- Email: [email protected]
CENTRAL HEMANGIOMA OF THE ANTERIOR MANDIBLE WITH AGGRESSIVE CLINICAL APPEARANCE
ABSTRACTS
e22
an effort to allow for early detection of the primary tumor and initiation of the appropriate therapy.
€ IS SJOGREN’S SYNDROME ANOTHER POSSIBLE AUTOIMMUNE COMPLICATION OF CHIKUNGUNYA FEVER?. LUIZ ALCINO MONTEIRO GUEIROS, ALESSANDRA CARVALHO, JAIR e CARNEIRO LEAO, AYSA PINHEIRO, PAULA TOCHE and, ANGELA DUARTE Chikungunya (CHIK) fever is a tropical arbovirosis characterized by sudden fever, headache, rash, and severe arthralgia. The disease has been suggested to act as a trigger for several autoimmune disorders, especially rheumatoid arthritis. This abstract reports 2 cases of Sj€ ogren syndrome (SS) following CHIK infection. Both patients were female and presented with fever, arthralgia, rash, and arthritis during CHIK outbreak in Recife, Brazil. After several months, they developed severe sicca symptoms and 1 of them presented with parotid enlargement. Clinical salivary gland biopsy and serologic examination rendered the diagnosis of SS for both patients. No systemic features of SS were noted. New evidence has pointed to the development of autoimmune inflammatory musculoskeletal diseases following CHIK fever, such as rheumatoid arthritis, spondylitis, and systemic lupus as a sequel of the infection. Nevertheless, SS has rarely been associated with CHIK and this association should be better evaluated.
ORAL SQUAMOUS CELL CARCINOMA AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: 2 CASES IN PATIENTS WITH FANCONI ANEMIA. FERNANDA GON¸CALVES SALUM, KAREN CHERUBINI, LILIANE SOARES YURGEL and, MARIA ANTONIA ZANCANARO DE FIGUEIREDO Fanconi anemia (FA) is an autosomal recessive disorder with the following important features: (1) progressive bone marrow failure and (2) development of malignancies. We report 2 cases of oral squamous cell carcinoma in male patients with FA who underwent hematopoietic stem cell transplantation. Both patients presented with oral lichenoid lesions, compatible with chronic graft vs host disease. In the first case, a 16-year-old patient presented with an extensive infiltrative and necrotic lesion on the border of the tongue. After biopsy, the diagnosis of squamous cell carcinoma was confirmed. The patient received chemotherapy and radiotherapy but died 4 months later. In the second case, a 26-year-old patient presented with an irregular white plaque on the border of the tongue. After histopathologic diagnosis confirmation, the carcinoma was surgically resected and the patient is under follow-up evaluation. Patients with FA have a high risk for oral cancer and their systematic follow-up is essential.
EPSTEIN-BARR POSITIVE ULCERS OF THE ORAL CAVITY ASSOCIATED WITH IMMUNOSUPPRESSION IN A PATIENT WITH CANCER. VANESSA TONETTO MARQUES, ADRIANO TADEU MARANGONI, ANA RAPHAELA DEZAN CURVO, LEANDRO DORIGAN DE MACEDO and, LARA MARIA ALENCAR RAMOS INNOCENTINI A 24-year-old man with synovial sarcoma was hospitalized for neutropenic fever after chemotherapy, complaining of
OOOO January 2020 gingival pain for 1 day. No lymph node involvement was detected during neck palpation. Intraoral exam revealed a purple lesion involving the attached gingiva on the maxilla and mandible, of increased size and with a detachable overlying white plaque. There was rapid evolution to ulcerated lesions, causing an inability to feed. We performed an incisional biopsy and referred the patient for anatomopathologic examination, polymerase chain reaction (PCR), and culture for fungi and bacteria, a prescription of chlorhexidine 0.12%, and empiric fluconazole and acyclovir. PCR was positive for Epstein-Barr virus (EBV) with 1095 copies, so the patient was maintained on acyclovir for 15 days. The patient had significant improvement in pain and the oral lesions regressed after this period. This case demonstrated that EBV commonly occurs in immunosuppressed patients and underscores the importance of dentists in the diagnosis and control of oral complications in the multiprofessional hospital team.
