- Email: [email protected]
Colorectal cancer screening with the contribution of general practitioner
270 WITH CANCER SCREENING OF GENERAL PRACTITIONER
COLORECTAL CONTRIBUTION
THE
P.Salvadori+,G.Castiglione**,S.Dei*+* A.S.C. +=U.S.L.lS,via Rozsalupi 53 U.O. Firense ; l **U.S.L. Empoli ; l *=c.s.p.o. 17 U.O. A.S.C. Castelfranco. The incidence of colorectal cancer is very high in the Municipalities of U.S.L. 18 ( Empoli and other Municipalities of the province of Florence ) . In fact the U.S.L. 18 is the first area for women and the second for man in the Province of Florence . the The incidence for men is 41.1 , while mean of Province is 38.7 and for women is 31.2 with the mean of Province of 27.0 : the 100,000 incidence rata is standardized on inhabitants and is related to the year 1987. Owing to this it was decided to carry out a some colorectal cancer screening program in Municipalities to all subjects aged 40-70 . At the present time we are able to present two concerning to some -results municioalities : Emnoli and Vinci . In this complianc‘e of invited population town the has been 46.25 8 ( 11,028 of 23,842 invited subjects ) . The compliance of 46 t is in part due to the contribution of General Practitioner. In fact every subject received to his address a personalized invitation letter by his own Family Doctor . The 5.5 t of population have had a positive colorectal test ( rehydrated Hemoccult ) . 617 of those have undergone either pancolonscopy or a left colonscopy and d.c. combination of barium enema.These are the results : 33 colorectal cancer ( 5 t) , 147 adenomas ( 24 not adenom. (6 5) 279 ( 46 t) 8) t 47 polipo with other colorectal pathology. The 67 t of "A" colorectal cancer diagnosed belong to stadio ( according to Astler h Coller Classification).
INCIDENTAL MINERVINI
R..
DEPARTMENT
ASYMITOMATK ADRENAL MASSES IS OPERATION REQUIRED? CECCHI M., VIGANO’ L.. FELIPE,-,t, R.. PAON, SEFKH CA.. FIORENTINI L. OF UROLOGY - UN,VEkS,TY OF WA
C..
pmbably nuligmm. How&. r)Kls k uill much mn&cny on whahw lclbrv & than 6 cm shdd k rurgkally handled. In our opinion. surgiul blencmiun r0, ksiim grmu dun 3 cm b diimacr rcprwcnu Lc ma l ppmp& diigooslic and thcmpuuk sppmsh ror opimizing UU pmgmri 0r IIKWS luio~ Ih* am All d umii Sk si k&u Icu IhM 3 Cm in diitir IYYC , bw bcidcncc d being malignnm. WC rd uul il L pmkmbk 10 lolbw lhsls jmlknu wilh cch~gmphy and CT-.
METASTATlC COLORECTAL CARCINOMA: DOES MITOM1CIN (WIG) INCREASE THE EFFICACY OFS-FLUOROURACIL (5-FU) LEUCORDVIN (LV)? L.
C +
SAMBATARO
Department
Hospital
of Internal - Rosa Hospital
24 patients
with
Medicine and - Eosa (NU)
metastatic
colorectal
Oncology
day
carcinoma
were
randomized: Group A (12 pts) received LV 200 mglm2 1.V. drip + S-FU 350 mg/mz, 1.V. push, days 1 - 5, every 3 weeks. Group B (12 pts) received the same schedule as group A plus I*w: 10 mg/ms, 1.V. days 1, every 6 weeks. of group A (25%) showed a partial response 3 pts. (PR). The median duration of response was 10 months. For group 8, PR was achieved in 4 pts (33%), the median duration being 7 months. Median survival for group A pts was 11 months (range 3 - 19) and for group B was B months (range 2 - 28). Differences in response and survival were not statistically significant. Severe leucopenia was observed in 1 pt. of group A (12%) and in 6 pts. of group B (50%); severe trombocytopenia, uas seen in 1 pt. of group A (12X), and 4 pts of group El (33%). See table
rlo 1.
Leucopenia Trombocytopenia
Gastro-intestinal
Table no 1 GROUP A 1 (12%) 1 (12%)
toxicity
GROUP B 6 (50%)
4 (33%) similar in
MS
both
groups.
