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Clinical significance of ploidy in carcinoma of the cervix
Volume 87 Number 2
Selected abstracts
usually rather sudden. Paracervical block may be repeated as many times as necessary with no loss of effectiveness. Forceps deliveries, inspection and repair of the cervix and vagina, manual removal of the placenta, and exploration of the uterus can be done easily without distress to the patient. In consultation, the authors did one version and breech extraction of a delayed second twin with a prolapse arm from a well contracted uterus. This was done slowly and easily without distress to the patient. The authors have also done several emergency dilatations and curettages for incomplete abortions, and hemorrhage, using combined paracervical and pudendal block when a recent meal precluded safe general anesthesia. These patients denied any distress or discomfort. Stuart 0. Silverberg.
British Medical Journal No. 5316. *Fessas, Ph., Doxiadis, S. A., and Valaes, T.: Neonatal Jaundice in Glucose-6-Phosphate-Dehydrogenase-Deficient Infants, P· ~
1Qh.tl tJJ.J,
No. 5317, December, 1962. ·*Atkin, N. B., and Richards, B. M.: Clinical Significance of Ploidy in Carcinoma of the Cervix: Its Relation to Prognosis, p. 1445.
Fessas, Doxiadis, and Valaes: Neonatal jaundice in Glucose-6-Phosphate-DehydrogenaseDeficient Infants, p. 1359. The incidence of deficiency of glucose-6-phosphate-dehydrogenase ( G-6-PD) among 786 ran-
287
domly selected newborn males at the Alexandra Maternity Hospital was 2.92 per cent. Only one of the 2 i neonates with G-6-PD deficiency and no other cause for hemolysis demonstrated marked jaundice. Among 43 male siblings of infants with the enzyme deficiency and severe neonatal hyperbilirubinemia there were 11 cases of severe jaundice. It is concluded that an additional genetic factor must be present to explain the development of severe neonatal jaundice in G-6-PD deficient babies. Edward E. Wallach
Atkin and Richards: Clinical Significance of Ploidy in Carcinoma of the Cervix, p. 1445. The relationship between ploidy, as determined by the DNA content and nuclear size and thf' clinical course of 224 patients with cervical carcinoma treated with radiotherapy was studied. Two types of chromosomal changes are recognizable in human tumor cells: ( 1) numerical or structural changes involving chromosomes, and ( 2) a change to the tetraploid state. The over-all figures suggest a highly significant difference in the cure rate in favor of the tetraploid group. That this phenomenon may be due to a biologic difference between the two groups of cells rather than to differences in radiosensitivity is suggested by the more favorable cure rate for th<' tetraploid group when treated surgically. Variation of ploidy may occur in some tumors, however, having both diploid and tetraploid cells in a mixture. Edward E. Wallach
Selected abstracts
usually rather sudden. Paracervical block may be repeated as many times as necessary with no loss of effectiveness. Forceps deliveries, inspection and repair of the cervix and vagina, manual removal of the placenta, and exploration of the uterus can be done easily without distress to the patient. In consultation, the authors did one version and breech extraction of a delayed second twin with a prolapse arm from a well contracted uterus. This was done slowly and easily without distress to the patient. The authors have also done several emergency dilatations and curettages for incomplete abortions, and hemorrhage, using combined paracervical and pudendal block when a recent meal precluded safe general anesthesia. These patients denied any distress or discomfort. Stuart 0. Silverberg.
British Medical Journal No. 5316. *Fessas, Ph., Doxiadis, S. A., and Valaes, T.: Neonatal Jaundice in Glucose-6-Phosphate-Dehydrogenase-Deficient Infants, P· ~
1Qh.tl tJJ.J,
No. 5317, December, 1962. ·*Atkin, N. B., and Richards, B. M.: Clinical Significance of Ploidy in Carcinoma of the Cervix: Its Relation to Prognosis, p. 1445.
Fessas, Doxiadis, and Valaes: Neonatal jaundice in Glucose-6-Phosphate-DehydrogenaseDeficient Infants, p. 1359. The incidence of deficiency of glucose-6-phosphate-dehydrogenase ( G-6-PD) among 786 ran-
287
domly selected newborn males at the Alexandra Maternity Hospital was 2.92 per cent. Only one of the 2 i neonates with G-6-PD deficiency and no other cause for hemolysis demonstrated marked jaundice. Among 43 male siblings of infants with the enzyme deficiency and severe neonatal hyperbilirubinemia there were 11 cases of severe jaundice. It is concluded that an additional genetic factor must be present to explain the development of severe neonatal jaundice in G-6-PD deficient babies. Edward E. Wallach
Atkin and Richards: Clinical Significance of Ploidy in Carcinoma of the Cervix, p. 1445. The relationship between ploidy, as determined by the DNA content and nuclear size and thf' clinical course of 224 patients with cervical carcinoma treated with radiotherapy was studied. Two types of chromosomal changes are recognizable in human tumor cells: ( 1) numerical or structural changes involving chromosomes, and ( 2) a change to the tetraploid state. The over-all figures suggest a highly significant difference in the cure rate in favor of the tetraploid group. That this phenomenon may be due to a biologic difference between the two groups of cells rather than to differences in radiosensitivity is suggested by the more favorable cure rate for th<' tetraploid group when treated surgically. Variation of ploidy may occur in some tumors, however, having both diploid and tetraploid cells in a mixture. Edward E. Wallach