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Clinical features of coinfection with TTV in hepatitis C virus–infected patients undergoing hemodialysis
June 2005
E95
Abstract ID 50464 Monday, June 20
Clinical features of coinfection with TTV in hepatitis C virus–infected patients undergoing hemodialysis B Hajarizadeh S Alavian Tehran Hepatitis Center, Tehran, Iran BACKGROUND: Transfusion-transmitted virus (TTV) was identified recently as a DNA virus associated with posttransfusion hepatitis. The significance of TTV in biochemical or histologic evidence of liver disease still remains uncertain. In this study, we investigated the frequency of TTV viremia in hepatitis C virus (HCV)–infected patients undergoing hemodialysis to determine weather TTV coinfection has any independent effect on liver enzymes abnormality. METHODS: We studied 37 HCV infected patients who were on dialysis in a dialysis center in Tehran, Iran. There were no other cofactors in patients to elevate the aminotransferase enzymes such as other kinds of hepatitis, hemochromatosis, sarcoidosis, history of recent MI, medications, etc. Sera were tested for TTV DNA by polymerase chain reaction (PCR). Alanine aminotransferase (ALT) level was measured for each patient on four continual occasions within 9 months, and the mean value was recorded in analysis. RESULTS: TTV DNA was detected in 7 patients (18.9%) who all had a prior history of transfusion. There were no significant differences in gender (p = 0.08), age (p = 0.36), and duration of dialysis (p = 0.38) between TTV positive and negative groups. Five patients (71.4%) of TTV positive patients had elevated ALT versus 19 patients (62.5%) in the other group. Therefore, ALT elevation didn’t differ significantly between TTV positive and negative patients (p = 1). CONCLUSIONS: This study suggests that TTV viremia doesn’t correlate with serum ALT elevation. If these patients are followed up continuously in future, it will be possible to determine weather TTV coinfection deteriorates hepatitis C course. Abstract ID 51839 Monday, June 20
Striking a balance between freedom and safety on a pediatric bone marrow transplant unit C Carriker J McDonald M Oden J Engemann K Kaye Duke University Medical Center BACKGROUND: The pediatric bone marrow transplant (BMT) unit at this university medical center is a 16-bed inpatient unit. From January 1 through March 19, 2004, 12 cases of adenovirus infection were identified on this unit. Ten of the 12 isolates were a single strain, suggesting nosocomial spread of the organism. METHODS: Cases were identified as patients with signs and symptoms of clinical illness and a positive culture for adenovirus. Medical records of all cases were reviewed. Infection control rounds, unit observations, and staff interviews were performed, and a multidisciplinary outbreak team was convened in order to identify potential factors contributing to the cluster of infections. RESULTS: Potential contributing factors identified included patient use of the unit’s lounge/playroom, patient/ family use of the unit’s washing machine, and suboptimal adherence to isolation and hand hygiene protocols. Prior
E95
Abstract ID 50464 Monday, June 20
Clinical features of coinfection with TTV in hepatitis C virus–infected patients undergoing hemodialysis B Hajarizadeh S Alavian Tehran Hepatitis Center, Tehran, Iran BACKGROUND: Transfusion-transmitted virus (TTV) was identified recently as a DNA virus associated with posttransfusion hepatitis. The significance of TTV in biochemical or histologic evidence of liver disease still remains uncertain. In this study, we investigated the frequency of TTV viremia in hepatitis C virus (HCV)–infected patients undergoing hemodialysis to determine weather TTV coinfection has any independent effect on liver enzymes abnormality. METHODS: We studied 37 HCV infected patients who were on dialysis in a dialysis center in Tehran, Iran. There were no other cofactors in patients to elevate the aminotransferase enzymes such as other kinds of hepatitis, hemochromatosis, sarcoidosis, history of recent MI, medications, etc. Sera were tested for TTV DNA by polymerase chain reaction (PCR). Alanine aminotransferase (ALT) level was measured for each patient on four continual occasions within 9 months, and the mean value was recorded in analysis. RESULTS: TTV DNA was detected in 7 patients (18.9%) who all had a prior history of transfusion. There were no significant differences in gender (p = 0.08), age (p = 0.36), and duration of dialysis (p = 0.38) between TTV positive and negative groups. Five patients (71.4%) of TTV positive patients had elevated ALT versus 19 patients (62.5%) in the other group. Therefore, ALT elevation didn’t differ significantly between TTV positive and negative patients (p = 1). CONCLUSIONS: This study suggests that TTV viremia doesn’t correlate with serum ALT elevation. If these patients are followed up continuously in future, it will be possible to determine weather TTV coinfection deteriorates hepatitis C course. Abstract ID 51839 Monday, June 20
Striking a balance between freedom and safety on a pediatric bone marrow transplant unit C Carriker J McDonald M Oden J Engemann K Kaye Duke University Medical Center BACKGROUND: The pediatric bone marrow transplant (BMT) unit at this university medical center is a 16-bed inpatient unit. From January 1 through March 19, 2004, 12 cases of adenovirus infection were identified on this unit. Ten of the 12 isolates were a single strain, suggesting nosocomial spread of the organism. METHODS: Cases were identified as patients with signs and symptoms of clinical illness and a positive culture for adenovirus. Medical records of all cases were reviewed. Infection control rounds, unit observations, and staff interviews were performed, and a multidisciplinary outbreak team was convened in order to identify potential factors contributing to the cluster of infections. RESULTS: Potential contributing factors identified included patient use of the unit’s lounge/playroom, patient/ family use of the unit’s washing machine, and suboptimal adherence to isolation and hand hygiene protocols. Prior