- Email: [email protected]
Comparative study: Arterial stiffness related factors between type 1 and type 2 diabetic patients
e156
Abstracts / Atherosclerosis 241 (2015) e149ee229
Aim: The aim of this study was to determine whether the decrease of the heart rate by ivabradine in patients with coronary artery disease is accompanied by hemodynamic changes, which could possibly lead to the improvement of the endothelial function. Methods: Patients were prescribed 2x5mg daily dose of ivabradine in addition to their treatment. Endothelial function was assessed at the beginning of the study and after the three months (þ/- 1 week), using EndoPAT 2000 (Itamar Medical, Israel), which belongs to the recent non-invasive methods for endothelial dysfunction assessment. Peripheral arterial tone was measured with special, modified plethysmographic biosensors. Results: There were 30 patients in the study, who were accepted based on the inclusion criteria. The average values of the RHI (reactive hyperemia index) before the treatment were 1,54 ± 0,30, which suggests the presence of endothelial dysfunction, whereas at the end of the study, RHI was 1,83 ± 0,36 (p< 0,0001). In addition, there was a significant progress of the augmentation index. AI at the beginning of the study was 21 ± 20 % and at the end of the study, 10 ± 21% (p< 0,0001) which suggests the progress of the arterial elasticity. There was observed statistically significant heart rate decrease from the original value 77 ± 7 beats per minute to 65 ± 6 beats per minute, p < 0,0001. Conclusion: There was observed positive effect of ivabradine treatment on the endothelial function, assessed with the Endo-PAT 2000.
* Corresponding author. Aim: Metabolic syndrome (MetS) is associated with adverse cardiovasular events, and impaired vascular function. The aim of this study is evaluation of possible role of supplementation of omega-3 polyunsaturated fatty acids (n-3 PUFA) on arterial stiffness and laboratory marker of oxidative stress (GPX) in patients with MetS. Methods: Total of 40 patients with MetS were enrolled. We evaluated endothelial function and arterial stiffness in subjects before and after three-month treatment with n-3 PUFA in dose 2.4g daily (800mg 3 times a day). Using the Endo-PAT2000 device (Itamar Medical Ltd. Caesarea, Israel), RHI (reactive hyperemia index) e a parameter of endothelial function and augmentation index (AI) e a parameter of arterial stiffness were measured. Plasmatic level of antioxidant enzyme (GPX e glutation peroxidase) was also evaluated. Results: The average values of the RHI before the treatment with n-3PUFA was 1,62 ± 0,42 , whereas 1.96 ± 0.62 at the end of the study (p<0.005). Augmentation index was 14.66 ± 19.55 and 9.21 ± 15.64 after the treatment (p¼0.003). We also observed statistically significant increase of the GPX plasma level (41,65 ± 8,90 vs. 45,20 ± 8,01), p¼0.000. Conclusion: We have observed significant improvement of the endothelial function and arterial stiffness with parallel antioxidant effect in subjects with MetS treated with n-3 PUFA in dose 2.4g daily.
