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CIGARETTE SMOKING IN PATIENTS WITH SCHIZOPHRENIA IN CHINA: A PROSPECTIVE, MULTI-CENTER STUDY
Abstracts
BSABS is one valid and useful tool for briefly evaluation of addiction in schizophrenia. doi:10.1016/j.schres.2010.02.785
Poster 25 CIGARETTE SMOKING IN PATIENTS WITH SCHIZOPHRENIA IN CHINA: A PROSPECTIVE, MULTI-CENTER STUDY Y.T. Xiang1,2, Chuan-Yue Wang1 Beijing Anding Hospital, Beijing, China; Chinese University of Hong Kong, Hong Kong, China
1
Background: Understanding the patterns of smoking and its sociodemographic and clinical correlates in schizophrenia patients is vitally important for policymakers and health care providers in the implementation of appropriat strategies and execution of effective measures to reduce its harmful consequences. However, to date there has been no study investigating rate of smoking involving both in- and out-patients with schizophrenia based on multi-center design in China. This study aimed to explore the rate of cigarette smoling and its socio-demographic and clinical characteristics in Chinese schizophrenia patients. Methods: In a multi-center, randomized, controlled, longitudinal study involving 19 mental health centers nationwide that represented a range of clinical settings in which schizophrenia patients receive treatment in China, 374 clinically stable patients with schizophrenia were interviewed at entry using standardized assessment instruments, and followed up for 1 - 2 years. Results: The study involved 19 mental health centers nationwide that represented a range of clinical settings in which schizophrenia patients receive treatment in China. The rate of cigarette smoking was 13.9% in the whole sample, and 26.2% in men and 3.5% in women. In univariate analyses, male sex, unemployment, alcohol consumption, older age, older age at onset, longer duration of illness, more frequent admissions, more sever hostility-excitement over the study period were significantly associated with cigarette smoking. In the multivariate analysis, more male sex, unemplyment, alcohol consumption, more frequent admissions, less severe positive and negative sympstoms at entry, smaller decline in negative symptoms and more deterioration in disorganized thoughts over the study period were independently associated with cigarette smoking. Discussion: The rate of cigarette smoking in chinese schizophrenia patients is considerably lower than most figures reported in the Western literature.
427
risk factors for the polysubstance abusers who developed acute psychotic symptoms not related to intoxication with substances. Methods: The sample consisted of one hundred patients, 51 male and 49 female. It was divided into four groups, experimental and three controls. Experimental group consisted of 30 polysubstance abusers with psychotic episode (18-27 years of age, 22.93 ±2.48 years). The first control group consisted of 30 polysubstance abusers without psychotic symptoms (23.97 ± 4.07 years), the second of 20 patients with acute psychotic disorder with polymorphic symptoms (25.40 ± 6.64) and the third consists of 20 patients with the first manic episode with psychotic symptoms (25.90 ± 6.22 years). Before filling in the battery of tests, patients with psychotic symptoms were examined with BPRS (the Brief Psychiatry Rating Scale) at the beginning and at the end of treatment in order to check the clinical condition and their ability to fulfill other scales. The instruments of self–examination that we used were: MCMI (The Millon Clinical Multiaxial Inventory), TPQ (Three-dimensional Personality Questionnaire) and the Social Psychiatric Scale. For the analysis of data we used various methods of uni-variant statistical analysis. Results: Our results showed that polysubstance abusers with psychotic episode have normal profile of personality with higher passive-aggressive dimension. Emotional instability was confirmed (novelty seeking (NS) component is high), but less than with the other polysubstance abusers without psychotic episode. The patterns of substance abuse in experimental group are milder than in the group of polysubstance abusers without psychosis. The beginning of abuse of substances is probably the same, but the amount of abused substances in experimental group is much smaller. Our results showed that 75% of patients in the experimental group takes cannabis, alcohol and tobacco, but polysubstance abusers without psychoses takes more often opiates or psychostimulants. Discussion: Paradoxically, more expressed pathology of personality and more severe patterns of substance abuse less often lead to appearance of psychotic symptoms. Experimental group does not have histrionic dimensions and clinical syndromes of alcohol and substance addiction as polysubstance abusers without psychosis, but they have more prominent passive-aggressive, schizoid, avoidant and schizotypal dimensions which are more often features of schizophrenic patients. We did not noticed specific social risk factors for appearance of psychosis, but we noticed visible social detachment among polysubstance abusers with psychotic episode (lower educational level, lower employment and willingness to work, lower social level and weaker social implementation). It would be interesting to follow up the patients in the experimental group and after several years to see how many of them would fulfill diagnostic criteria for chronic psychosis, possibly some of schizophrenia-spectrum disorders.
