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Cardiovascular reactivity to behavioral laboratory tests in normotensive, borderline hypertensive and hypertensive men
81 regulation of thirst and salt appetite are as yet unknown. Depletion of extracellular fluid, i.e., blood volume (e.g.. haemorrhage) provokes the liberation of angiotensin II and vasopressin, which helps fluid and pressure conservation, and thirst as well as a specific appetite for sodium. These processes work in a complementary way to restore blood volume (and pressure) to normal. Does the integration of this process take place in the anterior ventral hypothalamus? 1 have used two approaches in the investigation of this question. I have studied the behaviour of neural cells using the techniques of electrophysiology with iontophoresis in anaesthetised rats and ingestive and excretive behaviour of rats following a colchicine induced temporary lesion of this region. Cells in the medial ventral portion of the anterior hypothalamus respond to iontophoretic application of angiotensin II and vasopressin as well as to spontaneous or induced decreased in blood pressure and/or volume. A colchicine lesion in this region produces a decrease in urine volume and sodium excretion and the rats go into a concomitant positive sodium balance. Furthermore. a lesion of this type produces a decrease in blood pressure and a transient increase in sodium appetite. These results show that the medial ventral region of the anterior hypothalamus may be involved in the regulation of blood volume and perhaps in the sensing of and thus corrective responses to extracellular thirst.
PSYCHOPHYSIOLOGICAL REACTIONS NORADRENALINE AND ADRENALINE
TO
INFUSED
J.H.M. Tulen, P. Moleman, P.J. Blankestijn, A.J. Man in ‘t Veld, H.G. van Steenis, V.J.H.M. van den Heuij and F. Boomsma Erasmus University, Rotterdam, The Netherlands Effects of ‘chronic’ increased catecholamine (CA) levels on psychophysiological responses were studied during 6 h infusion of noradrenaline (NA) and adrenaline (A) in healthy subjects. Ten males (20-31 years) participated in three sessions each, all sessions 2 weeks apart, during which they received at random and double blind either a 6 h infusion of A (15 ng/kg/min), NA (30 ng/kg/min) or placebo (PLA:saline 5.4 ml/h) from 10.00-16.00 h. Heart rate, intraarterial blood pressure and respiration rate were recorded from 09.30-17.00 h. Blood samples for assay of CAs were obtained every hour. Subjective mood was assessed by means of the POMS and the STAI at 09.30. 13.00 and 17.00 h. A or NA did not result in changes in mood as compared with PLA. During infusion of A. plasma adrenaline increased IO-fold. while heart rate increased (6.8%) and mean blood pressure decreased (6.9%). NA infusion caused a S-fold increase in plasma noradrenaline, while heart rate decreased (3.9%) and blood pressure increased (6.6%). Both A and NA caused an increase in respiratory frequency. These data show that a
5-l&fold increase in circulating but significant cardiorespiratory mood.
CA levels results in moderate changes but no changes in
CARDIOVASCULAR REACTIVITY TO BEHAVIORAL LABORATORY TESTS IN NORMOTENSIVE, BORDERLINE HYPERTENSIVE AND HYPERTENSIVE MEN z, Mats Fredrikson Martti Tuomisto I.‘, Vaino Turjanmaa and Arto Uusitalo ’ ’ Karolinska Institute, Stockholm (Sweden) and z University of Tampere. Tampere (Finland)
’
Cardiovascular hyperreactivity is a potential risk factor of cardiovascular disorders. In this study normotensive (NT; n = 38). borderline hypertensive (BHT: n = 29) and hypertensive middle-aged men were subjected to behavioral laboratory tests: video game (VG), mental arithmetic (MA), social problem solving (SPS). imagery. habituation test. amusing film and the cold pressor test. Blood pressure was recorded with continuous intra-arterial tape recording method. Significant differences between NT and the hypertensive groups were found in systolic and diastolic blood pressure reactivity in SPS and VG. The most active tests (VG and MA) showed significant differences in heart rate reactivity between BHT and the other groups. A trend was found also in other tests. The results support the use of heart rate reactivity in active behavioral tests as a marker of borderline hypertensive phase and the hypothesis of blood pressure reactivity associated with social inhibition as a contributing factor to hypertension.
A CONTRIBUTION TO TION OF THE NATURE Heinz P. Turk Inst. fur ganzheitliche B.R.D.
