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Chromatographic column eliminates pre-filtration
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Technology news Filtration+Separation December 2008
Chromatographic column eliminates pre-filtration Developer of customised industrial scale separation technologies, Upfront Chromatography A/S, has launched the MabDirect MM Fixed-D 50 ml, a disposable chromatographic column based on Rhobust™, the company’s Expanded Bed Adsorption platform. The pre-sanitised antibody purification columns have been designed to eliminate the need for pre-filtration steps often required by columns, and in addition they retain the cost-effectiveness and flexibility associated with disposable chromatography. The MabDirect MM Fixed-D 50 ml columns are packed with MabDirect Mixed Mode adsorbent for the efficient purification of monoclonal antibodies and
provide a working capacity of approximately 30 g/L. The column units are stable to 1 M NaOH solution, to enable easy cleaning between-cycles. The construction of cost-effective, single-use columns from plastic is made possible as the design of the columns eliminates the generation of pressure during operation. The columns can be operated on the ÄKTA chromatography or similar systems, or alternatively with a peristaltic pump. Allan Lihme, technical director, Upfront Chromatography, commented: “The flexibility offered by the new disposable columns will be a major benefit for multi-product facilities such as CMOs and pharma pilot plants.” www.upfront-dk.com
Odotech, a spin-off company of the Engineering School of the École Polytechnique de Montréal, in Quebec, Canada, developed Electronic Nose, an odour monitoring technology, and this has since been developed into OdoWatch™, a continuous, automatic odour monitoring system for sewage works. Veolia Water Solutions & Technologies has the worldwide license to market OdoWatch™ solutions for the municipal water and wastewater sector.
Upfront Chromatography A/S, has launched the MabDirect, disposable chromatographic column based on the company’s Expanded Bed Adsorption platform, Rhobust™.
The monitor can be calibrated using olfactometry to respond in exactly the same way as
the human nose to identify a perceived odour, which means that it can distinguish between odours generated by a particular works and those originating from other sources. Using a number of electronic noses – typically between two and five depending on the size of the works – the technology analyses air samples at one minute intervals. The results are transmitted, using WiFi, Ethernet or similar network, to a computer where real-time modelling software merges them with data collected from the network’s weather station, and produces an ‘odour plume’, which is overlaid onto a map of the site and surrounding area. This plume, which can predict the odour impact up to 24 hours ahead, is colour-coded for odour
Pure Technologies has launched the SmartBall, a technology for use in sewer force mains. Designed to provide permanent structural monitoring for water and wastewater pipelines, the SmartBall rolls through pipelines to collect data on the condition of a pipe. An instrumented foam ball, the SmartBall is released into the water stream and allowed to traverse the pipeline with the flow. It then records acoustic activity, which is then evaluated to determine the location and magnitude of leaks and air pockets.
Monitoring odour in water and wastewater applications Odour generated by sewage works can be difficult to define and quantify. It is only recently that reliable sensors have been developed to detect and measure odours in a meaningful way.
Monitoring water and wastewater pipelines
Commenting on the product, Michael Higgins, vice president, Pure Technologies, said: “We have been extremely pleased with the SmartBall technology in terms of its accuracy, and how quickly it was accepted in the water industry. It is an incredibly advanced technology and is able to provide accurate leak information on important mains with minimal inconvenience to the water or wastewater utility.” www.puretechnologiesltd.com
Polymide membranes resist high temperatures Belgian-based track-etched membrane manufacturer, it4ip, has developed a range of polymide membranes made from pure polymeric film. The membranes pore size ranges from 20 nanometers up to 5 micrometers, in 12 μm or 23 μm thick based film.
