Clinical observation on hypophysectomized patients

911

ABSTRAOTS ftow during the coexisting 01' two suhsequent menstruations. Of ilarly treated except that the injections were administered on a tween the two menses, three experienced entirely new symptoms of and one other subject had an eight-rln.y period of spotting at the three- to four-day menstrual tlow.

five women sim!lay midway br· a painful nature, end of a normal

,J. THORXWELL WITHERSPOON.

Brochier, A.: The Use of Follicular Hormone in Premature Infants, Bull. Soc. d 'obst et de gynec. 23: 542, Hl34. Brochier systematically employed folliculin in doses of 1,000 International units in premature infants. Not one of the children so treated died, whereas premature infants of about the same weight and development anr1 born under the same conditions had a high inddence of death. A remarkable fart was that tlw infants treated with folheulin lost only a small amount of weight antl began to gain after the seeontl day. On the other hand, the untreated babies lost n g1·eat <1Pal of weight and di
Sure, J. H.:

Endocrine Headaches, WisconRin M. J. 33: 671, 1934.

The type of endocrine headaches varies. They may he periollkal, that is, preor postmenstrual, and are only occasionally continual. They may be hemieranial, temporal, parietal,, or oreipital. They may be ~uffident to incapacitate the patient, or may only be annoying. It is described as compressing or expanding. The author offers the following dassification as a eause for the headache: (1) Hypergonadism, (a) hyperestrinemia, (b) hyperprolanemia A; ( 2) hypogonadism, (a) hypoestrinemia, (b) hypoprolanemia A; (3) hypPr- and hypolutemia; (4) hyper- and hypoprolanemia B; ( 5) hypo· anll hyperthyroidism; ( 6) hyper- and hypopituitarism; ( 7) hyper- and hypoadrenalism. J. THORNWELL WI'l'HERRPOON. Skipp, W. M.:

Pituitary Headache, Endocrinology 18: 596, 1934.

Eleven patients suffering from pituitary headache (10 females and 1 male) were treated with posterior pituitary extract by mouth and subcutaneously, with disappearance of the heallaches. Pogterior lobe extract in tablet form was given orally and infundin hypodermically. The ea8e hi~tori('S of three of the patients are given in detail. Extracts of the anterior lobe were apparently without benefit. J. 'L'HOR!!'fWELL \VITHERSPOON.

Borovskaja, V. A.: Clinical Observation on Hypophysectomized Patients, Vestnik Bndocrinologii (Moskow) 4: 374, 1934. The author studying hypophysectomized patients found in all cases without exception extreme psychical slothfulness, somnolence, increasing corpulency, motor slow-

912

AMERICAN JOUR-"'AL OF OBSTETRICS AND CIYNECOLOClY

I!el:lS, and sharp decline of sexual ~ensitiveness. Return of vision i:; usually slight, in some cases vision was not restored. Headaches in the nmjority of easeB hecamP notieeably lessened. These cnm1•licat ions were treated wit it hypophyseal hormor~t•s, or continuous injections of Oravi,•lan (Sterile urine from t
•\LY:XAKJJRH ( ;.\lmU:Ll.\;>; /.,

Stern, D . .M.: The Zondek-Aschheim Test After Partial Hypophysectomy, Pro<.:. Roy. Soc. Med. London 27: 1501, 1931. In July, 1931, the then twenty·one-year-old patient was admitted for :;ign~ of acromegaly, bitemporal hemianopia of scotomatous type. l:lkiagram showed enlarged sella turcica. A :few days later '" large part of the anterior pituitary budy was extirpated, an adenomatouo grow! h. A year later she married, and in :Septemi.Jer, 193:l, n•alized that she wa~ pregnant. The Aschheim-Zondek reaction was fuurHI positive. Mhe passed through n normal pregnancy and was delivered in January, lt133, of a 7V:!-]JOUn.d nornml baby. The concentration of gonadotropic honnones was dl'tinitPly IJelovv normal. The reaction was negative six weeks po8tpartum. It renmins an open question whether these hormones were olerived from tltt' small fragment of remaining anterior pituitary body or hl!<1 8ollli' ot Iter ~oun·•·, "llt:h a~ embryonic trophoblast.

Arapo1f, D. A.: Homotransplantation, as a Method of Treatment of Endocrinopathies, Vcstnik Endoerinologii (.Mo0lww) 4: 439, 19iH. ln the treatment of certain endocrinopathies (such a~ ~ who had died from accidents. Glands we1·e taken from the corpse one to six huurs after death, were preserved in physiologic saline solution and kept on ice, until tlw re~ sults from iVassermann reaction >H're known. Glands wl'rl' implanted in ~uu· cutaneous tissue of abdomen or Jneast. In Jifteen cases of transplantation of testicle the method o£ Yoronoff was used. Permissimt for rwrforming tlw auto1>sy for the remontl of required gland~ \Yl!S granted hy the Prose<·uting Attornt·y in

1931. }'or transplantation of the hypophysis tlte gland of calf en1bryo, pig, and goat was used. 1'he human hypophysis was difficult to renwve. faym·able results were obtained with thyroid gland implant~.

,;heep,

'l'he moHt

Allen, E., Gardner, W. V., and Diddle, A. W.: Experiments with Theelin and Galactin on Growth and Function of the Mammary Glands of the Monkey, Endocrinology 19: 305, 1935. Ten Macacus monkeys weighing from i:,;Jl1.3 to ti,O?io gm. and at various stages of sexual maturity were injected with gnladin, or prolactin, with or without previous theelin treatment. Laetation was induee<:l in four mature animals anti in one animal just reaching sexual maturity, following the injections of six to nine rabbit units of galactin or prolactin. Three of the matur<' animals possesserl onp