Clinical and Applied Immunology Reviews AIMS and SCOPE Clinical and Applied Immunology Reviews (CAIR) presents timely peer reviewed articles in “mini review” and full length review format on all aspects of the immune system in healthy subjects and patients; the indications and interpretation of testing; the development and evaluation of new immunological procedures and regulatory issues related to the development of clinical tests and the management and accreditation of diagnostic laboratories. A focus of CAIR is “bench to bedside” or how discoveries in basic immunology have or will lead to improvements in the laboratory’s management of specific patient populations. Particularly, CAIR will cover: a) Discoveries in basic immunology and their potential relevance to the clinical and diagnostic immunology laboratory, including new cell surface markers, new components in cell signaling pathways, new cytokines, and chemokines and their receptors; b) The latest theories on the immune etiology,
immunopathogenesis and immunotherapy in HIV infection, cancer, autoimmunity and immunodeficiency; c) The latest advances in technology, including flow cytometry, molecular biology array technologies and automation, and development of new vaccines, adjuvants and novel immunotherapies; d) Recent developments in laboratory testing, including the evaluation of normal immunological parameters and functions, the diagnosis of specific infections and immune mediated diseases, and monitoring of disease activity and response to therapy; e) The development and the results of clinical trials, involving new vaccines or adjuvants, novel immunotherapy in cancer, immunodeficiency and HIV infection, and immune reconstitution following anti-retroviral therapy in HIV infection and in bone marrow transplantation; f) Clinical immunology case presentations which serve to highlight novel clinical immunology principles at the bench or the bedside.
Editor-in-Chief M.R.G. O’Gorman Northwestern University Medical School Children’s Memorial Hospital 2300 Children’s Plaza Chicago, IL 60614 E-mail:
[email protected] Editorial Board R.J. Ablin Park Ridge, NJ T. Alexander Akron, OH D. Askew Cincinnati, OH D. Asthana Miami, FL B. Autran Paris, France K. Beaman North Chicago, IL C. Lynne Burek Baltimore, MD B.H. Davis South Portland, ME Th.N. Denny Newark, NJ A.D. Donnenberg Pittsburgh, PA S.D. Douglas Philadelphia, PA M.A. Fletcher Miami, FL
J.D. Folds Chapel Hill, NC M. Golightly Stony Brook, NY M. Grant St. Johns, NF, Canada J.W. Gratama Rotterdam, The Netherlands H.A. Homburger Rochester, MN C.H. June Philadelphia, PA A.L. Landay Chicago, IL B.L. Myones Houston, TX R.M. Nakamura La Jolla, CA J. Oger Vancouver, BC, Canada L.M. Pachman Chicago, IL H.M.A. Paxton Baltimore, MD
S.F. Plaeger Bethesda, MD G. Rothe Regensburg, Germany R.F. Schell Madison, WI P.R. Scholl Chicago, IL J.L. Sever Washington, D.C. G.T. Stelzer Brentwood, TN R. Sutherland Toronto, ON, Canada J. Thomas Annapolis, MD G.K. Valet Martinsreid, Germany Y. Zhao Chicago, IL