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Computer tomographic and endocrine findings in schizophrenic patients with hyponatremia
86A
BIOL PSYCHIATRY 1991:29:43A- 185A
9a
Drug Abuse
THE HUMAN PITUITARY GLAND: AGE AND GENDER DIFFERENCES Murali Doraiswamy, M.D., ,l. Potts, M.D., Mustafa Husain, M.D. Scott Lurie, M.D., Gary Figiel, M.D., David Axelson, Patricio Escalona, M.D., C. NA, M.D., K. Rayasam, M.D., Orest Boyko, M.D., William McDonaI~, M.D., Everett Ellinwood, M.D., K. Ranga Kdshnan, M.D. Duke Universi~., Medical Center, Durham, NC 27710. MR images at i .5 Tesla were used to study the effects of age and gender on pituitary size and shape in a
sample of 71 normal volunteers (40 ,.,,omen) aged 21 to 82 years. For all subjects age was negatively correlated with pituitary height (r = - 0 .4 3 , p < 0.0002) and cross-sectional area. Visual examination of the gland revealed that a convex upper pituitary margin was significantly more common in females (p = 0.0015) and younger subjects (p = 0.009). This study provides normative data, which will in turn facilitate evaluation of pituitary morphology in psychiatric disorders with endocrine dysfunction.
9s COMPUTER TOMOGRAPHIC AND ENDOCRINE FINDINGS IN SCHIZOPHRENIC PATIE~S WITH HYPONATREMIA William B. Lawson, M.D., Ph.D., Darrell Kirch, M.D., Richard Shelton, M.D., David Daniels, M.D., Andrei Lager, M.D., Gary Robertson, M.D. Vanderbilt University Medical Center, Nashville, TN 37232. Hyponatremia is associated with significant morbidity and mortality in the mentally ill. The etiology remains unknown. We investigated computer tomographic correlates of the head in 18 DSM-m-R positive schizophrenics. Hyponatremic patients (serum sodium < 135 mEq/L) were more likely to show prefrontal atrophy (PFA) (5/5 versus 6/13, Fishers p < 0.05) or increased ventricular to brain ratio (VBR) (3/9 versus 0/l I). These patients were also given 30 mg/kg water loads, with plasma osmolality and vasopressin measured hourly. Patients with either PFA or VBR showed significantly lower plasma osmolalities. Vasopressin was measured by radioimmunoassay. The osmolality with measurable vasopressin levels was significantly lower for patients with PFA. No significant differences were seen on any of these measat'es for general atrophy of the brain, or third ventricle size.
DRUG ABUSE T h u r s d a y , M a y 9, 1 : 0 0 - 6 : 0 0 PM
96
Ponchartrain A
CSF NEUROPEPTIDE Y AND GROWTH HORMONE RELEASING HORMONE IN ALCOHOLICS AND NORMAL CONTROLS Alec Roy, M.B., Wade Berrettini, M.D., Ph.D., Judith De.long, Ph.D., Bryon Adinoff, M.D., Bernard Ravitz, M.D., Markku Linnoila, M.D., Ph.D. National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health (W.B.), Bethesda, MD; VA Medical Center and Medical Uniw.,rsity of South Carolina (BA), Charleston SC; and Hillside Hospital, Glen Oaks, NY 11004.
BIOL PSYCHIATRY 1991:29:43A- 185A
9a
Drug Abuse
THE HUMAN PITUITARY GLAND: AGE AND GENDER DIFFERENCES Murali Doraiswamy, M.D., ,l. Potts, M.D., Mustafa Husain, M.D. Scott Lurie, M.D., Gary Figiel, M.D., David Axelson, Patricio Escalona, M.D., C. NA, M.D., K. Rayasam, M.D., Orest Boyko, M.D., William McDonaI~, M.D., Everett Ellinwood, M.D., K. Ranga Kdshnan, M.D. Duke Universi~., Medical Center, Durham, NC 27710. MR images at i .5 Tesla were used to study the effects of age and gender on pituitary size and shape in a
sample of 71 normal volunteers (40 ,.,,omen) aged 21 to 82 years. For all subjects age was negatively correlated with pituitary height (r = - 0 .4 3 , p < 0.0002) and cross-sectional area. Visual examination of the gland revealed that a convex upper pituitary margin was significantly more common in females (p = 0.0015) and younger subjects (p = 0.009). This study provides normative data, which will in turn facilitate evaluation of pituitary morphology in psychiatric disorders with endocrine dysfunction.
9s COMPUTER TOMOGRAPHIC AND ENDOCRINE FINDINGS IN SCHIZOPHRENIC PATIE~S WITH HYPONATREMIA William B. Lawson, M.D., Ph.D., Darrell Kirch, M.D., Richard Shelton, M.D., David Daniels, M.D., Andrei Lager, M.D., Gary Robertson, M.D. Vanderbilt University Medical Center, Nashville, TN 37232. Hyponatremia is associated with significant morbidity and mortality in the mentally ill. The etiology remains unknown. We investigated computer tomographic correlates of the head in 18 DSM-m-R positive schizophrenics. Hyponatremic patients (serum sodium < 135 mEq/L) were more likely to show prefrontal atrophy (PFA) (5/5 versus 6/13, Fishers p < 0.05) or increased ventricular to brain ratio (VBR) (3/9 versus 0/l I). These patients were also given 30 mg/kg water loads, with plasma osmolality and vasopressin measured hourly. Patients with either PFA or VBR showed significantly lower plasma osmolalities. Vasopressin was measured by radioimmunoassay. The osmolality with measurable vasopressin levels was significantly lower for patients with PFA. No significant differences were seen on any of these measat'es for general atrophy of the brain, or third ventricle size.
DRUG ABUSE T h u r s d a y , M a y 9, 1 : 0 0 - 6 : 0 0 PM
96
Ponchartrain A
CSF NEUROPEPTIDE Y AND GROWTH HORMONE RELEASING HORMONE IN ALCOHOLICS AND NORMAL CONTROLS Alec Roy, M.B., Wade Berrettini, M.D., Ph.D., Judith De.long, Ph.D., Bryon Adinoff, M.D., Bernard Ravitz, M.D., Markku Linnoila, M.D., Ph.D. National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health (W.B.), Bethesda, MD; VA Medical Center and Medical Uniw.,rsity of South Carolina (BA), Charleston SC; and Hillside Hospital, Glen Oaks, NY 11004.