- Email: [email protected]
Clinical usefulness of subtraction CT scan image for lung cancer therapy
63 226 USE OF THE MAB 3F8 IN IMAGING SMALL-CELL LUNG CARCINOMA. SC Grant, L Kostakoglu, MG Krii, KMW Pisters, SDJ Yeh, SM Larson, RD Finn, NKV Cheung. Memorial Sloan-Kettering Cancer Center, New York, USA 3F8 is a mouse IgG, monoclonal antibody (MAb) specific for the disiilogangliiside GDZ.3F8 activates complement and is actiie in antibody dependant cellular cytotoxicii. Small cell lung cancer (SCLC) specimens studied by immunohistochemistry as well as SCLC cell lines have been strongly positive for GD~. An imaging study has been undertaken in SCLC patients (pts) using 9labelled MAb 3F8. A dose of 3F8 labelled with 2-10 mCi 131l/1.73m2 was injected. To date, two untreated pts, prior to the initiation of therapy, and seven previously treated pts have been studied. All had mediastinal or pulmonary parenchymal tumors. One had SCLC involvement of the femur and one had cervical lymph node and diffuse liver involvement. Scans were performed at 24,48,72 hours and at 7 days. Optimal images were obtained from 48 hours to 7 days after infusion. Radiolocaliiation to sites of disease was assessed. In all pts 3F8 scans were positive for intrathoracic tumors as well as all sites of extrathoracic disease detected by identified by chest x-ray, CT scans and radionucleotide scans. One pt had a nodule biopsied 72 hours post-infusion. Measured radioactivity in this tumor was twii that of surrounding tissue. Plasma pharmacokinetics were studied in five pts. Plasma t.&was - 18 hours. Antimouse antibody responses were measured. No toxicity was seen. We conclude a)3F8 localizes to sites of disease in SCLC A tie b) No toxicity has been observed c)The therapeutic role of MAb 3F8 in SCLC should be studied. The trial continues. Supported by Genetics Institute, Inc. & NIH Grant CA-091 49-l 5.
227 Clinical usefulness of subtraction image for lung cancer therapy S. ) T. K&o’ Naka~o~~L~~~~.~,~g~:::‘ ,,
CT
scan
N. Ohnuma l), H. Nomura’).
The First Departmentof InternalMedicine,Dokkyo University Schoolof Medicine, Tochlgi, Japan 2) Daiichiseiyaku CO. Ltd.Tokyo, Japan 1)
Purpose : The effectivemess of lung cancer therapy has been usually estimated chiefly comparing sizes of mass on chest X-ray films or CT scan images before and after therapy. But lung cancer is abundant in feeding vessels and the vascular permeability of those vessels increase irrespective tumor size. This time. we made an attempt to supplement the method of estimation of the effectiveness of lung cancer therapy by addmg assessment of vascular permeability of tumorous blood vessel by subtraction CT scan image. Subjects and Methods : In 7 patients wth lung cancer, at a slice level corresponding to tumor mass area on chest X-ray films. dynamic CT scanning was done during injection of 1001111 contrast medium (Iohexol 140) before and after therapy. Then, subtraction CT scan Images were obtained from the usual images. By comparing the two subtraction CT scan images obtained before and after therapy, the size and the vascular permeability of tumors were investigated. Results and Conclusion : The accuracy in estimating the changes of tumor size brought about the therapy could be increased by subtraction CT scan image. Furthermore, the permeability of tumor feeding vessels could be assessed by this method even in small masses. Prognosis of patients with highly increased permeability in tumor feeding vessels depicted by subtractions CT scan image was poor in spite of small tumor size. Subtraction CT scan image was useful for the accurate estimating of tumor size. The assessment of the tumorous feeding vessels made possible by this method could enrich the Information of tumor.
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lMMUNO8CiNllGRAPHY IN 8MALL CELL LUNG CANCER (8CLC):amcusexsnqafttumorstudywkh8GlMdb. H.B. KM, N. van Zandwfjk, CA. Hosfnsgsl, R. Valdes Dlmos. R.J.A.M. Mlchalldes,J. Hllkens. The Netherlands Cancer Institute Anton1van LeeuwenhoskHuls, Amsterdam.the Netherlands.
Diagnosis of mediastinal lymph node metastasis of lung cancer with Positron Emission Tomography using IlC-methionine Hidekl Miyazawa, Takashi Arai, Keizou Inagaki Takatomo Morita, Makoto Yano. Nakano National Chest Hospital, Tokyo, JAPAN.
MoAbs devsloped agsinst SClC have besn dMdsd Into 5 groups (dusters) [I]. Cluster 1 (SGI) antibodiesare dirscted agslnst Neural Cdl Adhesion Mdecule (N-CAM). N-CAM ls found In neurosndocrins tumors and several lxwmal tissues [2]. One of thess antlbodles, namely 123C3, hss bsen exten&ely studlsd In lmmunohlst~mlcal studies [3]. This MoAb v a high affinityfor the msd antigen In In vitro tests (K,: 1.04 10 /M). We hsve studled 123C3 In a mcuss imaging study,,,uslng a H89 rnouss xenograft tumor model. After labelllng with I 123C3 was Injected In nude mics carrying SCLC xenografts with a dlsmeter varying from 5 to 10 mm. Excellent lmsgss were achieved at 7 days after Injection. Detemlnstlon of tlssus counts showed thst hlgh tumor tissus ratios (varyingfrom + 3.98 for blood to + BO for bone) wers achisved and a slgnlfkant fmctlon of ths Injected dose (13.96%) was retalnsd In the tumor. Thess results certainlywsrrant further study In humans. Currently a dlnical study Is carded out In 8CLC patlsnts. 1. Bwerty P.C.L, et al. Lung Cancer 1988 (4): 15-X. 2. Patsl K., el al. Int. J. Cancer 1989 (44): 573-578. 3. 8chd D.J., et al. Int. J. Cancer 1988 (43 [email protected]): 34-40.
