- Email: [email protected]
Clinical and research utility of Alzheimer's biomarkers
Podium Presentations: Thursday, July 23, 2015
MCI into the framework. They will facilitate research into understanding NPS as a very early consequence of neurodegenerative disease in some cases, exploring targets for treatment and studying mechanisms of illness progression. The criteria will be subject to studies of reliability, concurrent validity, predictive validity and the development of biomarkers, ultimately leading to therapeutics.
P311
THURSDAY, JULY 23, 2015 ORAL SESSIONS O5-01 NEUROIMAGING: AMYLOID, TAU, AND THE AGING BRAIN O5-01-01
TAU AND AMYLOID DEPOSITS RELATE TO DISTINCTIVE CORTICAL ATROPHY PATTERNS IN COGNITIVELY NORMAL ELDERLY
Jorge Sepulcre1, Aaron P. Schultz2, Alex Becker3, Reisa A. Sperling4, Keith A. Johnson3, 1Harvard Medical School, Boston, MA, USA; 2 Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; 3Massachusetts General Hospital, Boston, MA, USA; 4Center for Alzheimer Research and Treatment, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. Contact e-mail: sepulcre@nmr. mgh.harvard.edu Background: Alzheimer’s disease neurodegeneration is a complex
phenomenon where misfolded amyloid-b (Ab) and Tau proteins accumulate in the human brain even decades before any cognitive manifestation. It has not been possible until recently to investigate in-vivo relationships of Tau, Ab, and atrophy. In this study, we aim to evaluate the brain spatial distribution of a novel PET Tau tracer –known as 18F-T807- and identify its association with Ab deposition and grey matter (GM) volume loss in a sample of cognitively normal participants in the Harvard Aging Brain Study. Methods: Eighty-eight subjects (mean age (SD): 76.2 (6.2), M/F: 39/49) underwent two PET imaging acquisitions and MRI. Using cerebellar grey reference, PiB PET data was expressed as DVR and T807 as SUVR. We used a voxel-based morphometry strategy to obtain the segmented GM volume maps of each individual. Finally, we used voxel-by-voxel regressions to investigate focal and distributed spatial correspondences between maps of 18F-T807, 11C-PiB and GM volume. Results: Tau deposits spatially correlate with in-situ atrophy in anterior medial and inferior temporal lobe areas (Figure A). Ab deposits and in-situ GM atrophy are spatially associated in a more widespread manner. We found negative spatial correlations
Table. THURSDAY, JULY 23, 2015 PLENARY SESSIONS PL-05 THURSDAY PLENARY PL-05-01
CLINICAL AND RESEARCH UTILITY OF ALZHEIMER’S BIOMARKERS
John C. Morris, Washington University School of Medicine, Knight Alzheimer’s Disease Research Center, St. Louis, MO, USA. Contact e-mail: [email protected]
Abstract not available. PL-05-02
OPEN CHALLENGES: REAL TIME DATA, NOVEL WAYS TO UNDERSTAND DEMENTIA
Stephen H. Friend, Sage Bionetworks, Seattle, WA, USA. Contact e-mail: [email protected]
Abstract not available.
Figure A.
MCI into the framework. They will facilitate research into understanding NPS as a very early consequence of neurodegenerative disease in some cases, exploring targets for treatment and studying mechanisms of illness progression. The criteria will be subject to studies of reliability, concurrent validity, predictive validity and the development of biomarkers, ultimately leading to therapeutics.
P311
THURSDAY, JULY 23, 2015 ORAL SESSIONS O5-01 NEUROIMAGING: AMYLOID, TAU, AND THE AGING BRAIN O5-01-01
TAU AND AMYLOID DEPOSITS RELATE TO DISTINCTIVE CORTICAL ATROPHY PATTERNS IN COGNITIVELY NORMAL ELDERLY
Jorge Sepulcre1, Aaron P. Schultz2, Alex Becker3, Reisa A. Sperling4, Keith A. Johnson3, 1Harvard Medical School, Boston, MA, USA; 2 Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; 3Massachusetts General Hospital, Boston, MA, USA; 4Center for Alzheimer Research and Treatment, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. Contact e-mail: sepulcre@nmr. mgh.harvard.edu Background: Alzheimer’s disease neurodegeneration is a complex
phenomenon where misfolded amyloid-b (Ab) and Tau proteins accumulate in the human brain even decades before any cognitive manifestation. It has not been possible until recently to investigate in-vivo relationships of Tau, Ab, and atrophy. In this study, we aim to evaluate the brain spatial distribution of a novel PET Tau tracer –known as 18F-T807- and identify its association with Ab deposition and grey matter (GM) volume loss in a sample of cognitively normal participants in the Harvard Aging Brain Study. Methods: Eighty-eight subjects (mean age (SD): 76.2 (6.2), M/F: 39/49) underwent two PET imaging acquisitions and MRI. Using cerebellar grey reference, PiB PET data was expressed as DVR and T807 as SUVR. We used a voxel-based morphometry strategy to obtain the segmented GM volume maps of each individual. Finally, we used voxel-by-voxel regressions to investigate focal and distributed spatial correspondences between maps of 18F-T807, 11C-PiB and GM volume. Results: Tau deposits spatially correlate with in-situ atrophy in anterior medial and inferior temporal lobe areas (Figure A). Ab deposits and in-situ GM atrophy are spatially associated in a more widespread manner. We found negative spatial correlations
Table. THURSDAY, JULY 23, 2015 PLENARY SESSIONS PL-05 THURSDAY PLENARY PL-05-01
CLINICAL AND RESEARCH UTILITY OF ALZHEIMER’S BIOMARKERS
John C. Morris, Washington University School of Medicine, Knight Alzheimer’s Disease Research Center, St. Louis, MO, USA. Contact e-mail: [email protected]
Abstract not available. PL-05-02
OPEN CHALLENGES: REAL TIME DATA, NOVEL WAYS TO UNDERSTAND DEMENTIA
Stephen H. Friend, Sage Bionetworks, Seattle, WA, USA. Contact e-mail: [email protected]
Abstract not available.
Figure A.