- Email: [email protected]
Cardiovascular and renal protection in coronary artery disease
Abstracts / Atherosclerosis 235 (2014) e192–e301
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cardiovascular disease (CVD) in a population. The e_COR is a national study with a laboratory component that is being performed in the 5 Portuguese regions. The aim of the present report was to estimate the prevalence of major CVD risk factors (RF) using the data collected in the young adult population from the 3 regions already completed.
Diabetes and Hypertension should be the subject of increased strategies for primary stage prevention of CVD.
Methods: This study was conducted on a sample of 294 individuals of both gender, between 18 and 34 years, residents in Lisbon, Center and North of Portugal. The data collected were obtained from a venous blood sample, a physical examination and a questionnaire, including clinical questions and lifestyle habits. RF were analysed following European Cardiology Society guidelines, unless stated otherwise. Statistical analysis was performed using the SPSS software v.17.0. Results: The study included 294 individuals (mean age 27.79 4.81 years; 47.6% male). Of the total sample, the prevalence rates were as follows: Inadequate diet (less than 5 pieces of fruit/vegetables a day), 75.2%; Overweight/obesity, 56.8%; physical inactivity (IPAC questionnaire), 56.4%; alcohol abuse, 56.1%; hypercholesterolemia (total cholesterol>240 mg/dl, LDL>145 mg/dl, apoB>120 mg/dl), 4.4%, 11.2%, 5.4%; smoking, 35%; low HDL, 16%; hypertriglyceridemia (>150mg/dl), 11.2%; hypertension, 8.2%; diabetes mellitus, 1%. Statistical differences were seen between genders for inadequate diet and alcohol abuse (higher in men, p¼0.003, P<0.001). A total of 92.3% have at least 1 RF and 3.1% presented 5 RF. Conclusion: The high rates of CVD RF in a young population, especially inadequate diet, overweight, alcohol abuse and physical inactivity, are of great concern for the prevention of CVD. Population strategies should be developed to change life styles in order to improve CV health.
EAS-0849. CARDIOVASCULAR AND RENAL PROTECTION IN CORONARY ARTERY DISEASE
71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0816. UNDERUTILIZATION OF STATINS IN ELDERLY PATIENTS HOSPITALIZED WITH CARDIOVASCULAR EVENTS A. Benavente Fernándeza, A. Escudero Brocalb, A. Salmerón-Garcíab a Internal Medicine., Baza Hospital., Granada, Spain; b Pharmacy department., Baza Hospital., Granada, Spain
Objectives: To analyze prescription omissions of statins in elderly patients hospitalized with cardiovascular problems in an attempt to find a link with said patients' hospitalization. Methods: Retrospective observational study from July-November 2013 with patients admitted to the Internal Medicine Unit. We included patients 65 with cardiovascular problems. Data collected: sex, age, previous CVD, cardiovascular risk factors (CVRF) and adherence to statin therapy (Morisky-Green-Scale). We collected Low-density lipoprotein cholesterol (LDL-C) values obtained <48 hours after admission. We evaluated the use of statins according to the European Guidelines on CVD prevention in clinical practice (version 2012). Exclusion criteria: patients transferred to other units and patients who died. Results: 60 patients were included: 48% male, 52% female; Average age was 80 (range ¼ 61-92), 75% with previous CVD (such as 30% Ischemic heart disease, 27% Atrial fibrillation and 20% Hypertensive heart disease). CVRF were: 75% Hypertension, 52% Dyslipidemia, 33% Diabetes, 18% Obesity, 15% Ex Smoker or Smoker. 40 of the patients were eligible for statin therapy, only 27 of them were actually on a statin (44% were at LDL-C goal). 13 patients were not on a statin due to: 77% prescription errors, 15% nonadherence to treatment and 8% contraindication to statins. 11 of the patients with prescription omissions of statins were hospitalized with Ischemic heart disease and 2 with cerebrovascular disease. These medication omissions involved: Statin therapy in 9 patients with diabetes and at least one CVRF (100% hypertension, 66% dyslipidemia, 22% obesity). Statin therapy in 4 patients with a documented history of cerebral (75%) or coronary diseases (25%). Conclusion: There are a large number of patients who should be on a statin but are not, or were on a statin but not at LDL-C goal. Elderly patients with
71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous
E. Bobescua, D. Dobreanub, L. Rogozeac, A. Pascuc, C. Strempeld, N. Alduleae, A. Covaciuc a
Faculty of Medicine DSMC, Transilvania University Brasov, Brasov, Romania; Faculty of Medicine DSMC, University of Medicine anf Pharmacy Tg Mures, Tg Mures, Romania; c Faculty of Medicine, Transylvania University Brasov, Brasov, Romania; d Cardiology, Clinic County Emergency Hospital Brasov, Brasov, Romania; e Children Clinic Hospital Brasov, University of Medicine anf Pharmacy Tg Mures, Brasov, Romania b
