 15, 16, 23-5. domain, the distinction between non-specific and bio-specific interactions with a ligand, and the distinction between reversible and irreversible inhibition. The latter concept is often confused with non-competitive inhibition in the mind of the student. A large number of dyes are currently available and the commonly used dyes Cibacron Blue F3GA and Procion Red HE3B may not be the most appropriate for all occasions. I should be grateful to hear of any novel separations achieved using dye-polysaccharide matrices, and full practical details of class experiments outlined here can be supplied on request.
REFERENCES 1Stockton, J, Pearson, A G M, West, L J, and Turner, A J (1978) Biochem Soc Trans, 6, 200-3. z Whittle, S R and Turner, A J (1978)JNeurochem, 31, 1453-9. 3Turner, A J, Pearson, A G M and Mason, R W (1979) in Developments in Biochemistry (Kisliuk, R L and Brown, G M, eds) Elsevier/North-Holland, vol 4, 501-6. 4 Allen, R L M (1964) Colour Chemistry, pub Nelson, pp 201-13. s Staal, G E J, Koster, J F, Kamp, H, van Miiligan-Boersma, L, and Veeger, C (1971)Biochim Biophys Acta, 227, 86-96. 6Kopperschliiger, G, Diezel, W, Freyer, R, Liebe, S, and Hofman, E (1971)EurJBiochem, 22, 40-5. 7Ryan, L D and Vestling, C S (1974)Arch Biochem Biophys, 160, 279-84. SThompson, S T, Cass, K H and Stellwagen, E (1975)Proc Nat Acad Sci USA, 72,669-72.
Biosynthetic Products for Cancer Therapy, Volume 2 by George R Pettit and G o r d o n M Cragg, pp 150. P l e n u m Press, New York a n d London. 1978. £18.85 This is the second volume of a series listing naturally occurring substances with proven anti-cancer or cytotoxic activity in which the literature is reviewed up to April 1976. The compounds have been classified according to chemical type (eg steroids, terpenoids and alkaloids) and biological origin (lower and higher plants and animals). Each entry comprises the chemical structure (when known), the common name, physical characteristics and the results of antineoplastic screening and/or cytotoxic evaluation with literature references. This collection of data is of interest to those involved in cancer chemotherapy indicating the wide range of biosynthetic structures possessing cytotoxic activity. It is a useful compilation dealing with an expanding topic - - a third volume will cover the literature up to November 1977. It should be emphasized that not all cytotoxic agents are necessarily useful in the treatment of cancer: a differential effect on neoplastic cells must also be demonstrated. W C J Ross Chester Beatty Research Institute Royal Cancer Hospital Fulham Road, London SW3
9 Blake, C C F (1974)Nature, 250, 284-5. 10 Blake, C C F (1977) Nature, 267,482-3. 11 Rossmann, M G, Moras, D and Olsen, K W (1974)Nature, 250, 194-9. lz Schultz, G E and Schirmer, R H (1974)Nature, 250, 142-4. x3 Jankowski, W J, yon Muenchhausen, W, Sulkowski, E, and Carter, W A (1976)Biochemistry, 15, 5182-7. 14 Illingworth, J A (1972) Biochem J, 129, 1119-24. x5 Edwards, M E, Singh, M and Tubbs, P K (1973)FEBSLett, 37, 155-8. 16 Ashton, A R and Polya, G M (1978)Biochem J, 175,501-6. ~7 Watson, D H, Harvey, M J and Dean, P D G (1978) Biochem J~ 173,591-6. is Baird, J K, Sherwood, R F, Carr, R J G, and Atkinson, A (1976) FEBSLett, 70, 61-6. 19 Heyns, W and de Moor, P (1974) Biochim Biophys Acta, 358, 1-13. 20 Sedmak, J J and Grossberg, S E (1977) Analyt Biochem, 79, 544-52. zl Thompson, S T and Stellwagen, E (1976) Proc Nat Acad Sci USA, 73, 361-5. z2 Weber, B H, Willeford, K, Moe, J G, and Piszkiewicz, D (1979) Biochem Biophys Res Commun, 86, 252-8. z3 Thompson, S T, Cass, R H and Stellwagen, E (1976) Analyt Biochem, 72,293-6. 24 De Abreu, R A, De Kok, A and Veeger, C (1977)FEBS Lett, 82, 89-92. 2s Apps, D K and Gleed, C D (1976) Biochem J, 159,441-3.