EAS-0911. ASSESSMENT OF THE RELATIONSHIP BETWEEN A NARROW FRAGMENTED QRS COMPLEX AND CORONARY SLOW FLOW
EAS-0932. EFFECTS OF HYPOLIPIDEMC THERAPY ON THE ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME
H.A. Cakmak 1, *, S. Aslan 2, M. Gul 2, O. Celik 2, A.K. Kalkan 2, D. Ozturk 2, O. Tasbulak 2, M.H. Satilmisoglu 2. 1 Cardiology, Rize Kackar Government Hospital, Rize, Turkey; 2 Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey
L. Merkovska*, L. Jedlickova, L. Jackova, J.A.N. Fedacko, D. Pella. 1st Department of Internal Medicine Louis Pasteur University Hospital, University hospital of Louis Pasteur, Kosice, Slovakia
* Corresponding author. Background: The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to the distal branch of a coronary artery in the absence of obstructive coronary artery disease (CAD). A narrow fragmented QRS (fQRS) has recently been reported as a significant predictor of sudden cardiac death in patients with idiopathic dilated cardiomyopathy. The present study aimed to investigate the relationship between a narrow fQRS on the admission electrocardiogram (ECG) and CSF on coronary angiography. Methods: A total of 112 patients with angiographically proven coronary slow flow and 53 control subjects with normal coronary flow were included in the study. Coronary flow was quantified by thrombolysis in myocardial infarction (TIMI) frame count (TFC). The patients were divided into two groups according to the presence or absence of a narrow fQRS complex on the admission ECG. Results: The incidence of narrow fQRS was significantly higher in the CSF group compared to controls (P ¼ 0.007). Moreover, the extent of CSF was significantly greater in the fQRS(þ) group compared to the non-fragmented group (P < 0.001). A significant correlation was also found between mean TFC values and fQRS (r ¼ 0.383,P < 0.001). On multivariate analysis, only CSF (odds ratio: 2.66, 95% confidence interval: 1.075e6.62, P ¼ 0.03) was a significant independent predictor for narrow fQRS, after adjustment for other parameters. Conclusion: The narrow fQRS is a simple, inexpensive, and readily available noninvasive ECG parameter that may be a new potential indicator of myocardial damage in patients with CSF. EAS-0917. OMEGA-3 PUFAS IMPROVED ENDOTHELIAL DYSFUNCTION AND ARTERIAL STIFFNESS WITH A PARALLEL ANTIOXIDANT EFFECT IN PATIENTS WITH METABOLIC SYNDROME L. Jackova*, L. Jedlickova, L. Merkovska, J. Fedacko, T. Lopuchovsky, D. Pella. 1st Department of Internal Medicine Faculty of Medicine Pavol Jozef Safarik University, University hospital of Louis Pasteur, Kosice, Slovakia
* Corresponding author. Aim: The aim of the our study was to compare the efficiency and impact of hypolipidemics (statin monotherapy and combination therapy with statin) on the endothelial function in a select group of people. Methods: Total of 74 patients with MetS were enrolled. We evaluated ED and lipid profile in subjects before and after three-month treatment in 3 groups (statin monotherapy, combination therapy with statin e statin þfibrates, statin þ n3-PUFA). Using the Endo-PAT2000 device.RHI decreases with dysfunction and a threshold <1.67 is considered abnormal. The EndoPAT-derived augmentation index (AI) provides a measure of arterial stiffness by considering the timing and magnitude of this wave reflection in the digital pulse. AI represents the relative contribution of augmented pressure due to wave reflection to the pressure wave form. Laboratory markers of ED e GPX were taken also.Lipid profile were analysed by using rountine lab. Results: LDL cholesterol was(2,22 ± 0,80 vs 3,22 ± 1,19, p < 0,05), TAG ( 1,61 ± 1,04 vs 2,42 ± 2,19, p < 0,05), HDL(p < 0,05) The measured RHI for patients with MS before and after treatment in all treatment groups was 1,75 ± 0,54 versus 2,02 ± 0,71 (p ¼ 0,0001). Augmentation index was 15,91 ± 18,85 vs 11,25 ± 14,43 (p ¼ 0,0001).GPX plasma levels was also significant increased after treatment (48,53 ± 10,52 vs 45,61 ± 10,50, p < 0,05). Conclusion: We have observated improved ED and lipid profil with parallel antioxidant effect in subjects with MetS treated with statin monotherapy and combination therapy with statin.
EAS-0949. COMPARATIVE STUDY: ARTERIAL STIFFNESS RELATED BETWEEN TYPE 1 AND TYPE 2 DIABETIC PATIENTS
FACTORS
S. Enkhjargal 1, *, S. Sonomtseren 2, U. Shuumarjav 1. 1 Department of pathology, Mongolian national university of medical science, Ulaanbaatar, Mongolia; 2 Department of endocrinology, Mongolian national university of medical science, Ulaanbaatar, Mongolia
* Corresponding author.
