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CAROTID INFLAMMATION INDEPENDENTLY PREDICTS INCREASED ONE-YEAR CARDIOVASCULAR EVENT RATE
1956 JACC April 5, 2016 Volume 67, Issue 13
Prevention CAROTID INFLAMMATION INDEPENDENTLY PREDICTS INCREASED ONE-YEAR CARDIOVASCULAR EVENT RATE Poster Contributions Poster Area, South Hall A1 Sunday, April 03, 2016, 9:45 a.m.-10:30 a.m. Session Title: Contemporary Issues in Preventive Cardiology II Abstract Category: 33. Prevention: Clinical Presentation Number: 1191-382 Authors: Georgios Benetos, Konstantinos Toutouzas, Maria Drakopoulou, Fotini Mitropoulou, Iosif Koutagiar, Charalampia Nikolaou, Nikolaos Barampoutis, Periklis Davlouros, Elias Siores, Dimitris Tousoulis, First Department of Cardiology, Athens School of Medicine, Athens, Greece
Background: Inflammation is a characteristic of vulnerable atherosclerotic plaque. Microwave radiometry (MWR) allows the noninvasive assessment of the internal temperature of carotid arteries, reflecting inflammation. The aim of the present study was to evaluate the prognostic role of carotid inflammation, as assessed by MWR, in patients with documented coronary artery disease (CAD). Methods: Consecutive patients with significant CAD were included in the study. Maximum carotid plaque thickness was assessed in all carotids by ultrasound. ΔT by MWR was assigned as the temperature difference (maximal minus minimum) along the carotid artery. ΔT ≥0.90°C was assigned as high ΔT. Major cardiovascular event (MACE) was defined as death, stroke, myocardial infarction or revascularization. All patients were followed-up clinically for one year.
Results: In total 216 patients were included in the study. Thirty six patients (16.66%) had high ΔT temperatures bilaterally. MACE was 22.2% in the group with bilateral high ΔT and 3.9% in non-high ΔT group (p<0.001). By multivariate analysis, ΔT was independently associated with MACE, when adjusted for sex, age contemporary risk factors, number of vessels with significant stenosis and maximum carotid plaque thickness (OR: 6.21, 95% CI 1.73-22.37, p=0.005). In Kaplan-Meier plots patients with bilateral high ΔT showed higher event rate (log-rank p<0.001, figure) Conclusions: Bilateral carotid inflammation predicts high one-year cardiovascular event rates.
Prevention CAROTID INFLAMMATION INDEPENDENTLY PREDICTS INCREASED ONE-YEAR CARDIOVASCULAR EVENT RATE Poster Contributions Poster Area, South Hall A1 Sunday, April 03, 2016, 9:45 a.m.-10:30 a.m. Session Title: Contemporary Issues in Preventive Cardiology II Abstract Category: 33. Prevention: Clinical Presentation Number: 1191-382 Authors: Georgios Benetos, Konstantinos Toutouzas, Maria Drakopoulou, Fotini Mitropoulou, Iosif Koutagiar, Charalampia Nikolaou, Nikolaos Barampoutis, Periklis Davlouros, Elias Siores, Dimitris Tousoulis, First Department of Cardiology, Athens School of Medicine, Athens, Greece
Background: Inflammation is a characteristic of vulnerable atherosclerotic plaque. Microwave radiometry (MWR) allows the noninvasive assessment of the internal temperature of carotid arteries, reflecting inflammation. The aim of the present study was to evaluate the prognostic role of carotid inflammation, as assessed by MWR, in patients with documented coronary artery disease (CAD). Methods: Consecutive patients with significant CAD were included in the study. Maximum carotid plaque thickness was assessed in all carotids by ultrasound. ΔT by MWR was assigned as the temperature difference (maximal minus minimum) along the carotid artery. ΔT ≥0.90°C was assigned as high ΔT. Major cardiovascular event (MACE) was defined as death, stroke, myocardial infarction or revascularization. All patients were followed-up clinically for one year.
Results: In total 216 patients were included in the study. Thirty six patients (16.66%) had high ΔT temperatures bilaterally. MACE was 22.2% in the group with bilateral high ΔT and 3.9% in non-high ΔT group (p<0.001). By multivariate analysis, ΔT was independently associated with MACE, when adjusted for sex, age contemporary risk factors, number of vessels with significant stenosis and maximum carotid plaque thickness (OR: 6.21, 95% CI 1.73-22.37, p=0.005). In Kaplan-Meier plots patients with bilateral high ΔT showed higher event rate (log-rank p<0.001, figure) Conclusions: Bilateral carotid inflammation predicts high one-year cardiovascular event rates.