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Children's depression rating scale-revised (CDRS-R): Preliminary data on the validity of the Arabic version
S168
IACAPAP 2012 – 20th World congress / Neuropsychiatrie de l’enfance et de l’adolescence 60S (2012) S140–S196
controls. The WTC showed the spectrum distribution of correlation coefficient, particularly the significant functional connectivity at the frequency of 0.06 Hz. Results indicated that the dysregulation of emotional network which is centered in prefrontal lobe and cognitive network which is centered in temporal lobe should be the potential cause of the long-term depressed mind state. And the WTC method also showed the potential to be a new approach to reveal the neurophysiological mechanisms of depression. http://dx.doi.org/10.1016/j.neurenf.2012.04.241
Mo-P-1130
Predictors and moderators of relapse in depressed youth G.J. Emslie Psychiatry, University of Texas Southwestern Medical Center, 8589, USA Current guidelines for antidepressant treatment recommend continuing treatment for at least 6–9 months; however, there is limited data on predicting who will relapse. We previously reported on the first pediatric randomized discontinuation study. Responders to 12 weeks of fluoxetine were randomized (n = 102) to continue fluoxetine or switch to placebo for 6 months (Emslie et al., 2008). Controlling for severity and age, the probability of relapse based on the omnibus main effect of medication was significant (P = .0004). While the main effect of gender was not significant, the 2-way interaction of medication x gender was significant (P = .016). Predicted odds of relapse among those remaining on fluoxetine was 8.864 higher for females than males (adjusted OR = 8.864, 95% CI = 1.836–42.784, P = .05). Also, youth reporting residual symptoms after acute treatment had 4.099 times the odds of relapsing than those without residual symptoms (adjusted OR = 4.099, 95% CI = 1.57–10.64, P = .0037). Comorbid disorders, cognitive, and family factors will be discussed. http://dx.doi.org/10.1016/j.neurenf.2012.04.242
Mo-P-1131
The mood and feelings questionnaire: Preliminary data on psychometrics and validity in a clinical sample L. Tavitian ∗ , S. Bawab , M. Atwi , N. Hariz , P. Zeinoun , M. Khani , Z. Nahas , F.T. Maalouf Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon ∗ Corresponding author.
The purpose of this study was to provide clinicians in the Arab World with a screening tool for depression among children and adolescents. Child and parent versions of the Mood and Feelings Questionnaire (MFQ-C and MFQP respectively) were therefore translated to Arabic and administered along with the Strengths and Difficulties Questionnaire (SDQ) to 62 children and adolescents and their parents seeking treatment at the AUBMC child psychiatry clinic. DSM-IV diagnoses were generated based on clinical interviews by a psychiatrist blinded to the self-report data. MFQ-C and MFQ-P yielded a unifactorial solution with item loadings ranging from .41 to .84 with 32.82% of the variance explained on MFQ-C and .43 to .84 with 34.39% of the variance explained on MFQ-P. Internal consistency for both versions was excellent (MFQ-P: ␣ = .91; MFQ-C: ␣ = .93) and Inter informant agreement was moderate (r = .55, P < .01) with good convergent validity with SDQ emotional symptoms subscales child (r = .56, P < .01) and parent forms (r = .54, P < .01). Satisfactory divergent validity with no significant correlation with SDQ hyperactivity subscales was noted. The MFQ-C and MFQ-P significantly differentiated between those in a current depressive episode and participants with other psychiatric disorders (Child: DEP, n = 11; Other, n = 31; P < .05; Parent: DEP, n = 12; Other, n = 48; P < .01). In conclusion, these results provide preliminary evidence that the Arabic MFQ is a valid tool for use in clinical settings. http://dx.doi.org/10.1016/j.neurenf.2012.04.243
Mo-P-1132
Children’s depression rating scale-revised (CDRS-R): Preliminary data on the validity of the Arabic version
N. Hariz ∗ , M. Atwi , S. Bawab , L. Tavitian , P. Zeinoun , M. Khani , Z. Nahas , F.T. Maalouf Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon ∗ Corresponding author. The Children’s Depression Rating Scale-Revised (CDRS-R) is a semi-structured interview widely used for the assessment of depression in children and adolescents. The aim of this study is the development and validation of an Arabic version of this scale. The CDRS-R was translated into Arabic and back-translated into English; the finalized Arabic version was administered to 20 outpatients aged 12 to 18 who were diagnosed with Major Depressive Disorder, and 19 healthy controls of the same age range. The participants additionally were administered the Arabic versions of the Beck Depression Inventory II (BDIII) and the Strengths and Difficulties Questionnaire (SDQ). The mean CDRS-R scores were 49.15 (standard deviation: 7.17) for the depressed group and 19.58 (standard deviation: 5.06) for the control group; the scores obtained by the two groups were significantly different (Mann Whitney’s U = 1.00, P < .001, effect size = –.85). Furthermore, the participants’ scores on the CDRS-R correlated significantly with those on the BDI-II (Spearman’s rho = .758, P < .001), the SDQ Total Difficulties Score (Spearman’s rho = .714, P < .001) and the SDQ Emotional Subscale Score (Spearman’s rho = .719, P < .001). These preliminary results reflect good discriminant and concurrent validity of the Arabic version of the CDRS-R. http://dx.doi.org/10.1016/j.neurenf.2012.04.244 Mo-P-1133
The relationship between childhood and adolescent life adversities and adolescent depressive symptoms: The differential role of gender M.C. St Clair a,∗ , T. Croudace a , J. Herbert b , P.B. Jones a , I.M. Goodyer a Department of Psychiatry, University of Cambridge, Cambridge, UK b Department of Physiology, Development and Neurosciences, University of Cambridge, Cambridge, UK ∗ Corresponding author.
