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Chorioretinitis with a combined defect in T and B lymphocytes and granulocytes: a new syndrome successfully treated with dialyzable leukocyte extracts (transfer factor)
Blood flow HYperte-lW Cardiac output Arterial pressure
Adenoma
Pltultary stone
normal menses were restored after removal of the stone, but the prolactin response to thyrotropin-releasing hormone (TM-f) remained abnormal. Two years after the patient underwent surgery galactonhea rearrred. although her menses remained regular. This report emphasizes the need for proforged follow-up in such patients; it also emphasizes that human pro&tin may be produced in vitro and thus may provide a useful tool for further investigation.
A 26 year old woman with a “pituitary stone” was found to have a prolactin-producing adenoma. The grossly calcified adenoma was functional in vitro and produced large amounts of prolactin, but no gowth hormone cx thyroid-stimulating hormone (TSH). Galactorrhea ceased and
of a pituitary stone. Am J Med
Amenorrhea
von Westarp C, Weir BKA, Shnitka TK: Characterization 1980: 68: 949-954.
Pituitary culture
Prdactln
This study focuses on the potentfal importance of the phenomenon of tissue autoregulation as a factor in vascular resfstance. Neruly all indivfdual organ systems can locally &just their vascular resistance (autoregulate) to maintain appropriate blood flow, so that the sum of all the tissue resistances determines the total blood flow through the circufation (cardiac output). The extent to whfch these focal autoregutatory mechanff can influence hemodynamic events associated with various types of hypertension is evaluated. It is concluded that even slight fluM retention over periods of weeks and months enables autoregufatory mechanisms to sustain a 50 per cent inorease in arterial pressure with only a 5 per cent observed increase in cardiac output. The evfdence indicates that regulation of cardiac output cannot explain the cause of hypertension, but local autoregulation of flow must be carefully considered if we are to understand fully the hemodynamic events associated with various forms of hypertension.
Cowley AW: The concept of autoregulation of total blood flow and its role in hyperten-ion. Am J h4ed 1980; 68: 906-916.
Autoregulation Vascular resistance
C-peptMe suppression Hypoglycemia Islet cell hyperplasia Hyperglucagofwmia
Cell-mediated immunity Agammaglobulinemia Dialyzable leukocyte extracts Plasma therapy
The clinical and immunologic features of a patient with chorioretinitis. and a combined defect of T and B lymphocytes and granulocytes are described; the fatter (defective granulocyte function) has not hfo been reported in patients with combined immunode ficiency. Dramatic remission of the active ocular lesion was achieved within two months after the initiation of therapy with dialyzable leukocyte extracts (transfer factor), indicating that such therapy may prove to be beneficial in treating other patients with chorioretinitis and T-cell deficiency.
Kyong CA, Wilson GB. Fudenberg HH. Goust JM. Richardson P. Eckerd J: Chorioretinitis with a combined defect in T and B lymphocytes and granulocytes: a new synborne successfully treated with dialyzable leukocyte extracts (transfer factor). Am J h&d 1980; 68: 955-961.
Granulocyte function
Chorioretinitis
A patient with biopsy-proved biliary cirrhosis and previous gastrojejunostomy and portacaval anastomosis experienced episodes of severe hypoglycemia. She was found to have hyperinsulinemia and hyperglucagonemia. An oral glucose tolerance test showed a postgastrectomy hypoglycemic response Results of the intravenous tolbutamide test were diagnostic for insulincma, but results of the intravenous glucagon test and prolonged fast (96 horrs) were not. Failure to suppress C-peptide normally on two occasions during insulin-induced hypoglycemia led to a diagnosis of pancreatogenous hyperinsulinemia.
Brennan MD, Service FJ. Carpenter A-M, Rubenstein AH, Edis AJ: Dragnosis of pancreatic islet hyperplasia causing hypoglycemia in a patient with portacaval anastomosis. Am J h4ed 1980; 68: 941-948.
Pancreas Hyperinsullnemia
Adenoma
Pltultary stone
normal menses were restored after removal of the stone, but the prolactin response to thyrotropin-releasing hormone (TM-f) remained abnormal. Two years after the patient underwent surgery galactonhea rearrred. although her menses remained regular. This report emphasizes the need for proforged follow-up in such patients; it also emphasizes that human pro&tin may be produced in vitro and thus may provide a useful tool for further investigation.
A 26 year old woman with a “pituitary stone” was found to have a prolactin-producing adenoma. The grossly calcified adenoma was functional in vitro and produced large amounts of prolactin, but no gowth hormone cx thyroid-stimulating hormone (TSH). Galactorrhea ceased and
of a pituitary stone. Am J Med
Amenorrhea
von Westarp C, Weir BKA, Shnitka TK: Characterization 1980: 68: 949-954.
Pituitary culture
Prdactln
This study focuses on the potentfal importance of the phenomenon of tissue autoregulation as a factor in vascular resfstance. Neruly all indivfdual organ systems can locally &just their vascular resistance (autoregulate) to maintain appropriate blood flow, so that the sum of all the tissue resistances determines the total blood flow through the circufation (cardiac output). The extent to whfch these focal autoregutatory mechanff can influence hemodynamic events associated with various types of hypertension is evaluated. It is concluded that even slight fluM retention over periods of weeks and months enables autoregufatory mechanisms to sustain a 50 per cent inorease in arterial pressure with only a 5 per cent observed increase in cardiac output. The evfdence indicates that regulation of cardiac output cannot explain the cause of hypertension, but local autoregulation of flow must be carefully considered if we are to understand fully the hemodynamic events associated with various forms of hypertension.
Cowley AW: The concept of autoregulation of total blood flow and its role in hyperten-ion. Am J h4ed 1980; 68: 906-916.
Autoregulation Vascular resistance
C-peptMe suppression Hypoglycemia Islet cell hyperplasia Hyperglucagofwmia
Cell-mediated immunity Agammaglobulinemia Dialyzable leukocyte extracts Plasma therapy
The clinical and immunologic features of a patient with chorioretinitis. and a combined defect of T and B lymphocytes and granulocytes are described; the fatter (defective granulocyte function) has not hfo been reported in patients with combined immunode ficiency. Dramatic remission of the active ocular lesion was achieved within two months after the initiation of therapy with dialyzable leukocyte extracts (transfer factor), indicating that such therapy may prove to be beneficial in treating other patients with chorioretinitis and T-cell deficiency.
Kyong CA, Wilson GB. Fudenberg HH. Goust JM. Richardson P. Eckerd J: Chorioretinitis with a combined defect in T and B lymphocytes and granulocytes: a new synborne successfully treated with dialyzable leukocyte extracts (transfer factor). Am J h&d 1980; 68: 955-961.
Granulocyte function
Chorioretinitis
A patient with biopsy-proved biliary cirrhosis and previous gastrojejunostomy and portacaval anastomosis experienced episodes of severe hypoglycemia. She was found to have hyperinsulinemia and hyperglucagonemia. An oral glucose tolerance test showed a postgastrectomy hypoglycemic response Results of the intravenous tolbutamide test were diagnostic for insulincma, but results of the intravenous glucagon test and prolonged fast (96 horrs) were not. Failure to suppress C-peptide normally on two occasions during insulin-induced hypoglycemia led to a diagnosis of pancreatogenous hyperinsulinemia.
Brennan MD, Service FJ. Carpenter A-M, Rubenstein AH, Edis AJ: Dragnosis of pancreatic islet hyperplasia causing hypoglycemia in a patient with portacaval anastomosis. Am J h4ed 1980; 68: 941-948.
Pancreas Hyperinsullnemia