Abstracts / Atherosclerosis 241 (2015) e149ee229
Objective: The aim of the study is to evaluate the correlation of vascular stiffness and contributed risk factors among the people with Type 1 DM (T1DM) and Type 2 DM (T2DM). Methods: We used hospital-based onetime cross-sectional study for 79 DM patients aged 18-55 (mean age 40.99 ± 10.81) who were involved. Materials are collected by questionnaire, physical examination, blood analyzes and vascular stiffness is measured by VaSera VS-1000 device. Results: All participants are divided into two groups T1DM (n ¼ 28) and T2DM (n¼52). Using simple correlation analysis cardio-ankle vascular index (CAVI) has positive statistical correlation with age (r¼0.664, p¼0.001), visceral fat (r¼0.391, p¼0.002), systolic pressure (r¼0.402, p¼0.002), diastolic pressure (r¼0.433, p¼0.001) HbA1C (p¼0.003) and hemoglobin (p ¼ 0.03) respectively. Using Independent-samples T-test analysis the age (p ¼ 0.001), BMI (p ¼ 0.001), visceral fat (p ¼ 0.001) and CAVI (p ¼ 0.001) was statistically increased in T2DM patients than T1DM patients. In T1DM group the CAVI has positive statistical correlation with age(r¼0.43, p¼0.03), HbA1C (p¼0.003), hemoglobin (p¼0.01) and in T2DM group CAVI has positive statistical correlation with age (r¼0.61, p¼0.001), systolic and diastolic pressure (p¼0.001) respectively. Conclusion: However age, abdominal obesity and hypertension are the risk factor of vascular stiffness in patients with DM, its more necessary to control the HbA1C in T1DM patients and hypertension in T2DM patients to prevent from chronic vascular complication. EAS-0960. ARTERIAL STIFFNESS AND LEFT ATRIAL VOLUME HYPERTENSIVE AND NORMOTENSIVE SUBJECTS
INDEX
IN
M. Rojek*, M. Rajzer, D. Czarnecka. I Department of Cardiology Interventional Electrocardiology and Hypertension, Medical College Jagiellonian University, Cracow, Poland
* Corresponding author.
e157
S. Aurelian 1, *, A. Zamfirescu 1, M. Ghinescu 2, J. Aurelian 3, A. Capisizu 4. 1 Geriatric, Hospital “Sf Luca”, Bucharest, Romania; 2 Family Medicine, University Titu Maiorescu, Bucharest, Romania; 3 Social Medicine, University of Medicine “Carol Davila”, Bucharest, Romania; 4 Geriatric Medicine, University of Medicine “Carol Davila” Hospital “Sf. Luca”, Bucharest, Romania
* Corresponding author. Aim: Many researches with controversial results have studied the association between the number of components of metabolic syndrome and severity of subclinical atherosclerosis expressed by the pulse wave velocity(PWV). Objective: We evaluated arterial stiffness in overweight and obese subjects by studying the aortic augmentation index(AixAo), PWVao and carotid intima-media thickness(IMT). Method: Observational six month study included 145 patients; the mean age 72.85±10.07y. For PWV measurement we used a noninvasive method, an oscillometric device (Arteriograph, TensioMed Ltd.). High-resolution Bmode carotid ultrasonography was performed. Results: Over 1/3 of patients with metabolic syndrome were present and uncontrolled hypertension. Statistically is significant correlation(90%) between decrease LDL and decrease arterial stiffness(r¼-0.160, p¼0.059). Mean value of HDL-C was 51.52±15.35mg/dl, an increase of 40% from the target value. Is significant correlation between endothelial dysfunction Aixao and heart rate(Pearson r¼- 0.198, p¼0.017). It shows a high value of IMT(mean1.17±0.3 mm) among diabetics compared to non-diabetic group(p<0.001). Conclusion: The prevalence of obesity with age is high especially in people over 75 years. The rate of patient with high cardio-vascular risk among the elderly presenting metabolic syndrome is higher but does not show an increase proportional to the number of components that define this syndrome.
