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Comparison of the analgesic effects of intravenous nalbuphine and pentazocine in patients with postoperative pain
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studied in young and elderly women. Using the methodology of Sensory Decision Theory, ability to discriminate between suprathreshold shocks (d’) and response bias were also assessed. No difference in threshold was observed between the young and elderly groups but the elderly women were poorer at discriminating between suprathreshold shocks than the young women. These results were interpreted to reflect the integrity of high-threshold dental pulp afferents in the elderly and a central nervous system deficit on the part of the elderly for discriminating between such shocks. Significant age differences in response bias were also observed. Elderly subjects were biased against reporting shock as very faint pain compared to the young subjects and they restricted the range of their criteria across the 6-point rating scale. Comparison of the analgesic effects of intravenous nalbuphine and pentazotine in patients with postoperative pain. - T. Tammisto and I. Tigerstedt, Acta anaesth. scand., 21 (1977) 390-394 One hundred patients, who were in pain during the immediate postoperative period after upper abdominal operations, were included in this doubleblind, between-patient, two-dose study. During NzO+halothane relaxant anesthesia no analgesics were given. The patients received 0.07 mg/kg or 0.14 mg/kg of nalbuphine or 0.3 mg/kg or 0.6 mg/kg of pentazocine by intravenous injection. Pain and side effects were assessed for 4 h after administration of the test drug, or until the pain returned to the pre-injection level, when a conventional analgesic was given. The onset of pain relief was similar and the peak effect occurred about 0.5 h after the injection of both drugs. On a milligram basis, nalbuphine seemed to be about 3 times as potent as pentazocine. The duration of action seemed to be slightly longer after nalbuphine, but 2.5 h after the injection the pain had returned to preinjection level in two-thirds of tlz patients, even after the higher doses of both drugs. Except for sleepiness, there were few side effects and they were similar after both drugs. No psychotomimetic effects were observed. PSYCHOLOGY
Transcutaneous electrical stimulation: a double-blind trial of its efficacy for pain. - G. Thorsteinsson, WI. Stonnington, G.K. Stillwell and L.R. Elveback, Arch. phys. Med., 58 (1977) 8-13 A double-blind trial was carried out using a stimulator and a placebo device on patients who had chronic pain to determine the effectiveness of transcutaneous electrical stimulation in controlling pain. Ninety-three patients were studied, and 83 of these completed the Minnesota ?Aulti.phasic Personality Inventory (MMPI). Thirty-three patients had low-back pain and 24 had neuropathies. The stimulator was more effective than the placebo during treatment when used over the center of pain (P < 0.005) or over an unrelated nerve trunk (P < 0.01) and after treatment over the center of pain (P <<0.05). The stimulator was significantly more effective than the placebo in neuropathies when stimulating over the related nerve trunk (PC 0.005),
studied in young and elderly women. Using the methodology of Sensory Decision Theory, ability to discriminate between suprathreshold shocks (d’) and response bias were also assessed. No difference in threshold was observed between the young and elderly groups but the elderly women were poorer at discriminating between suprathreshold shocks than the young women. These results were interpreted to reflect the integrity of high-threshold dental pulp afferents in the elderly and a central nervous system deficit on the part of the elderly for discriminating between such shocks. Significant age differences in response bias were also observed. Elderly subjects were biased against reporting shock as very faint pain compared to the young subjects and they restricted the range of their criteria across the 6-point rating scale. Comparison of the analgesic effects of intravenous nalbuphine and pentazotine in patients with postoperative pain. - T. Tammisto and I. Tigerstedt, Acta anaesth. scand., 21 (1977) 390-394 One hundred patients, who were in pain during the immediate postoperative period after upper abdominal operations, were included in this doubleblind, between-patient, two-dose study. During NzO+halothane relaxant anesthesia no analgesics were given. The patients received 0.07 mg/kg or 0.14 mg/kg of nalbuphine or 0.3 mg/kg or 0.6 mg/kg of pentazocine by intravenous injection. Pain and side effects were assessed for 4 h after administration of the test drug, or until the pain returned to the pre-injection level, when a conventional analgesic was given. The onset of pain relief was similar and the peak effect occurred about 0.5 h after the injection of both drugs. On a milligram basis, nalbuphine seemed to be about 3 times as potent as pentazocine. The duration of action seemed to be slightly longer after nalbuphine, but 2.5 h after the injection the pain had returned to preinjection level in two-thirds of tlz patients, even after the higher doses of both drugs. Except for sleepiness, there were few side effects and they were similar after both drugs. No psychotomimetic effects were observed. PSYCHOLOGY
Transcutaneous electrical stimulation: a double-blind trial of its efficacy for pain. - G. Thorsteinsson, WI. Stonnington, G.K. Stillwell and L.R. Elveback, Arch. phys. Med., 58 (1977) 8-13 A double-blind trial was carried out using a stimulator and a placebo device on patients who had chronic pain to determine the effectiveness of transcutaneous electrical stimulation in controlling pain. Ninety-three patients were studied, and 83 of these completed the Minnesota ?Aulti.phasic Personality Inventory (MMPI). Thirty-three patients had low-back pain and 24 had neuropathies. The stimulator was more effective than the placebo during treatment when used over the center of pain (P < 0.005) or over an unrelated nerve trunk (P < 0.01) and after treatment over the center of pain (P <<0.05). The stimulator was significantly more effective than the placebo in neuropathies when stimulating over the related nerve trunk (PC 0.005),