- Email: [email protected]
Clinical Characteristics and Psychological Associations of Cancer Chemotherapy–Related Side Effects in Patients with Lung Cancer
Annals of Oncology 25 (Supplement 4): iv481–iv485, 2014 doi:10.1093/annonc/mdu352.15
psycho-oncology 1384P
CLINICAL CHARACTERISTICS AND PSYCHOLOGICAL ASSOCIATIONS OF CANCER CHEMOTHERAPY–RELATED SIDE EFFECTS IN PATIENTS WITH LUNG CANCER
abstracts
Aim: Psychological distress and chemotherapy-related side effects frequently co-occur in patients with lung cancer (LC). Clinical experience suggests that LC is associated with psychological distress that may contribute to worse chemotherapy-related side effects. Using questionnaires, we tried to describe clinical characteristics of psychological distress and chemotherapy-related side effects, and to examine the influence of psychological distress on side effects among LC patients during chemotherapy.
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_4/iv485/2242075 by guest on 25 October 2019
M.M. Li1, X. Lou2, Y. Zhou3, L. Zhou4 1 Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, CHINA 2 Department of Nursing Psychology, West China Hospital, Chengdu, CHINA 3 Department of Preventive Medicine, West China School of Public Health, Chengdu, CHINA 4 Department of Thoracic Cancer, Cancer Center, West China Hospital of Sichuan University, Chengdu, CHINA
Methods: Patients with LC receiving chemotherapy completed an assessment that captured clinical characteristics, psychological state (anxiety, depression and insomnia) and treatment-related side effects (nausea, vomiting, constipation and fatigue). Psychological distress was assessed by Hospital Anxiety and Depression Scale and by Pittsburgh Sleep Quality Index (PSQI). Nausea, vomiting and constipation were examined as defined by the National Cancer Institute Common Terminology Criteria for Adverse Events, while fatigue was scored on a 10-point scale ranging from 0 =“not present” to 10 = “as bad as you can imagine”. Results: In total, 93 patients with a mean age of 58 years joined this study. Grade 0 to 3 toxicity occurred in 100% of the patients. Patients with LC who were younger than 58 years, female, retired from work, and had less medical insurance were significantly likely to experience more severe vomiting ( p = 0.018), constipation ( p = 0.004), fatigue ( p = 0.004) and nausea ( p = 0.047). On the other side, patients with LC who were female, had poor living conditions, and retired from work were significantly likely to experience more severe insomnia ( p = 0.014), anxiety and depression ( p = 0.030 and p = 0.004 respectively) and insomnia ( p = 0.002). Those with more severe depression complaints had significantly more vomiting ( p = 0.035), while those with more severe anxiety and insomnia complaints had significantly more fatigue ( p = 0.038 and p = 0.000 respectively). Conclusions: Psychological distress is a prevalent problem in LC and it was associated with an increased treatment-related side effect during chemotherapy. Improving psychological health can be a possible solution to decrease chemotherapy-related side effects so that may reduce treatment interruptions, improve the cure rate and increase quality of life following treatment. Disclosure: All authors have declared no conflicts of interest.
© European Society for Medical Oncology 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].
psycho-oncology 1384P
CLINICAL CHARACTERISTICS AND PSYCHOLOGICAL ASSOCIATIONS OF CANCER CHEMOTHERAPY–RELATED SIDE EFFECTS IN PATIENTS WITH LUNG CANCER
abstracts
Aim: Psychological distress and chemotherapy-related side effects frequently co-occur in patients with lung cancer (LC). Clinical experience suggests that LC is associated with psychological distress that may contribute to worse chemotherapy-related side effects. Using questionnaires, we tried to describe clinical characteristics of psychological distress and chemotherapy-related side effects, and to examine the influence of psychological distress on side effects among LC patients during chemotherapy.
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_4/iv485/2242075 by guest on 25 October 2019
M.M. Li1, X. Lou2, Y. Zhou3, L. Zhou4 1 Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, CHINA 2 Department of Nursing Psychology, West China Hospital, Chengdu, CHINA 3 Department of Preventive Medicine, West China School of Public Health, Chengdu, CHINA 4 Department of Thoracic Cancer, Cancer Center, West China Hospital of Sichuan University, Chengdu, CHINA
Methods: Patients with LC receiving chemotherapy completed an assessment that captured clinical characteristics, psychological state (anxiety, depression and insomnia) and treatment-related side effects (nausea, vomiting, constipation and fatigue). Psychological distress was assessed by Hospital Anxiety and Depression Scale and by Pittsburgh Sleep Quality Index (PSQI). Nausea, vomiting and constipation were examined as defined by the National Cancer Institute Common Terminology Criteria for Adverse Events, while fatigue was scored on a 10-point scale ranging from 0 =“not present” to 10 = “as bad as you can imagine”. Results: In total, 93 patients with a mean age of 58 years joined this study. Grade 0 to 3 toxicity occurred in 100% of the patients. Patients with LC who were younger than 58 years, female, retired from work, and had less medical insurance were significantly likely to experience more severe vomiting ( p = 0.018), constipation ( p = 0.004), fatigue ( p = 0.004) and nausea ( p = 0.047). On the other side, patients with LC who were female, had poor living conditions, and retired from work were significantly likely to experience more severe insomnia ( p = 0.014), anxiety and depression ( p = 0.030 and p = 0.004 respectively) and insomnia ( p = 0.002). Those with more severe depression complaints had significantly more vomiting ( p = 0.035), while those with more severe anxiety and insomnia complaints had significantly more fatigue ( p = 0.038 and p = 0.000 respectively). Conclusions: Psychological distress is a prevalent problem in LC and it was associated with an increased treatment-related side effect during chemotherapy. Improving psychological health can be a possible solution to decrease chemotherapy-related side effects so that may reduce treatment interruptions, improve the cure rate and increase quality of life following treatment. Disclosure: All authors have declared no conflicts of interest.
© European Society for Medical Oncology 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].