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Book Reviews
thesis: Inhibition of 5 hydroxytryptophan; Decarboxylating enzymes: Block of serotonin catabolism: Aldehyde oxidation versus reduction; LSD 25: Hallucinogenic drugs; Isoergine; Therapeutic use of hallucinogens; Serotonin antagonists. There is an extensive glossary, a detailed bibliography and a good index. This volume will be very useful to undergraduates and to post-graduates moving into the subject.
centrioles in growth regulation of mammalian cells. The reviews are of high standard and they are well illustrated with glossy photographs and diagrams.
Hearing: Physiological bases and psychophysies-~dited by RAINER KLINKE and RAINER HARTMANN. 399 pp. 1983. Springer, Berlin. DM 68. $27.
There has been a tremendous amount of research into the structure and properties of the fibrous proteins in cytoplasm. The microtubules (25 nm diameter) consist of tubulin and microtubule associated proteins (MAP 1, MAP 2) tau. Microfilaments (6 rim) consist of actin, alpha actin, filamin, myosin, tropomyosin and vinculin. Intermediate filaments (10 nm) include desmin or skeletin, prekeratin, vimentin and acidic fibrillary protein. These systems take part in cell motility, growth, change of shape, secretion, cell division and uptake of material. They are of fundamental importance on the life of cells and tissues. The roles of the cytoskeletal system and the biochemical systems involved are fully discussed in this book which is well illustrated and has an extensive bibliography. It lives up to the high reputation of the preceding volumes in this series.
This volume contains the proceedings of the 6th International Symposium on Hearing, held at Bad Nauheim, in 1983. Fifty-seven papers are presented and they are grouped under the following headings: (1) Inner ear mechanisms and cochlear emissions; (2) Auditory nerve and cochlear nucleus, central and centrifugal auditory systems; (3) Binaural interaction: (4) Psychophysics: (5) Pitch perception; (6) Speech and hearing impairment. There are 3 review articles: these are on Hair cells, receptors with motor capacity; Binaural phenomena; and Psychoacoustics of normal and impaired listerners. Each paper is presented with a bibliography with full titles of papers. There is also a short edited discussion after each paper. This volume will be very useful to those wishing to get up to date with specific problems associated with hearing, and also for those readers who would like to know what is happening in associated aspects of the subject. Structure and function in excitable cells--edited by D. C. CHANG, I. TASAK1, W. J. ADELMAN and H. R. LEUCHTAG. 499 pp. 1983. Plenum Press, New York. $65. This volume is based on a series of papers given at a conference at Woods Hole on the structure and function of excitable cells. The contributions have been expanded and brought up to date so as to present the reader with a balanced view of current developments. The volume is in four main sections: (1) Fine structure in excitable cells (EM and freeze etching determined structure of membranes, axoplasm, node of Ranvier (ionic channels); (2) Cellular excitation, recent findings and models (membrane conductance, single channel currents, patch clamp, gating systems); (3) Electrochemistry and electrophysics tcharged membranes, flux coupling, axolemma-ectoplasm complex, single-filing channels); (4) Proteins in excitation (reconstitution of nerve membrane sodium channels, tyrosinated tubulin necessary for membrane excitability). The general standard of the review articles is very high and they are well supported by excellent EM pictures. Most of the articles could be understood by a third year undergraduate and the volume would form a valuable supplement to the normal text book accounts of the structure and function of excitable cells. It will also be useful for readers wishing to get up to date with the subject. Cell and muscle motility. Volume 3--edited by R. M. DOWBEN and J. W. SHAY. 3ll pp. 1983. Plenum Press, New York. $39.50. This volume contains reviews on the following subjects: intermediate filaments in striated muscle--Review of structural studies in embryonic and adult skeletal and cardiac muscle; Biochemistry and structure of mammalian neurofilaments; Organization of contractile fibers in smooth muscle; Regulation of muscle contraction; Membrane system and cytoskeletal elements of mammalian myocardial cells; Control of gene expression in muscle development; Cloning of contractile protein; Role of microtubules and
Cell and muscle motility. Volume 5, The Cytoskeleton~ edited by J. W. SHAY. 416 pp. 1984. Plenum Press, New York. $39.50.
Issues and reviews in teratology. Volume l--edited by H. KALTER. 354 pp. 1983. Plenum Press, New York. $45. Thalidomide gave a stimulus to the screening of drugs for teratological effects, and as a result there has been an expansion of the literature and information about embryonic defects caused by drugs, viruses, and chemicals. The present volume sets the stage. The reviews are entitled: Teratology, spectrum of a science; Problems in human teratology; Cytogenetics of human reproductive wastage; Twenty years of the etiology of congenital malformations in Finland; Genome and chromosome mutation; Developmental toxicity and non human primates; interspecies comparisons; Teratogenic risk assessment; Thalidomide and embryonic sensory peripheral neuropathy; Restorative growth in mammalian embryos; Mechanism ot" acetozalamide teratogenesis. The volume is dedicated to Josef Warkany on the occasion of his 80th birthday, in recognition of his contribution to the study of chondrodystrophy and the Laurence-Moon-Biedl syndrome and to the development of the science of teratology.
Papers in biochemistry edited by J. HERRIOTT, G. JACOBSON, J. MARMUR and W. PARSON. 643 pp. 1984. Adison Wesley, London. £17.05. This paperback contains photographic reprints of 79 papers on various aspects of Biochemistry to help students understand that textbook facts come from the literature and often depend on interpretation. The main topics are protein structure and function, enzyme catalysis, structure and function of co-enzymes, carbohydrate metabolism, electron transport, photosynthesis, lipids and membranes, steroids, nucleic acids, amino acids, genetic code, Bacteriophage lambda, cyclic AMP, neuropeptides, nerve action potential, ACh receptor and Rhodopsin. Most of the classic papers that you expect are here and the volume will be very useful in providing students with a volume of original material that takes them almost as close to the real subject as the laboratory bench. The volume should also easily save its own price in wear and tear on library bound copies of the journals.