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Complications following temporomandibular joint replacement: a 10 year retrospective review
Oral Presentation Findings: As a result, the engineered recombinant Kazecin shows specific inactivating ribosome, inhibition translation, and being degraded in vitro and in vivo. More importantly, Kazecin causes an effective inhibition of the growth of SAS-induced xenograft tumors in nude mice. Such a therapeutic effect is also supported by histological data showing that tumor tissue in direct contact with Kazecin has undergone through different phases of apoptotic progression, whereas, tumor tissue not in direct contact with the drug remains normal. Thus, the cytotoxic effect of the drug is constrained, as our original envisaged, and its spread limited. Conclusions: Overall, the concept of ‘Kamikaze ribotoxin’ provides an alternative tactic to immunotoxin therapy for the design of therapeutic protein drugs.
e105
http://dx.doi.org/10.1016/j.ijom.2015.08.678
prevent post-operative infection. The use of antimicrobials has been proven to be effective in the prevention of infection in clean–contaminated reconstruction cases, reduce post-operative morbidity and reduce the length of hospital stay. However there is not yet a consensus on what antimicrobial agents are most appropriate or the duration of these regimes. With evidence suggesting prolonged antibiotic schedules are increasing the risk of antibiotic resistance, which may in turn be predisposing these patients to infection, this review looks at prescribing patterns across the United Kingdom and determines rationale behind this practice. The purpose of this review was to investigate the differences in prescribing practices between maxillofacial oncology centres, with the aim of facilitating continuity of care and working towards a national consensus on best practice for prophylactic antibiotic regimes in head and neck oncology free tissue transfer cases. A literature review was carried out to determine if any guidelines on antibiotic prescribing have been proposed. Information about prescribing practices was gathered using a questionnaire which was sent to maxillofacial units within the UK. This information included antibiotic type, dose, mode of delivery, duration and whether any additional risk factors impacted on these choices. Whether these guidelines were approved by the microbiology team within the hospital was also recorded. The results of this review will be presented along with how this correlates to guidance from our microbiology colleagues.
An acute rapidly developing plunging ranula
http://dx.doi.org/10.1016/j.ijom.2015.08.680
References Stirpe, F., & Battelli, M. G. (2006). Ribosome-inactivating proteins: progress and problems. Cell Mol Life Sci, 63, 1850–1866. Endo, Y., & Wool, I. G. (1982). The site of action of alpha-sarcin on eukaryotic ribosomes The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid. J Biol Chem, 257, 9054–9060.
G. Logan ∗ , O. Sheikh, D. Komath, B. Visavadia Northwick Park Hospital, London, UK Objective: The presentation of an acute rapidly developing plunging ranula is rare. It typically develops ingradual and progressive fashion. This report looks at a rare case of a plunging ranula presenting acutely in a 1 year old child. The condition progressed rapidly and required emergency surgery. Case report: An 11 year old male attended accident and emergency with a rapidly re-enlarged floor of mouth swelling, following and an attempted decompression earlier in the day within the outpatients department. The patient was unable to close their mouth, due to the size of the lesion, with the tongue pushed upwards and deviating to the opposing side of the mouth. Computerise tomography confirmed the diagnosis of a plunging ranula of 3.8 cm by 2.5 cm. The child was taken to theatre for decompression and excision of the offending sublingual gland. Two months following surgery there is no evidence of recurrence. Conclusion: This is an example of a rapidly progressing ranula and highlights the need to proceed with caution while decompressing the lesion prior to definitive excision of the offending gland. To the best of our knowledge this is only the second case of a plunging ranula progressing acutely and rapidly requiring emergency surgery. http://dx.doi.org/10.1016/j.ijom.2015.08.679 A comparison of prophylactic antibiotic regimes for clean–contaminated free flap tissue transfer for oncology patients within UK maxillofacial oncology units A. Loughlin ∗ , E. Gilks, A. Al-Rikabi, C. Thomas University Hospital Wales, Cardiff, United Kingdom Prophylactic antibiotics are commonly prescribed in free tissue transfer procedures in head and neck oncology to
Complications following temporomandibular joint replacement: a 10 year retrospective review W.S. McKenzie, P.J. Louis ∗ University of Alabama at Birmingham, Birmingham, USA Objective: The aim of this study is to review the complications associated with TMJ total joint replacement (TJR) surgery. Methods: Retrospective review of 178 joint replacements performed on 106 patients at the University of Alabama at Birmingham from 2000 to 2010 was completed. IRB approval for the review was obtained. Data regarding gender, past medical history, prosthesis manufacturer, nature of the complication, and need for additional procedures was obtained from the medical records. Findings: Eight joints (4.5%) developed infection of the prosthesis, all requiring removal despite antibiotic therapy. Forty-seven patients (44.3%) had post-operative facial nerve dysfunction of the temporal or marginal branches, however, only nine (8.5%) were permanent. Seven patients (6.6%) required revision of the prosthesis due to either malocclusion of condylar prosthesis dislocation. Six joints (3.5%) developed heterotopic bone requiring debridement due to pain and trismus. There were no intra-operative or post-operative vascular events. Conclusions: This study provides insight into the incidence, management, and outcomes of temporomandibular joint replacement complications over a 10-year period. Nerve injury was the most common complication followed by hardware revision due to malocclusion, infection, and heterotopic bone. http://dx.doi.org/10.1016/j.ijom.2015.08.681
