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Chondroblastic Osteosarcoma: Case Report
ORAL AND MAXILLOFACIAL PATHOLOGY e146 Abstracts analysis of the PTPN11 gene showed a mutation and the patient was diagnosed with NS. Treatment was performed with drugs and some GCL reappeared, so surgery was done. The patient has been followed up for 4 years. Few cases of NS show MGCL, but they can be instructive when obtaining a diagnosis.
PE-070 - RADIOPROTECTIVE INTRAORAL APPLIANCE AS SOLE RADIOTHERAPY FOR CARCINOMA OF LIP: CASE REPORT. MARIO RODRIGUES DE MELO FILHO, BRENO AMARAL ROCHA, MARIA BETÂNIA DE OLIVEIRA PIRES, LUCIANNE MAIA COSTA LIMA, ANGEL DA SILVA MARTINEZ, EDIMILSON MARTINS DE FREITAS, HERCÍLIO MARTELLI JÚNIOR. UNIVERSIDADE ESTADUAL DE MONTES CLAROSeUNIMONTES. Radioprotective oral appliances can be used during radiotherapy (RT) to prevent radiation-induced oral complications. Three women and 2 men with squamous cell carcinoma (SCC) of the lip (T1-T2N0M0), age 46 to 72 years, were eligible for curative RT with electron beam (60 to 66 Gy) and the use of personalized radioprotective oral appliances. Patients were evaluated before, during, and after RT for xerostomia and mucositis with scales (Eisbruch et al and World Health Organization). One patient complained of mild oral dryness that did not interfere with function; the others showed no xerostomia. Except for the tumor margins, protected areas of the oral mucosa showed no radiation mucositis, nor did patients experience taste alterations. The oral appliances prevented unnecessary irradiation of normal tissues, thus reducing the risk of morbidity in the form of mucositis and osteoradionecrosis. Treated patients had no signs of recurrence. Acknowledgment: FAPEMIG.
PE-071 - CASTLEMAN’S DISEASE: CASE REPORT. ADRIANA BORGES OLIVEIRA, LAIRA RENATA LEMOS SANTOS, JÉSSICA OLIVEIRA MELO SILVA, VIVIANE ALMEIDA SARMENTO, PATRÍCIA LEITE RIBEIRO LAMBERTI, ANTONIO FERNANDO PEREIRA FALCÃO, DAVI SILVA CARVALHO CURI. FEDERAL UNIVERSITY OF BAHIA. Castleman’s disease (CD) is a rare, atypical, lymphoproliferative disease that occurs in three histopathological variants: hyaline vascular, plasma cell, and mixed. Woman, 61, had painless, mobile lymphadenopathy in the left anterior cervical region that was associated with abdominal distension and enlargement of the submandibular glands. After biopsy and histopathological evaluation, a diagnosis of CD/hyaline vascular variant was made. Therapy with corticosteroids plus two sessions of chemotherapy (cyclophosphamide, hydroxydaunomycin, Oncovin, and prednisone [CHOP] and CHOP plus rituximab [R-CHOP]) was undertaken. The patient developed mucositis. The differential diagnosis and management of this condition are discussed.
PE-072 - ODONTOGENIC KERATOCYSTOF THE JAW: CASE REPORT. SAMARA RAMOS DE SOUZA, PIETRY DY TARSO INÃ ALVES MALAQUIAS, BRÁULIO CARNEIRO JÚNIOR, VIVIANE ALMEIDA SARMENTO, ROBERTO ALMEIDA DE AZEVEDO, RAFAEL FERNANDES DE ALMEIDA NERI, SAMARA ARMOS DE SOUZA. FACULDADE DE ODONTOLOGIA UFBA. Keratocystic odontogenic tumor (KOT) is a lesion that affects the gnathic bones, mainly in the posterior jaw area. Clinical and radiographic characteristics include asymptomatic volumetric
OOOO February 2014 increase and lack of cortical bone expansion and are related to an impacted tooth. However, the diagnosis can be confused for others when the lesion presents in other areas, such as the periapical region. In these cases, different management is recommended. This paper reports a case of KOT that demonstrated clinical and radiographic findings resembling those of radicular cyst and is designed to educate professionals who may see this lesion, such as endodontists and pathologists, about the possibility of a periapical presentation.