a
Previous research has indicated that childhood experiences may influence the expression of depressive symptoms in the context of upsetting events in later life. We investigated the interrelationships between childhood adversity (up to age 5), childhood emotional temperament, adolescent upsetting life events and depressive symptoms (age 14 and 17). We conducted structural equation modelling separately for males and females. We found that childhood adversity and childhood emotionality were related to depressive symptoms at age 14 in both genders, but that negative life events in early and late adolescence were only related to depressive symptoms in females. In both genders, depressive symptoms in early adolescence were related to negative life events in late adolescence. Emotionality was also related to late adolescent life events in females only. We conclude that both childhood and proximal adversities increase depressive symptoms for female adolescents, while only childhood adversity increased depressive symptoms in male adolescents. http://dx.doi.org/10.1016/j.neurenf.2012.04.245 Mo-P-1134
Childhood bereavement, depressive disorder and development of object relations
F. Piperno , D. Tardiola ∗ , E. Catino , E. Di Lucia Department of Pediatrics and Child Neurology and Psychiatry, Policlinico Umberto I, Sapienza, Roma, Italy ∗ Corresponding author. According to international literature, bereaved children present an higher risk to develop an internalizing disorder because of a deep impact of the grief on
IACAPAP 2012 – 20th World congress / Neuropsychiatrie de l’enfance et de l’adolescence 60S (2012) S140–S196
controls. The WTC showed the spectrum distribution of correlation coefficient, particularly the significant functional connectivity at the frequency of 0.06 Hz. Results indicated that the dysregulation of emotional network which is centered in prefrontal lobe and cognitive network which is centered in temporal lobe should be the potential cause of the long-term depressed mind state. And the WTC method also showed the potential to be a new approach to reveal the neurophysiological mechanisms of depression. http://dx.doi.org/10.1016/j.neurenf.2012.04.241
Mo-P-1130
Predictors and moderators of relapse in depressed youth G.J. Emslie Psychiatry, University of Texas Southwestern Medical Center, 8589, USA Current guidelines for antidepressant treatment recommend continuing treatment for at least 6–9 months; however, there is limited data on predicting who will relapse. We previously reported on the first pediatric randomized discontinuation study. Responders to 12 weeks of fluoxetine were randomized (n = 102) to continue fluoxetine or switch to placebo for 6 months (Emslie et al., 2008). Controlling for severity and age, the probability of relapse based on the omnibus main effect of medication was significant (P = .0004). While the main effect of gender was not significant, the 2-way interaction of medication x gender was significant (P = .016). Predicted odds of relapse among those remaining on fluoxetine was 8.864 higher for females than males (adjusted OR = 8.864, 95% CI = 1.836–42.784, P = .05). Also, youth reporting residual symptoms after acute treatment had 4.099 times the odds of relapsing than those without residual symptoms (adjusted OR = 4.099, 95% CI = 1.57–10.64, P = .0037). Comorbid disorders, cognitive, and family factors will be discussed. http://dx.doi.org/10.1016/j.neurenf.2012.04.242
Mo-P-1131
The mood and feelings questionnaire: Preliminary data on psychometrics and validity in a clinical sample L. Tavitian ∗ , S. Bawab , M. Atwi , N. Hariz , P. Zeinoun , M. Khani , Z. Nahas , F.T. Maalouf Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon ∗ Corresponding author.