CENTRAL HEMANGIOMA OF THE ANTERIOR MANDIBLE WITH AGGRESSIVE CLINICAL APPEARANCE. MATEUS DUTRA SANTANA, GUSTAVO BARROSO MELLO ALVES, BRUNO COSTA FERREIRA, LEONEL PORTO DE CARVALHO, ALEXANDRE MAURITY DE PAULA AFONSO, BRUNO AUGUSTO BENEVENUTO DE e ANDRADE and, MARIO JOSE ROMANACH Central hemangioma (CH) of the jaws is a rare benign vascular neoplasm of variable radiographic appearance. A 32-yearold man was referred for evaluation of an ulcerated mass on the anterior mandible causing facial asymmetry for the last 6 months. The patient reported progressive growth and bleeding episodes. Intraoral examination revealed an erythematous and necrotic swelling in the lower anterior gingiva. Computerized tomography revealed a well-defined multilocular hypodense lesion involving the mandibular symphysis, containing hyperdense foci, with expansion and destruction of the buccal cortical bone, and teeth displacement and mobility. High blood content was detected during aspiration and surgical enucleation was performed after tumor embolization. Microscopically, large arterial blood vessels of variable sizes were observed, some of them containing intravascular concentric calcifications, confirming the diagnosis of CH. During a follow-up period of 6 months, the patient had no recurrence. CH of the jaws may show an aggressive clinical appearance, mimicking malignancy.
EMBRYONAL RHABDOMYOSARCOMA. JOSE FRANCISCO TORRES ANGUIANO, ISRAEL VIVANCO PEREZ, OSMAR ADAN CARCAMO IDIAQUEZ, DIEGO ACEVEDO CANTORAN, CARLOS MANUEL ROA ENCARNACION, ADOLFO NAVARRO ZARATE and, NANCY TRUJILLO GARCIA A 7-month-old female infant was sent to the clinic diagnosed by the oncology unit with embryonal rhabdomyosarcoma. The disease was detected at the time of her birth. She showed an increase in volume in the nasolabial region that was treated as a hemangioma without response to treatment. Diagnosis was established through a Tru-Cut (MeritMedical, South Jordan, UT) biopsy and it was confirmed with immunohistochemistry. The treatment was established with chemotherapy, then, she was sent to our clinical unit for assessment and surgical treatment. The contrasted tomography suggested tumor of the nasogenian
e22
an effort to allow for early detection of the primary tumor and initiation of the appropriate therapy.
€ IS SJOGREN’S SYNDROME ANOTHER POSSIBLE AUTOIMMUNE COMPLICATION OF CHIKUNGUNYA FEVER?. LUIZ ALCINO MONTEIRO GUEIROS, ALESSANDRA CARVALHO, JAIR e CARNEIRO LEAO, AYSA PINHEIRO, PAULA TOCHE and, ANGELA DUARTE Chikungunya (CHIK) fever is a tropical arbovirosis characterized by sudden fever, headache, rash, and severe arthralgia. The disease has been suggested to act as a trigger for several autoimmune disorders, especially rheumatoid arthritis. This abstract reports 2 cases of Sj€ ogren syndrome (SS) following CHIK infection. Both patients were female and presented with fever, arthralgia, rash, and arthritis during CHIK outbreak in Recife, Brazil. After several months, they developed severe sicca symptoms and 1 of them presented with parotid enlargement. Clinical salivary gland biopsy and serologic examination rendered the diagnosis of SS for both patients. No systemic features of SS were noted. New evidence has pointed to the development of autoimmune inflammatory musculoskeletal diseases following CHIK fever, such as rheumatoid arthritis, spondylitis, and systemic lupus as a sequel of the infection. Nevertheless, SS has rarely been associated with CHIK and this association should be better evaluated.
ORAL SQUAMOUS CELL CARCINOMA AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: 2 CASES IN PATIENTS WITH FANCONI ANEMIA. FERNANDA GON¸CALVES SALUM, KAREN CHERUBINI, LILIANE SOARES YURGEL and, MARIA ANTONIA ZANCANARO DE FIGUEIREDO Fanconi anemia (FA) is an autosomal recessive disorder with the following important features: (1) progressive bone marrow failure and (2) development of malignancies. We report 2 cases of oral squamous cell carcinoma in male patients with FA who underwent hematopoietic stem cell transplantation. Both patients presented with oral lichenoid lesions, compatible with chronic graft vs host disease. In the first case, a 16-year-old patient presented with an extensive infiltrative and necrotic lesion on the border of the tongue. After biopsy, the diagnosis of squamous cell carcinoma was confirmed. The patient received chemotherapy and radiotherapy but died 4 months later. In the second case, a 26-year-old patient presented with an irregular white plaque on the border of the tongue. After histopathologic diagnosis confirmation, the carcinoma was surgically resected and the patient is under follow-up evaluation. Patients with FA have a high risk for oral cancer and their systematic follow-up is essential.