doi:10.1016/j.schres.2010.02.786
doi:10.1016/j.schres.2010.02.787
Poster 26
Poster 27
PROFILE OF POLYSUBSTANCE ABUSERS WITH THE ACUTE PSYCHOTIC EPISODE
THE AUSTRALIAN SCHIZOPHRENIA RESEARCH BANK (ASRB): AN EXAMPLE OF ERESEARCH
Milan Zdravkovic Institute of Mental Health, Belgrade, Serbia
Frans Henskens1,2, Vaughan Carr1,6, Stan Catts1,3, Assen Jablensky1,4, Patricia Michie1,2, Carmel Loughland1,2, Kathryn McCabe1,2, Bryan Mowry1,3, Aslam Nasir1,2, Christos Pantelis1,5, Paul Rasser1,2, David Paul1,2, Jacki Richards1,2, Ulrich Schall1,2, Rodney Scott1,2 1 Schizophrenia Research Institute (SRI) Sydney, NSW, Australia; 2 University of Newcastle, Newcastle, NSW, Australia; 3University of Queensland, Brisbane, QLD, Australia; 4University of Western Australia Perth, WA, Australia; 5University of Melbourne, Melbourne, VIC, Australia; 6University of New South Wales, Sydney, NSW, Australia
Background: Nowadays it is very unusual, among young people who misuse drugs, to find individuals who abuse only one psychoactive substance. So, the trend of using many substances was observed. In Serbia it is noticed that appearance of psychotic episodes is growing in this group of young patients. The aims of this study is to try to discover personality dimensions, social characteristics and possible
BSABS is one valid and useful tool for briefly evaluation of addiction in schizophrenia. doi:10.1016/j.schres.2010.02.785
Poster 25 CIGARETTE SMOKING IN PATIENTS WITH SCHIZOPHRENIA IN CHINA: A PROSPECTIVE, MULTI-CENTER STUDY Y.T. Xiang1,2, Chuan-Yue Wang1 Beijing Anding Hospital, Beijing, China; Chinese University of Hong Kong, Hong Kong, China
1
Background: Understanding the patterns of smoking and its sociodemographic and clinical correlates in schizophrenia patients is vitally important for policymakers and health care providers in the implementation of appropriat strategies and execution of effective measures to reduce its harmful consequences. However, to date there has been no study investigating rate of smoking involving both in- and out-patients with schizophrenia based on multi-center design in China. This study aimed to explore the rate of cigarette smoling and its socio-demographic and clinical characteristics in Chinese schizophrenia patients. Methods: In a multi-center, randomized, controlled, longitudinal study involving 19 mental health centers nationwide that represented a range of clinical settings in which schizophrenia patients receive treatment in China, 374 clinically stable patients with schizophrenia were interviewed at entry using standardized assessment instruments, and followed up for 1 - 2 years. Results: The study involved 19 mental health centers nationwide that represented a range of clinical settings in which schizophrenia patients receive treatment in China. The rate of cigarette smoking was 13.9% in the whole sample, and 26.2% in men and 3.5% in women. In univariate analyses, male sex, unemployment, alcohol consumption, older age, older age at onset, longer duration of illness, more frequent admissions, more sever hostility-excitement over the study period were significantly associated with cigarette smoking. In the multivariate analysis, more male sex, unemplyment, alcohol consumption, more frequent admissions, less severe positive and negative sympstoms at entry, smaller decline in negative symptoms and more deterioration in disorganized thoughts over the study period were independently associated with cigarette smoking. Discussion: The rate of cigarette smoking in chinese schizophrenia patients is considerably lower than most figures reported in the Western literature.
