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Carcinoma of the Urinary Bladder Category T3NxMo Treated by the Combination of Radium Implant and External Irradiation: Second Report
I1
ONCOLOGY AND CHEMOTHERAPY
years old and every 6 months thereafter until the child is 4 years old. P. R. R. 10 references
Editorial comment. The authors compared examinations that were used in the surveillance of children with aniridia who later suffered Wilms tumor. Surprisingly, an IVP detected an asymptomatic mass in only 1 of 9 children. The authors propose more frequent use of ultrasonography to disclose an asymptomatic and impalpable renal mass. M. M. Renal Cell Carcinoma in Children R. B. RANEY, JR., N. PALMER, W.W. SUTOW, E. BAUM AND
Division of Oncology, Children's Hospital, Philadelphia, Pennsylvania, Division of Pathology, Children's Hospital, Columbus, Ohio, Divisions of Pediatrics and Pathology, M. D. Anderson Hospital, Houston, Texas, and Division of Hematology-Oncology, Children's Memorial Hospital, Chicago, Illinois A. AYALA,
Med. Ped. Oncol., 11: 91-98, 1983 The authors have outlined the clinical details and treatment results in 20 children with renal cell carcinoma at 4 pediatric oncology treatment centers. To facilitate comparison between the renal cell carcinoma study patients and children with Wilms tumor the authors followed the grouping system used in the Second National Wilms Tumor study to stage the extent of tumor at diagnosis. Based on the data of the study the authors conclude that 1) renal cell carcinoma in children is similar to its counterpart in adults, 2) renal cell carcinoma has a worse prognosis than Wilms tumor except for the earlier stage, 3) nephrectomy alone is adequate treatment for group 1 renal cell carcinoma and 4) young age (<11 years old) may be prognostically favorable. P. R. R. 2 figures, 2 tables, 30 references
Editorial comment. The authors combined the findings in 20 children with renal cell carcinoma observed at 4 pediatric treatment centers and noted that the disease in children appears to mimick that in adults. The primary treatment mode is surgical excision. Radiation and chemotherapy are adjuncts, especially when curative surgery cannot be performed. Preoperative embolization may be worthwhile for children with large tumors, when complete removal is not believed feasible preoperatively. M. M. Carcinoma of the Urinary Bladder Category T 3 NxMo Treated by the Combination of Radium Implant and External Irradiation: Second Report
B.
VANDERWERF-MESSING, R. S. MENON AND w. C. J. HOP, Departments of Radiotherapy, Pathology and Statistics, Rotterdam Radiotherapy Institute, Rotterdam, The Netherlands
1249
and 2 deaths of progressive renal insufficiency. From their analysis it is evident that the degree of differentiation, vascular invasion and perivesical infiltration results in an unfavorable prognosis. The authors state that prognosis with this treatment protocol is at least as good as the Rotterdam experience with preoperative irradiation followed by simple cystectomy. H. D. P.