Objective: comparison of the relationship between arterial sitfness indices and left atrial volume index (LAVI) in hypertensive and normotensive subjects. Material and methods: study and control group were randomly recruited among Morawica town inhabitants (Poland). Study group (AH)- 41 treatment-naive hypertnesives, stage 1. or 2. (20 men and 21 women). Control group (NonAH)- 60 normotensives (32 men and 28 women). Anthropometric and demographic data were collected via questionnaire. Clinical examination included: standard office blood pressure measurements using Omron M5-I; arterial siffness measurements: carotid-femoral pulse wave velocity (PWV) and central blood pressure (cSBP, cDBP, cPP) using Shygmocor®; echocardiographic left atrial volume determination (LAV) by Simpson method using VIVID-7 GE followed by LAVI calculation (LAVI ¼ LAV/body surface area). Results: AH was older (56,9 vs 50,2 yrs, p¼0,0002) exhibiting higher BMI (28,2 vs 26,3 kg/m2, p¼0,03) and higher office SBP (149,5 vs 138,6 mmHg, p¼0,04) and DBP (91,1 vs 85,7 mmHg, p¼0,02) than NonAH. PWV did not differ among groups. cSBP (136,3 vs 126,8 mmHg, p¼0,02) and cDBP (90,8 vs 84,9 mmHg, p¼0,01) were higher in AH. LAVI was significantly higher in AH than in NonAH (27,8 vs 24,3 ml/m2, p¼0,003). In AH, LAVI correlated positively only with cSBP (r¼0,33, p¼0,04). In NonAH, LAVI correlated positively with age (r¼ 0,27, p¼0,03), BMI (r¼0,39, p¼0,02) and cSBP (r¼0,27, p¼04). Conclusions: Hypertensive subjects represent higher values of LAVI. In this group it depends mainly on central hemodynamics, while in the group of normotensives LAVI is additionally determined by age and body mass index.
Imaging EAS-0016. DETERMINATION OF HEMODYNAMIC FEATURES IN ELDERLY PATIENTS WITH METABOLIC SYNDROME Ă
Characteristics
Coefficient of correlation
p
Aixao with HR PWVao with LDL SBPao with CKD
0.198 0.160 0.231
0.017 0.059 0.005
Abstracts / Atherosclerosis 241 (2015) e149ee229
Aim: The aim of this study was to determine whether the decrease of the heart rate by ivabradine in patients with coronary artery disease is accompanied by hemodynamic changes, which could possibly lead to the improvement of the endothelial function. Methods: Patients were prescribed 2x5mg daily dose of ivabradine in addition to their treatment. Endothelial function was assessed at the beginning of the study and after the three months (þ/- 1 week), using EndoPAT 2000 (Itamar Medical, Israel), which belongs to the recent non-invasive methods for endothelial dysfunction assessment. Peripheral arterial tone was measured with special, modified plethysmographic biosensors. Results: There were 30 patients in the study, who were accepted based on the inclusion criteria. The average values of the RHI (reactive hyperemia index) before the treatment were 1,54 ± 0,30, which suggests the presence of endothelial dysfunction, whereas at the end of the study, RHI was 1,83 ± 0,36 (p< 0,0001). In addition, there was a significant progress of the augmentation index. AI at the beginning of the study was 21 ± 20 % and at the end of the study, 10 ± 21% (p< 0,0001) which suggests the progress of the arterial elasticity. There was observed statistically significant heart rate decrease from the original value 77 ± 7 beats per minute to 65 ± 6 beats per minute, p < 0,0001. Conclusion: There was observed positive effect of ivabradine treatment on the endothelial function, assessed with the Endo-PAT 2000.