427
risk factors for the polysubstance abusers who developed acute psychotic symptoms not related to intoxication with substances. Methods: The sample consisted of one hundred patients, 51 male and 49 female. It was divided into four groups, experimental and three controls. Experimental group consisted of 30 polysubstance abusers with psychotic episode (18-27 years of age, 22.93 ±2.48 years). The first control group consisted of 30 polysubstance abusers without psychotic symptoms (23.97 ± 4.07 years), the second of 20 patients with acute psychotic disorder with polymorphic symptoms (25.40 ± 6.64) and the third consists of 20 patients with the first manic episode with psychotic symptoms (25.90 ± 6.22 years). Before filling in the battery of tests, patients with psychotic symptoms were examined with BPRS (the Brief Psychiatry Rating Scale) at the beginning and at the end of treatment in order to check the clinical condition and their ability to fulfill other scales. The instruments of self–examination that we used were: MCMI (The Millon Clinical Multiaxial Inventory), TPQ (Three-dimensional Personality Questionnaire) and the Social Psychiatric Scale. For the analysis of data we used various methods of uni-variant statistical analysis. Results: Our results showed that polysubstance abusers with psychotic episode have normal profile of personality with higher passive-aggressive dimension. Emotional instability was confirmed (novelty seeking (NS) component is high), but less than with the other polysubstance abusers without psychotic episode. The patterns of substance abuse in experimental group are milder than in the group of polysubstance abusers without psychosis. The beginning of abuse of substances is probably the same, but the amount of abused substances in experimental group is much smaller. Our results showed that 75% of patients in the experimental group takes cannabis, alcohol and tobacco, but polysubstance abusers without psychoses takes more often opiates or psychostimulants. Discussion: Paradoxically, more expressed pathology of personality and more severe patterns of substance abuse less often lead to appearance of psychotic symptoms. Experimental group does not have histrionic dimensions and clinical syndromes of alcohol and substance addiction as polysubstance abusers without psychosis, but they have more prominent passive-aggressive, schizoid, avoidant and schizotypal dimensions which are more often features of schizophrenic patients. We did not noticed specific social risk factors for appearance of psychosis, but we noticed visible social detachment among polysubstance abusers with psychotic episode (lower educational level, lower employment and willingness to work, lower social level and weaker social implementation). It would be interesting to follow up the patients in the experimental group and after several years to see how many of them would fulfill diagnostic criteria for chronic psychosis, possibly some of schizophrenia-spectrum disorders.
doi:10.1016/j.schres.2010.02.786
doi:10.1016/j.schres.2010.02.787
Poster 26
Poster 27
PROFILE OF POLYSUBSTANCE ABUSERS WITH THE ACUTE PSYCHOTIC EPISODE
THE AUSTRALIAN SCHIZOPHRENIA RESEARCH BANK (ASRB): AN EXAMPLE OF ERESEARCH
Milan Zdravkovic Institute of Mental Health, Belgrade, Serbia
Frans Henskens1,2, Vaughan Carr1,6, Stan Catts1,3, Assen Jablensky1,4, Patricia Michie1,2, Carmel Loughland1,2, Kathryn McCabe1,2, Bryan Mowry1,3, Aslam Nasir1,2, Christos Pantelis1,5, Paul Rasser1,2, David Paul1,2, Jacki Richards1,2, Ulrich Schall1,2, Rodney Scott1,2 1 Schizophrenia Research Institute (SRI) Sydney, NSW, Australia; 2 University of Newcastle, Newcastle, NSW, Australia; 3University of Queensland, Brisbane, QLD, Australia; 4University of Western Australia Perth, WA, Australia; 5University of Melbourne, Melbourne, VIC, Australia; 6University of New South Wales, Sydney, NSW, Australia
Background: Nowadays it is very unusual, among young people who misuse drugs, to find individuals who abuse only one psychoactive substance. So, the trend of using many substances was observed. In Serbia it is noticed that appearance of psychotic episodes is growing in this group of young patients. The aims of this study is to try to discover personality dimensions, social characteristics and possible