Clinical research for treatment of ossifying fibroma in the jaws of children

290 (WGCNA). Differentially expressed lncRNAs were verified in OCs tissues (n = 45) using quantitative reverse transcriptasepolymerase chain reaction (qRT-PCR) and further confirmed in another patient cohort (n = 103) by in situ hybridisation. The effects of lncRNA on cell migration and invasion were assessed by knockdown or knock-in in vitro. Results: A total of 815 lncRNAs and 1783 mRNA were differentially expressed between OC tissues and non-tumour tissues. WGCNA showed that one co-expression network was significantly enriched for epithelial cell differentiation, among which, tissue differentiation-inducing non-protein coding RNA (TINCR) was significantly downregulated. Both PCR and ISH analyses validated down-regulation of TINCR in tumour tissues compared with controls. TINCR expression was associated with tumour size, differentiation, lymph metastasis status, and clinical stage in patients with OCs. TINCR low patients had a poorer survival. COX regression analysis showed that TINCR can be served as an independent prognostic factor for patients with OCs. More, upregulation of TINCR dramatically suppressed cell migration and invasion. Knockdown of TINCR enhanced cell migration contrarily. Conclusion: Our study suggests that downregulation of TINCR plays a role in OCs progression, at least partially, by regulating epithelial differentiation-associated genes. http://dx.doi.org/10.1016/j.ijom.2017.02.975 Clinical research for treatment of ossifying fibroma in the jaws of children Y. Liu ∗ , X.F. Shan, L. Zhang, Z.G. Cai Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China Background: A high recurrence rate of ossifying fibroma (OF) in the jaws of children has been noticed by surgeons. It must be treated properly for children’s physical and mental health. Objectives: To evaluate recurrence rate of different surgical methods of OF in the jaws of children. Methods: A retrospective study was carried out for patients below the age of 18 years with ossifying fibroma of the jaws treated in Department of Oral and Maxillofacial surgery, Peking University School and Hospital of Stomatology, China between 1991 and 2016. Patients with complete clinical, pathological, radiological and follow-up data were selected. Recurrence rates of different surgical methods were compared. Findings: 44 patients met the selection criteria comprising of 30 males and 14 females. The age ranged 3–18 years with a medium age of 11 years. 20 cases were located in the mandible and 23 in the maxilla. One was multiple OFs in both jaws. Forty patients were subjected to surgical treatment. Seven cases got curettage, 8 cases got local excision and 25 cases got extended resection. Ten of them relapsed with the recurrence rate of 25%. The recurrence rate of curettage was 71.4% (5/7), and 50% (4/8) for local excision. As for extended resection, it was 4% (1/25). Different jaws were also different, 33.3% (7/21) in maxilla and 15.8% (3/19) in mandible. Conclusions: The recurrence rate of extended resection for OF in the jaw of children was lower than local excision and curettage. OF occurred in maxilla was easier to relapse than in mandible. http://dx.doi.org/10.1016/j.ijom.2017.02.976

Chondrosarcoma in the head and neck region: a retrospective analysis of the clinicopathological features and treatment outcomes from a single-institute database Z.Q. Liu ∗ , Z. Tian, Z.H. Ren, R. Yang, W. Cao, T. Ji Ninth People’s Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, China Objective: Head and neck chondrosarcomas are rare, and their clinical outcomes are not well understood. The aim of this study was to identify the factors that influenced the prognoses of 38 head and neck chondrosarcoma cases from a single institution. Methods: Data from the patients who were treated for head and neck chondrosarcomas in the Oral and Maxillofacial Department of Head and Neck Oncology from 2005 to 2015 were retrieved for the study. The overall survival (OS) and disease-free survival (DFS) were analysed in terms of demographic, histological and therapeutic factors. Results: A total of 38 patients were treated in the defined time period, including 11 male and 27 female patients. The median age at presentation was 36.5 years, with a mean of 39.4 ± 17.33. The median follow-up period was 58 months, with a mean of 50.08 ± 32.08 months. The Kaplan–Meier (KM) curves of the OS according to the grades of the conventional tumours revealed borderline significance (P = 0.056) with the best survival among the patients with grade I tumours. The patients with mandibular tumours exhibited significantly better survival than did those with maxillary-skull base tumours (P = 0.046). Conclusion: Tumours occurring in the maxilla and skull base region exhibited worse prognoses than did those in the mandibular region. Moreover, the grade I conventional chondrosarcomas were associated with better survival than were the other conventional chondrosarcomas. http://dx.doi.org/10.1016/j.ijom.2017.02.977 Resection of benign parapharyngeal and deep parotid tumours: do we need to split the mandible for access? S. Mattine ∗ , B. Edwards Worcester Royal Hospital, Worcester, United Kingdom Background: Most small tumours of the deep parotid lobe can be resected adequately through transcervical/retromandibular approach. However, additional access procedures such as lip-split mandibulotomy or inverted L osteotomy have been recommended for removal of larger deep parotid and parapharyngeal tumours. These access procedures are associated with significantly higher incidence of complications and morbidity. Methods: We present our initial review of nine patients presenting with large deep parotid, parapharyngeal and skull bases tumours, where the tumour was resected through only a transcervical/retromandibular approach without splitting the mandible. Results: Complete excision of tumours was achieved in all nine patients. Conclusions: We demonstrate that resection of large benign tumours of deep parotid, parapharyngeal and some skull base area can be achieved adequately through a transcervical approach alone, avoiding additional access procedures requiring splitting