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Colloidal Gold: A new perspective for cytochemical marking Royal Microscopical Society Microscopy Handbooks
Camp. Biochem.
Phwiol.
0300-9629/90 $3.00 + 0.00 c 1990 Pergamon Press plc
Vol. 95A,No. 4.pp.639-640,1990
Printed in Great Britain
BOOK REVIEWS
L. F. Press,
Drugs and the Athlete-G. I. WADLER AND B. HAINLINE. 353 pp. 1989. F. A. DAVIS, Philadelphia. $45.
Natural macrocyclic ligand complexes such as porphyrin (iron), chlorophyll (Mg), vitamin B12 (cobalt), the antibiotic nonactin (potassium) and the synthetic phthalocyanines (copper) have been studied for many years. The development of new synthetic structures such as the crown polyethers, cryptands. cyclophanes, cyclodextrins and the cyclic antibiotics, present a new range of interesting compounds that could be of use as membrane carriers, molecular recognition, drugs or transistors. Their synthesis, kinetics, thermodynamics and electrochemistry are fully discussed in this interesting book.
Anabolic steroids, human growth hormone, amphetamine, cocaine, phenylpropanolamine, ephedrine, caffeine, barbiturates, benzodiazepines, alcohol, marijuana, narcotics, blood doping and erythropoietin, have been used by some athletes to improve performance and reduce stress. This book considers the effects of each of these drugs, the types of athletes who use drugs, their antecedents, the detection and management of drug abuse, the legal aspects and the national and international regulations.
The Chemistry of Macrocylic Ligand Complexes--By LINDOY. 269pp. 1989. Cambridge University Cambridge. $69.50.
Intestinal Metabolism of Xenobiotics-Edited by A. KOSTER., E. RICHTER., F. LAUTERB~CH and F. HARTMANN. Progress in Pharmacology and Clinical Pharmacology, Volume 7. No. 2. 338 pp. 1989. Gustav Fischer, New York. $96.50 (paperback). The intestinal wall can metabolise a range of xenobiotics and most drug metabolizing systems can be found there. This volume describes the preparation of intestinal tissue: microsomal and cytosolic fractions of mammalian intestine; Isolated epithelial cells; P450; omega oxidation; glucuronidation and sulfation; CSH; oxidases, diaphorase, esterases and hydrolase; tumorigenesis; absorption of lipids; glucagon-like immunoreactivity: metabolism of drugs, narcotics. contraceptive steroids. diphenolic laxatives; MAO: T-2 toxin. The intestine is a defensive wall and this volume summarises the biochemical defences present.
Surface Structures of Microorganisms and their Interactions with the Mammalian Host-Edited by E. SCHRINNER. M. H. RICHMOND, G. SEIBERT and U. SCHWARTZ. 267 pp. 1988. VCH, Weinheim. $69.
Bacteria, yeasts, fungi and protozoa infecting mammalian hosts attach onto the surface of the host cells and interact with the surfaces. This workshop volume discusses the role of endotoxins, murein degradation products, bacterial surface proteins, peptidoglycan monomers, bacterial adhesins, proteinases and polyanions. hopanoids and sterol surrogates in the attachement process.
Colloidal Gold: a New Perspective for Cytochemical Marking-By J. E. BEESLEY. Royal Microscopical Society Microscopy Handbooks, No. 17. 59 pp. 1989. Oxford Scientific Publications, Oxford. $12.95 (paperback).
Use of Animal Models for Research in Human Nutrition Edited by A. C. BEYXEN and C. E. WEST. 190~~. 1988. Karger. Base]. $112; Sfr 168.
Colloidal gold probes have been developed for immunocytochemical marking to detect antigens in situ. This practical book gives details of gold probes; antibodies for immunolabelling: preparation of protein-gold probes; buffers for immunolabelling: fixation; gold probes for use in electron microscopy; use in light microscopy; multiple labelling techniques; controls; quantitation; non-microscopical techniques (electrophoresis); problems with the technique and how to overcome them; and the future (identification in living cells). This book will be very useful to all those using or starting to use gold labelling.