2 figures, 1 table, 3 references
Cancer of the Urinary Bladder Category T 2 , T 3 (NxMo) Treated by Interstitial Radium Implant: Second Report B. VANDERWERF-MESSING, R. MENON AND W. C. J. HOP, Rotterdam Radiotherapy Institute and Erasmus University, Rotterdam, The Netherlands
Int. J. Rad. Oncol. Biol. Phys., 9: 481-485 (Apr.) 1983 A total of 328 patients with stage T2 and 63 with stage T3 bladder tumors not >5 cm. in diameter forms the basis of this report. In each case there was no evidence of nodal involvement or metastases. All patients were treated with 3 courses of external radiation to the pelvic midline (each treatment delivering 3.5 Gy) followed by a radium implant. Over-all, 5-year survival for the stage T2 category was 56 per cent and for the T3 category it was 39 per cent, while the 10-year survival rates were 37 and 13 per cent, respectively. Poor prognostic factors were > 1 transurethral resection before treatment, an abnormal excretory urogram and poorly differentiated tumors. Patients with stage T3 disease who did not have any of these unfavorable factors had a prognosis similar to those with T2 cancer in whom the incidence of these unfavorable factors was less. The authors conclude that survival after this form of treatment is better for patients with stage T2 disease (in the absence of any abnormal prognostic factors) than with any other treatment modality. In patients with T2 cancer and poor prognostic factors and those with T3 disease the authors already have altered their treatment to provide a total of 40 Gy external radiation followed by a reduced dose of radium implantation (radium 55 per cent). D. K. M. 2 figures, 5 tables, 14 references
Presumptive Downstaging From Preoperative Irradiation for Bladder Cancer as Determined by Flow Cytometry: Preliminary Report F. A. KLEIN, w. F. WHITMORE, JR., R. M. WOLF, H. w. HERR, P. C. SOGANI, L. STAIANO-COICO AND M. R. MELAMED, Urology Service of the Department of Surgery and the Cytology Service of the Department of Pathology, Memorial Sloan Kettering Cancer Center, Cornell University Medical College, New York, New York
Int. J. Rad. Oncol. Biol. Phys., 9: 177-180 (Feb.) 1983
Int. J. Rad. Oncol. Biol. Phys., 9: 487-491 (Apr.) 1983
Forty-one patients with bladder cancer (T3NxMO) not >5 cm. in diameter were treated by 3 X 350 rad external radiation, radium implantation at reduced dose and an additional 3,000 rad external radiation. All 41 patients have been followed for ~1 year and the 5-year uncorrected actuarial survival was 57 per cent. Causes of death were intercurrent disease without evidence of bladder cancer (5), bladder cancer (8) and complications (2). Significant complications were seen in 8 patients (19.5 per cent) and include local necrosis, stone formation, ileus
A total of 28 patients with incompletely resected clinical stage T3 grade II or III bladder tumors forms the basis of this report. The patients were treated with 2,000 rad external radiation delivered to the whole pelvis in 5 days followed by cystectomy 1 to 14 days later. Before and after radiation, barbotage specimens were obtained from the bladder and subjected to flow cytometry. Before radiation all patients had positive flow cytometry specimens with an aneuploid stemline. Post-radiation flow cytometry specimens were examined and a complete
ONCOLOGY AND CHEMOTHERAPY
years old and every 6 months thereafter until the child is 4 years old. P. R. R. 10 references
Editorial comment. The authors compared examinations that were used in the surveillance of children with aniridia who later suffered Wilms tumor. Surprisingly, an IVP detected an asymptomatic mass in only 1 of 9 children. The authors propose more frequent use of ultrasonography to disclose an asymptomatic and impalpable renal mass. M. M. Renal Cell Carcinoma in Children R. B. RANEY, JR., N. PALMER, W.W. SUTOW, E. BAUM AND
Division of Oncology, Children's Hospital, Philadelphia, Pennsylvania, Division of Pathology, Children's Hospital, Columbus, Ohio, Divisions of Pediatrics and Pathology, M. D. Anderson Hospital, Houston, Texas, and Division of Hematology-Oncology, Children's Memorial Hospital, Chicago, Illinois A. AYALA,
Med. Ped. Oncol., 11: 91-98, 1983 The authors have outlined the clinical details and treatment results in 20 children with renal cell carcinoma at 4 pediatric oncology treatment centers. To facilitate comparison between the renal cell carcinoma study patients and children with Wilms tumor the authors followed the grouping system used in the Second National Wilms Tumor study to stage the extent of tumor at diagnosis. Based on the data of the study the authors conclude that 1) renal cell carcinoma in children is similar to its counterpart in adults, 2) renal cell carcinoma has a worse prognosis than Wilms tumor except for the earlier stage, 3) nephrectomy alone is adequate treatment for group 1 renal cell carcinoma and 4) young age (<11 years old) may be prognostically favorable. P. R. R. 2 figures, 2 tables, 30 references
Editorial comment. The authors combined the findings in 20 children with renal cell carcinoma observed at 4 pediatric treatment centers and noted that the disease in children appears to mimick that in adults. The primary treatment mode is surgical excision. Radiation and chemotherapy are adjuncts, especially when curative surgery cannot be performed. Preoperative embolization may be worthwhile for children with large tumors, when complete removal is not believed feasible preoperatively. M. M. Carcinoma of the Urinary Bladder Category T 3 NxMo Treated by the Combination of Radium Implant and External Irradiation: Second Report
B.
