Chromatographic Data (1980)

Cmkpod

RF

Rt

R2

Rs

R

cEI2

H-

aH H H H H H CH, H H H

CEi, =h as cl cl cl cl & -3 QcHg

EHs ~wzs!35

H a i&L& Et s Br

&

s2

0.38 0.50 0.33 0.15 0.46 0.58 0.69 0.73 0.63 0.36 0.47 0.49

0_39 0.49 0.54 0.16 0.43 0.52 O-62 0.64 0.66 0.36 0.47 0.51

TABLE !!sC TLC RL; VAL?ES OF FLUORENONE NiTRQ DERIVATIVES (J. Pie$how&i 2nd Irobrzut, C/km. Anal. (WmspW). 23 (1978) 174) Thin !!ayer: SoIventri:

siruf01 (swy Kavakf, votkg sx = Bemew. s* = 1g-DicbIoroIxlmse. s, = cycrollexme4 examle(l:1).

s. = cydo-

Czecho&akia~.

(1:3:2).

exao--

oroform (lt2). s, = cydcss = n-HexaQe+sorofoim (1:4). & = Hex2none_ sr = ChioroforriL & = EthyI acetate. WlighL

IktcctiCO:

s,

St

s,

S6

ss

S6

s,

S8

sb

FlUOICIXOOC

0.44

2-Nioo%uorenone 27-DinimIIuorenone 2,4,7-Trit~it~o%uorone

0.38 0.24 0.41

0.27 026 025 0.30

020 0.92 0s 0.98

0.53 0.51 0.76 0.94

0.54 0.40 0.25 0.42

0.96 0.76 O-47 0.60

098 038 O.% 0.99

0.95 0.94 0.76 0.83

093 0.94 0.96 091s

TABLE

1155

TLC Rp VALUES PURlTIES (IL M_ M&lane, Thin !ayer:

soI%mltt DetectiO3lI

OF MEPERIDlNi R

J. Wood,

AND

ITS S-C

nrnxMEDrATEs

F. _Mstsui and E G. Lowing,

Silica ~1 GF pnxoated

plates (B

- ’ Ethyl FzLczta~cIO mol-dioxane-eere

J.

Phrm. Sci., 67 hsmments,

RF

N43enzyW~ acid l-Methy!4piiper~.~~ acid Ethyf 4-phenyI4piperidkcarbo_syIate l-F3enzyi4pbenyl-+piperidinecarboxyk acid Methyl l-sethyI4phenyi4-piperidinecarboxyIate N-Bemyibis(2-hydiiqzthy&amine MepeIidiGe Ethyl l-ethyI-4phenyL4-piperidkcarboxy.late Dietbyl N-berI.zyiirIlin~te l-zemyl4pbenyl4cyanopiperidine N-BemyIbis(2xblometby&miae Ethyl 1-benzyl4p~yl4piperidinecarboxylate

0.00 0.00 0.10 0.20 0.39 O-42 0.47 :z 0.72 O-73 0.75

LM-

(1978) 961%

Toronto, chxda). ammonium hy-

droxide (5&5Oz2O:lOrlrl)_ UV Light at 254 om and dilute potassium iodobismutbate-

Z#

AND

CEXROBiL4TOGtiEEK

D3

DATA (1930)

TABLE 1156 TLC RF VALUES OF SOME ANTIBIOTKS (yu, D_ Sixsin, V. N. Omel%henko and V. V. Onopricnk~, Arrtibt-om, 23 (1978) 583) Thin iayer: soxvents:

Mt%IlOiUycin

AzaIomycinF RiWIlycin

TABLE

silica gel KsK. s, = water-ethan01-aQt0ne (7:2:1)_ S+ = Ethyl a.cer2~ti~mer (211:Z upper Iayer). S, = rerk-Butanobphosphate buffer (2% upper layer). S4 = Methauokthyl acetate (1 :I). ss = 90 % Methanol-ch!&oform (1:4).

Sl

S2

S,

S4

S5

0.60 o_aO 0.83

0.00 0.00 0.15

0.34 0.34 0.54

0.35 0.20 0.57

0.50 0.50 0.78

.

1157

TLC RF VALUES OF DIMETACRIN AND ITS METABOLITES (J. Neye and H. Fenner, Arch. Pharm. (Weinheim). 311 (1978) 1045) Thin layer : Solvents:

D&eCt.k:

Dimetacrin 2-Hydrozqdimetacrin V==t== 2-Hydw&zsmethy~~--_ Y)imetacrin-N-oxide

Fzw sheets (Merck). ChIoroform-l-propkonc. ammonia (50:50:2). BesIzxl~thYl acetate-&anol-conc_ ammonia (40:40:40:2). Cyclohexax-chloroform-diethyiamine (7:2:1). Benzen+dioxzul~tokonc_ ammonia (50:40:5:5). Diethyl ether-1,2-&hIorocthaa~ethylamine (60:60:5).

Kiedgel60 St s: S, s, Ss

= = = = =

D, = Scanner LB 2722 for ICC derivatives. Dz = Cenic-Ivsulfate and phosphoric acid for phenolic compounds.

0.66 0.51 0.36 020 0.14

0.49 0.41 0.25 0.16 0.07

0.46 0.03 0.12 0.00 0.00

0.75 0.53 0.54 0% 0.02

0.57 0.19 0.29 0.06 0.0