Cardiac donor heart dysfunction: Evidence for catecholamine-mediated myocardial injury

84A

JACC Vol. 15, NQ. 2 A al-y1

ABSTRACI'S

LEFT !ENmcuLAR PATIENTS: A

DuALmy

SuBTFtAm ANQloaRApHY IN UNE DIMAL SUBTRACTION lECH?+llQUE

Brain dead organ donor from cardiac organ donati myocardlal dysfunction.

(ate

3723. ~~05 vs QHD):

DHD (n-7) Normals (n-14)

*880 fl34 1848 2238

862 *92.2 &265 i6.6 1218 71.2 fS.0 f200 1) Organ donors

*<.05 1816 +3.9 18.6 il.8 with

+1230 64 2,249 f16 658 48 f95 $7.0

540 2132 457 979 D have SCh

contraction despite no This uncoupling of DHD with exposure to hi neuroeransrsltter,

INCREASED

. 2) em

EXPRESSION OF

SURGICAUYDENERVATED, P IllH VENTRICULAR

that

cludiacieinnuYation-

tmnsolanuttion (CT) occurs in

normal total

B receptor

the surgically

de

(NE) and adenylate cyclase (AC) in materialprepared from right and left ventricular mya~rdi from transplant recipients with normal function who were retransplanted for gr atheroscleresis (SE?): *qt0.05 Crou m TX (10) 212.4 f9.0 25.1 23.1 f4.6 222 119 94.7 75.2 18.6 30.5 35.6 238 817 NU (68) 23.6 23.3 Il.4 21.6 a2.0 +12 292 tnonml innervated Vti from organ donor controls; renol; Forsk-forskolin; NE-norepinephtine

se during ijometric hangrip (A[NE]cs-,w=34&til3pg/ml).

CO~C~~S~OO: Early a&r CT the mwcardium does not release NE.

suggestingdenktion. Late after irr. the maknitv of Patientscan substantial,but subnormal,quantities&f NE in-responseto e @ physiologic stimuli,suggesting&at limitedsympathetic ~axutsintbemajorityofuansp~tedhumanh

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