In
conclusion,
toxicity sponse
to rate
the inclusion 5-FU + LV, whitout and survival.
of
NMC added
influencing
marked
the
re-
COLORECTAL CONTRIBUTION
THE
P.Salvadori+,G.Castiglione**,S.Dei*+* A.S.C. +=U.S.L.lS,via Rozsalupi 53 U.O. Firense ; l **U.S.L. Empoli ; l *=c.s.p.o. 17 U.O. A.S.C. Castelfranco. The incidence of colorectal cancer is very high in the Municipalities of U.S.L. 18 ( Empoli and other Municipalities of the province of Florence ) . In fact the U.S.L. 18 is the first area for women and the second for man in the Province of Florence . the The incidence for men is 41.1 , while mean of Province is 38.7 and for women is 31.2 with the mean of Province of 27.0 : the 100,000 incidence rata is standardized on inhabitants and is related to the year 1987. Owing to this it was decided to carry out a some colorectal cancer screening program in Municipalities to all subjects aged 40-70 . At the present time we are able to present two concerning to some -results municioalities : Emnoli and Vinci . In this complianc‘e of invited population town the has been 46.25 8 ( 11,028 of 23,842 invited subjects ) . The compliance of 46 t is in part due to the contribution of General Practitioner. In fact every subject received to his address a personalized invitation letter by his own Family Doctor . The 5.5 t of population have had a positive colorectal test ( rehydrated Hemoccult ) . 617 of those have undergone either pancolonscopy or a left colonscopy and d.c. combination of barium enema.These are the results : 33 colorectal cancer ( 5 t) , 147 adenomas ( 24 not adenom. (6 5) 279 ( 46 t) 8) t 47 polipo with other colorectal pathology. The 67 t of "A" colorectal cancer diagnosed belong to stadio ( according to Astler h Coller Classification).
INCIDENTAL MINERVINI
R..
DEPARTMENT
ASYMITOMATK ADRENAL MASSES IS OPERATION REQUIRED? CECCHI M., VIGANO’ L.. FELIPE,-,t, R.. PAON, SEFKH CA.. FIORENTINI L. OF UROLOGY - UN,VEkS,TY OF WA
C..
pmbably nuligmm. How&. r)Kls k uill much mn&cny on whahw lclbrv & than 6 cm shdd k rurgkally handled. In our opinion. surgiul blencmiun r0, ksiim grmu dun 3 cm b diimacr rcprwcnu Lc ma l ppmp& diigooslic and thcmpuuk sppmsh ror opimizing UU pmgmri 0r IIKWS luio~ Ih* am All d umii Sk si k&u Icu IhM 3 Cm in diitir IYYC , bw bcidcncc d being malignnm. WC rd uul il L pmkmbk 10 lolbw lhsls jmlknu wilh cch~gmphy and CT-.
METASTATlC COLORECTAL CARCINOMA: DOES MITOM1CIN (WIG) INCREASE THE EFFICACY OFS-FLUOROURACIL (5-FU) LEUCORDVIN (LV)? L.
C +
SAMBATARO
Department
Hospital
of Internal - Rosa Hospital
24 patients
with
Medicine and - Eosa (NU)
metastatic
colorectal
Oncology
day
carcinoma
were
randomized: Group A (12 pts) received LV 200 mglm2 1.V. drip + S-FU 350 mg/mz, 1.V. push, days 1 - 5, every 3 weeks. Group B (12 pts) received the same schedule as group A plus I*w: 10 mg/ms, 1.V. days 1, every 6 weeks. of group A (25%) showed a partial response 3 pts. (PR). The median duration of response was 10 months. For group 8, PR was achieved in 4 pts (33%), the median duration being 7 months. Median survival for group A pts was 11 months (range 3 - 19) and for group B was B months (range 2 - 28). Differences in response and survival were not statistically significant. Severe leucopenia was observed in 1 pt. of group A (12%) and in 6 pts. of group B (50%); severe trombocytopenia, uas seen in 1 pt. of group A (12X), and 4 pts of group El (33%). See table
rlo 1.
Leucopenia Trombocytopenia
Gastro-intestinal
Table no 1 GROUP A 1 (12%) 1 (12%)
toxicity
GROUP B 6 (50%)
4 (33%) similar in
MS
both
groups.
In
conclusion,
toxicity sponse
to rate
the inclusion 5-FU + LV, whitout and survival.
of
NMC added
influencing
marked
the
re-