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Chondroma of the Bladder: A Case Report and Review of the Literature
Accepted Manuscript Title: Chondroma of the Bladder: A Case Report and Review of the Literature Author: Ngii Tazeh, Kevin Scott, Shivashankar Damodaran, Wei Huang, Tracy Downs PII: DOI: Reference:
S0090-4295(17)30465-X http://dx.doi.org/doi: 10.1016/j.urology.2017.04.041 URL 20431
To appear in:
Urology
Received date: Accepted date:
22-2-2017 25-4-2017
Please cite this article as: Ngii Tazeh, Kevin Scott, Shivashankar Damodaran, Wei Huang, Tracy Downs, Chondroma of the Bladder: A Case Report and Review of the Literature, Urology (2017), http://dx.doi.org/doi: 10.1016/j.urology.2017.04.041. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Chondroma of the Bladder: A Case Report and Review of the Literature Ngii Tazeha, *, Kevin Scottc, Shivashankar Damodarana, Wei Huangb, Tracy Downsa
a, bDepartments
of Urology and Pathology
University of Wisconsin Hospital and Clinics 1685 Highland Avenue Madison, WI 53705 Tel.: 6082658825
cDickinson
Urology Clinic
1005 South Hemlock Street Iron Mountain, MI 49801 Tel.: 9067748110
*Corresponding Author: [email protected]
Key words: bladder, chondroma, benign, transurethral resection, cystoscopy
Abstract word count: 102
Financial Disclosure The authors declare that they have no relevant financial interests or conflicts of interest.
Manuscript word count: 1176
1
Page 1 of 4
Abstract Chondromas are benign tumors composed of mature hyaline cartilage (1). Extra-skeletal presentation of chondromas is extremely rare and mostly occur in the soft tissues of the extremities, mainly the hands and feet (1, 2). There are currently only three case reports in the literature of chondroma of the urinary bladder (3, 4, 5). Here, we present a case of urinary bladder chondroma with low proliferative potential managed by transurethral resection.
Case Presentation/Literature Review A 72-year-old female presented with micro-hematuria, urinary frequency and urgency. Cystoscopy revealed a 1-2 cm exophytic sessile anterior bladder wall mass with benign-appearing overlaying urothelium (fig 1). Transurethral resection revealed an avascular core (picture not shown). Histology revealed benign urothelium with nodular fragments of bland mature hyaline cartilage interspersed within the lamina propria and adjacent to muscularis propria (fig 2a and b). The tumor was pauci-cellular with no cytologic atypia. S100 and vimentin were positive; p53, p63 and pancytokeratin were negative. Ki-67 was < 1%. Pathologic diagnosis was chondroma of the bladder. Cystoscopic surveillance is ongoing and with no evidence of recurrence two years out from her initial diagnosis. Extra-skeletal chondromas are rare mostly cutaneous non-invasive benign tumors of mature hyaline cartilage (1, 2, 3). Rare reports exist of genitourinary soft tissue chondromas, with only three case reports of bladder chondromas prior to this report (4, 5, 6, 7, 8). Because of its rarity, there is no standard management. All reported cases were managed primarily with transurethral resection and cystoscopic surveillance. Complete resection is considered curative (3), although because of reported local recurrence rates of 15-20% (3) and lack of spontaneous regression (4), ongoing surveillance is recommended. References 1. Bahnassy M, Abdul-Khalik. Soft tissue chondroma: A case report and literature review. Oman Med J. 2009; 24(4): 296–299 2. Rapini RP, Bolognia JL, Jorizzo JL. Dermatology: 2-Volume Set. St. Louis: Mosby. 2007. ISBN 1-4160-2999-0. 3. Cho S, Horvai A. Chondro-osseous lesions of soft tissue. Surgical Pathology Clinics. 2015; 8(3): 419-444 4. Reichard C, Robert S, Rubin BP et al. Scrotal extra-osseous chondroma: Case report of an exceedingly unusual presentation and review of the literature. Case Rep Clin Path. 2014; 1:14-16 5. Sloan SE, Rapoport JM. Prostatic chondroma. Urology. 1985; 25(3):319321 6. Pauwels CF, Van den Broecke C, Demeyer JM, De Potter CR. Chondroma of the bladder. Virchows Arch. 1998; 432 (3): 299-300
2
Page 2 of 4
7. Perrino CM, Pohar KS, Zynger DL. Urinary bladder chondroma. Virchows Arch. 2012; 460: 437-438 8. Carter MD, Rendon RA, Merrimen J. A rare case of bladder chondroma. Can Urol Assoc J. 2015; 9:E136-E138
3
Page 3 of 4
Figure 1: Cystoscopic view of the lesion on the anterior bladder wall.