It is often difficult or unethical to carry out controlled nutritional experiments on humans. For this reason, it is necessary to use animal models. This book discusses the use of animals in the regulation of metabolism of branched chain amino acids; the relation between nutrition and infectious diseases: animal models of diet induced atherosclerosis; indeed obesity; diet and diabetes; gall stone formation; and experimental carcinogenesis. Blood Substitutes: Preparation, Physiology and Medical Applications. Edited by K. C. LOWE. 187 pp. 1988. VCH, New York. $I 10.
Receptors, Membrane Transport and Signal TransductionEdited by A. E. EVAGELOPOLJLOS.J. P. CHAGEUX, L. PACKER, T. G. SOTIROUDIS. and K. W. A. WIRTZ 387 pp. 1989. Springer, Berlin. DM 168.
Dextrans. gelatins or hydroxyethyl starch can be substitutes for plasma and Ruorocarbons can be a substitute for hemoglobin. A polymerized pyridoxylated hemoglobin solution can be used as an oxygen carrier. It has an intravascular half-life of 25 hr and a P,, of 20 torr. There has been a great deal of interest in the use of perfluorochemical emulsions as oxygen carriers, and though there are some adverse reactions (intravascular complement activation). it should be possible in the near future to have a reasonable reliable complete blood substitute. This will be free from AIDS and Hepatitis B (problems associated with normal blood transfusion). The advances are described in this book.
This is a volume in the NATO advanced studies series on a meeting held in Greece in August 1988. The papers discuss G proteins, adenylate cyclase, protein phosphorylation, protein tyrosine kinases related to oncogene products, membrane receptors and neurotransmitters. membrane transport and bioenergetics. There is much of interest in this rapidly developing field, and it is a pity that one of the five editors did not present an overall summary of the new developments presented in this book. That is what editors are there for! 639
Phwiol.
0300-9629/90 $3.00 + 0.00 c 1990 Pergamon Press plc
Vol. 95A,No. 4.pp.639-640,1990
Printed in Great Britain
BOOK REVIEWS
L. F. Press,
Drugs and the Athlete-G. I. WADLER AND B. HAINLINE. 353 pp. 1989. F. A. DAVIS, Philadelphia. $45.
Natural macrocyclic ligand complexes such as porphyrin (iron), chlorophyll (Mg), vitamin B12 (cobalt), the antibiotic nonactin (potassium) and the synthetic phthalocyanines (copper) have been studied for many years. The development of new synthetic structures such as the crown polyethers, cryptands. cyclophanes, cyclodextrins and the cyclic antibiotics, present a new range of interesting compounds that could be of use as membrane carriers, molecular recognition, drugs or transistors. Their synthesis, kinetics, thermodynamics and electrochemistry are fully discussed in this interesting book.
Anabolic steroids, human growth hormone, amphetamine, cocaine, phenylpropanolamine, ephedrine, caffeine, barbiturates, benzodiazepines, alcohol, marijuana, narcotics, blood doping and erythropoietin, have been used by some athletes to improve performance and reduce stress. This book considers the effects of each of these drugs, the types of athletes who use drugs, their antecedents, the detection and management of drug abuse, the legal aspects and the national and international regulations.
The Chemistry of Macrocylic Ligand Complexes--By LINDOY. 269pp. 1989. Cambridge University Cambridge. $69.50.
