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Comparison of morphological and biochemical analyses made on fine needle aspiration biopsies from patients with carcinoma of the prostate (CaP)
74s
B-058 smvmy ~~~~0~ IN THE RI!XTFOLM%UP OF THE COI@Li%% ~RROG~ BLOCKADE 1% PROSTATIC CARCINOMA. Navaxro M.A., *Agui16 F., GuaxdiciM., Bonnin M.R., Rose1 Per Hormone Unit (Bioohemistry Service), Urology Service*. Hospital de Bellvitge, Barcelona, Spain. The measurement of salivary testosterone (SLT) in patients with prostatic caroinoma after medical or surgical orohieotomy is a good tool to evaluate the andxogenioity of these patients in a long-term follow-up. The aplioability of this parameter for the next monitoring of the complete androgen bloookade need to be investigated. We have studied 63 serum testosterone (ST) a,& SLT samples by RIB method from 4 patients with prostatic oaroinonw at 2 hours intervals d?y) and Leuprolide (1 mg,/dtyr). ST for 48 hotis after the administration of Flutamide (450 values were: 355’224; 3892 173; 277% 176; 61% 102 ng,/dl Y 2%~) in eaoh patient respeotively, by the same way SLT values were 5,6*2.4; 5.4’ 2.4; 4.72 1.8; 3*1.4 ndiil. Those levels were significative differents (p
groups. B-060 ~pwlsonoflRmphol~IcslsndbiodteatwiarrslyssslaadewtfinenaedleaspirationbrapslesfrMR patientswith esrclmms of the prostate(Cap). Hasenson M., Lundh 6.. Stege R., Carlstrbm K. and Pousette A. Karolinska Institutet, Huddinge University Hospital, Sweden. The aim of this stu&q was to investigate a paxjible relationship between the tissue content (per ug of DNA) of PAP and PSA on one hand and cytological findings on the other. Fine needle biopsies from 55 patients with untreated CaP (Tz-4; Gl -3; MD_ 1) were used. Three biopsies from the came tumour area were pooled for Cytological and biochemical analysis. PAP and PSA were determined with commercial RIA kits. DNA was determined uslng Hoechst 33258 stain. Cytological grading was performed according to Esposti. DNA, PAP and PSA were detected in all specimens. Significant associations ( Kruskal-Wallis-test) were found between PAP/DNA- and PSV’DNA-ratios end tumour grading (figure). Determination of PAP end PSA in fine needle biopsy aspirates 5
B-058 smvmy ~~~~0~ IN THE RI!XTFOLM%UP OF THE COI@Li%% ~RROG~ BLOCKADE 1% PROSTATIC CARCINOMA. Navaxro M.A., *Agui16 F., GuaxdiciM., Bonnin M.R., Rose1 Per Hormone Unit (Bioohemistry Service), Urology Service*. Hospital de Bellvitge, Barcelona, Spain. The measurement of salivary testosterone (SLT) in patients with prostatic caroinoma after medical or surgical orohieotomy is a good tool to evaluate the andxogenioity of these patients in a long-term follow-up. The aplioability of this parameter for the next monitoring of the complete androgen bloookade need to be investigated. We have studied 63 serum testosterone (ST) a,& SLT samples by RIB method from 4 patients with prostatic oaroinonw at 2 hours intervals d?y) and Leuprolide (1 mg,/dtyr). ST for 48 hotis after the administration of Flutamide (450 values were: 355’224; 3892 173; 277% 176; 61% 102 ng,/dl Y 2%~) in eaoh patient respeotively, by the same way SLT values were 5,6*2.4; 5.4’ 2.4; 4.72 1.8; 3*1.4 ndiil. Those levels were significative differents (p
groups. B-060 ~pwlsonoflRmphol~IcslsndbiodteatwiarrslyssslaadewtfinenaedleaspirationbrapslesfrMR patientswith esrclmms of the prostate(Cap). Hasenson M., Lundh 6.. Stege R., Carlstrbm K. and Pousette A. Karolinska Institutet, Huddinge University Hospital, Sweden. The aim of this stu&q was to investigate a paxjible relationship between the tissue content (per ug of DNA) of PAP and PSA on one hand and cytological findings on the other. Fine needle biopsies from 55 patients with untreated CaP (Tz-4; Gl -3; MD_ 1) were used. Three biopsies from the came tumour area were pooled for Cytological and biochemical analysis. PAP and PSA were determined with commercial RIA kits. DNA was determined uslng Hoechst 33258 stain. Cytological grading was performed according to Esposti. DNA, PAP and PSA were detected in all specimens. Significant associations ( Kruskal-Wallis-test) were found between PAP/DNA- and PSV’DNA-ratios end tumour grading (figure). Determination of PAP end PSA in fine needle biopsy aspirates 5