Central Adiposity is Related with Oxidative Stress Markers in Overweight Perimenopausal Women

Diabetes-Metabolic Syndrome

Conclusion: Our findings suggest an association between

213

This work was supported by grant DGAPA-UNAM PAPIIT:

central

adiposity

and

LPO

and

GPx

in

overweight

perimenopausal women IN306517.

Central Adiposity is Related with

DOI: 10.1016/j.freeradbiomed.2017.10.226

Oxidative Stress Markers in Overweight Perimenopausal Women Martha A. Sanchez-Rodriguez1, Mariano Zacarias-Flores2, Elsa A. Correa-Muñoz1, and Victor Manuel A. MendozaNuñez1 1

Facultad

de

Estudios

Superiores

Zaragoza,

National

Autonomous University of Mexico (UNAM), Mexico 2

Hospital Gustavo Baz Prada, Instituto de Salud del Estado

214 Inhibition of Resveratrol Glucosides against AGEs Formation Minzhou Liu1, Feng Tang1, Hui Cao2, Jianbo Xiao2, and

de México, Mexico

Xiaoqing Chen1

Background: Obesity is known to induce systemic oxidative

1

stress (OS) through various mechanisms. In women, during

2

perimenopausal period, many changes are present, like central adiposity gain, which is a component of metabolic syndrome. The waist–to-height ratio (WHtR) is a new anthropometric marker of central obesity. Objective: To assess the relationship between the OS markers and WHtR in perimenopausal women. Methods: We carried out a cross-sectional study with 483 perimenopausal women (40-59 yrs) from Mexico City. We measured plasma lipoperoxide levels (LPO) by the TBARS assay,

erythrocyte

superoxide

dismutase

(SOD)

and

glutathione peroxidase (GPx), and total plasma antioxidant status with Randox kits. Also, we measured the weight, height, and circumference of the waist of all women. Body mass index (BMI; weight in kilograms divided by the square of height in meters), and WHtR (waist circumference divided by height in centimeters) were calculated for the analysis. We stratify the women according to the World Health Organization as normal weight (BMI: <25 kg/m2), overweight (BMI: 25.00-29.99 kg/m2) and obesity (BMI:

Central South University, People's Republic of China

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau Resveratrol and its derivatives are the most important sources of dietary stilbenoids. Resveratrol’s glucosides such as resveratrol 3-O-β-D-glucoside and resveratrol 2-O-β-Dglucoside possess many advantages than resveratrol, such as higher hydrophilic and apparent benefits. Herein, the inhibition against fructose-derived advanced glycation end products (AGEs) formation of resveratrol glucosides was compared. The position of glucoside was found to be an important factor affecting inhibitory effect against AGEs formation. Resveratrol O-glucosides attached in the position of C-2, C-3, C-3' or C-4' showed slightly higher inhibition against AGEs formation than that of resveratrol. The antiAGEs activity is correlated with DPPH radical scavenging capacity but not the methylglyoxal trapping capacity. DOI: 10.1016/j.freeradbiomed.2017.10.227

>30 kg/m ); besides, we obtained the quartiles of WHtR of 2

normal weight women to compare OS markers. Results: LPO levels increased and GPx activity decreased in the women classified in the third (WHtR: 0.61-0.64) and fourth quartile (WHtR; >0.64); the other markers did not change. A positive correlation between LPO and WHtR (r=0.346, p< 0.0001), and negative between GPx and the same index (r=-0.333, p< 0.0001) in overweight women were found. In normal weight and obese women, we did not see any relationship.

SfRBM 2017

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