Candida and Candidosis by F C O d d s , pp 382. 64 tables, 26 figs a n d 3 colour plates. Leicester University Press, Leicester, U K . 1979. £16.00 A major requirement of any textbook is that it should form a ready source of information on any aspect of the subject and in this respect Candida and candidosis most certainly conforms. The headings of the twenty-seven chapters accurately describe the contents and enable the reader to quickly find the available data on any particular aspect. Moreover, the information is clearly presented, in most instances by useful tables and/or figures compiled from the relevant original publications, and the consensus of opinion clearly and briefly stated in the text. The references, of which there are more than 2000, provide an easy source of more detailed information if required. However, it, is not only a reference book. The author has produced a very readable text which will stimulate those with only a specialized interest to broaden their outlook and knowledge of this important subject. Biochemical aspects, for instance, are mainly within chapters 2, 3, 4, 24, and 25 bat there is much relevant material elsewhere. There are remarkably few typographical errors; the presentation is pleasing and robust and, these days, the price is not high. Definitely recommended. Medical Mycology Section J C Gentles University of Glasgow Glasgow, Scotland
BIOCHEMICAL EDUCATION
July 1979 vol 7 no 3
TABLE 1 Examples of enzymes purified by chromatography on immobilized Cibacron Blue F3GA, Blue Dextran or Procion Red HE3B
NAD +-dependent d e h y d r o g e n a s e s
N A D P + - d e p e n d dehydrogenases ent
Kinases
Lactate DH Malate DH Glyceraldehyde 3-phosphate DH Alcohol DH Pyruvate DH
Glucose 6-phosphate DH Glutamate DH 6-phosphogluconate DH Glutathione reductase Aldehyde reductase
Adenylate kinase Pyruvate kinase Phosphofructokinase Phosphoglycerate kinase NAD+-kinase
DH = dehydrogenase. These examples are merely illustrative and are by no means comprehensive. For further details see refs 1-3, 5-8, 15, 16, 23-5. domain, the distinction between non-specific and bio-specific interactions with a ligand, and the distinction between reversible and irreversible inhibition. The latter concept is often confused with non-competitive inhibition in the mind of the student. A large number of dyes are currently available and the commonly used dyes Cibacron Blue F3GA and Procion Red HE3B may not be the most appropriate for all occasions. I should be grateful to hear of any novel separations achieved using dye-polysaccharide matrices, and full practical details of class experiments outlined here can be supplied on request.
REFERENCES 1Stockton, J, Pearson, A G M, West, L J, and Turner, A J (1978) Biochem Soc Trans, 6, 200-3. z Whittle, S R and Turner, A J (1978)JNeurochem, 31, 1453-9. 3Turner, A J, Pearson, A G M and Mason, R W (1979) in Developments in Biochemistry (Kisliuk, R L and Brown, G M, eds) Elsevier/North-Holland, vol 4, 501-6. 4 Allen, R L M (1964) Colour Chemistry, pub Nelson, pp 201-13. s Staal, G E J, Koster, J F, Kamp, H, van Miiligan-Boersma, L, and Veeger, C (1971)Biochim Biophys Acta, 227, 86-96. 6Kopperschliiger, G, Diezel, W, Freyer, R, Liebe, S, and Hofman, E (1971)EurJBiochem, 22, 40-5. 7Ryan, L D and Vestling, C S (1974)Arch Biochem Biophys, 160, 279-84. SThompson, S T, Cass, K H and Stellwagen, E (1975)Proc Nat Acad Sci USA, 72,669-72.