VANDERWERF-MESSING, R. S. MENON AND w. C. J. HOP, Departments of Radiotherapy, Pathology and Statistics, Rotterdam Radiotherapy Institute, Rotterdam, The Netherlands
1249
and 2 deaths of progressive renal insufficiency. From their analysis it is evident that the degree of differentiation, vascular invasion and perivesical infiltration results in an unfavorable prognosis. The authors state that prognosis with this treatment protocol is at least as good as the Rotterdam experience with preoperative irradiation followed by simple cystectomy. H. D. P.
2 figures, 1 table, 3 references
Cancer of the Urinary Bladder Category T 2 , T 3 (NxMo) Treated by Interstitial Radium Implant: Second Report B. VANDERWERF-MESSING, R. MENON AND W. C. J. HOP, Rotterdam Radiotherapy Institute and Erasmus University, Rotterdam, The Netherlands
Int. J. Rad. Oncol. Biol. Phys., 9: 481-485 (Apr.) 1983 A total of 328 patients with stage T2 and 63 with stage T3 bladder tumors not >5 cm. in diameter forms the basis of this report. In each case there was no evidence of nodal involvement or metastases. All patients were treated with 3 courses of external radiation to the pelvic midline (each treatment delivering 3.5 Gy) followed by a radium implant. Over-all, 5-year survival for the stage T2 category was 56 per cent and for the T3 category it was 39 per cent, while the 10-year survival rates were 37 and 13 per cent, respectively. Poor prognostic factors were > 1 transurethral resection before treatment, an abnormal excretory urogram and poorly differentiated tumors. Patients with stage T3 disease who did not have any of these unfavorable factors had a prognosis similar to those with T2 cancer in whom the incidence of these unfavorable factors was less. The authors conclude that survival after this form of treatment is better for patients with stage T2 disease (in the absence of any abnormal prognostic factors) than with any other treatment modality. In patients with T2 cancer and poor prognostic factors and those with T3 disease the authors already have altered their treatment to provide a total of 40 Gy external radiation followed by a reduced dose of radium implantation (radium 55 per cent). D. K. M. 2 figures, 5 tables, 14 references
Presumptive Downstaging From Preoperative Irradiation for Bladder Cancer as Determined by Flow Cytometry: Preliminary Report F. A. KLEIN, w. F. WHITMORE, JR., R. M. WOLF, H. w. HERR, P. C. SOGANI, L. STAIANO-COICO AND M. R. MELAMED, Urology Service of the Department of Surgery and the Cytology Service of the Department of Pathology, Memorial Sloan Kettering Cancer Center, Cornell University Medical College, New York, New York
Int. J. Rad. Oncol. Biol. Phys., 9: 177-180 (Feb.) 1983
Int. J. Rad. Oncol. Biol. Phys., 9: 487-491 (Apr.) 1983
Forty-one patients with bladder cancer (T3NxMO) not >5 cm. in diameter were treated by 3 X 350 rad external radiation, radium implantation at reduced dose and an additional 3,000 rad external radiation. All 41 patients have been followed for ~1 year and the 5-year uncorrected actuarial survival was 57 per cent. Causes of death were intercurrent disease without evidence of bladder cancer (5), bladder cancer (8) and complications (2). Significant complications were seen in 8 patients (19.5 per cent) and include local necrosis, stone formation, ileus
A total of 28 patients with incompletely resected clinical stage T3 grade II or III bladder tumors forms the basis of this report. The patients were treated with 2,000 rad external radiation delivered to the whole pelvis in 5 days followed by cystectomy 1 to 14 days later. Before and after radiation, barbotage specimens were obtained from the bladder and subjected to flow cytometry. Before radiation all patients had positive flow cytometry specimens with an aneuploid stemline. Post-radiation flow cytometry specimens were examined and a complete