EPSTEIN-BARR POSITIVE ULCERS OF THE ORAL CAVITY ASSOCIATED WITH IMMUNOSUPPRESSION IN A PATIENT WITH CANCER. VANESSA TONETTO MARQUES, ADRIANO TADEU MARANGONI, ANA RAPHAELA DEZAN CURVO, LEANDRO DORIGAN DE MACEDO and, LARA MARIA ALENCAR RAMOS INNOCENTINI A 24-year-old man with synovial sarcoma was hospitalized for neutropenic fever after chemotherapy, complaining of
OOOO January 2020 gingival pain for 1 day. No lymph node involvement was detected during neck palpation. Intraoral exam revealed a purple lesion involving the attached gingiva on the maxilla and mandible, of increased size and with a detachable overlying white plaque. There was rapid evolution to ulcerated lesions, causing an inability to feed. We performed an incisional biopsy and referred the patient for anatomopathologic examination, polymerase chain reaction (PCR), and culture for fungi and bacteria, a prescription of chlorhexidine 0.12%, and empiric fluconazole and acyclovir. PCR was positive for Epstein-Barr virus (EBV) with 1095 copies, so the patient was maintained on acyclovir for 15 days. The patient had significant improvement in pain and the oral lesions regressed after this period. This case demonstrated that EBV commonly occurs in immunosuppressed patients and underscores the importance of dentists in the diagnosis and control of oral complications in the multiprofessional hospital team.
CENTRAL HEMANGIOMA OF THE ANTERIOR MANDIBLE WITH AGGRESSIVE CLINICAL APPEARANCE. MATEUS DUTRA SANTANA, GUSTAVO BARROSO MELLO ALVES, BRUNO COSTA FERREIRA, LEONEL PORTO DE CARVALHO, ALEXANDRE MAURITY DE PAULA AFONSO, BRUNO AUGUSTO BENEVENUTO DE e ANDRADE and, MARIO JOSE ROMANACH Central hemangioma (CH) of the jaws is a rare benign vascular neoplasm of variable radiographic appearance. A 32-yearold man was referred for evaluation of an ulcerated mass on the anterior mandible causing facial asymmetry for the last 6 months. The patient reported progressive growth and bleeding episodes. Intraoral examination revealed an erythematous and necrotic swelling in the lower anterior gingiva. Computerized tomography revealed a well-defined multilocular hypodense lesion involving the mandibular symphysis, containing hyperdense foci, with expansion and destruction of the buccal cortical bone, and teeth displacement and mobility. High blood content was detected during aspiration and surgical enucleation was performed after tumor embolization. Microscopically, large arterial blood vessels of variable sizes were observed, some of them containing intravascular concentric calcifications, confirming the diagnosis of CH. During a follow-up period of 6 months, the patient had no recurrence. CH of the jaws may show an aggressive clinical appearance, mimicking malignancy.
EMBRYONAL RHABDOMYOSARCOMA. JOSE FRANCISCO TORRES ANGUIANO, ISRAEL VIVANCO PEREZ, OSMAR ADAN CARCAMO IDIAQUEZ, DIEGO ACEVEDO CANTORAN, CARLOS MANUEL ROA ENCARNACION, ADOLFO NAVARRO ZARATE and, NANCY TRUJILLO GARCIA A 7-month-old female infant was sent to the clinic diagnosed by the oncology unit with embryonal rhabdomyosarcoma. The disease was detected at the time of her birth. She showed an increase in volume in the nasolabial region that was treated as a hemangioma without response to treatment. Diagnosis was established through a Tru-Cut (MeritMedical, South Jordan, UT) biopsy and it was confirmed with immunohistochemistry. The treatment was established with chemotherapy, then, she was sent to our clinical unit for assessment and surgical treatment. The contrasted tomography suggested tumor of the nasogenian