OdoWatch™ is a continuous, automatic odour monitoring system for sewage works.
concentration, making it easy for the operator to assess the odour impact and, take steps to eliminate it. www.veoliawater.com
The membrane is available in roll stock and manufactured to ISO9001:2000. Developed in extremely resistant polyimide, it4ip says the track-etched membrane is suitable for demanding applications such as fuel cell, water purification and those requiring high temperature resistance ( 300° C), radiation resistance, and chemical resistance. www.it4ip.be
Technology news Filtration+Separation December 2008
Chromatographic column eliminates pre-filtration Developer of customised industrial scale separation technologies, Upfront Chromatography A/S, has launched the MabDirect MM Fixed-D 50 ml, a disposable chromatographic column based on Rhobust™, the company’s Expanded Bed Adsorption platform. The pre-sanitised antibody purification columns have been designed to eliminate the need for pre-filtration steps often required by columns, and in addition they retain the cost-effectiveness and flexibility associated with disposable chromatography. The MabDirect MM Fixed-D 50 ml columns are packed with MabDirect Mixed Mode adsorbent for the efficient purification of monoclonal antibodies and
provide a working capacity of approximately 30 g/L. The column units are stable to 1 M NaOH solution, to enable easy cleaning between-cycles. The construction of cost-effective, single-use columns from plastic is made possible as the design of the columns eliminates the generation of pressure during operation. The columns can be operated on the ÄKTA chromatography or similar systems, or alternatively with a peristaltic pump. Allan Lihme, technical director, Upfront Chromatography, commented: “The flexibility offered by the new disposable columns will be a major benefit for multi-product facilities such as CMOs and pharma pilot plants.” www.upfront-dk.com
Odotech, a spin-off company of the Engineering School of the École Polytechnique de Montréal, in Quebec, Canada, developed Electronic Nose, an odour monitoring technology, and this has since been developed into OdoWatch™, a continuous, automatic odour monitoring system for sewage works. Veolia Water Solutions & Technologies has the worldwide license to market OdoWatch™ solutions for the municipal water and wastewater sector.
Upfront Chromatography A/S, has launched the MabDirect, disposable chromatographic column based on the company’s Expanded Bed Adsorption platform, Rhobust™.
The monitor can be calibrated using olfactometry to respond in exactly the same way as
the human nose to identify a perceived odour, which means that it can distinguish between odours generated by a particular works and those originating from other sources. Using a number of electronic noses – typically between two and five depending on the size of the works – the technology analyses air samples at one minute intervals. The results are transmitted, using WiFi, Ethernet or similar network, to a computer where real-time modelling software merges them with data collected from the network’s weather station, and produces an ‘odour plume’, which is overlaid onto a map of the site and surrounding area. This plume, which can predict the odour impact up to 24 hours ahead, is colour-coded for odour
Pure Technologies has launched the SmartBall, a technology for use in sewer force mains. Designed to provide permanent structural monitoring for water and wastewater pipelines, the SmartBall rolls through pipelines to collect data on the condition of a pipe. An instrumented foam ball, the SmartBall is released into the water stream and allowed to traverse the pipeline with the flow. It then records acoustic activity, which is then evaluated to determine the location and magnitude of leaks and air pockets.
Monitoring odour in water and wastewater applications Odour generated by sewage works can be difficult to define and quantify. It is only recently that reliable sensors have been developed to detect and measure odours in a meaningful way.
Monitoring water and wastewater pipelines
Commenting on the product, Michael Higgins, vice president, Pure Technologies, said: “We have been extremely pleased with the SmartBall technology in terms of its accuracy, and how quickly it was accepted in the water industry. It is an incredibly advanced technology and is able to provide accurate leak information on important mains with minimal inconvenience to the water or wastewater utility.” www.puretechnologiesltd.com
Polymide membranes resist high temperatures Belgian-based track-etched membrane manufacturer, it4ip, has developed a range of polymide membranes made from pure polymeric film. The membranes pore size ranges from 20 nanometers up to 5 micrometers, in 12 μm or 23 μm thick based film.
OdoWatch™ is a continuous, automatic odour monitoring system for sewage works.
concentration, making it easy for the operator to assess the odour impact and, take steps to eliminate it. www.veoliawater.com
The membrane is available in roll stock and manufactured to ISO9001:2000. Developed in extremely resistant polyimide, it4ip says the track-etched membrane is suitable for demanding applications such as fuel cell, water purification and those requiring high temperature resistance ( 300° C), radiation resistance, and chemical resistance. www.it4ip.be