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CARDIAC EFFECTS OF POLYCYSTIC OVARY SYNDROME
A1412 JACC April 1, 2014 Volume 63, Issue 12
Prevention Cardiac Effects of Polycystic Ovary Syndrome Poster Contributions Hall C Sunday, March 30, 2014, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Gender, Race/Ethnicity, and Preventive Interventions Abstract Category: 20. Prevention: Clinical Presentation Number: 1219-134 Authors: Christina Wei, Sheldon Litwin, Georgia Regents University, Department of Internal Medicine and Division of Cardiology, Augusta, GA, USA Objective: The hormonal-metabolic milieu in women with polycystic ovary syndrome (PCOS) contributes to cardiovascular risk clustering. We performed a meta-analysis to systematically review the effect of PCOS on the cardiovascular system. Methods: We searched PUBMED for studies comparing echocardiographic parameters or presence of coronary calcium (CAC) in women with PCOS and age- and BMI- matched controls. The pooled standardized mean differences (SMD) were fitted to random effect models to calculate the overall effect size estimates. Results: Thirteen studies totaling 660 PCOS patients were eligible. PCOS is associated with moderate increase in left ventricular mass (5 studies; SMD = 0.60, 95%CI: 0.38 - 0.81; p < 0.00), small increase in left atrial diameter (5 studies; SMD = 0.32, 95%CI: 0.12 - 0.53; p < 0.00), moderate decrease in peak early diastolic filling velocity (4 studies; SMD = -0.37, 95%CI: -0.60 - -0.14; p < 0.00), and small decrease in E/A (6 studies; SMD= -0.29, 95%CI: -0.48 - -0.10; p < 0.00). Ejection fraction and deceleration time differences did not reach significance. Women with PCOS have a tendency for positive CAC (4 studies; OR = 1.48, 95%CI: 0.91 - 2.41; p = 0.12). Conclusion: Compared with matched controls, women with PCOS have higher left ventricle mass and left atria size, and abnormal mitral flow parameters. Some of these changes are present in women with PCOS in their third decade of life, findings which may be harbingers of clinically significant heart disease later in life.
Prevention Cardiac Effects of Polycystic Ovary Syndrome Poster Contributions Hall C Sunday, March 30, 2014, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Gender, Race/Ethnicity, and Preventive Interventions Abstract Category: 20. Prevention: Clinical Presentation Number: 1219-134 Authors: Christina Wei, Sheldon Litwin, Georgia Regents University, Department of Internal Medicine and Division of Cardiology, Augusta, GA, USA Objective: The hormonal-metabolic milieu in women with polycystic ovary syndrome (PCOS) contributes to cardiovascular risk clustering. We performed a meta-analysis to systematically review the effect of PCOS on the cardiovascular system. Methods: We searched PUBMED for studies comparing echocardiographic parameters or presence of coronary calcium (CAC) in women with PCOS and age- and BMI- matched controls. The pooled standardized mean differences (SMD) were fitted to random effect models to calculate the overall effect size estimates. Results: Thirteen studies totaling 660 PCOS patients were eligible. PCOS is associated with moderate increase in left ventricular mass (5 studies; SMD = 0.60, 95%CI: 0.38 - 0.81; p < 0.00), small increase in left atrial diameter (5 studies; SMD = 0.32, 95%CI: 0.12 - 0.53; p < 0.00), moderate decrease in peak early diastolic filling velocity (4 studies; SMD = -0.37, 95%CI: -0.60 - -0.14; p < 0.00), and small decrease in E/A (6 studies; SMD= -0.29, 95%CI: -0.48 - -0.10; p < 0.00). Ejection fraction and deceleration time differences did not reach significance. Women with PCOS have a tendency for positive CAC (4 studies; OR = 1.48, 95%CI: 0.91 - 2.41; p = 0.12). Conclusion: Compared with matched controls, women with PCOS have higher left ventricle mass and left atria size, and abnormal mitral flow parameters. Some of these changes are present in women with PCOS in their third decade of life, findings which may be harbingers of clinically significant heart disease later in life.