* Corresponding author. Aim: Metabolic syndrome (MetS) is associated with adverse cardiovasular events, and impaired vascular function. The aim of this study is evaluation of possible role of supplementation of omega-3 polyunsaturated fatty acids (n-3 PUFA) on arterial stiffness and laboratory marker of oxidative stress (GPX) in patients with MetS. Methods: Total of 40 patients with MetS were enrolled. We evaluated endothelial function and arterial stiffness in subjects before and after three-month treatment with n-3 PUFA in dose 2.4g daily (800mg 3 times a day). Using the Endo-PAT2000 device (Itamar Medical Ltd. Caesarea, Israel), RHI (reactive hyperemia index) e a parameter of endothelial function and augmentation index (AI) e a parameter of arterial stiffness were measured. Plasmatic level of antioxidant enzyme (GPX e glutation peroxidase) was also evaluated. Results: The average values of the RHI before the treatment with n-3PUFA was 1,62 ± 0,42 , whereas 1.96 ± 0.62 at the end of the study (p<0.005). Augmentation index was 14.66 ± 19.55 and 9.21 ± 15.64 after the treatment (p¼0.003). We also observed statistically significant increase of the GPX plasma level (41,65 ± 8,90 vs. 45,20 ± 8,01), p¼0.000. Conclusion: We have observed significant improvement of the endothelial function and arterial stiffness with parallel antioxidant effect in subjects with MetS treated with n-3 PUFA in dose 2.4g daily.
EAS-0911. ASSESSMENT OF THE RELATIONSHIP BETWEEN A NARROW FRAGMENTED QRS COMPLEX AND CORONARY SLOW FLOW
EAS-0932. EFFECTS OF HYPOLIPIDEMC THERAPY ON THE ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME
H.A. Cakmak 1, *, S. Aslan 2, M. Gul 2, O. Celik 2, A.K. Kalkan 2, D. Ozturk 2, O. Tasbulak 2, M.H. Satilmisoglu 2. 1 Cardiology, Rize Kackar Government Hospital, Rize, Turkey; 2 Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey
L. Merkovska*, L. Jedlickova, L. Jackova, J.A.N. Fedacko, D. Pella. 1st Department of Internal Medicine Louis Pasteur University Hospital, University hospital of Louis Pasteur, Kosice, Slovakia
* Corresponding author. Background: The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to the distal branch of a coronary artery in the absence of obstructive coronary artery disease (CAD). A narrow fragmented QRS (fQRS) has recently been reported as a significant predictor of sudden cardiac death in patients with idiopathic dilated cardiomyopathy. The present study aimed to investigate the relationship between a narrow fQRS on the admission electrocardiogram (ECG) and CSF on coronary angiography. Methods: A total of 112 patients with angiographically proven coronary slow flow and 53 control subjects with normal coronary flow were included in the study. Coronary flow was quantified by thrombolysis in myocardial infarction (TIMI) frame count (TFC). The patients were divided into two groups according to the presence or absence of a narrow fQRS complex on the admission ECG. Results: The incidence of narrow fQRS was significantly higher in the CSF group compared to controls (P ¼ 0.007). Moreover, the extent of CSF was significantly greater in the fQRS(þ) group compared to the non-fragmented group (P < 0.001). A significant correlation was also found between mean TFC values and fQRS (r ¼ 0.383,P < 0.001). On multivariate analysis, only CSF (odds ratio: 2.66, 95% confidence interval: 1.075e6.62, P ¼ 0.03) was a significant independent predictor for narrow fQRS, after adjustment for other parameters. Conclusion: The narrow fQRS is a simple, inexpensive, and readily available noninvasive ECG parameter that may be a new potential indicator of myocardial damage in patients with CSF. EAS-0917. OMEGA-3 PUFAS IMPROVED ENDOTHELIAL DYSFUNCTION AND ARTERIAL STIFFNESS WITH A PARALLEL ANTIOXIDANT EFFECT IN PATIENTS WITH METABOLIC SYNDROME L. Jackova*, L. Jedlickova, L. Merkovska, J. Fedacko, T. Lopuchovsky, D. Pella. 1st Department of Internal Medicine Faculty of Medicine Pavol Jozef Safarik University, University hospital of Louis Pasteur, Kosice, Slovakia