PE-073 - CHALLENGES IN THE DIAGNOSIS AND TREATMENT OF PEMPHIGUS VULGARIS: CLINICAL CASE REPORTS. THAMIRES SILVA SOUZA, ANDRÉ LUCAS D’ALMEIDA LYRIO DOS SANTOS, DAVI SILVA CARVALHO CURI, VINICIUS VIEIRA, ANTÔNIO FERNANDO PEREIRA FALCÃO, PATRICIA LEITE RIBEIRO LAMBERTI, VIVIANE ALMEIDA SARMENTO. FEDERAL UNIVERSITY OF BAHIA. Bullous autoimmune diseases are lesions in which autoantibodies are produced against the structural components that maintain cell-cell and cell-matrix adhesion in the skin and mucous membranes. They include disorders in which the bubbles are found in the basal membrane zone and those where bubbles form within the epidermis (pemphigus vulgaris, pemphigus foliaceus, and other subtypes). Due to the considerable overlap in clinical presentation of these conditions, diagnosing autoimmune bullous conditions of the skin and oral mucosa can be a challenge. In the last decade, there have been advances in the diagnosis of autoimmune bullous conditions. Two cases of bullous lesions diagnosed as pemphigus vulgaris were discussed, along with proper clinical management and differential diagnostic issues.
PE-074 - CHONDROBLASTIC OSTEOSARCOMA: CASE REPORT. FERNANDA TENÓRIO LOPES BARBOSA, BRUNNO SANTOS DE FREITAS SILVA, ALINE CARVALHO BATISTA, ELISMAURO FRANCISCO DE MENDONÇA, MARÍLIA OLIVEIRA MORAIS, FERNANDA PAULA YAMAMOTO. UNIVERSIDADE FEDERAL DE GOIÁS. Osteosarcoma is a rare malignant neoplasm in the jaws originating from mesenchymal cells that can form bone and osteoid tissue. The three histological patterns are osteoblastic, fibroblastic, and chondroblastic. Young man, 18, was referred to our service with an asymptomatic firm nodule present for 1 month in the posterior region of the mandible. Imaging revealed an osteolytic lesion associated with widening of the periodontal ligament space and root reabsorption, extra-lingual cortical reabsorption, and absence of calcification or “sun ray appearance.” Histopathological specimens revealed numerous spindle and oval-shaped pleomorphic cells with few osteoid and chondroid formations, compatible with a diagnosis of chondroblastic osteosarcoma. Surgical resection, adjuvant chemotherapy, and tibia graft were the chosen treatment. No recurrence or metastasis developed in 1 year of follow-up. This case emphasizes the importance of identifying the histological type of osteosarcoma to define the prognosis of chondroblastic osteosarcoma in young patients.
PE-075 - CHONDROBLASTIC OSTEOSARCOMA: DIAGNOSTIC DIFFICULTIES IN INCISIONAL BIOPSY. LARA CRISTINA OLIVER GIMENEZ, BRUNO TAVARES SEDASSARI, LILIAN CALDAS QUIRINO, CIBELE
PE-070 - RADIOPROTECTIVE INTRAORAL APPLIANCE AS SOLE RADIOTHERAPY FOR CARCINOMA OF LIP: CASE REPORT. MARIO RODRIGUES DE MELO FILHO, BRENO AMARAL ROCHA, MARIA BETÂNIA DE OLIVEIRA PIRES, LUCIANNE MAIA COSTA LIMA, ANGEL DA SILVA MARTINEZ, EDIMILSON MARTINS DE FREITAS, HERCÍLIO MARTELLI JÚNIOR. UNIVERSIDADE ESTADUAL DE MONTES CLAROSeUNIMONTES. Radioprotective oral appliances can be used during radiotherapy (RT) to prevent radiation-induced oral complications. Three women and 2 men with squamous cell carcinoma (SCC) of the lip (T1-T2N0M0), age 46 to 72 years, were eligible for curative RT with electron beam (60 to 66 Gy) and the use of personalized radioprotective oral appliances. Patients were evaluated before, during, and after RT for xerostomia and mucositis with scales (Eisbruch et al and World Health Organization). One patient complained of mild oral dryness that did not interfere with function; the others showed no xerostomia. Except for the tumor margins, protected areas of the oral mucosa showed no radiation mucositis, nor did patients experience taste alterations. The oral appliances prevented unnecessary irradiation of normal tissues, thus reducing the risk of morbidity in the form of mucositis and osteoradionecrosis. Treated patients had no signs of recurrence. Acknowledgment: FAPEMIG.
PE-071 - CASTLEMAN’S DISEASE: CASE REPORT. ADRIANA BORGES OLIVEIRA, LAIRA RENATA LEMOS SANTOS, JÉSSICA OLIVEIRA MELO SILVA, VIVIANE ALMEIDA SARMENTO, PATRÍCIA LEITE RIBEIRO LAMBERTI, ANTONIO FERNANDO PEREIRA FALCÃO, DAVI SILVA CARVALHO CURI. FEDERAL UNIVERSITY OF BAHIA. Castleman’s disease (CD) is a rare, atypical, lymphoproliferative disease that occurs in three histopathological variants: hyaline vascular, plasma cell, and mixed. Woman, 61, had painless, mobile lymphadenopathy in the left anterior cervical region that was associated with abdominal distension and enlargement of the submandibular glands. After biopsy and histopathological evaluation, a diagnosis of CD/hyaline vascular variant was made. Therapy with corticosteroids plus two sessions of chemotherapy (cyclophosphamide, hydroxydaunomycin, Oncovin, and prednisone [CHOP] and CHOP plus rituximab [R-CHOP]) was undertaken. The patient developed mucositis. The differential diagnosis and management of this condition are discussed.