Intestinal Metabolism of Xenobiotics-Edited by A. KOSTER., E. RICHTER., F. LAUTERB~CH and F. HARTMANN. Progress in Pharmacology and Clinical Pharmacology, Volume 7. No. 2. 338 pp. 1989. Gustav Fischer, New York. $96.50 (paperback). The intestinal wall can metabolise a range of xenobiotics and most drug metabolizing systems can be found there. This volume describes the preparation of intestinal tissue: microsomal and cytosolic fractions of mammalian intestine; Isolated epithelial cells; P450; omega oxidation; glucuronidation and sulfation; CSH; oxidases, diaphorase, esterases and hydrolase; tumorigenesis; absorption of lipids; glucagon-like immunoreactivity: metabolism of drugs, narcotics. contraceptive steroids. diphenolic laxatives; MAO: T-2 toxin. The intestine is a defensive wall and this volume summarises the biochemical defences present.
Surface Structures of Microorganisms and their Interactions with the Mammalian Host-Edited by E. SCHRINNER. M. H. RICHMOND, G. SEIBERT and U. SCHWARTZ. 267 pp. 1988. VCH, Weinheim. $69.
Bacteria, yeasts, fungi and protozoa infecting mammalian hosts attach onto the surface of the host cells and interact with the surfaces. This workshop volume discusses the role of endotoxins, murein degradation products, bacterial surface proteins, peptidoglycan monomers, bacterial adhesins, proteinases and polyanions. hopanoids and sterol surrogates in the attachement process.
Colloidal Gold: a New Perspective for Cytochemical Marking-By J. E. BEESLEY. Royal Microscopical Society Microscopy Handbooks, No. 17. 59 pp. 1989. Oxford Scientific Publications, Oxford. $12.95 (paperback).
Use of Animal Models for Research in Human Nutrition Edited by A. C. BEYXEN and C. E. WEST. 190~~. 1988. Karger. Base]. $112; Sfr 168.
Colloidal gold probes have been developed for immunocytochemical marking to detect antigens in situ. This practical book gives details of gold probes; antibodies for immunolabelling: preparation of protein-gold probes; buffers for immunolabelling: fixation; gold probes for use in electron microscopy; use in light microscopy; multiple labelling techniques; controls; quantitation; non-microscopical techniques (electrophoresis); problems with the technique and how to overcome them; and the future (identification in living cells). This book will be very useful to all those using or starting to use gold labelling.
It is often difficult or unethical to carry out controlled nutritional experiments on humans. For this reason, it is necessary to use animal models. This book discusses the use of animals in the regulation of metabolism of branched chain amino acids; the relation between nutrition and infectious diseases: animal models of diet induced atherosclerosis; indeed obesity; diet and diabetes; gall stone formation; and experimental carcinogenesis. Blood Substitutes: Preparation, Physiology and Medical Applications. Edited by K. C. LOWE. 187 pp. 1988. VCH, New York. $I 10.
Receptors, Membrane Transport and Signal TransductionEdited by A. E. EVAGELOPOLJLOS.J. P. CHAGEUX, L. PACKER, T. G. SOTIROUDIS. and K. W. A. WIRTZ 387 pp. 1989. Springer, Berlin. DM 168.
Dextrans. gelatins or hydroxyethyl starch can be substitutes for plasma and Ruorocarbons can be a substitute for hemoglobin. A polymerized pyridoxylated hemoglobin solution can be used as an oxygen carrier. It has an intravascular half-life of 25 hr and a P,, of 20 torr. There has been a great deal of interest in the use of perfluorochemical emulsions as oxygen carriers, and though there are some adverse reactions (intravascular complement activation). it should be possible in the near future to have a reasonable reliable complete blood substitute. This will be free from AIDS and Hepatitis B (problems associated with normal blood transfusion). The advances are described in this book.
This is a volume in the NATO advanced studies series on a meeting held in Greece in August 1988. The papers discuss G proteins, adenylate cyclase, protein phosphorylation, protein tyrosine kinases related to oncogene products, membrane receptors and neurotransmitters. membrane transport and bioenergetics. There is much of interest in this rapidly developing field, and it is a pity that one of the five editors did not present an overall summary of the new developments presented in this book. That is what editors are there for! 639