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Circulating Nucleic Acids Special Issue
Clinical Biochemistry 48 (2015) 931
Contents lists available at ScienceDirect
Clinical Biochemistry journal homepage: www.elsevier.com/locate/clinbiochem
Editorial
Circulating Nucleic Acids Special Issue
Since the tremendous success of the use of circulating (fetal) nucleic acids for the non-invasive diagnosis of fetal chromosomal aneuploidies, the use of circulating nucleic acids for other applications along with critical aspects of current applications has gained great interest. This special issue of Clinical Biochemistry gives an anthology of exemplary papers on preanalytical, methodological, and bioinformatic aspects in this field, the need for and use of quality controls, the use of targets other than DNA, and critical aspects that need to be considered for clinical implementation. Given the fact that circulating nucleic acids (CNA) have been detected in all bodily fluids, i.e. serum, plasma, spinal fluid, urine; and given the fact that all layers of biological and diagnostic information present in the genome i.e. DNA, RNA, noncoding RNA, methylated
RNA, can be detected using CNA, it can be predicted that this approach will become a diagnostic tool for many diseases, i.e. not only for prenatal diagnostics, but also cancer, neurodegenerative diseases, cardiovascular diseases, pregnancy-associated diseases and many more.
http://dx.doi.org/10.1016/j.clinbiochem.2015.08.021 0009-9120/© 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Rossa W.K. Chiu The Chinese University of Hong Kong, Hong Kong E-mail address: [email protected]. Cees B.M. Oudejans VU University Medical Center, Amsterdam, The Netherlands E-mail address: [email protected].
Contents lists available at ScienceDirect
Clinical Biochemistry journal homepage: www.elsevier.com/locate/clinbiochem
Editorial
Circulating Nucleic Acids Special Issue
Since the tremendous success of the use of circulating (fetal) nucleic acids for the non-invasive diagnosis of fetal chromosomal aneuploidies, the use of circulating nucleic acids for other applications along with critical aspects of current applications has gained great interest. This special issue of Clinical Biochemistry gives an anthology of exemplary papers on preanalytical, methodological, and bioinformatic aspects in this field, the need for and use of quality controls, the use of targets other than DNA, and critical aspects that need to be considered for clinical implementation. Given the fact that circulating nucleic acids (CNA) have been detected in all bodily fluids, i.e. serum, plasma, spinal fluid, urine; and given the fact that all layers of biological and diagnostic information present in the genome i.e. DNA, RNA, noncoding RNA, methylated
RNA, can be detected using CNA, it can be predicted that this approach will become a diagnostic tool for many diseases, i.e. not only for prenatal diagnostics, but also cancer, neurodegenerative diseases, cardiovascular diseases, pregnancy-associated diseases and many more.
http://dx.doi.org/10.1016/j.clinbiochem.2015.08.021 0009-9120/© 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Rossa W.K. Chiu The Chinese University of Hong Kong, Hong Kong E-mail address: [email protected]. Cees B.M. Oudejans VU University Medical Center, Amsterdam, The Netherlands E-mail address: [email protected].