e105
http://dx.doi.org/10.1016/j.ijom.2015.08.678
prevent post-operative infection. The use of antimicrobials has been proven to be effective in the prevention of infection in clean–contaminated reconstruction cases, reduce post-operative morbidity and reduce the length of hospital stay. However there is not yet a consensus on what antimicrobial agents are most appropriate or the duration of these regimes. With evidence suggesting prolonged antibiotic schedules are increasing the risk of antibiotic resistance, which may in turn be predisposing these patients to infection, this review looks at prescribing patterns across the United Kingdom and determines rationale behind this practice. The purpose of this review was to investigate the differences in prescribing practices between maxillofacial oncology centres, with the aim of facilitating continuity of care and working towards a national consensus on best practice for prophylactic antibiotic regimes in head and neck oncology free tissue transfer cases. A literature review was carried out to determine if any guidelines on antibiotic prescribing have been proposed. Information about prescribing practices was gathered using a questionnaire which was sent to maxillofacial units within the UK. This information included antibiotic type, dose, mode of delivery, duration and whether any additional risk factors impacted on these choices. Whether these guidelines were approved by the microbiology team within the hospital was also recorded. The results of this review will be presented along with how this correlates to guidance from our microbiology colleagues.
An acute rapidly developing plunging ranula
http://dx.doi.org/10.1016/j.ijom.2015.08.680
References Stirpe, F., & Battelli, M. G. (2006). Ribosome-inactivating proteins: progress and problems. Cell Mol Life Sci, 63, 1850–1866. Endo, Y., & Wool, I. G. (1982). The site of action of alpha-sarcin on eukaryotic ribosomes The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid. J Biol Chem, 257, 9054–9060.
G. Logan ∗ , O. Sheikh, D. Komath, B. Visavadia Northwick Park Hospital, London, UK Objective: The presentation of an acute rapidly developing plunging ranula is rare. It typically develops ingradual and progressive fashion. This report looks at a rare case of a plunging ranula presenting acutely in a 1 year old child. The condition progressed rapidly and required emergency surgery. Case report: An 11 year old male attended accident and emergency with a rapidly re-enlarged floor of mouth swelling, following and an attempted decompression earlier in the day within the outpatients department. The patient was unable to close their mouth, due to the size of the lesion, with the tongue pushed upwards and deviating to the opposing side of the mouth. Computerise tomography confirmed the diagnosis of a plunging ranula of 3.8 cm by 2.5 cm. The child was taken to theatre for decompression and excision of the offending sublingual gland. Two months following surgery there is no evidence of recurrence. Conclusion: This is an example of a rapidly progressing ranula and highlights the need to proceed with caution while decompressing the lesion prior to definitive excision of the offending gland. To the best of our knowledge this is only the second case of a plunging ranula progressing acutely and rapidly requiring emergency surgery. http://dx.doi.org/10.1016/j.ijom.2015.08.679 A comparison of prophylactic antibiotic regimes for clean–contaminated free flap tissue transfer for oncology patients within UK maxillofacial oncology units A. Loughlin ∗ , E. Gilks, A. Al-Rikabi, C. Thomas University Hospital Wales, Cardiff, United Kingdom Prophylactic antibiotics are commonly prescribed in free tissue transfer procedures in head and neck oncology to
Complications following temporomandibular joint replacement: a 10 year retrospective review W.S. McKenzie, P.J. Louis ∗ University of Alabama at Birmingham, Birmingham, USA Objective: The aim of this study is to review the complications associated with TMJ total joint replacement (TJR) surgery. Methods: Retrospective review of 178 joint replacements performed on 106 patients at the University of Alabama at Birmingham from 2000 to 2010 was completed. IRB approval for the review was obtained. Data regarding gender, past medical history, prosthesis manufacturer, nature of the complication, and need for additional procedures was obtained from the medical records. Findings: Eight joints (4.5%) developed infection of the prosthesis, all requiring removal despite antibiotic therapy. Forty-seven patients (44.3%) had post-operative facial nerve dysfunction of the temporal or marginal branches, however, only nine (8.5%) were permanent. Seven patients (6.6%) required revision of the prosthesis due to either malocclusion of condylar prosthesis dislocation. Six joints (3.5%) developed heterotopic bone requiring debridement due to pain and trismus. There were no intra-operative or post-operative vascular events. Conclusions: This study provides insight into the incidence, management, and outcomes of temporomandibular joint replacement complications over a 10-year period. Nerve injury was the most common complication followed by hardware revision due to malocclusion, infection, and heterotopic bone. http://dx.doi.org/10.1016/j.ijom.2015.08.681