PE-072 - ODONTOGENIC KERATOCYSTOF THE JAW: CASE REPORT. SAMARA RAMOS DE SOUZA, PIETRY DY TARSO INÃ ALVES MALAQUIAS, BRÁULIO CARNEIRO JÚNIOR, VIVIANE ALMEIDA SARMENTO, ROBERTO ALMEIDA DE AZEVEDO, RAFAEL FERNANDES DE ALMEIDA NERI, SAMARA ARMOS DE SOUZA. FACULDADE DE ODONTOLOGIA UFBA. Keratocystic odontogenic tumor (KOT) is a lesion that affects the gnathic bones, mainly in the posterior jaw area. Clinical and radiographic characteristics include asymptomatic volumetric
OOOO February 2014 increase and lack of cortical bone expansion and are related to an impacted tooth. However, the diagnosis can be confused for others when the lesion presents in other areas, such as the periapical region. In these cases, different management is recommended. This paper reports a case of KOT that demonstrated clinical and radiographic findings resembling those of radicular cyst and is designed to educate professionals who may see this lesion, such as endodontists and pathologists, about the possibility of a periapical presentation.
PE-073 - CHALLENGES IN THE DIAGNOSIS AND TREATMENT OF PEMPHIGUS VULGARIS: CLINICAL CASE REPORTS. THAMIRES SILVA SOUZA, ANDRÉ LUCAS D’ALMEIDA LYRIO DOS SANTOS, DAVI SILVA CARVALHO CURI, VINICIUS VIEIRA, ANTÔNIO FERNANDO PEREIRA FALCÃO, PATRICIA LEITE RIBEIRO LAMBERTI, VIVIANE ALMEIDA SARMENTO. FEDERAL UNIVERSITY OF BAHIA. Bullous autoimmune diseases are lesions in which autoantibodies are produced against the structural components that maintain cell-cell and cell-matrix adhesion in the skin and mucous membranes. They include disorders in which the bubbles are found in the basal membrane zone and those where bubbles form within the epidermis (pemphigus vulgaris, pemphigus foliaceus, and other subtypes). Due to the considerable overlap in clinical presentation of these conditions, diagnosing autoimmune bullous conditions of the skin and oral mucosa can be a challenge. In the last decade, there have been advances in the diagnosis of autoimmune bullous conditions. Two cases of bullous lesions diagnosed as pemphigus vulgaris were discussed, along with proper clinical management and differential diagnostic issues.
PE-074 - CHONDROBLASTIC OSTEOSARCOMA: CASE REPORT. FERNANDA TENÓRIO LOPES BARBOSA, BRUNNO SANTOS DE FREITAS SILVA, ALINE CARVALHO BATISTA, ELISMAURO FRANCISCO DE MENDONÇA, MARÍLIA OLIVEIRA MORAIS, FERNANDA PAULA YAMAMOTO. UNIVERSIDADE FEDERAL DE GOIÁS. Osteosarcoma is a rare malignant neoplasm in the jaws originating from mesenchymal cells that can form bone and osteoid tissue. The three histological patterns are osteoblastic, fibroblastic, and chondroblastic. Young man, 18, was referred to our service with an asymptomatic firm nodule present for 1 month in the posterior region of the mandible. Imaging revealed an osteolytic lesion associated with widening of the periodontal ligament space and root reabsorption, extra-lingual cortical reabsorption, and absence of calcification or “sun ray appearance.” Histopathological specimens revealed numerous spindle and oval-shaped pleomorphic cells with few osteoid and chondroid formations, compatible with a diagnosis of chondroblastic osteosarcoma. Surgical resection, adjuvant chemotherapy, and tibia graft were the chosen treatment. No recurrence or metastasis developed in 1 year of follow-up. This case emphasizes the importance of identifying the histological type of osteosarcoma to define the prognosis of chondroblastic osteosarcoma in young patients.
PE-075 - CHONDROBLASTIC OSTEOSARCOMA: DIAGNOSTIC DIFFICULTIES IN INCISIONAL BIOPSY. LARA CRISTINA OLIVER GIMENEZ, BRUNO TAVARES SEDASSARI, LILIAN CALDAS QUIRINO, CIBELE