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Chlorinated dioxins and dibenzofurans in perspective
Rnrrr;, C., C~iOUDHARY, G. and IC~rx, L. H. (Eds) Chlorinated Dioxins and Dibenzojwans in Perspective, 570 pp ., 559.95 . ISBN 0-87371-056-8 . Chelsea, MI : Lewis (1986) . C~rr.oxtxe~t~o dibenzoP-dioxines and dibenzofurans have become famous with the public and are believed to be of high significance not only after the accident in Seveao, Italy, but after the detection of these compounds of high acute and chronic toxicity in all samples of environment. This volume was developed from the papers of a symposium held in September 1985 during the 186th National Meeting of the American Chemical Society in Miami Beach. Thirty-seven chapters describe human exposure, incineration emissions, soil contamination, bioassays and analytical procedures as well as methods of synthesis and those of destruction. This issue gives the newest data of the exposure by measuring human samples (adipose tissue and mother milk). It is remarkable that results from many parts of the world show equal concentrations, with the exception of North Vietnam. The most advanced analytical techniques are listed . This book is therefore especially valuable for analysts and environmental scientists and engineers. As some chapters are devoted to destruction and removal of dioxines and furanes, the book additionally is valuable for technicians and governmental officials and all who are involved with hazardous waste sites. H. F. HAPKE
O~sw, N. Y., VEDA, C. M. P. M., Dus, W. O., Le'rtttl .tu, C. M. L. and Rew, I. (Instituto Batsman, Säo Paulo, Brasil) The possible role of para-pepsin in the preparation of anti-venom sera . Mem. Inst . Batsman 49, 41 (1987) . Tm:, Aurxoas demonstrate that commercial pepsin, subjected to DEAE chromatography, gives a far superior product and one free of endotoxins for the purification of antivenins. F. E. RUS.~LL
WEISCH, F. (Ed.) Approaches ro Elucidate Mechanisms in Teratogenesis, 285 pp., 579.95 (U .S . and Canada), ISBN 0-89116-584-3. Washington, DC : Hemisphere. CHEMICAL. teratogenesis is one of the most important toxic effects. To predict the effect regarding the protection of humans, animals and plants as well, it is necessary to analyse the biological effectivity on the gonads and the developing fetus, i.e. the prenatal toxicity in animal experiments . Forty-one contributors present new data on pharmacokinetics and phalmacodynamics of some chemicals in pregnant animals. They also discuss the problems of extrapolation of these results. Fifteen chapters and the report on a panel discussion are the result of the 8th Chemical Industry Institute of Technology Conference on Toxicology held in April 1986 . The Conference was entitled `Approaches to Elucidate Mechanisms in Teratogenesis' . The papers presented at this conference are published in this book and are devoted to the mechanisms of teratogenesis, structure-response relationships at the cellular and subcellular level and the role of maternal toxicity. This book is valuable not only for toxicologists but for pharmacologists and biologists or embryologists. H. F. HAPKE
MAT'l'octcs, A. R. Chemistry and Toxicology of Pyrrolizidine Alkaloids, 393 pp ., numerous figures, tables and reaction schemes. London : Academic Press (1987) . "PvxxoL.LZLDIxE alkaloids (PAs) are found in a large number of plant species occurring throughout the world. Many of them are cytotoxic and these are often responsible for poisoning livestock and people ; they include some of the relatively few substances oa~llrring in higher plants which are known to be carcinogens. That there is a growing interest in these compounds is shown by an inorease of some 50% in the number of annual literature references relating to their chemistry and biology during the past decade." This first paragraph of the preface shows the importance of pyrrolizidiae alkaloids being investigated by numerous groups all over the world. The first 5 chapters deal with chemical aspects such as plant sources, extraction and structure analysis, syatheaes, and physical as well as chemical properties . A second part (3 chapters) is devoted to metabolism, pharmacology, toxicology and biochemistry . Three more chapters report on human poisoning, cell~amaging effects, carcinogeaicity and aatitumor activity, and the last chapter shows relationships betwcen structure, metabolism and toxicity-thus covering the whole field of toxicology.
O~sw, N. Y., VEDA, C. M. P. M., Dus, W. O., Le'rtttl .tu, C. M. L. and Rew, I. (Instituto Batsman, Säo Paulo, Brasil) The possible role of para-pepsin in the preparation of anti-venom sera . Mem. Inst . Batsman 49, 41 (1987) . Tm:, Aurxoas demonstrate that commercial pepsin, subjected to DEAE chromatography, gives a far superior product and one free of endotoxins for the purification of antivenins. F. E. RUS.~LL
WEISCH, F. (Ed.) Approaches ro Elucidate Mechanisms in Teratogenesis, 285 pp., 579.95 (U .S . and Canada), ISBN 0-89116-584-3. Washington, DC : Hemisphere. CHEMICAL. teratogenesis is one of the most important toxic effects. To predict the effect regarding the protection of humans, animals and plants as well, it is necessary to analyse the biological effectivity on the gonads and the developing fetus, i.e. the prenatal toxicity in animal experiments . Forty-one contributors present new data on pharmacokinetics and phalmacodynamics of some chemicals in pregnant animals. They also discuss the problems of extrapolation of these results. Fifteen chapters and the report on a panel discussion are the result of the 8th Chemical Industry Institute of Technology Conference on Toxicology held in April 1986 . The Conference was entitled `Approaches to Elucidate Mechanisms in Teratogenesis' . The papers presented at this conference are published in this book and are devoted to the mechanisms of teratogenesis, structure-response relationships at the cellular and subcellular level and the role of maternal toxicity. This book is valuable not only for toxicologists but for pharmacologists and biologists or embryologists. H. F. HAPKE
MAT'l'octcs, A. R. Chemistry and Toxicology of Pyrrolizidine Alkaloids, 393 pp ., numerous figures, tables and reaction schemes. London : Academic Press (1987) . "PvxxoL.LZLDIxE alkaloids (PAs) are found in a large number of plant species occurring throughout the world. Many of them are cytotoxic and these are often responsible for poisoning livestock and people ; they include some of the relatively few substances oa~llrring in higher plants which are known to be carcinogens. That there is a growing interest in these compounds is shown by an inorease of some 50% in the number of annual literature references relating to their chemistry and biology during the past decade." This first paragraph of the preface shows the importance of pyrrolizidiae alkaloids being investigated by numerous groups all over the world. The first 5 chapters deal with chemical aspects such as plant sources, extraction and structure analysis, syatheaes, and physical as well as chemical properties . A second part (3 chapters) is devoted to metabolism, pharmacology, toxicology and biochemistry . Three more chapters report on human poisoning, cell~amaging effects, carcinogeaicity and aatitumor activity, and the last chapter shows relationships betwcen structure, metabolism and toxicity-thus covering the whole field of toxicology.