- Email: [email protected]
Clinical behavior of HPV-negative and HPV-positive vulvar cancers
Letters to the Editor
Sigrid Regauer Institute of Pathology, Medical University Graz, 8036 Graz, Austria Corresponding author at: Institute of Pathology, Reference Centre for Anogenital Diseases, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, Austria. Fax: +43 316 38 43 29. E-mail address: [email protected]. Olaf Reich Department of Gynecology, Medical University Graz, 8036 Graz, Austria 10 May 2013 http://dx.doi.org10.1016/j.ygyno.2013.05.041
Clinical behavior of HPV-negative and HPV-positive vulvar cancers
To the Editor: We thank the authors for their interest in our paper. They pose a conceptually interesting and potentially practice-changing question. Regrettably, our retrospective review did not include information on the etiology of the carcinomatous vulvar lesions. HPV testing of vulvar cancers is not routine at our institution, and the presence of lichen sclerosus was not documented consistently enough to allow confident
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conclusions about the risk of recurrence or the possible benefits of treatment of lichen sclerosus with topical steroids. One of our inclusion criteria was the presence of invasive cancer, and we have no data relevant to the authors' discussion of management of VIN. We believe our core conclusion: that women with close but clear margins can be managed expectantly. We did suggest that further prospective research is needed, and the authors' suggestions and ongoing research are one of those possible avenues. We look forward to the release of the manuscript that the authors mentioned describing the clinical course of HPV-negative vulvar cancers. Conflict of interest statement The authors declare that there are no conflicts of interest to report.
Yevgeniya J. Ioffe⁎ L. Stewart Massad Washington University in St Louis School of Medicine, Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, USA E-mail address: [email protected] (Y.J. Ioffe). ⁎Corresponding author at: 660 S. Euclid Ave, 4th floor Maternity Building, St Louis, MO 63110, USA. Fax: +1 314 362 2893. 24 June 2013
http://dx.doi.org/10.1016/j.ygyno.2013.06.040
Sigrid Regauer Institute of Pathology, Medical University Graz, 8036 Graz, Austria Corresponding author at: Institute of Pathology, Reference Centre for Anogenital Diseases, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, Austria. Fax: +43 316 38 43 29. E-mail address: [email protected]. Olaf Reich Department of Gynecology, Medical University Graz, 8036 Graz, Austria 10 May 2013 http://dx.doi.org10.1016/j.ygyno.2013.05.041
Clinical behavior of HPV-negative and HPV-positive vulvar cancers
To the Editor: We thank the authors for their interest in our paper. They pose a conceptually interesting and potentially practice-changing question. Regrettably, our retrospective review did not include information on the etiology of the carcinomatous vulvar lesions. HPV testing of vulvar cancers is not routine at our institution, and the presence of lichen sclerosus was not documented consistently enough to allow confident
247
conclusions about the risk of recurrence or the possible benefits of treatment of lichen sclerosus with topical steroids. One of our inclusion criteria was the presence of invasive cancer, and we have no data relevant to the authors' discussion of management of VIN. We believe our core conclusion: that women with close but clear margins can be managed expectantly. We did suggest that further prospective research is needed, and the authors' suggestions and ongoing research are one of those possible avenues. We look forward to the release of the manuscript that the authors mentioned describing the clinical course of HPV-negative vulvar cancers. Conflict of interest statement The authors declare that there are no conflicts of interest to report.
Yevgeniya J. Ioffe⁎ L. Stewart Massad Washington University in St Louis School of Medicine, Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, USA E-mail address: [email protected] (Y.J. Ioffe). ⁎Corresponding author at: 660 S. Euclid Ave, 4th floor Maternity Building, St Louis, MO 63110, USA. Fax: +1 314 362 2893. 24 June 2013
http://dx.doi.org/10.1016/j.ygyno.2013.06.040