Biosynthetic Products for Cancer Therapy, Volume 2 by George R Pettit and G o r d o n M Cragg, pp 150. P l e n u m Press, New York a n d London. 1978. £18.85 This is the second volume of a series listing naturally occurring substances with proven anti-cancer or cytotoxic activity in which the literature is reviewed up to April 1976. The compounds have been classified according to chemical type (eg steroids, terpenoids and alkaloids) and biological origin (lower and higher plants and animals). Each entry comprises the chemical structure (when known), the common name, physical characteristics and the results of antineoplastic screening and/or cytotoxic evaluation with literature references. This collection of data is of interest to those involved in cancer chemotherapy indicating the wide range of biosynthetic structures possessing cytotoxic activity. It is a useful compilation dealing with an expanding topic - - a third volume will cover the literature up to November 1977. It should be emphasized that not all cytotoxic agents are necessarily useful in the treatment of cancer: a differential effect on neoplastic cells must also be demonstrated. W C J Ross Chester Beatty Research Institute Royal Cancer Hospital Fulham Road, London SW3
9 Blake, C C F (1974)Nature, 250, 284-5. 10 Blake, C C F (1977) Nature, 267,482-3. 11 Rossmann, M G, Moras, D and Olsen, K W (1974)Nature, 250, 194-9. lz Schultz, G E and Schirmer, R H (1974)Nature, 250, 142-4. x3 Jankowski, W J, yon Muenchhausen, W, Sulkowski, E, and Carter, W A (1976)Biochemistry, 15, 5182-7. 14 Illingworth, J A (1972) Biochem J, 129, 1119-24. x5 Edwards, M E, Singh, M and Tubbs, P K (1973)FEBSLett, 37, 155-8. 16 Ashton, A R and Polya, G M (1978)Biochem J, 175,501-6. ~7 Watson, D H, Harvey, M J and Dean, P D G (1978) Biochem J~ 173,591-6. is Baird, J K, Sherwood, R F, Carr, R J G, and Atkinson, A (1976) FEBSLett, 70, 61-6. 19 Heyns, W and de Moor, P (1974) Biochim Biophys Acta, 358, 1-13. 20 Sedmak, J J and Grossberg, S E (1977) Analyt Biochem, 79, 544-52. zl Thompson, S T and Stellwagen, E (1976) Proc Nat Acad Sci USA, 73, 361-5. z2 Weber, B H, Willeford, K, Moe, J G, and Piszkiewicz, D (1979) Biochem Biophys Res Commun, 86, 252-8. z3 Thompson, S T, Cass, R H and Stellwagen, E (1976) Analyt Biochem, 72,293-6. 24 De Abreu, R A, De Kok, A and Veeger, C (1977)FEBS Lett, 82, 89-92. 2s Apps, D K and Gleed, C D (1976) Biochem J, 159,441-3.
Candida and Candidosis by F C O d d s , pp 382. 64 tables, 26 figs a n d 3 colour plates. Leicester University Press, Leicester, U K . 1979. £16.00 A major requirement of any textbook is that it should form a ready source of information on any aspect of the subject and in this respect Candida and candidosis most certainly conforms. The headings of the twenty-seven chapters accurately describe the contents and enable the reader to quickly find the available data on any particular aspect. Moreover, the information is clearly presented, in most instances by useful tables and/or figures compiled from the relevant original publications, and the consensus of opinion clearly and briefly stated in the text. The references, of which there are more than 2000, provide an easy source of more detailed information if required. However, it, is not only a reference book. The author has produced a very readable text which will stimulate those with only a specialized interest to broaden their outlook and knowledge of this important subject. Biochemical aspects, for instance, are mainly within chapters 2, 3, 4, 24, and 25 bat there is much relevant material elsewhere. There are remarkably few typographical errors; the presentation is pleasing and robust and, these days, the price is not high. Definitely recommended. Medical Mycology Section J C Gentles University of Glasgow Glasgow, Scotland