Figure 2: H & E stained representative sections of the tumor. (A) x40 magnification, showing bland cartilaginous nodule on the left side and benign urothelium on the right side. (B) x400 magnification of the chondroma nodule from (A) showing the chondrocytes.
4
Page 4 of 4
S0090-4295(17)30465-X http://dx.doi.org/doi: 10.1016/j.urology.2017.04.041 URL 20431
To appear in:
Urology
Received date: Accepted date:
22-2-2017 25-4-2017
Please cite this article as: Ngii Tazeh, Kevin Scott, Shivashankar Damodaran, Wei Huang, Tracy Downs, Chondroma of the Bladder: A Case Report and Review of the Literature, Urology (2017), http://dx.doi.org/doi: 10.1016/j.urology.2017.04.041. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Chondroma of the Bladder: A Case Report and Review of the Literature Ngii Tazeha, *, Kevin Scottc, Shivashankar Damodarana, Wei Huangb, Tracy Downsa
a, bDepartments
of Urology and Pathology
University of Wisconsin Hospital and Clinics 1685 Highland Avenue Madison, WI 53705 Tel.: 6082658825
cDickinson
Urology Clinic
1005 South Hemlock Street Iron Mountain, MI 49801 Tel.: 9067748110
*Corresponding Author: [email protected]
Key words: bladder, chondroma, benign, transurethral resection, cystoscopy
Abstract word count: 102
Financial Disclosure The authors declare that they have no relevant financial interests or conflicts of interest.
Manuscript word count: 1176
1
Page 1 of 4
Abstract Chondromas are benign tumors composed of mature hyaline cartilage (1). Extra-skeletal presentation of chondromas is extremely rare and mostly occur in the soft tissues of the extremities, mainly the hands and feet (1, 2). There are currently only three case reports in the literature of chondroma of the urinary bladder (3, 4, 5). Here, we present a case of urinary bladder chondroma with low proliferative potential managed by transurethral resection.
Case Presentation/Literature Review A 72-year-old female presented with micro-hematuria, urinary frequency and urgency. Cystoscopy revealed a 1-2 cm exophytic sessile anterior bladder wall mass with benign-appearing overlaying urothelium (fig 1). Transurethral resection revealed an avascular core (picture not shown). Histology revealed benign urothelium with nodular fragments of bland mature hyaline cartilage interspersed within the lamina propria and adjacent to muscularis propria (fig 2a and b). The tumor was pauci-cellular with no cytologic atypia. S100 and vimentin were positive; p53, p63 and pancytokeratin were negative. Ki-67 was < 1%. Pathologic diagnosis was chondroma of the bladder. Cystoscopic surveillance is ongoing and with no evidence of recurrence two years out from her initial diagnosis. Extra-skeletal chondromas are rare mostly cutaneous non-invasive benign tumors of mature hyaline cartilage (1, 2, 3). Rare reports exist of genitourinary soft tissue chondromas, with only three case reports of bladder chondromas prior to this report (4, 5, 6, 7, 8). Because of its rarity, there is no standard management. All reported cases were managed primarily with transurethral resection and cystoscopic surveillance. Complete resection is considered curative (3), although because of reported local recurrence rates of 15-20% (3) and lack of spontaneous regression (4), ongoing surveillance is recommended. References 1. Bahnassy M, Abdul-Khalik. Soft tissue chondroma: A case report and literature review. Oman Med J. 2009; 24(4): 296–299 2. Rapini RP, Bolognia JL, Jorizzo JL. Dermatology: 2-Volume Set. St. Louis: Mosby. 2007. ISBN 1-4160-2999-0. 3. Cho S, Horvai A. Chondro-osseous lesions of soft tissue. Surgical Pathology Clinics. 2015; 8(3): 419-444 4. Reichard C, Robert S, Rubin BP et al. Scrotal extra-osseous chondroma: Case report of an exceedingly unusual presentation and review of the literature. Case Rep Clin Path. 2014; 1:14-16 5. Sloan SE, Rapoport JM. Prostatic chondroma. Urology. 1985; 25(3):319321 6. Pauwels CF, Van den Broecke C, Demeyer JM, De Potter CR. Chondroma of the bladder. Virchows Arch. 1998; 432 (3): 299-300
2
Page 2 of 4
7. Perrino CM, Pohar KS, Zynger DL. Urinary bladder chondroma. Virchows Arch. 2012; 460: 437-438 8. Carter MD, Rendon RA, Merrimen J. A rare case of bladder chondroma. Can Urol Assoc J. 2015; 9:E136-E138
3
Page 3 of 4
Figure 1: Cystoscopic view of the lesion on the anterior bladder wall.
Figure 2: H & E stained representative sections of the tumor. (A) x40 magnification, showing bland cartilaginous nodule on the left side and benign urothelium on the right side. (B) x400 magnification of the chondroma nodule from (A) showing the chondrocytes.
4
Page 4 of 4