* Corresponding author. Aim: The aim of the our study was to compare the efficiency and impact of hypolipidemics (statin monotherapy and combination therapy with statin) on the endothelial function in a select group of people. Methods: Total of 74 patients with MetS were enrolled. We evaluated ED and lipid profile in subjects before and after three-month treatment in 3 groups (statin monotherapy, combination therapy with statin e statin þfibrates, statin þ n3-PUFA). Using the Endo-PAT2000 device.RHI decreases with dysfunction and a threshold <1.67 is considered abnormal. The EndoPAT-derived augmentation index (AI) provides a measure of arterial stiffness by considering the timing and magnitude of this wave reflection in the digital pulse. AI represents the relative contribution of augmented pressure due to wave reflection to the pressure wave form. Laboratory markers of ED e GPX were taken also.Lipid profile were analysed by using rountine lab. Results: LDL cholesterol was(2,22 ± 0,80 vs 3,22 ± 1,19, p < 0,05), TAG ( 1,61 ± 1,04 vs 2,42 ± 2,19, p < 0,05), HDL(p < 0,05) The measured RHI for patients with MS before and after treatment in all treatment groups was 1,75 ± 0,54 versus 2,02 ± 0,71 (p ¼ 0,0001). Augmentation index was 15,91 ± 18,85 vs 11,25 ± 14,43 (p ¼ 0,0001).GPX plasma levels was also significant increased after treatment (48,53 ± 10,52 vs 45,61 ± 10,50, p < 0,05). Conclusion: We have observated improved ED and lipid profil with parallel antioxidant effect in subjects with MetS treated with statin monotherapy and combination therapy with statin.
EAS-0949. COMPARATIVE STUDY: ARTERIAL STIFFNESS RELATED BETWEEN TYPE 1 AND TYPE 2 DIABETIC PATIENTS
FACTORS
S. Enkhjargal 1, *, S. Sonomtseren 2, U. Shuumarjav 1. 1 Department of pathology, Mongolian national university of medical science, Ulaanbaatar, Mongolia; 2 Department of endocrinology, Mongolian national university of medical science, Ulaanbaatar, Mongolia
* Corresponding author.
Abstracts / Atherosclerosis 241 (2015) e149ee229
Objective: The aim of the study is to evaluate the correlation of vascular stiffness and contributed risk factors among the people with Type 1 DM (T1DM) and Type 2 DM (T2DM). Methods: We used hospital-based onetime cross-sectional study for 79 DM patients aged 18-55 (mean age 40.99 ± 10.81) who were involved. Materials are collected by questionnaire, physical examination, blood analyzes and vascular stiffness is measured by VaSera VS-1000 device. Results: All participants are divided into two groups T1DM (n ¼ 28) and T2DM (n¼52). Using simple correlation analysis cardio-ankle vascular index (CAVI) has positive statistical correlation with age (r¼0.664, p¼0.001), visceral fat (r¼0.391, p¼0.002), systolic pressure (r¼0.402, p¼0.002), diastolic pressure (r¼0.433, p¼0.001) HbA1C (p¼0.003) and hemoglobin (p ¼ 0.03) respectively. Using Independent-samples T-test analysis the age (p ¼ 0.001), BMI (p ¼ 0.001), visceral fat (p ¼ 0.001) and CAVI (p ¼ 0.001) was statistically increased in T2DM patients than T1DM patients. In T1DM group the CAVI has positive statistical correlation with age(r¼0.43, p¼0.03), HbA1C (p¼0.003), hemoglobin (p¼0.01) and in T2DM group CAVI has positive statistical correlation with age (r¼0.61, p¼0.001), systolic and diastolic pressure (p¼0.001) respectively. Conclusion: However age, abdominal obesity and hypertension are the risk factor of vascular stiffness in patients with DM, its more necessary to control the HbA1C in T1DM patients and hypertension in T2DM patients to prevent from chronic vascular complication. EAS-0960. ARTERIAL STIFFNESS AND LEFT ATRIAL VOLUME HYPERTENSIVE AND NORMOTENSIVE SUBJECTS
INDEX
IN
M. Rojek*, M. Rajzer, D. Czarnecka. I Department of Cardiology Interventional Electrocardiology and Hypertension, Medical College Jagiellonian University, Cracow, Poland
* Corresponding author.
