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Collagens in scar carcinoma of the lung
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We examined Ii monoclonal antibodies (AB) that had been defined for peripheral blood cells, in order to find out whether these antibodies were also capable of recognising antigen structures of carcinomas of the lung and, if necessary, of their metastases. We were particularly successful with the antibodies OKT 9, VEP 9 and S 39. VEP 9 helped us to differentiate to a large extent between the intermediary form of the smallcell bronchial carcinoma and the oat-cell type. On the other hand, there were common features in respect of the binding of VEP 9 between the intermediary type of the smallcell bronchial carcinoma and the non-small cell bronchial carcinomas. It is possible that this may lead to consequences in respect of differential therapy.
methods. In the tumor tissues, it was found that the average of the total amount of GAG was more than 7.9 times as high as that in adenocarcinoma of the lung, and that hyalutonic acid and chondroitin sulfate were main constituents of mesothelioma GAG. However, there was no significant difference in the content of dermatan sulfate and heparan sulfate between this neoplasm and adenocarcinoma. In the pleural fluid, the amount of hyaluronic acid was about 40 to 230 times higher than that in adenocarcinoma of the lung with the increment of chondroitin sulfate (11-87 times). These findings suggest that a marked increase in the total amount of GAG and the elevation of either the hyaluronic acid or the chondoitin sulfate level, or both, are characteristic abnormalities in malignant pleural mesothelioma.
Collagens in Scar Carcinoma of the Lung. Ei-Torky, M., Giltman, L.I., Dabbous, M. Department of Pathology and Biochemistry, University of Tennessee Center for the Health Sciences, Memphis, TN 38163, U.S.A. Am. J. Pathol. 121: 322-326, 1985. Immunohistopathologic and biochemical studies of different collagen types extracted from human scar carcinoma of the lungs have been carried out for definition and evaluation of which types of collagen are involved in the scarring mechanism of such tumors. Tumor homogenates treated with 0.5 M acetic acid and followed by limited proteolysis with pepsin and then by fractional salt precipitation, demonstrated that Type I collagen constitutes the major collagenous component in addition to a significant increase in Type V collagen extracted from human scar carcinoma of the lung. However, when normal membranoalveolar peripheral lung tissues were processed under the same experimental condition, Type III and IV collagens were relatively higher. Immunohistochemical studies were carried out, and the results confirmed the data above. Furthermore, these studies demonstrated a relative localized increase in Type III collagen in the area surrounding the tumor acini, which suggested that these areas are of active and recent scar formation. This supports the current concept of the scar origin as a desmoplastic reaction of the host tissues toward the neoplastic cell growth,
Adbestos Burden and the Pathology o f Lung Cancer.
Glycosaminoglycan in Malignant Pleural Mesothelioma.
5, CLINICAL ASSESSMENT Bronchial Carcinoma in P a t i e n t s below 40 Years of Age.
Nakano, T., FuJii, J., Tamura, S. et al. Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya City, Hyogo, Japan. Cancer 57: i06-i10, 1986. The quantitative analysis on glycosaminoglycan (GAG) in the tumor tissues of five patients with malignant pleural mesothelioma and in the pleural fluid of two patients was performed with the use of biochemical
Warnock, M.L., Isenberg, W. Department of Pathology, University of California, San Francisco, CA, U.S.A; Chest 89: 20-26, 1986. To determine whether we could distinguish asbestos-related lung cancer from unrelated ones, we typed and quantified by electronoptical methods the asbestos fibers in the lungs of 75 men with lung cancer. All but eight men had some history of asbestos exposure. On the basis of combined amosite and crocidolite (AC) concentrations, we divided the subjects into three groups5(AC fibers per gram ~f dry ~ung); low ( < i 0 ) ~ intermediate (i0- to i0-), and high (
Stamatis, G., Greschuchna, D. Ruhrlandklinik, D-4300 Essen-Heidhausen 16, Germany. Prax. Klin. Pneumol. 39: 805-806, 1985. A review of the literature and of our present observations shows that patients below 40 years of age with bronchial carcinoma have a greater 3-year survival chance than those who are older, despite the fact
We examined Ii monoclonal antibodies (AB) that had been defined for peripheral blood cells, in order to find out whether these antibodies were also capable of recognising antigen structures of carcinomas of the lung and, if necessary, of their metastases. We were particularly successful with the antibodies OKT 9, VEP 9 and S 39. VEP 9 helped us to differentiate to a large extent between the intermediary form of the smallcell bronchial carcinoma and the oat-cell type. On the other hand, there were common features in respect of the binding of VEP 9 between the intermediary type of the smallcell bronchial carcinoma and the non-small cell bronchial carcinomas. It is possible that this may lead to consequences in respect of differential therapy.
