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CLINICAL STATUS AND PULMONARY FUNCTION (PF) IN CHRONIC (>30 YEARS) ASTHMATICS
October 2007, Vol 132, No. 4_MeetingAbstracts
Abstract: Poster Presentations | October 2007
CLINICAL STATUS AND PULMONARY FUNCTION (PF) IN CHRONIC (>30 YEARS) ASTHMATICS Zinobia Khan, MD*; Albert Miller, MD, FCCP.; Kyungmee Kim, MD; Anthony Mastellone, MD; Moses Bachan, MD Caritas mary Immaculate Hospital, Jamaica, NY
Chest. 2007;132(4_MeetingAbstracts):507. doi:10.1378/chest.132.4_MeetingAbstracts.507
Abstract PURPOSE: Asthma is the most common chronic lung disease. We have characterized clinical status and PF in chronic patients compared to those of lesser duration. METHODS: Chronic >=30 years, control =10–15 years duration. All patients were non-smokers/ smoked < 10pack year (quit >30 years) and no other lung disease. Data obtained: gender, age, BMI, FEV1, FEV1% predicted pre and postbronchodilator(BD), FVC, FEV1/FVC, DLCO, BD and inhaled corticosteroid (ICS) usage. Definition: change in serial studies as >150 mL for FEV1, >10% for DLCO, FEV1/FVC greater of pre or post BD. RESULTS: Chronic group=64 patients (47 females). Mean age 54, 14 > 65 years, 16 <40. 35 obese, 14 morbidly; 22 overweight. For DLCO: 32 >80, 26 =60 –80, 6 <60. Of these 6, age 62 to 79, FEV1/FVC normal in 5. 26 patients >1 studies. Of these, 10 had a change in DLCO unrelated to change in FEV1. For FEV1/FVC: 42 >70%, 12 =60 −70, 8 =50–60, 2 <50. For FEV1%: 11 >80%, 26 =60–80, 27 <60. 98% used BD+ICS. Control group=29 patients (14 females). Mean age 33, 3 > 65 years, 25 <40. 9 obese, 3 morbidly; 7 overweight. For DLCO: 18 >80, 11 =60–80, none <60. For FEV1/FVC: 25 >70%, none =60–70, 3 =50–60, 1 <50. For FEV1%: 15 >80%, 8 =60–80, 6 <60. 62% used BD. CONCLUSION: In this inner city community hospital, a typical chronic asthmatic uses BD/ICS, has 75% chance of being female, 90% being overweight/obese, 50% having mild/severe reduction in DLCO. A change in DLCO is not associated with a consistent change in FEV1. In both groups there was a similar frequency of mild/moderate decrease in DLCO but a severe decrease was seen only in the chronic group (10%). Of these 6 patients only one had a reduced FEV1/FVC. CLINICAL IMPLICATIONS: A chronic asthmatic is likely: obese, female, 50%chance of low DLCO. Severe decrease in DLCO was seen only in the chronic group; these were older and did not show obvious airways obstruction. DISCLOSURE: Zinobia Khan, None.
Wednesday, October 24, 2007 12:30 PM - 2:00 PM
Abstract: Poster Presentations | October 2007
CLINICAL STATUS AND PULMONARY FUNCTION (PF) IN CHRONIC (>30 YEARS) ASTHMATICS Zinobia Khan, MD*; Albert Miller, MD, FCCP.; Kyungmee Kim, MD; Anthony Mastellone, MD; Moses Bachan, MD Caritas mary Immaculate Hospital, Jamaica, NY
Chest. 2007;132(4_MeetingAbstracts):507. doi:10.1378/chest.132.4_MeetingAbstracts.507
Abstract PURPOSE: Asthma is the most common chronic lung disease. We have characterized clinical status and PF in chronic patients compared to those of lesser duration. METHODS: Chronic >=30 years, control =10–15 years duration. All patients were non-smokers/ smoked < 10pack year (quit >30 years) and no other lung disease. Data obtained: gender, age, BMI, FEV1, FEV1% predicted pre and postbronchodilator(BD), FVC, FEV1/FVC, DLCO, BD and inhaled corticosteroid (ICS) usage. Definition: change in serial studies as >150 mL for FEV1, >10% for DLCO, FEV1/FVC greater of pre or post BD. RESULTS: Chronic group=64 patients (47 females). Mean age 54, 14 > 65 years, 16 <40. 35 obese, 14 morbidly; 22 overweight. For DLCO: 32 >80, 26 =60 –80, 6 <60. Of these 6, age 62 to 79, FEV1/FVC normal in 5. 26 patients >1 studies. Of these, 10 had a change in DLCO unrelated to change in FEV1. For FEV1/FVC: 42 >70%, 12 =60 −70, 8 =50–60, 2 <50. For FEV1%: 11 >80%, 26 =60–80, 27 <60. 98% used BD+ICS. Control group=29 patients (14 females). Mean age 33, 3 > 65 years, 25 <40. 9 obese, 3 morbidly; 7 overweight. For DLCO: 18 >80, 11 =60–80, none <60. For FEV1/FVC: 25 >70%, none =60–70, 3 =50–60, 1 <50. For FEV1%: 15 >80%, 8 =60–80, 6 <60. 62% used BD. CONCLUSION: In this inner city community hospital, a typical chronic asthmatic uses BD/ICS, has 75% chance of being female, 90% being overweight/obese, 50% having mild/severe reduction in DLCO. A change in DLCO is not associated with a consistent change in FEV1. In both groups there was a similar frequency of mild/moderate decrease in DLCO but a severe decrease was seen only in the chronic group (10%). Of these 6 patients only one had a reduced FEV1/FVC. CLINICAL IMPLICATIONS: A chronic asthmatic is likely: obese, female, 50%chance of low DLCO. Severe decrease in DLCO was seen only in the chronic group; these were older and did not show obvious airways obstruction. DISCLOSURE: Zinobia Khan, None.
Wednesday, October 24, 2007 12:30 PM - 2:00 PM