THE SCIENTIFIC OF MOODS
Psychologie
D 8183
APPRECIA-
Rottach-Egern,
Moods represent essential right hemispherical qualities. Experiencing and being aware of them are substantial characteristics of artistic wealth of invention creative power and also meditation. A full display and development of the creative and intelligent potential faculties as well as of the personality itself depends on the consideration and promotion of the particular processing of experiencing moods. Practical ways of considerating and promoting them will be demonstrated. Increasingly the promotion of mood experiences and their awareness consideration become more important in the field of Medicine and Psychotherapy. The progression of psychosomatic and mental diseases has its causes in our Western civilization. which shows a nonobservance and lack of interrelations to all sorts of right hemispherical types of experiences.
PSYCHOPHYSIOLOGICAL REACTIONS NORADRENALINE AND ADRENALINE
TO
INFUSED
J.H.M. Tulen, P. Moleman, P.J. Blankestijn, A.J. Man in ‘t Veld, H.G. van Steenis, V.J.H.M. van den Heuij and F. Boomsma Erasmus University, Rotterdam, The Netherlands Effects of ‘chronic’ increased catecholamine (CA) levels on psychophysiological responses were studied during 6 h infusion of noradrenaline (NA) and adrenaline (A) in healthy subjects. Ten males (20-31 years) participated in three sessions each, all sessions 2 weeks apart, during which they received at random and double blind either a 6 h infusion of A (15 ng/kg/min), NA (30 ng/kg/min) or placebo (PLA:saline 5.4 ml/h) from 10.00-16.00 h. Heart rate, intraarterial blood pressure and respiration rate were recorded from 09.30-17.00 h. Blood samples for assay of CAs were obtained every hour. Subjective mood was assessed by means of the POMS and the STAI at 09.30. 13.00 and 17.00 h. A or NA did not result in changes in mood as compared with PLA. During infusion of A. plasma adrenaline increased IO-fold. while heart rate increased (6.8%) and mean blood pressure decreased (6.9%). NA infusion caused a S-fold increase in plasma noradrenaline, while heart rate decreased (3.9%) and blood pressure increased (6.6%). Both A and NA caused an increase in respiratory frequency. These data show that a
5-l&fold increase in circulating but significant cardiorespiratory mood.
CA levels results in moderate changes but no changes in
CARDIOVASCULAR REACTIVITY TO BEHAVIORAL LABORATORY TESTS IN NORMOTENSIVE, BORDERLINE HYPERTENSIVE AND HYPERTENSIVE MEN z, Mats Fredrikson Martti Tuomisto I.‘, Vaino Turjanmaa and Arto Uusitalo ’ ’ Karolinska Institute, Stockholm (Sweden) and z University of Tampere. Tampere (Finland)
’
Cardiovascular hyperreactivity is a potential risk factor of cardiovascular disorders. In this study normotensive (NT; n = 38). borderline hypertensive (BHT: n = 29) and hypertensive middle-aged men were subjected to behavioral laboratory tests: video game (VG), mental arithmetic (MA), social problem solving (SPS). imagery. habituation test. amusing film and the cold pressor test. Blood pressure was recorded with continuous intra-arterial tape recording method. Significant differences between NT and the hypertensive groups were found in systolic and diastolic blood pressure reactivity in SPS and VG. The most active tests (VG and MA) showed significant differences in heart rate reactivity between BHT and the other groups. A trend was found also in other tests. The results support the use of heart rate reactivity in active behavioral tests as a marker of borderline hypertensive phase and the hypothesis of blood pressure reactivity associated with social inhibition as a contributing factor to hypertension.
A CONTRIBUTION TO TION OF THE NATURE Heinz P. Turk Inst. fur ganzheitliche B.R.D.
THE SCIENTIFIC OF MOODS
Psychologie
D 8183
APPRECIA-
Rottach-Egern,
Moods represent essential right hemispherical qualities. Experiencing and being aware of them are substantial characteristics of artistic wealth of invention creative power and also meditation. A full display and development of the creative and intelligent potential faculties as well as of the personality itself depends on the consideration and promotion of the particular processing of experiencing moods. Practical ways of considerating and promoting them will be demonstrated. Increasingly the promotion of mood experiences and their awareness consideration become more important in the field of Medicine and Psychotherapy. The progression of psychosomatic and mental diseases has its causes in our Western civilization. which shows a nonobservance and lack of interrelations to all sorts of right hemispherical types of experiences.