Objectives: Aims: In patients with stable angina (SA) and non ST acute coronary syndrome (unstable angina-UA, acute myocardial infarction with ST elevation - STEMI and without ST elevation – NSTEMI) incidence of sudden cardiac death, other major acute cardiovascular events (MACE), blood pressure control and renal function were evaluated in relation with administration of drugs with reducing effects on oxidative stress, platelets hyperactivity and endothelial dysfunction. Methods: Methods: 400 patients (pts) with coronary artery disease were divided in 8 groups: Group SA T – 40 pts with SA, Group UA T - 62 pts with UA , Group STEMI T – 42 pts with STEMI and Group NSTEMI T - 62 pts with NSTEMI treated with drugs with complementary mechanisms mentioned above; Group SA – 38 pts with SA, Group UA - 60 pts with UA , Group STEMI – 40 pts with STEMI and Group NSTEMI - 60 pts with NSTEMI treated with drugs without mentioned proprieties. Biomarkers for oxidative stress, platelets hyperactivity, endothelial dysfunction, kidney disease, blood pressure values and MACE were evaluated for 2 years of follow up. Results: Results: In patients with stable angina and non ST acute coronary syndrome treatment with drugs with mentioned effects was followed by significant reduction in incidence of sudden cardiac death (p< 0.05), cardiovascular death (p< 0.05), nonfatal AMI (p< 0.025), improving of blood pressure control (p< 0.05), and renal function (p< 0.05) in comparison with control group. Decreased incidence of oxidative stress, platelets hyperactivity and endothelial dysfunction in groups treated by drugs with mentioned effects was significantly correlated with reduced incidence of MACE. Conclusion: In patients with stable and non ST acute coronary syndrome, a significantly reduced incidence of: sudden death, other cardiovascular death, acute myocardial infarction and a significantly improved blood pressure control and renal function were observed in groups treated with drugs with reducing effect on oxidative stress, platelets hyperactivity and endothelial dysfunction in comparison with control groups. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0974. TERC POLYMORPHISM, LEUKOCYTE TELOMERE LENGTH AND THE SURVIVAL LENGTH IN PATIENTS AFTER HEART TRANSPLANTATION. D. Dlouhaa, J. Hubaceka, Y. Vymetalovab, V. Vancurab, I. Malekb a Center of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4, Czech Republic; b Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague 4, Czech Republic
Objectives: In humans, leukocyte telomere length (LTL) is getting shorter progressively with age, and is frequently reported to be inversely associated with aging-related diseases. So far there are no studies investigate correlation of LTL on survival length in patients after heart transplantation. There is a number of complications in these patients about which it is
e287
cardiovascular disease (CVD) in a population. The e_COR is a national study with a laboratory component that is being performed in the 5 Portuguese regions. The aim of the present report was to estimate the prevalence of major CVD risk factors (RF) using the data collected in the young adult population from the 3 regions already completed.
Diabetes and Hypertension should be the subject of increased strategies for primary stage prevention of CVD.
Methods: This study was conducted on a sample of 294 individuals of both gender, between 18 and 34 years, residents in Lisbon, Center and North of Portugal. The data collected were obtained from a venous blood sample, a physical examination and a questionnaire, including clinical questions and lifestyle habits. RF were analysed following European Cardiology Society guidelines, unless stated otherwise. Statistical analysis was performed using the SPSS software v.17.0. Results: The study included 294 individuals (mean age 27.79 4.81 years; 47.6% male). Of the total sample, the prevalence rates were as follows: Inadequate diet (less than 5 pieces of fruit/vegetables a day), 75.2%; Overweight/obesity, 56.8%; physical inactivity (IPAC questionnaire), 56.4%; alcohol abuse, 56.1%; hypercholesterolemia (total cholesterol>240 mg/dl, LDL>145 mg/dl, apoB>120 mg/dl), 4.4%, 11.2%, 5.4%; smoking, 35%; low HDL, 16%; hypertriglyceridemia (>150mg/dl), 11.2%; hypertension, 8.2%; diabetes mellitus, 1%. Statistical differences were seen between genders for inadequate diet and alcohol abuse (higher in men, p¼0.003, P<0.001). A total of 92.3% have at least 1 RF and 3.1% presented 5 RF. Conclusion: The high rates of CVD RF in a young population, especially inadequate diet, overweight, alcohol abuse and physical inactivity, are of great concern for the prevention of CVD. Population strategies should be developed to change life styles in order to improve CV health.