e157
S. Aurelian 1, *, A. Zamfirescu 1, M. Ghinescu 2, J. Aurelian 3, A. Capisizu 4. 1 Geriatric, Hospital “Sf Luca”, Bucharest, Romania; 2 Family Medicine, University Titu Maiorescu, Bucharest, Romania; 3 Social Medicine, University of Medicine “Carol Davila”, Bucharest, Romania; 4 Geriatric Medicine, University of Medicine “Carol Davila” Hospital “Sf. Luca”, Bucharest, Romania
* Corresponding author. Aim: Many researches with controversial results have studied the association between the number of components of metabolic syndrome and severity of subclinical atherosclerosis expressed by the pulse wave velocity(PWV). Objective: We evaluated arterial stiffness in overweight and obese subjects by studying the aortic augmentation index(AixAo), PWVao and carotid intima-media thickness(IMT). Method: Observational six month study included 145 patients; the mean age 72.85±10.07y. For PWV measurement we used a noninvasive method, an oscillometric device (Arteriograph, TensioMed Ltd.). High-resolution Bmode carotid ultrasonography was performed. Results: Over 1/3 of patients with metabolic syndrome were present and uncontrolled hypertension. Statistically is significant correlation(90%) between decrease LDL and decrease arterial stiffness(r¼-0.160, p¼0.059). Mean value of HDL-C was 51.52±15.35mg/dl, an increase of 40% from the target value. Is significant correlation between endothelial dysfunction Aixao and heart rate(Pearson r¼- 0.198, p¼0.017). It shows a high value of IMT(mean1.17±0.3 mm) among diabetics compared to non-diabetic group(p<0.001). Conclusion: The prevalence of obesity with age is high especially in people over 75 years. The rate of patient with high cardio-vascular risk among the elderly presenting metabolic syndrome is higher but does not show an increase proportional to the number of components that define this syndrome.
Objective: comparison of the relationship between arterial sitfness indices and left atrial volume index (LAVI) in hypertensive and normotensive subjects. Material and methods: study and control group were randomly recruited among Morawica town inhabitants (Poland). Study group (AH)- 41 treatment-naive hypertnesives, stage 1. or 2. (20 men and 21 women). Control group (NonAH)- 60 normotensives (32 men and 28 women). Anthropometric and demographic data were collected via questionnaire. Clinical examination included: standard office blood pressure measurements using Omron M5-I; arterial siffness measurements: carotid-femoral pulse wave velocity (PWV) and central blood pressure (cSBP, cDBP, cPP) using Shygmocor®; echocardiographic left atrial volume determination (LAV) by Simpson method using VIVID-7 GE followed by LAVI calculation (LAVI ¼ LAV/body surface area). Results: AH was older (56,9 vs 50,2 yrs, p¼0,0002) exhibiting higher BMI (28,2 vs 26,3 kg/m2, p¼0,03) and higher office SBP (149,5 vs 138,6 mmHg, p¼0,04) and DBP (91,1 vs 85,7 mmHg, p¼0,02) than NonAH. PWV did not differ among groups. cSBP (136,3 vs 126,8 mmHg, p¼0,02) and cDBP (90,8 vs 84,9 mmHg, p¼0,01) were higher in AH. LAVI was significantly higher in AH than in NonAH (27,8 vs 24,3 ml/m2, p¼0,003). In AH, LAVI correlated positively only with cSBP (r¼0,33, p¼0,04). In NonAH, LAVI correlated positively with age (r¼ 0,27, p¼0,03), BMI (r¼0,39, p¼0,02) and cSBP (r¼0,27, p¼04). Conclusions: Hypertensive subjects represent higher values of LAVI. In this group it depends mainly on central hemodynamics, while in the group of normotensives LAVI is additionally determined by age and body mass index.
Imaging EAS-0016. DETERMINATION OF HEMODYNAMIC FEATURES IN ELDERLY PATIENTS WITH METABOLIC SYNDROME Ă
Characteristics
Coefficient of correlation
p
Aixao with HR PWVao with LDL SBPao with CKD
0.198 0.160 0.231
0.017 0.059 0.005