methods. In the tumor tissues, it was found that the average of the total amount of GAG was more than 7.9 times as high as that in adenocarcinoma of the lung, and that hyalutonic acid and chondroitin sulfate were main constituents of mesothelioma GAG. However, there was no significant difference in the content of dermatan sulfate and heparan sulfate between this neoplasm and adenocarcinoma. In the pleural fluid, the amount of hyaluronic acid was about 40 to 230 times higher than that in adenocarcinoma of the lung with the increment of chondroitin sulfate (11-87 times). These findings suggest that a marked increase in the total amount of GAG and the elevation of either the hyaluronic acid or the chondoitin sulfate level, or both, are characteristic abnormalities in malignant pleural mesothelioma.
Collagens in Scar Carcinoma of the Lung. Ei-Torky, M., Giltman, L.I., Dabbous, M. Department of Pathology and Biochemistry, University of Tennessee Center for the Health Sciences, Memphis, TN 38163, U.S.A. Am. J. Pathol. 121: 322-326, 1985. Immunohistopathologic and biochemical studies of different collagen types extracted from human scar carcinoma of the lungs have been carried out for definition and evaluation of which types of collagen are involved in the scarring mechanism of such tumors. Tumor homogenates treated with 0.5 M acetic acid and followed by limited proteolysis with pepsin and then by fractional salt precipitation, demonstrated that Type I collagen constitutes the major collagenous component in addition to a significant increase in Type V collagen extracted from human scar carcinoma of the lung. However, when normal membranoalveolar peripheral lung tissues were processed under the same experimental condition, Type III and IV collagens were relatively higher. Immunohistochemical studies were carried out, and the results confirmed the data above. Furthermore, these studies demonstrated a relative localized increase in Type III collagen in the area surrounding the tumor acini, which suggested that these areas are of active and recent scar formation. This supports the current concept of the scar origin as a desmoplastic reaction of the host tissues toward the neoplastic cell growth,
Adbestos Burden and the Pathology o f Lung Cancer.
Glycosaminoglycan in Malignant Pleural Mesothelioma.
5, CLINICAL ASSESSMENT Bronchial Carcinoma in P a t i e n t s below 40 Years of Age.
Nakano, T., FuJii, J., Tamura, S. et al. Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya City, Hyogo, Japan. Cancer 57: i06-i10, 1986. The quantitative analysis on glycosaminoglycan (GAG) in the tumor tissues of five patients with malignant pleural mesothelioma and in the pleural fluid of two patients was performed with the use of biochemical
Warnock, M.L., Isenberg, W. Department of Pathology, University of California, San Francisco, CA, U.S.A; Chest 89: 20-26, 1986. To determine whether we could distinguish asbestos-related lung cancer from unrelated ones, we typed and quantified by electronoptical methods the asbestos fibers in the lungs of 75 men with lung cancer. All but eight men had some history of asbestos exposure. On the basis of combined amosite and crocidolite (AC) concentrations, we divided the subjects into three groups5(AC fibers per gram ~f dry ~ung); low ( < i 0 ) ~ intermediate (i0- to i0-), and high (
Stamatis, G., Greschuchna, D. Ruhrlandklinik, D-4300 Essen-Heidhausen 16, Germany. Prax. Klin. Pneumol. 39: 805-806, 1985. A review of the literature and of our present observations shows that patients below 40 years of age with bronchial carcinoma have a greater 3-year survival chance than those who are older, despite the fact