EAS-0849. CARDIOVASCULAR AND RENAL PROTECTION IN CORONARY ARTERY DISEASE
71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0816. UNDERUTILIZATION OF STATINS IN ELDERLY PATIENTS HOSPITALIZED WITH CARDIOVASCULAR EVENTS A. Benavente Fernándeza, A. Escudero Brocalb, A. Salmerón-Garcíab a Internal Medicine., Baza Hospital., Granada, Spain; b Pharmacy department., Baza Hospital., Granada, Spain
Objectives: To analyze prescription omissions of statins in elderly patients hospitalized with cardiovascular problems in an attempt to find a link with said patients' hospitalization. Methods: Retrospective observational study from July-November 2013 with patients admitted to the Internal Medicine Unit. We included patients 65 with cardiovascular problems. Data collected: sex, age, previous CVD, cardiovascular risk factors (CVRF) and adherence to statin therapy (Morisky-Green-Scale). We collected Low-density lipoprotein cholesterol (LDL-C) values obtained <48 hours after admission. We evaluated the use of statins according to the European Guidelines on CVD prevention in clinical practice (version 2012). Exclusion criteria: patients transferred to other units and patients who died. Results: 60 patients were included: 48% male, 52% female; Average age was 80 (range ¼ 61-92), 75% with previous CVD (such as 30% Ischemic heart disease, 27% Atrial fibrillation and 20% Hypertensive heart disease). CVRF were: 75% Hypertension, 52% Dyslipidemia, 33% Diabetes, 18% Obesity, 15% Ex Smoker or Smoker. 40 of the patients were eligible for statin therapy, only 27 of them were actually on a statin (44% were at LDL-C goal). 13 patients were not on a statin due to: 77% prescription errors, 15% nonadherence to treatment and 8% contraindication to statins. 11 of the patients with prescription omissions of statins were hospitalized with Ischemic heart disease and 2 with cerebrovascular disease. These medication omissions involved: Statin therapy in 9 patients with diabetes and at least one CVRF (100% hypertension, 66% dyslipidemia, 22% obesity). Statin therapy in 4 patients with a documented history of cerebral (75%) or coronary diseases (25%). Conclusion: There are a large number of patients who should be on a statin but are not, or were on a statin but not at LDL-C goal. Elderly patients with
71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous
E. Bobescua, D. Dobreanub, L. Rogozeac, A. Pascuc, C. Strempeld, N. Alduleae, A. Covaciuc a
Faculty of Medicine DSMC, Transilvania University Brasov, Brasov, Romania; Faculty of Medicine DSMC, University of Medicine anf Pharmacy Tg Mures, Tg Mures, Romania; c Faculty of Medicine, Transylvania University Brasov, Brasov, Romania; d Cardiology, Clinic County Emergency Hospital Brasov, Brasov, Romania; e Children Clinic Hospital Brasov, University of Medicine anf Pharmacy Tg Mures, Brasov, Romania b
Objectives: Aims: In patients with stable angina (SA) and non ST acute coronary syndrome (unstable angina-UA, acute myocardial infarction with ST elevation - STEMI and without ST elevation – NSTEMI) incidence of sudden cardiac death, other major acute cardiovascular events (MACE), blood pressure control and renal function were evaluated in relation with administration of drugs with reducing effects on oxidative stress, platelets hyperactivity and endothelial dysfunction. Methods: Methods: 400 patients (pts) with coronary artery disease were divided in 8 groups: Group SA T – 40 pts with SA, Group UA T - 62 pts with UA , Group STEMI T – 42 pts with STEMI and Group NSTEMI T - 62 pts with NSTEMI treated with drugs with complementary mechanisms mentioned above; Group SA – 38 pts with SA, Group UA - 60 pts with UA , Group STEMI – 40 pts with STEMI and Group NSTEMI - 60 pts with NSTEMI treated with drugs without mentioned proprieties. Biomarkers for oxidative stress, platelets hyperactivity, endothelial dysfunction, kidney disease, blood pressure values and MACE were evaluated for 2 years of follow up. Results: Results: In patients with stable angina and non ST acute coronary syndrome treatment with drugs with mentioned effects was followed by significant reduction in incidence of sudden cardiac death (p< 0.05), cardiovascular death (p< 0.05), nonfatal AMI (p< 0.025), improving of blood pressure control (p< 0.05), and renal function (p< 0.05) in comparison with control group. Decreased incidence of oxidative stress, platelets hyperactivity and endothelial dysfunction in groups treated by drugs with mentioned effects was significantly correlated with reduced incidence of MACE. Conclusion: In patients with stable and non ST acute coronary syndrome, a significantly reduced incidence of: sudden death, other cardiovascular death, acute myocardial infarction and a significantly improved blood pressure control and renal function were observed in groups treated with drugs with reducing effect on oxidative stress, platelets hyperactivity and endothelial dysfunction in comparison with control groups. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0974. TERC POLYMORPHISM, LEUKOCYTE TELOMERE LENGTH AND THE SURVIVAL LENGTH IN PATIENTS AFTER HEART TRANSPLANTATION. D. Dlouhaa, J. Hubaceka, Y. Vymetalovab, V. Vancurab, I. Malekb a Center of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4, Czech Republic; b Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague 4, Czech Republic
Objectives: In humans, leukocyte telomere length (LTL) is getting shorter progressively with age, and is frequently reported to be inversely associated with aging-related diseases. So far there are no studies investigate correlation of LTL on survival length in patients after heart transplantation. There is a number of complications in these patients about which it is