The purpose of this study was to provide clinicians in the Arab World with a screening tool for depression among children and adolescents. Child and parent versions of the Mood and Feelings Questionnaire (MFQ-C and MFQP respectively) were therefore translated to Arabic and administered along with the Strengths and Difficulties Questionnaire (SDQ) to 62 children and adolescents and their parents seeking treatment at the AUBMC child psychiatry clinic. DSM-IV diagnoses were generated based on clinical interviews by a psychiatrist blinded to the self-report data. MFQ-C and MFQ-P yielded a unifactorial solution with item loadings ranging from .41 to .84 with 32.82% of the variance explained on MFQ-C and .43 to .84 with 34.39% of the variance explained on MFQ-P. Internal consistency for both versions was excellent (MFQ-P: ␣ = .91; MFQ-C: ␣ = .93) and Inter informant agreement was moderate (r = .55, P < .01) with good convergent validity with SDQ emotional symptoms subscales child (r = .56, P < .01) and parent forms (r = .54, P < .01). Satisfactory divergent validity with no significant correlation with SDQ hyperactivity subscales was noted. The MFQ-C and MFQ-P significantly differentiated between those in a current depressive episode and participants with other psychiatric disorders (Child: DEP, n = 11; Other, n = 31; P < .05; Parent: DEP, n = 12; Other, n = 48; P < .01). In conclusion, these results provide preliminary evidence that the Arabic MFQ is a valid tool for use in clinical settings. http://dx.doi.org/10.1016/j.neurenf.2012.04.243
Mo-P-1132
Children’s depression rating scale-revised (CDRS-R): Preliminary data on the validity of the Arabic version
N. Hariz ∗ , M. Atwi , S. Bawab , L. Tavitian , P. Zeinoun , M. Khani , Z. Nahas , F.T. Maalouf Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon ∗ Corresponding author. The Children’s Depression Rating Scale-Revised (CDRS-R) is a semi-structured interview widely used for the assessment of depression in children and adolescents. The aim of this study is the development and validation of an Arabic version of this scale. The CDRS-R was translated into Arabic and back-translated into English; the finalized Arabic version was administered to 20 outpatients aged 12 to 18 who were diagnosed with Major Depressive Disorder, and 19 healthy controls of the same age range. The participants additionally were administered the Arabic versions of the Beck Depression Inventory II (BDIII) and the Strengths and Difficulties Questionnaire (SDQ). The mean CDRS-R scores were 49.15 (standard deviation: 7.17) for the depressed group and 19.58 (standard deviation: 5.06) for the control group; the scores obtained by the two groups were significantly different (Mann Whitney’s U = 1.00, P < .001, effect size = –.85). Furthermore, the participants’ scores on the CDRS-R correlated significantly with those on the BDI-II (Spearman’s rho = .758, P < .001), the SDQ Total Difficulties Score (Spearman’s rho = .714, P < .001) and the SDQ Emotional Subscale Score (Spearman’s rho = .719, P < .001). These preliminary results reflect good discriminant and concurrent validity of the Arabic version of the CDRS-R. http://dx.doi.org/10.1016/j.neurenf.2012.04.244 Mo-P-1133
The relationship between childhood and adolescent life adversities and adolescent depressive symptoms: The differential role of gender M.C. St Clair a,∗ , T. Croudace a , J. Herbert b , P.B. Jones a , I.M. Goodyer a Department of Psychiatry, University of Cambridge, Cambridge, UK b Department of Physiology, Development and Neurosciences, University of Cambridge, Cambridge, UK ∗ Corresponding author.
a
Previous research has indicated that childhood experiences may influence the expression of depressive symptoms in the context of upsetting events in later life. We investigated the interrelationships between childhood adversity (up to age 5), childhood emotional temperament, adolescent upsetting life events and depressive symptoms (age 14 and 17). We conducted structural equation modelling separately for males and females. We found that childhood adversity and childhood emotionality were related to depressive symptoms at age 14 in both genders, but that negative life events in early and late adolescence were only related to depressive symptoms in females. In both genders, depressive symptoms in early adolescence were related to negative life events in late adolescence. Emotionality was also related to late adolescent life events in females only. We conclude that both childhood and proximal adversities increase depressive symptoms for female adolescents, while only childhood adversity increased depressive symptoms in male adolescents. http://dx.doi.org/10.1016/j.neurenf.2012.04.245 Mo-P-1134
Childhood bereavement, depressive disorder and development of object relations
F. Piperno , D. Tardiola ∗ , E. Catino , E. Di Lucia Department of Pediatrics and Child Neurology and Psychiatry, Policlinico Umberto I, Sapienza, Roma, Italy ∗ Corresponding author. According to international literature, bereaved children present an higher risk to develop an internalizing disorder because of a deep impact of the grief on