Positron emission tomography (PET) using IIC-methionine is useful for the diagnosis of lung cancer. We examined whether it has a capability for the diagnosis of mediastinal lymph node metastasis from primary lung cancer. We used respirationated scan, positron angiography and DAR ?Deferential absorption ratio) to obtain a semiquantitative value. Eighteen patients were studied using PET and CT before undergoing an operation. The results were compared with pathological findings of the dissected nodes. The anatomical location of the mediastinal lymph nodes were correctly visualized. There was a significant difference (p
227 Clinical usefulness of subtraction image for lung cancer therapy S. ) T. K&o’ Naka~o~~L~~~~.~,~g~:::‘ ,,
CT
scan
N. Ohnuma l), H. Nomura’).
The First Departmentof InternalMedicine,Dokkyo University Schoolof Medicine, Tochlgi, Japan 2) Daiichiseiyaku CO. Ltd.Tokyo, Japan 1)
Purpose : The effectivemess of lung cancer therapy has been usually estimated chiefly comparing sizes of mass on chest X-ray films or CT scan images before and after therapy. But lung cancer is abundant in feeding vessels and the vascular permeability of those vessels increase irrespective tumor size. This time. we made an attempt to supplement the method of estimation of the effectiveness of lung cancer therapy by addmg assessment of vascular permeability of tumorous blood vessel by subtraction CT scan image. Subjects and Methods : In 7 patients wth lung cancer, at a slice level corresponding to tumor mass area on chest X-ray films. dynamic CT scanning was done during injection of 1001111 contrast medium (Iohexol 140) before and after therapy. Then, subtraction CT scan Images were obtained from the usual images. By comparing the two subtraction CT scan images obtained before and after therapy, the size and the vascular permeability of tumors were investigated. Results and Conclusion : The accuracy in estimating the changes of tumor size brought about the therapy could be increased by subtraction CT scan image. Furthermore, the permeability of tumor feeding vessels could be assessed by this method even in small masses. Prognosis of patients with highly increased permeability in tumor feeding vessels depicted by subtractions CT scan image was poor in spite of small tumor size. Subtraction CT scan image was useful for the accurate estimating of tumor size. The assessment of the tumorous feeding vessels made possible by this method could enrich the Information of tumor.
27.8
229
lMMUNO8CiNllGRAPHY IN 8MALL CELL LUNG CANCER (8CLC):amcusexsnqafttumorstudywkh8GlMdb. H.B. KM, N. van Zandwfjk, CA. Hosfnsgsl, R. Valdes Dlmos. R.J.A.M. Mlchalldes,J. Hllkens. The Netherlands Cancer Institute Anton1van LeeuwenhoskHuls, Amsterdam.the Netherlands.
Diagnosis of mediastinal lymph node metastasis of lung cancer with Positron Emission Tomography using IlC-methionine Hidekl Miyazawa, Takashi Arai, Keizou Inagaki Takatomo Morita, Makoto Yano. Nakano National Chest Hospital, Tokyo, JAPAN.
MoAbs devsloped agsinst SClC have besn dMdsd Into 5 groups (dusters) [I]. Cluster 1 (SGI) antibodiesare dirscted agslnst Neural Cdl Adhesion Mdecule (N-CAM). N-CAM ls found In neurosndocrins tumors and several lxwmal tissues [2]. One of thess antlbodles, namely 123C3, hss bsen exten&ely studlsd In lmmunohlst~mlcal studies [3]. This MoAb v a high affinityfor the msd antigen In In vitro tests (K,: 1.04 10 /M). We hsve studled 123C3 In a mcuss imaging study,,,uslng a H89 rnouss xenograft tumor model. After labelllng with I 123C3 was Injected In nude mics carrying SCLC xenografts with a dlsmeter varying from 5 to 10 mm. Excellent lmsgss were achieved at 7 days after Injection. Detemlnstlon of tlssus counts showed thst hlgh tumor tissus ratios (varyingfrom + 3.98 for blood to + BO for bone) wers achisved and a slgnlfkant fmctlon of ths Injected dose (13.96%) was retalnsd In the tumor. Thess results certainlywsrrant further study In humans. Currently a dlnical study Is carded out In 8CLC patlsnts. 1. Bwerty P.C.L, et al. Lung Cancer 1988 (4): 15-X. 2. Patsl K., el al. Int. J. Cancer 1989 (44): 573-578. 3. 8chd D.J., et al. Int. J. Cancer 1988 (43 [email protected]): 34-40.
Positron emission tomography (PET) using IIC-methionine is useful for the diagnosis of lung cancer. We examined whether it has a capability for the diagnosis of mediastinal lymph node metastasis from primary lung cancer. We used respirationated scan, positron angiography and DAR ?Deferential absorption ratio) to obtain a semiquantitative value. Eighteen patients were studied using PET and CT before undergoing an operation. The results were compared with pathological findings of the dissected nodes. The anatomical location of the mediastinal lymph nodes were correctly visualized. There was a significant difference (p